Cloning has finally generated immunologically compatible embryonic stem cells for older humans: two men aged 35 and 75. It may also generate significantly fewer tumor-causing mutations than the popular induced pluripotent stem cell (iPSC) method of making ES cells.
A scientific study found that even moderately heavy drinking impairs cognition in...
Many dyslexics weren’t born with less grey matter, according to a surprising recent study....
New work from Rice University researchers shows promise for zeroing in on cancer’s core decision...
Size doesn’t matter as long as long as you can get the job done. That said, one may be forgiven the impression that larger molecules—antibodies and related constructs, or T cells themselves being used in immunotherapies—were preferentially presented at American Association of Cancer Research annual conference
The potential of immunotherapies drew large interest at this year's American Association for Cancer Research annual meeting. And the new data are particularly striking for their clinical results—reporting once uncommon at this basic research meeting.
In successful research, any one path can quickly lead to new paths of even more promising results. This branching out of a research project couldn’t be more true than for a team of researchers at the UCSD’s Jacobs School of Engineering. UCSD researchers have developed “nanosponges” that were initially designed as a platform for cancer drug delivery and now are being developed to soak up the dangerous pore-forming toxin produced by MRSA.
Riken Institute brass want co-authors of the “acid bath” stem cell papers to retract one, after appeal, citing deliberate misconduct. But two developments may complicate this. First, lead author Haruko Obokata refuses to accept it. And Kenneth Lee has become the first scientist outside the co-authors to publicly claim that, following the latest protocol for acid bath cells, he may have made them.
At least two camps have formed in the “breast cancer stem cell” world. One camp believes most cancers may come from stem cells—or stem-like progenitors—gone awry. Others agree cancers can be most virulent when reaching a stem cell-like state—but believe they may come from both stem cells and mature cells gone awry.
Cardiac arrhythmia is one of the most common diseases encountered in clinical cardiology. High-speed electrophysiological imaging using fluorescent probes has yielded tremendous insights into the basic mechanisms of arrhythmias and the effects of anti-arrhythmic drugs. However, optical mapping, as it is known to the cardiac research community, has remained relegated to the isolated (i.e. explanted) heart.
Researchers have another answer to the question of how females can generate so much blood—enough for two blood systems—during pregnancy. The answer is stem cells, as is so often the case lately when a question has something to do with underlying biological mechanisms.
Binge drinking impairs the healing of broken bones. It can do this weeks after a binge. And it can leave in its wake permanently inferior bone, according to recent studies. One reason: alcohol slows down mesenchymal (bone, fat, and cartilage) stem cells (MSCs), in the bloodstream, trying to home to fracture sites. And when MSCs finally reach fracture sites, alcohol keeps them from properly replacing lost cells.
Labs globally are electrified by the notion that just “stressing out” ordinary adult cells may turn them into pluripotent stem cells like the “induced pluripotent stem cells” (iPSCs) of Nobel Prize winner Shinya Yamanaka. But is this about co-opting an evolutionarily conserved, natural way of making young cells out of old? Or is it an unnatural way of hastening old cells’ death?
When the neural stem cells in our brains get older, they create far fewer neurons. This plays a role in neurodegenerative diseases from Alzheimer’s to Parkinson’s. It also plays a role in our increasingly deficient ability to simply find those car keys. New research is changing that paradigm.
Nuts are in the news: a recent study has offered evidence for a big reason our bodies are so nuts for nuts. They are apparently almost all our big brains needed to survive— thus almost all we ate— from 1.4 to 2.4 million years ago.
A large global team of reproduction experts has found a way to even the score for older women seeking pregnancy using a process called preimplantation genetic diagnosis (PGD).
A major mystery in heart disease—why most people who develop serious heart disease have normal blood pressure and cholesterol—may have been solved in a “tremendously significant” study. Some are already calling the study “important” and “frame-shifting.” The study—Multi-Ethnic Study of Atherosclerosis—found that coronary artery calcium scans can often more accurately predict heart disease than cholesterol and blood pressure readings.
Immunotherapy—the art and science of training peoples’ immune systems to fight their own cancers—was named Breakthrough of the Year by Science. Prominently mentioned was an approach seeing clinical success: genetically tweaking patients’ own T cells to make them more potent, proliferative, and targeted.
The partial model for Obamacare—Massachusetts’ near-universal health care program, adopted in 2006—resulted in measurably improved health. According to a study conducted by researchers from Harvard University and the University of Michigan—with help from the Centers for Disease Control (CDC)—the health of Massachusetts residents rose more in the first five years of the program than did the health of residents in other New England states.