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Lab-designed Global HIV Vaccine Promising in Monkeys

October 25, 2013 12:46 pm | News | Comments

The considerable diversity of HIV worldwide represents a critical challenge for designing an effective HIV vaccine. Now, a scientific team has shown that bioinformatically optimized HIV vaccine antigens might be useful in the design of a global HIV vaccine.

Doubling Forces to Extend Glioblastoma Survival

October 25, 2013 11:53 am | News | Comments

A novel combination of two oral targeted drugs dramatically slowed the growth of glioblastoma brain tumors in mice and significantly extended the animals’ survival, scientists report.                   

Review Highlights Side Effects of Daily Aspirin Dosage

October 24, 2013 1:57 pm | News | Comments

Researchers have published the most comprehensive review of the benefits and risks of a daily dose of prophylactic aspirin and warn that greater understanding of side effects is needed.                   

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New Eye Treatment Effective in Laboratory Tests

October 23, 2013 1:01 pm | News | Comments

A promising technique for treating human eye disease has proven effective in preclinical studies and may lead to new treatments to prevent blindness, according to new experiments.                    

Nanoparticles Deliver 'One-two Punch' to Aggressive Tumors

October 22, 2013 12:04 pm | News | Comments

To overcome triple negative breast cancer's eventual resistance to drugs, chemical engineers have designed nanoparticles that now only carry a cancer drug, but also carry short strands of RNA that can shut off one of the genes that cancer cells use to escape the drug.

Database of Disease Genes IDs Drug Therapies

October 15, 2013 11:37 am | News | Comments

 Researchers have created a massive online database that matches thousands of genes linked to cancer and other diseases with various drugs that target those genes.                       

New MS Treatment is Promising in Mice

October 10, 2013 11:53 am | News | Comments

Scientists have identified a set of compounds that may be used to treat MS in a new way: by boosting a population of progenitor cells that can in turn repair MS-damaged nerve fibers.                   

Drug Can Target Deadly Breast Cancer

October 4, 2013 1:40 pm | News | Comments

Often deadly “triple-negative” breast cancers might be effectively treated in many cases with a drug that targets a previously unknown vulnerability in the tumors, according to a new study.  Researchers found blocking cystine from entering triple-negative breast cancer cells can significantly inhibited their growth in culture and when the cancer cells were transplanted into mice.

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Nanoparticle Vaccine Offers Better Protection

September 26, 2013 12:02 pm | News | Comments

Engineers have developed a new type of nanoparticle that protects a vaccine long enough to generate a strong immune response— not only in the lungs, but also in mucosal surfaces far from the vaccination site, such as the gastrointestinal and reproductive tracts.

Antidepressant Use Linked to Higher Diabetes Risk

September 25, 2013 1:04 pm | News | Comments

Clinicians should be extra vigilant when prescribing antidepressants as they could pose a risk of type 2 diabetes, researchers have warned. A systematic review showed that people taking antidepressants are at a higher risk of type 2 diabetes.

New Cancer Drug Helps Pain in Resistant Prostate Cancer

September 25, 2013 12:13 pm | News | Comments

Abiraterone acetate, a recently FDA-approved drug used to treat men with metastatic castration-resistant prostate cancer and marketed as Zytiga, significantly delays progression of pain and quality of life deterioration when taken in conjunction with prednisone. The design of the study emphasized the importance of patient reported-outcomes in evaluating new treatments.

Human Brain Tumor Cells Erased in Mice

September 23, 2013 11:21 am | News | Comments

Working with mice, researchers have discovered that weeks of treatment with a repurposed FDA-approved drug halted the growth of— and ultimately left no detectable trace of— brain tumor cells taken from adult human patients. The scientists targeted a mutation in the IDH1 gene first identified in human brain tumors called gliomas by a team cancer researchers in 2008.

Dog Food Additive May Prevent Chemo Side Effect

September 20, 2013 12:35 pm | News | Comments

Working with cells in test tubes and in mice, researchers have discovered that a chemical commonly used as a dog food preservative may prevent the kind of painful nerve damage found in the hands and feet of four out of five cancer patients taking the chemotherapy drug Taxol.

