Scientists are reporting ‘laboratory resurrections’ of several 2-3-billion-year-old proteins that are ancient ancestors of the enzymes that enable today’s antibiotic-resistant bacteria to shrug off huge doses of penicillins, cephalosporins and other modern drugs.
Studying HIV-1, the most common and infectious HIV subtype, scientists have identified 25 human proteins ‘stolen’ by the virus that may be critical to its ability to infect new cells.
Researchers have discovered that a specialized receptor, normally found in the nose, is also in blood vessels throughout the body, sensing small molecules created by microbes that line mammalian intestines, and responding to these molecules by increasing blood pressure.
The overuse of antibiotics has created strains of bacteria resistant to medication, making the diseases they cause difficult to treat, or even deadly. Now, a research team has identified a weakness in at least one superbug that scientists may be able to medically exploit.
Researchers have found a new way to accelerate a workhorse instrument that identifies proteins. The high-speed technique could help diagnose cancer sooner and point to new drugs for treating a wide range of conditions.
The gloriously colored, iridescent feathers of the male peacock aren't what they seem on the surface. They look that way largely because the feathers contain nanometer-scale protein structures that break up incoming light waves, recombine, and reflect them as rich, vibrant colors.
A team of researchers has shown that the concept of how the speed of creation affects performance also applies to how a protein they studied impacts circadian clock function.
Researchers have discovered that a gold-dwelling bacterium excretes a small molecule capable of forming solid gold.
Devising a method for more precise and less invasive treatment of cancer tumors, a team led by researchers from the UCLA Henry Samueli School of Engineering and Applied Science has developed a degradable nanoscale shell to carry proteins to cancer cells and stunt the growth of tumors without damaging healthy cells.
Scientists at the Walter and Eliza Hall Institute have for the first time visualized the molecular changes in a critical cell death protein that force cells to die. The finding provides important insights into how cell death occurs, and could lead to new classes of medicines that control whether diseased cells live or die.
Just as the body can become resistant to antibiotics, certain methods of killing cancer tumors can end up creating resistant tumor cells. But a University of Central Florida professor has found a protein present in several types of cancer, including breast and ovarian cancer, which could be helpful in preventing tumors from coming back.
The diverse complexity seen amongst individual species within the animal kingdom evolved from a surprisingly small gene pool. The key to morphological and behavioral complexity, a growing body of scientific evidence suggests, is the regulation of gene expression by a family of DNA-binding proteins called “transcription factors.”
A protein known as Sp2 is key to the proper creation of neurons from stem cells, according to researchers at North Carolina State University. Understanding how this protein works could enable scientists to “program” stem cells for regeneration, which has implications for neural therapies.
Scientists at The Scripps Research Institute have determined the structure of Ltn1, a recently discovered “quality-control” protein that is found in the cells of all plants, fungi, and animals. Ltn1 appears to be essential for keeping cells’ protein-making machinery working smoothly. It may also be relevant to human neurodegenerative diseases.
The spread of cancer cells may be slowed by targeting the protein km23-1. A motor protein that transports cargo within the cell, km23-1 is also involved in the movement or migration of cells. Migration is necessary for cancer to spread, so understanding this cell movement is important for development of better cancer treatments.
Agilent Technologies introduced GeneSpring GX 11.5, an expansion of its bioinformatics software into visualizing and analyzing multiple types of biological data. GeneSpring GX 11.5 now interprets exon microarray, proteomics, and metabolomics experiments together for the first time, using a familiar interface.
Millipore launched the SNAP i.d. protein detection system that allows researchers to produce high quality Western blots in 22 minutes. The SNAP i.d. system is compatible with all membrane types and detection methods, such as chemiluminescence and fluorescence.
The NI Protein Assay is a highly sensitive, colorimetric protein assay that overcomes interference of common laboratory agents present in protein solutions.
The Waters SYNAPT G2 System features new QuanTof and enhanced High Definition MS technologies intended to accelerate scientists toward their research goals.
Eksigent introduces the cHiPLC-nanoflex System, delivering improved reproducibility and ease of use to proteomics research. The system is a docking station for up to three microfluidic chips that contain nanoLC or trap columns.
caption Figure 1: Analysis of 2-D gel by Dymension software showing proteins that are up or down-regulated three hours after delta-tocotrienol treatment.
Proteome Discoverer software now features integrated protein annotation powered by the InforSense Virtual Machine (IVM).
Beckman Coulter announces an advanced version of its eXPert software for the Optima L-XP Series Ultracentrifuges. The new Optima eXPert software delivers important capabilities for academic, biopharmaceutical, and bioprocessing users in protein, virus, and vaccine development.
This 2D gel imager can analyze silver stained proteins derived from a prostate cancer (LNCaP) cell line treated with delta-tocotrienol, (a form of Vitamin E). Users can obtain meaningful data through manipulation of the gel images being produced to find out what is happening at the molecular level.
Quadrupole time-of-flight liquid chromatography/mass spectrometer uses high definition TOF technology to provide mass accuracy, mass resolution, dynamic range, sensitivity and speed. It can be used in proteomics, metabolomics and other applications.