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The Lead

Early Statin Use May Give Long-term Heart Benefits

November 19, 2014 2:57 pm | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

Research shows that taking a cholesterol-lowering drug for five years in middle age can lower heart and death risks for decades afterward. The benefits seem to grow over time and may last for life.               

Imaging Method Could Improve Asthma Treatment

November 14, 2014 12:21 pm | News | Comments

A team of researchers have used a laser beam trap to examine how drug particles from...

WHO Sees Few Promising Ebola Drugs in Pipeline

November 14, 2014 6:57 am | by The Associated Press | News | Comments

A top official with the U.N. health agency says few experimental therapies are currently...

The Odd Ouster of Sanofi’s Former CEO

November 13, 2014 9:29 am | by Ryan Bushey, Associate Editor | Articles | Comments

Chris Viehbacher, the high-flying pharma executive, had his career with Sanofi...

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Gene Study Boosts Interest in Heart Drug

November 12, 2014 5:57 pm | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

Scientists have discovered gene mutations that give people naturally lower cholesterol levels and cut their risk of heart disease in half. That discovery may have a big implication for a blockbuster heart drug.           

Altered Milk Protein Can Deliver AIDS Drug to Infants

November 12, 2014 8:30 am | News | Comments

A novel method of altering a protein in milk to bind with an antiretroviral drug promises to greatly improve treatment for infants and young children suffering from HIV/AIDS, according to new research.              

Ebola Health Lessons: A Wake-up Call

November 11, 2014 8:30 am | by Stephanie Guzowski, Editor, Drug Discovery & Development | Articles | Comments

After months of delayed, fragmented responses, the international medical community recognized Ebola as a threat to global health security. Here’s where the situation stands today as well as questions raised and lessons learned.        

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Vaccine Spray May Not Work for Swine Flu in Kids

November 6, 2014 3:55 pm | by Mike Stobbe - AP Medical Writer - Associated Press | News | Comments

The nasal spray version of the flu vaccine did not protect young children against swine flu last winter and might not work again this year, health officials said Thursday.                       

Cancer Immunotherapy Toxic to Obese Rats

November 3, 2014 2:30 pm | News | Comments

Immunotherapy that can be effective against tumors in young, thin mice can be lethal to obese ones, a new study has found. The findings suggest a possible link between body fat and the risk of toxicity from some types of immunotherapy.     

Study IDs Possible Target to Treat Cocaine Addiction

October 31, 2014 12:07 pm | News | Comments

A new study has identified a potential target for therapies to treat cocaine addiction. Investigators found evidence that changing one amino acid in a subunit of an important receptor protein alters whether cocaine-experienced animals will resume drug seeking after a period of cocaine abstinence.

Patient-relevant Preclinical Models Using Image-guided Small Animal Irradiation

October 28, 2014 11:33 am | by Dr. Rajendra Kumari, Chief Scientific Officer, PRECOS Ltd., a Crown Bioscience Company | Articles | Comments

Radiotherapy is a primary, adjuvant or neoadjuvant treatment for a number of different cancers, such as glioblastoma, breast, lung and prostate. Image-guided radiation therapy (IGRT) is used to reduce the amount of radiation delivered to the normal tissue surrounding the targeted tumor. However, in the preclinical setting, the use of IGRT is less common.

Heart Drug Helps Treat ALS in Mice

October 27, 2014 2:31 pm | News | Comments

Digoxin, a medication used in the treatment of heart failure, may be adaptable for the treatment of amyotrophic lateral sclerosis (ALS), a progressive, paralyzing disease, suggests new research.                  

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Medical Pot Dilemma: Where to Get the First Seeds?

October 27, 2014 8:25 am | by Carla K. Johnson - AP Medical Writer - Associated Press | News | Comments

As more states legalize medical marijuana, there's one stage in the process nobody wants to talk about: the part where people still have to break the law.                            

WHO: Millions of Ebola Vaccine Doses Ready in 2015

October 24, 2014 10:00 am | by Maria Cheng - AP Medical Writer - Associated Press | News | Comments

The World Health Organization says millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines will start being tested in March.                 

Scientists to Use Tiny Particles to Fight Big Diseases

October 23, 2014 12:49 pm | Videos | Comments

Physicians will tell you: They are not winning the war on ovarian cancer. But researchers have combined medicine and advanced nanotechnological engineering to create a smarter, more targeted therapy that could overcome the most lethal gynecologic cancer.

