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Human 3D Skin Models

April 10, 2013 1:36 pm | by Scott Hickman, Marketing Manager, Toxicology, BioReliance Corporation | Articles | Comments

The development of the 3D reconstructed human skin micronucleus (RSMN) assay is the first to overcome the limitations of traditional cell culture methods. It can provide a more biologically relevant result than standard 2D in vitro genotoxicity assays, since it provides a functional stratum corneum, which accounts for permeability and appears to have a normal dermal metabolic capability.

Decoding Cancer Metastasis

May 6, 2013 12:25 pm | by Christina Smith | Articles | Comments

Combining two biological approaches, a research team from University of Michigan broke down the...

Platelet Rich Plasma Significantly Improves Clinical Outcomes in Patients with Tennis Elbow

March 21, 2013 11:58 am | News | Comments

Platelet rich plasma (PRP) therapy has been used to manage pain associated with torn tendons,...

Platelet Rich Plasma Significantly Improves Clinical Outcomes in Patients with Tennis Elbow

March 21, 2013 11:58 am | News | Comments

Platelet rich plasma (PRP) therapy has been used to manage pain associated with torn tendons,...

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Life Science Pulse

Salamanders Hold Solution to 'Perfect' Regeneration

May 21, 2013 11:45 am | News | Comments

Salamanders’ immune systems are key to their remarkable ability to regrow limbs, and could also underpin their ability to regenerate spinal cords, brain tissue and even parts of their hearts, scientists have found. New research found that when immune cells known as macrophages were systemically removed, salamanders lost their ability to regenerate a limb and instead formed scar tissue.

New Immune System Discovered

May 21, 2013 11:22 am | News | Comments

Mucus may be slimy and gross, but a research team has discovered that it is also home to a powerful immune system that could change the way doctors treat a number of diseases. In this previously undocumented immune system, researchers uncovered bacteria-infecting viruses known as bacteriophage, which shield the body from invading infection.

A New Way to Open Clogged Arteries

May 21, 2013 11:03 am | News | Comments

Over the past few decades, scientists have developed many devices that can reopen clogged arteries, including angioplasty balloons and metallic stents. While generally effective, each of these treatments has drawbacks, including the risk of side effects.

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Epigenetics Can Predict Postpartum Depression

May 21, 2013 10:04 am | News | Comments

Researchers say they have discovered specific chemical alterations in two genes that, when present during pregnancy, reliably predict whether a woman will develop postpartum depression. The epigenetic modifications, which alter the way genes function without changing the underlying DNA sequence, can apparently be detected in the blood of pregnant women during any trimester.

'Lifespan Machine' Monitors Worm Aging

May 20, 2013 12:00 pm | by Harvard Medical School | News | Comments

The worm’s tail wriggles, a micrometer-scale twitch. A scanner captures the new posture. Software recognizes the motion. Life goes on in the Lifespan Machine, a new system devised in the lab of Walter Fontana that, essentially, counts dead worms.

Multitasking Neurons Enhance Brain Flexibility

May 20, 2013 11:40 am | News | Comments

Over the past few decades, neuroscientists have made much progress in mapping the brain by deciphering the functions of individual neurons that perform very specific tasks, such as recognizing the location or color of an object. However, there are many neurons, especially in brain regions that perform sophisticated functions such as thinking and planning, that don’t fit into this pattern.

New MATH Method for Head, Neck Cancer

May 20, 2013 11:05 am | News | Comments

A new method of measuring the variety of genetic mutations found in cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer. The research describes how a new way of measuring tumor heterogeneity was a better predictor of survival than are most traditional risk factors in a small group of patients with squamous cell carcinoma of the head and neck. 

Osteoarthritis Progression Halted

May 20, 2013 10:30 am | News | Comments

Scientists have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, they now have evidence that the bone underneath the cartilage is also a key player and exacerbates the damage.

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UK Measles Surge Years After Vaccine Scare

May 20, 2013 6:00 am | by MARIA CHENG - AP Medical Writer - Associated Press | News | Comments

More than a decade ago, British parents refused to give measles shots to at least a million children because of a vaccine scare that raised the specter of autism. Now, health officials are scrambling to catch up and stop a growing epidemic of the contagious disease. This year, the U.K. has had more than 1,200 cases of measles, after a record number of nearly 2,000 cases last year.

Researchers Aim to Map the 'Food Genome'

May 19, 2013 1:42 pm | by MARY CLARE JALONICK - Associated Press - Associated Press | News | Comments

Do your kids love chocolate milk? It may have more calories on average than you thought. Same goes for soda. Until now, the only way to find out what people in the United States eat and how many calories they consume has been government data, which can lag behind the rapidly expanding and changing food marketplace.

Obesity Linked to 'Vicious Cycle' in Brain

May 17, 2013 11:58 am | News | Comments

With obesity reaching epidemic levels in some parts of the world, scientists have only begun to understand why it is such a persistent condition. A new study reports the discovery of a molecular chain of events in the brains of obese rats that undermined their ability to suppress appetite and to increase calorie burning.

