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The Lead

Precision Medicine Shaping the Future of Cancer Research

March 27, 2015 10:32 am | by Columbia University | News | Comments

Nearly 50 years after the “war on cancer” was declared in the United States, precision medicine presages an era of increased understanding of the molecular basis of cancer and of the ability to design treatments tailored to a patient’s own genetic profile, a panel of experts said.

MRI Based on Sugar Molecule Tells Cancerous From Noncancerous Cells

March 27, 2015 9:48 am | by Johns Hopkins University | News | Comments

Results of a study suggest that MRI could one day make biopsies more effective or even replace...

Why Some HPV Infections Go Away and Others Become Cancer

March 25, 2015 11:05 am | by Duke University | News | Comments

Immune system response isn't as crucial as activity of the infected cells themselves.

Nanotechnology Platform Shows Promise for Treating Pancreatic Cancer

March 25, 2015 10:43 am | by Shaun Mason, UCLA | News | Comments

Scientists at UCLA’s California NanoSystems Institute and Jonsson Comprehensive Cancer Center...

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Blueprint Medicine Files for $100M IPO

March 24, 2015 5:02 pm | by Ryan Bushey, Associate Editor | News | Comments

The biotech firm is making a big bet on precision medicine.

US Anti-drugs Work in Colombia Uses Cancer-linked Herbicide

March 23, 2015 9:40 am | by Joshua Goodman, Associated Press | News | Comments

New labeling on the world's most popular weed killer as a likely cause of cancer is raising more questions for an aerial spraying program in Colombia that underpins U.S.-financed efforts to wipe out cocaine crops.

New Hope for Beating Deadly Hereditary Stomach and Breast Cancers

March 20, 2015 10:07 am | by University of Otago | News | Comments

Deadly familial stomach and lobular breast cancers could be successfully treated at their earliest stages, or even prevented, by existing drugs that have been newly identified by University of Otago cancer genetics researchers.

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Tumors Dedifferentiated by Chemo May Spawn New Paradigm

March 19, 2015 11:16 am | by Cynthia Fox, Science Writer | Articles | Comments

A Harvard University and Waterloo University team has found that a common breast cancer chemotherapy (chemo) can create stem-like cancer cells out of more differentiated tumor cells.

Scientists Trace Genomic Evolution of High-risk Leukemia

March 19, 2015 10:53 am | by St. Jude Children's Research Hospital | News | Comments

Highly sensitive genomic analysis of acute lymphoblastic leukemia cells reveals for the first time how the malignant cells evolve to cause relapse.

Obese Women 40 percent More Likely to Get Cancer

March 18, 2015 12:00 pm | by Cancer Research UK | News | Comments

Obese women have around a 40 percent greater risk of developing a weight-related cancer in their lifetime than women of a healthy weight, according to new figures* released by Cancer Research UK Tuesday.

A Single-Cell Breakthrough

March 18, 2015 10:35 am | by Marla Vacek Broadfoot, Ph.D. | News | Comments

The human gut is a remarkable thing. Every week the intestines regenerate a new lining, sloughing off the equivalent surface area of a studio apartment and refurbishing it with new cells. This year researchers figured out a way to isolate and grow thousands of these elusive cells in the laboratory at one time.

Study Reveals Treatment for Women with Breast Cancer Suffering Cognitive Difficulties

March 17, 2015 12:48 pm | by Reggie Kumar, UCLA | News | Comments

Mental training exercises developed at the Jonsson Comprehensive Cancer Center have been shown to help mitigate the effects of "chemo brain"

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Study Confirms Key Targets of New Anti-Cancer Drug Candidates

March 17, 2015 10:19 am | by TSRI | News | Comments

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have confirmed the ribosome assembly process as a potentially fertile new target for anti-cancer drugs by detailing the essential function of a key component in the assembly process.

Scientists Discover How to Change Human Leukemia Cells Into Harmless Immune Cells

March 17, 2015 9:58 am | by Christopher Vaughan, Stanford Medicine | News | Comments

After a chance observation in the lab, researchers found a method that can force dangerous leukemia cells in the lab to mature into harmless immune cells called macrophages.

Is HRT for Menopause Staging a Comeback?

March 16, 2015 2:08 pm | by Cynthia Fox, Science Writer | Articles | Comments

Many recent meta-studies find hormone replacement therapy lengthens life after all. This may be leading to a comeback for the once hugely popular menopause treatment.