Cancer Drug Resistance Has an ‘Off Switch’

October 21, 2014 11:29 am | Videos | Comments

Scientists have uncovered details about how cancer is able to become drug resistant over time, a phenomenon that occurs because cancer cells within the same tumor aren’t identical.                     

Experimental Drug Restores Pleasure-seeking Behavior in Bipolar Patients

October 20, 2014 11:05 am | News | Comments

A drug being studied as a fast-acting mood-lifter restored pleasure-seeking behavior independent of— and ahead of— its other antidepressant effects, in an NIH trial.                         

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Copper May Be Prostate Cancer’s Fatal Flaw

October 15, 2014 3:13 pm | News | Comments

Researchers have found a way to kill prostate cancer cells by delivering a trove of copper along with a drug that selectively destroys the diseased cells brimming with the mineral, leaving non-cancer cells healthy.           

Q&A: How Plasma Transfusions, Antibodies Fight Ebola

October 15, 2014 1:19 pm | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

A Dallas nurse being treated for Ebola has received a plasma transfusion from a doctor who beat his own infection with the deadly virus after getting a similar treatment. The reason: Antibodies in the blood of a survivor may help a patient fight off the germ.

Reversing Idiopathic Pulmonary Fibrosis

October 14, 2014 2:42 pm | by Cynthia Fox, Science Writer | Articles | Comments

Lethal fibrosis in lungs of mice with idiopathic pulmonary fibrosis (IPF) can be reversed, say researchers. No drug on the market can do this. But the crew pulled it off, in mice, by temporarily restoring (a mimic of) one of the body’s own anti-fibrosis agents, sharply reduced in IPF: microRNA-29.

Chemical from Broccoli Sprouts Promising Against Autism

October 14, 2014 11:41 am | News | Comments

Results of a small clinical trial suggest that a chemical derived from broccoli sprouts— and best known for claims that it can help prevent certain cancers— may ease classic behavioral symptoms in those with autism spectrum disorders (ASDs).   

Bacterial Defense Policies

October 13, 2014 2:14 pm | News | Comments

A research team has used high-resolution cryo-electron microscopy to obtain novel insights into the ultrastructural changes in an intracellular machine associated with the acquisition of resistance to the antibiotic erythromycin.      

Researchers Begin Ebola Vaccine Study in Africa

October 9, 2014 5:52 pm | by The Associated Press | News | Comments

The first study of a possible Ebola vaccine is underway in Africa: University of Maryland researchers say three health care workers in Mali received the experimental shots.                       

Marburg, Ebola’s Relative, Cured in Monkeys

October 9, 2014 8:30 am | by Cynthia Fox, Science Writer | Articles | Comments

An experimental drug saved the lives of 16 of 16 monkeys with the Marburg virus, a killer near-indistinguishable from Ebola, which caused the death of a Ugandan health worker Oct. 6.                  

Gene Mutation Could Prevent Weight Gain from High-sugar Diet

October 7, 2014 1:38 pm | News | Comments

Imagine being able to take a pill that lets you eat all of the ice cream, cookies, and cakes that you wanted– without gaining any weight. New research found a new way to suppress the obesity that accompanies a high-sugar diet, pinning it down to a key gene that pharmaceutical companies have already developed drugs to target.

Green Tea-based ‘Missiles’ May Kill Cancer Cells

October 7, 2014 1:17 pm | News | Comments

Green tea has long been known for its anti-oxidant, anti-cancer, anti-aging and anti-microbial properties. Now, a group of researchers has taken the health benefits of green tea to the next level by using one of its ingredients to develop a drug delivery system.

Wine Antioxidant Slows Acne

October 1, 2014 3:28 pm | News | Comments

Got grapes? UCLA researchers have demonstrated how resveratrol, an antioxidant derived from grapes and found in wine, works to inhibit growth of the bacteria that causes acne. The team also found that combining resveratrol with a common acne medication, benzoyl peroxide, may enhance the drug's ability to kill the bacteria and could translate into new treatments.  

Early Antibiotic Use Linked to Childhood Obesity Risk

September 30, 2014 2:22 pm | News | Comments

The use of broad-spectrum antibiotics by children before the age of 24 months was associated with increased risk of obesity in early childhood, according to a new study.                       

Drug and Device Firms Paid $3.5B to Care Providers

September 30, 2014 2:02 pm | by Ricardo Alonso-Zaldivar - Associated Press - Associated Press | News | Comments

Striving to shine a light on potential ethical conflicts in medicine, the Obama administration is releasing data on drug company payments to tens of thousands of individual doctors.                    

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