Lyophilization, also known as freeze-drying, is a critical technology for the food industry, pharmaceuticals and biotech. However, the process, which removes water from products at low temperatures and low pressure, is expensive, time-consuming and has remained unchanged for the last 50 years.
There is a great unmet need for improved preclinical models, with functional immunity, to drive...
Exchanging Out TFA from Synthetic Peptide Preparations: Why it’s Important and How to do it EffectivelyNovember 4, 2015 9:02 am | by Ivona Strug and Timothy Nadler, EMD Millipore Corporation | Comments
In this case study, we show how Trifluoroacetate (TFA) salts hamper peptide analysis by FTIR...
Early metastatic breast cancer cells are, strikingly, far more like stem cells than other tumor...
For an intense global program called 1000 Girls-1000 Futures, the NYAS recently sought 60 women willing to devote a full year to mentees from Mexico alone. NYAS head Ellis Rubenstein told the presser Mexican supporters were “terrified” no one would step up. But 170 woman researchers—and counting— stepped up worldwide.
ELISA – Enzyme-Linked Immunosorbent Assay – is a commonly used biochemical technique for the evaluation of an antigen or antibody in a sample. This technique is used in a wide range of applications, including: clinical diagnostics, plant pathology, the detection of food allergens and drug screening.
Understanding drug safety is a tricky thing. The use of direct-to-patient (or consumer) registry data is a new approach, and one that is quite different from the highly controlled world of clinical trials. Some worry about whether patients will be accurate and honest reporters. Will these patients be reliable, and will they provide clinically generalizable information?
Like a bad teenager, in 95 percent of all amyotrophic lateral sclerosis (ALS) cases, a protein called TDP-43 leaves its home— the nucleus of motor neuron cells—to congregate, in suspect fashion, in the cytoplasm. In a study published in Science this summer, the Johns Hopkins University (JHU) team of pathologist Phillip Wong, Ph.D., offered new insight into this molecular rebellion.
Embryonic stem (ES) cell-like stem cells made from adult cells—and morphed into eye cells—are not rejected by the immune system, according to “humanized mouse” data in Cell Stem Cell.
The technique of Surface Plasmon Resonance (SPR), allows scientists to monitor biomolecular binding interactions label-free, in real-time and using automation. For those of you thinking about, or planning on, using SPR, this article offers insights on how to use the technique successfully, gained from working with this technique for a number of years.
The National Institutes of Health has awarded 13 grants for a landmark, multi-site study that will follow 10,000 children over 10 years to observe how substance use affects the brain, and the findings could help guide important public policy decisions.
Young female and male Johns Hopkins University (JHU) Medical School M.D.’s and Ph.D.’s receive equal numbers of key National Institutes of Health (NIH) grants, says a recent Journal of Women’s Health study.
The agency wants more insight into the company's data and marketing materials supporting the effectiveness of their product.
The wave of new and emerging technologies is significantly impacting the data capabilities and utilization of data in life sciences and drug development research. With the increasing public popularity of wearable devices and mobile health applications, coupled with growth in the use of social media, more data streams are available to researchers looking to extract meaningful information.
Storing health data in the cloud is predicted to be an industry worth $1 billion by 2018.
Doug Hilton, Ph.D., is head of the Walter and Eliza Hall Institute of Medical Research, Australia’s oldest research institute. He has launched innovative gender-gap initiatives many scientists say far outpace those in the US. He wrote about it in Nature, and scientists reacted in Bioscience Technology. He responds here.
Nanoparticles are between 1 and 100 nanometers in size.Scientists can harness them for drug delivery, to combat disease, for filtering fresh drinking water, and much more. Now, researchers from MIT and the Federal University of Goias in Brazil have developed a new technique that uses ultraviolet (UV) light to extract man-made pollutants from soil and water.
Three studies, analyzing in different ways the leading ALS gene, came to what is being called a “remarkably” similar conclusion: the most common form of ALS may be caused by clogged pores in brain cell nuclear membranes.
A new Molecular Psychiatry study has found a robust relationship between obesity at age 50—as measured by body mass index (BMI)—and both earlier age, and severity, of Alzheimer’s disease (AD).