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Brain-damaging Side Effects Force Army to Pull Mefloquine

September 19, 2013 3:00 am | by PAULINE JELINEK - Associated Press - Associated Press | News | Comments

The top doctor for Green Berets and other elite Army commandos has told troops to immediately stop taking mefloquine, an anti-malaria drug found to cause permanent brain damage in rare cases. The ban among special operations forces is the latest development in a long-running controversy over over mefloquine.

Possible 'Chemo Brain' Antidote Discovered

September 18, 2013 12:30 pm | News | Comments

A research team has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central nervous system, producing mental fogginess similar to “chemo brain.” The researchers also report they’ve discovered an existing drug compound that appears to counteract or rescue brain cells from the adverse effects of the breast cancer drug.

Scientists Create Potent, Improved Version of Anticancer Drug

September 17, 2013 11:49 am | News | Comments

Scientists have found a way to make dramatic improvements to the cancer cell-killing power of vinblastine, one of the most successful chemotherapy drugs of the past few decades. The team’s modified versions of vinblastine showed 10 to 200 times greater potency than the clinical drug.

Hitting the Mark

September 17, 2013 10:54 am | by Skip Derra | Articles | Comments

Researchers from Columbia University Medical Center, working with collaborators at the Hospital for Special Surgery, created a fleet of “nano-robots” that can home in on specific cells and mark them with a fluorescent tag for drug therapy or destruction.

Drug-resistant Bacteria Kill More than 23,000 Annually

September 16, 2013 1:07 pm | by MIKE STOBBE AND LINDSEY TANNER, Associated Press | News | Comments

For the first time, the government is estimating how many people die from drug-resistant bacteria each year - more than 23,000, or about as many as those killed annually by flu. The Centers for Disease Control and Prevention released the number to spotlight the growing threat of germs that are hard to treat because they've become resistant to drugs.

Path That Makes Antidepressants Act Quicker Discovered

September 16, 2013 12:25 pm | News | Comments

The reasons behind why it often takes people several weeks to feel the effect of newly prescribed antidepressants remains somewhat of a mystery– and likely, a frustration to both patients and physicians. Researchers have been working to find out why and if there is anything that can be done to shorten the time in which antidepressants kick in.

Codeine May Increase Sensitivity to Pain

September 12, 2013 11:22 am | News | Comments

Using large and frequent doses of the painkiller codeine may actually produce heightened sensitivity to pain, without the same level of relief offered by morphine, according to new research. The study is believed to be the world's first experimental study comparing the pain relieving and pain worsening effects of both codeine and morphine.

Down Syndrome Equivalent Reversed in Mice

September 5, 2013 11:32 am | News | Comments

Researchers have identified a compound that dramatically bolsters learning and memory when given to mice with a Down syndrome-like condition on the day of birth. The study reports that the single-dose treatment appears to enable the cerebellum of the rodents’ brains to grow to a normal size.

Whole Virus HIV Vaccine Excels in Trial

September 4, 2013 12:24 pm | News | Comments

Phase 1 Clinical Trial (SAV CT 01) of the first and only preventative HIV vaccine based on a genetically modified killed whole virus (SAV001-H) has been successfully completed with no adverse effects in all patients, Western and Sumagen Canada Inc. announced.

Synthetic Polymer Could Stop HIV Spread

September 3, 2013 11:49 am | News | Comments

A precisely designed macromolecule that mimics the binding of HIV to immune system cells could be used to stop the virus from physically entering the body, according to a new study. The researchers created the large molecule with several sugar molecules, known as glycopolymers.

TB Has Surprising Family Tree

September 3, 2013 11:42 am | Videos | Comments

For years, physicians around the world have watched as strain after strain of the deadly bacteria mycobacterium tuberculosis evolves resistance to drugs. A new method of analyzing whole genome sequences of TB, applied to a massive set of strains of the bacteria collected from clinics around the world, has revealed 39 new genes associated with elevated drug resistance.

Brain Scans Could Predict Response to Antipsychotic Medication

August 15, 2013 10:35 am | News | Comments

Researchers from King’s College London and the University of Nottingham have identified neuroimaging markers in the brain which could help predict whether people with psychosis respond to antipsychotic medications or not. Identifying individuals at greatest risk of not responding to existing medications could help in the search for improved medications, and may eventually help clinicians personalize treatment plans.

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