Immunotherapy: New Hope for Patients With Advanced Lung Cancer

March 16, 2015 10:45 am | by Columbia University | News | Comments

First steps toward precision medicine for a deadly disease.

Stem Cells Lurking in Tumors Can Resist Treatment

March 16, 2015 10:27 am | by Michael C. Purdy, Washington University in St. Louis | News | Comments

Scientists are eager to make use of stem cells’ extraordinary power to transform into nearly any kind of cell, but that ability also is cause for concern in cancer treatment. Malignant tumors contain stem cells, prompting worries among medical experts that the cells’ transformative powers help cancers escape treatment.

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Researchers Unlock the Mysteries of Wound Healing

March 16, 2015 9:39 am | by Jill Goetz, UA News | News | Comments

A multidisciplinary research team discovers how cells know to rush to a wound and heal it – opening the door to new treatments for diabetes, heart disease and cancer. Researchers at the University of Arizona have discovered what causes and regulates collective cell migration, one of the most universal but least understood biological processes in all living organisms.

Study: Tetanus Shot May Aid Treatment of Deadly Brain Cancer

March 12, 2015 10:09 am | by Malcolm Ritter, AP Science Writer | News | Comments

Can a tetanus shot help treat brain cancer? A small study hints that it might.

Skin Tumors Develop Specific Mutations to Resist Drug

March 11, 2015 10:26 am | by Krista Conger, Stanford School of Medicine | News | Comments

Basal cell carcinomas develop mutations in a protein on the Hedgehog pathway to evade a common drug therapy. Targeting another portion of the pathway may be an effective alternative treatment.                                                            

Childhood Leukemia Study Reveals Disease Subtypes, New Treatment Option

March 10, 2015 10:12 am | by Pete Farley, UCSF | News | Comments

One of every eight patients might benefit from highly successful lymphoma drugs.                              

Breakthrough Therapies Target Cancers in 2015

March 10, 2015 9:39 am | by Bevin Fletcher, Associate Editor | Articles | Comments

Getting a new drug to market is difficult, but the U.S. Food and Drug Administration (FDA) offers a number of ways to help the process along for promising drugs that have potential against serious diseases.  One of these options is designation as a breakthrough therapy. This year a number of these therapies are targeted at fighting cancer.

Researchers Map "Genomic Landscape" of Childhood Adrenocortical Tumors for First Time

March 9, 2015 10:15 am | by St. Jude Children's Research Hospital | News | Comments

In an advance that could lead to better identification of malignant pediatric adrenocortical tumors, and ultimately to better treatment, researchers have mapped the “genomic landscape” of these rare childhood tumors. Their genomic mapping has revealed unprecedented details, not only of the aberrant genetic and chromosomal changes that drive the cancer, but the sequence of those changes that trigger it.

DNA Safeguard May Be Key in Cancer Treatment

March 6, 2015 10:05 am | by Krishna Ramanujan, Cornell University | News | Comments

Researchers have developed a new technique to understand the actions of key proteins required for cancer cells to proliferate.                      

'Stem Cell' Test Could Identify Most Aggressive Breast Cancers

March 5, 2015 10:03 am | by The Institute of Cancer Research | News | Comments

Testing breast cancer cells for how closely they resemble stem cells could identify women with the most aggressive disease, a new study suggests.                   

Mouse Study Finds Extra Oxygen May Spur Tumor-Fighting Cells

March 4, 2015 4:35 pm | by Lauran Neergaard, AP Medical Writer | News | Comments

A provocative study in mice suggests something as simple as breathing in extra oxygen might give immune cells a boost in attacking cancer.                    

Protein May Be Key to Cancer's Deadly Resurgences

March 3, 2015 4:29 pm | by Pete Farley, University of California San Francisco | News | Comments

Tumor recurrence following a period of remission is the main cause of death in cancer. The ability of cancer cells to remain dormant during and following therapy, only to be reactivated at a later time, frequently with greater aggressiveness, is one of the least-understood aspects of the disease.

New Nanodevice Defeats Drug Resistance

March 3, 2015 10:33 am | by Anne Trafton, MIT | News | Comments

Tiny particles embedded in gel can turn off drug-resistance genes, then release cancer drugs.                            

Newly-Found T Memory Stem Cells May Be Key to Gene Therapy

February 27, 2015 10:41 am | by Cynthia Fox, Science Writer | Articles | Comments

Genetically engineered T memory stem cells (Tscm) can last more than 12 years in patients’ bodies, and can continually generate appropriate T cell armies for them, says an innovative study looking at two historic clinical trials.     

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