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Key Molecular Pathways to Alzheimer’s Identified

July 25, 2013 10:55 am | News | Comments

Key molecular pathways that ultimately lead to late-onset Alzheimer’s disease, the most common form of the disorder, have been identified by researchers. The study, which used a combination of systems biology and cell biology tools, presents a new approach to Alzheimer’s disease research and highlights several new potential drug targets.

Genetic Discovery Can Help Prevent Kidney Stones

July 25, 2013 9:59 am | News | Comments

The discovery of a gene's function in E. coli and other bacteria might lead to a probiotic to prevent the most common type of kidney stone, according to a new study. The team made the discovery during a study of genes in Acetobacter aceti, a harmless bacterium that is typically used to convert wine to vinegar.

Biomaterials Can Benefit from 'Mussel' Strength

July 24, 2013 10:56 am | News | Comments

Researchers have unraveled the secret to byssus threads, the tiny natural bungee cords that mussels use to dangle loosely from rocks, piers or ships. Byssus threads, they found, are composed of a well-designed combination of soft, stretchy material on one end and much stiffer material on the other.

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Nano-coating Can Preserve Vaccines

July 22, 2013 11:19 am | News | Comments

For the first time, scientists are working on developing a ‘nano-coating’ that would protect a vaccine from its environment both in transit and for storage. Using the latest chemistry advances, researchers hope to show how nano-silica can be grown around individual vaccine molecules, enabling a vaccine to be taken anywhere in the world without refrigeration.

3-D Structure of Key Glucose Regulator Analyzed

July 18, 2013 11:09 am | News | Comments

An international team has determined and analyzed the three-dimensional atomic structure of the human glucagon receptor. The receptor, found mainly on liver and kidney cells, helps regulate glucose levels in the bloodstream and is the target of potential therapeutic agents for type 2 diabetes.

Ocean Microbe Could Treat Anthrax, MRSA

July 18, 2013 10:31 am | News | Comments

A research team has discovered a new chemical compound from an ocean microbe in a preliminary research finding that could one day set the stage for new treatments for anthrax and other ailments such as methicillin-resistant Staphylococcus aureus (MRSA).

Nano Drug Crosses Blood-Brain Tumor Barrier

July 18, 2013 10:06 am | News | Comments

An experimental drug in early development for aggressive brain tumors can cross the blood-brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a new study. The laboratory and animal study also shows how the agent, called SapC-DOPS, targets tumor cells and blood vessels.

Leachables and Extractables as Factors Effecting Assay Results

July 17, 2013 9:53 am | by Kyle T. Harris, BioScience Applications Manager, Porex Corp. | Articles | Comments

Technological advancements of analytical instrumentation platforms coupled with demand for higher sensitivity in many life science applications have led to a critical need for significant improvement in the cleanliness of plastic consumables. 

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MS Drug Promising for Heart Failure Prevention

July 17, 2013 9:38 am | News | Comments

A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle, a disorder that often leads to heart failure, researchers report. Cardiac hypertrophy, which afflicts one in 500 people, can be caused by high blood pressure or inherited through genes that control contraction of the heart.

Drug Candidate Can Increase Endurance

July 15, 2013 9:24 am | News | Comments

An international group of scientists has shown that a drug candidate designed by scientists significantly increases exercise endurance in animal models. These findings could lead to new approaches to helping people with conditions that acutely limit exercise tolerance.

Potential Markers for Childhood Arthritis Severity Found

July 12, 2013 11:39 am | News | Comments

Children who suffer from arthritis could one day receive more targeted treatment thanks to potential markers for the severity of the disorder. The early results of a world-first study looking have shown that changes in the levels of particular molecules known as prostanoids in the blood of these patients may predict the course of arthritis more accurately and help provide more individualized treatment.

Resuscitating Dead Data with Unified Laboratory Intelligence

July 10, 2013 10:35 am | by Ryan Sasaki, Director of Global Strategy, ACD/Labs | Articles | Comments

A recent survey from the International Data Corporation (IDC) suggests that knowledge workers spend 15-35% of their time searching for information. A previous study by the same firm estimated that an enterprise with 1,000 knowledge workers loses a minimum of $6 million a year in the time workers spend searching for, and not finding, needed information. These types of issues are very relevant in the pharmaceutical and chemical industries.