Auto Emissions Transform Cholesterol

May 17, 2013 11:44 am | News | Comments

Academic researchers have found that breathing motor vehicle emissions triggers a change in high-density lipoprotein (HDL) cholesterol, altering its cardiovascular protective qualities so that it actually contributes to clogged arteries. 

Method Allows Closer Look at Developing Embryos

May 17, 2013 11:12 am | News | Comments

An international team of scientists using a new X-ray method recorded the internal structure and cell movement inside a living frog embryo in greater detail than ever before. This result showcases a new method to advance biological research and the search for new treatments for genetic diseases.

Study Suggest New Roles for ECMO

May 17, 2013 10:48 am | News | Comments

Extracorporeal membrane oxygenation (ECMO), a procedure traditionally used during cardiac surgeries and in the ICU that functions as an artificial replacement for a patient's heart and lungs, has also been used to resuscitate cardiac arrest victims in Japan, Taiwan and South Korea.

Stem Cells Generate Immune System in Mice

May 17, 2013 10:36 am | News | Comments

Raising hopes for cell-based therapies, researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory. In mice, the tissue can be used to foster the development of white blood cells the body needs to mount healthy immune responses and to prevent harmful autoimmune reactions.

WHO says single yellow fever shot is enough

May 17, 2013 3:55 am | by The Associated Press | News | Comments

The World Health Organization says a yellow fever booster vaccination given 10 years after the initial shot isn't necessary. The U.N.'s global health agency said Friday that its expert group on immunization believes a single dose of vaccination is sufficient to confer lifelong immunity against the disease.

Nanogel Secretes Insulin on Demand

May 16, 2013 11:49 am | News | Comments

Injectable nanoparticles developed at MIT may someday eliminate the need for patients with Type 1 diabetes to constantly monitor their blood-sugar levels and inject themselves with insulin. The nanoparticles were designed to sense glucose levels in the body and respond by secreting the appropriate amount of insulin, thereby replacing the function of pancreatic islet cells, which are destroyed in patients with Type 1 diabetes.

‘Brainbow’ Imaging Gets Upgraded

May 16, 2013 11:31 am | News | Comments

The breakthrough technique that allowed scientists to obtain one-of-a-kind, colorful images of the myriad connections in the brain and nervous system is about to get a significant upgrade. A group of Harvard researchers has made a host of technical improvements in the “Brainbow” imaging technique.

Maturing Teenage Brain Explored

May 16, 2013 11:08 am | News | Comments

Despite adolescence being a high-risk time for developing major psychiatric and drug dependence disorders, very little is known about the teenage brain. A new research project aims to shed light on what happens to the brain as young people mature.

Skin Cancer Linked to Reduced Alzheimer's Risk

May 15, 2013 5:01 pm | by Einstein | News | Comments

People who have non-melanoma skin cancer may be less likely to develop Alzheimer's disease, according to new research. The study showed that individuals with skin cancer were nearly 80 percent less likely to develop Alzheimer's disease compared with people who did not have skin cancer. No such association was found with other types of dementia, such as vascular dementia.

Stem Cells Recovered from Embryo Clones

May 15, 2013 12:39 pm | by MALCOLM RITTER - AP Science Writer - Associated Press | News | Comments

Scientists have finally recovered stem cells from cloned human embryos, a longstanding goal that could lead to new treatments for such illnesses as Parkinson's disease and diabetes. A prominent expert called the work a landmark, but noted that a different, simpler technique now under development may prove more useful.

New Biomaterial Can Improve Implant Success

May 15, 2013 12:16 pm | News | Comments

Expensive, state-of-the-art medical devices and surgeries often are thwarted by the body’s natural response to attack something in the tissue that appears foreign. Now, engineers have demonstrated in mice a way to prevent this sort of response.

Using Clay to Grow Bone

May 15, 2013 11:57 am | News | Comments

New research reports that synthetic silicate nanoplatelets (also known as layered clay) can induce stem cells to become bone cells without the need of additional bone-inducing factors. Synthetic silicates are made up of simple or complex salts of silicic acids.

Brains Re-wire to Compensate After Damage

May 15, 2013 10:56 am | News | Comments

Scientists have advanced our understanding of brain plasticity by showing that the brain forms complex new circuits after damage, often far from the damaged site, to compensate for lost function. The study identified the exact regions of the brain that take over when a learning and memory center, known as the hippocampus, is damaged.

New Drug Slows Alzheimer's

May 15, 2013 10:17 am | News | Comments

A drug developed by scientists at the Salk Institute for Biological Studies, known as J147, reverses memory deficits and slows Alzheimer's disease in aged mice following short-term treatment. The findings may pave the way to a new treatment for Alzheimer's disease in humans.

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