Plant-made Drug Reverses Breathing Paralysis

July 8, 2013 7:02 pm | by Arizona State University | News | Comments

Paralytic drugs like succinylcholine (SC) are often used during surgery or when critically ill patients require endotracheal intubation. But if the drug is not swiftly cleared from the patient’s system, the results can be deadly. A new study shows that the plant-produced recombinant human enzyme butyrylcholinesterase (BChE) can rapidly reverse paralysis of the airways (or apnea) caused by succinylcholine.

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Compounds Identified to Battle Adenovirus

July 3, 2013 11:56 am | News | Comments

Scientists have identified two promising candidates for the development of drugs against human adenovirus, a cause of ailments ranging from colds to gastrointestinal disorders to pink eye. The researchers sifted through thousands of compounds to determine which might block the effects of a key viral enzyme they had previously studied in atomic-level detail.

Asthma Meds Improve Cognition in Down Syndrome Mice

July 3, 2013 11:27 am | News | Comments

An existing FDA-approved drug improves cognitive function in a mouse model of Down syndrome, according to a new study. The drug, an asthma medication called formoterol, strengthened nerve connections in the hippocampus, a brain center used for spatial navigation, paying attention and forming new memories, the study says.

Nerve Cells Can Work in Different Ways with Same Result

July 1, 2013 4:31 pm | News | Comments

Doctors’ ability to predict which drugs will work with individual patients may be influenced by recent University of Missouri research that found seemingly identical neurons can behave the same even though they are built differently under the surface.

Protein Clumps Linked to Why Alzheimer’s Drugs Rarely Help

July 1, 2013 9:08 am | News | Comments

Recent studies, however, suggest that the real culprit behind Alzheimer’s may be small Aβ clumps called oligomers that appear in the brain years before plaques develop. In unraveling oligomers’ molecular structure, scientists discovered that Aβ has a vastly different organization in oligomers than in amyloid plaques.

AstraZeneca Selects Location for New Global R&D Center and Corporate Headquarters

June 21, 2013 10:18 am | News | Comments

AstraZeneca announced that its new UK-based global research and development center and corporate headquarters will be located at the Cambridge Biomedical Campus on the southern outskirts of the city. By 2016, the new site will house a workforce of approximately 2,000.

Alzheimer's Drug Restores Lost Brain Connections

June 18, 2013 10:02 am | News | Comments

The first experimental drug to boost brain synapses lost in Alzheimer’s disease has been developed by researchers. The drug, called NitroMemantine, combines two FDA-approved medicines to stop the destructive cascade of changes in the brain that destroys the connections between neurons, leading to memory loss and cognitive decline.

Researchers Tackle MERS with SARS Approach

June 18, 2013 9:46 am | News | Comments

A pair of researchers who in the past created compounds to block the SARS virus are now tackling the new Middle East respiratory syndrome coronavirus, or MERS-CoV. The team's successful work on SARS paved the way for them to swiftly work on MERS CoV, reducing parts of the process that would normally take years to a matter of month.

Melanoma Tumors 'Eradicated' in Mice

June 17, 2013 11:10 am | News | Comments

Researchers eradicated most melanoma tumors by exposing them to a fast-acting virus, according to a report in the Journal of Virology. Melanoma is the deadliest type of skin cancer and can spread throughout the body and even into the brain.

Toxin Testing Helps Treat Spine Injuries, MS Symptoms

June 17, 2013 10:28 am | News | Comments

A medical test previously developed to measure a toxin found in tobacco smokers has been adapted to measure the same toxin in people suffering from spinal cord injuries and multiple sclerosis, offering a potential tool to reduce symptoms.

HIV Treatment Can Protect Injection Drug Users

June 12, 2013 3:06 pm | by MIKE STOBBE - AP Medical Writer - Associated Press | News | Comments

Doctors should consider giving a daily AIDS drug to another high risk group to help prevent infections - people who shoot heroin, methamphetamines or other injection drugs, U.S. health officials say. A similar recommendation is already in place for gay men and heterosexual couples at high risk of catching HIV, the virus that causes AIDS.

Diabetes, Dementia Share a 'Vicious Cycle'

June 11, 2013 10:08 am | News | Comments

A study looks at the close link between diabetes and dementia, which can create a vicious cycle. Diabetes-associated episodes of low blood sugar may increase the risk of developing dementia, while having dementia or even milder forms of cognitive impairment may increase the risk of experiencing low blood sugar, according to the study.

Technology Safely Delivers Vaccines to the Gut

June 11, 2013 9:53 am | News | Comments

A new technology under development by an academic–industry partnership protects oral vaccines from destruction by the digestive system. From the mouth to the small intestine, the digestive system presents a series of challenges designed to protect us by killing ingested bacteria.

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