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'Personalized' Vaccines Help Treat Chronic Leukemia

August 7, 2013 10:26 am | News | Comments

Scientists report that they observed a strong and selective immune response in chronic lymphocytic leukemia (CLL) patients who received, shortly after donor transplant, several doses of a “personalized” tumor vaccine, composed of their own inactivated leukemia cells combined with an immune stimulant.

New Drug Targets Resistant TB

August 5, 2013 11:44 am | News | Comments

A new drug capable of inhibiting growth of Mycobacterium tuberculosis has been reported. The findings may improve therapeutic options for the treatment of drug resistant tuberculosis (TB). One-third of the world’s population is latently infected with M. tuberculosis and more than a million people die of TB each year.

Ultrasound Patch Heals Venous Ulcers

August 1, 2013 2:36 pm | News | Comments

In a small clinical study, researchers administered a new method for treating chronic wounds using a novel ultrasound applicator that can be worn like a band-aid. The applicator delivers low-frequency, low-intensity ultrasound directly to wounds, and was found to significantly accelerate healing.

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Compounds Block Most Common Infections

August 1, 2013 11:25 am | News | Comments

Scientists are reporting progress in the search for the first broad-spectrum drugs to combat human rhinoviruses (HRVs), which cause humanity’s most common infectious diseases. Although many HRV infections cause mild disease, they can lead to dangerous complications for millions of people with asthma and chronic obstructive pulmonary disease.

New Compound Kills Aggressive Prostate Cancer

July 31, 2013 10:16 am | News | Comments

One major hallmark of cancer cells is their ability to survive under stressful conditions. A new study reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress.

New Targets for Aggressive Breast Cancer Found

July 29, 2013 10:40 am | News | Comments

A team of scientists has identified genes that are potential targets for therapeutic drugs against aggressive breast cancer. Out of the 1.5 million women diagnosed with breast cancer in the world annually, nearly one in seven of these is classified as triple negative.

Molecular 'Robots' Help Build Targeted Drugs

July 29, 2013 10:17 am | News | Comments

Many drugs, such as agents for cancer or autoimmune diseases, have nasty side effects because while they kill disease-causing cells, they also affect healthy cells. Now, a new study has demonstrated a technique for developing more targeted drugs, by using molecular “robots” to hone in on more specific populations of cells.

Steroids Found in Vitamin B Supplement

July 26, 2013 6:12 pm | by The Associated Press | News | Comments

The Food and Drug Administration is warning consumers to avoid a vitamin B dietary supplement from Healthy Life Chemistry by Purity First because it contains two potentially dangerous anabolic steroids. The agency says the company's B-50 supplements tested positive for methasterone and and dimethazine.

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Silky Implants Can Stop Epilepsy Spread

July 26, 2013 10:45 am | News | Comments

Silk has walked straight off the runway and into the lab. According to a new study, silk implants placed in the brain of laboratory animals and designed to release a specific chemical, adenosine, may help stop the progression of epilepsy.

Blocking Biosimilars

July 25, 2013 11:38 am | by Ted Agres | Articles | Comments

As the U.S. Food and Drug Administration (FDA) continues to finalize regulations to establish a pathway for approving biopharmaceutical or biosimilar drugs, leading branded drug manufacturers are looking ahead and lobbying state legislatures to enact laws that would limit the substitution of biogenerics for brand-name drugs.

Key Molecular Pathways to Alzheimer’s Identified

July 25, 2013 10:55 am | News | Comments

Key molecular pathways that ultimately lead to late-onset Alzheimer’s disease, the most common form of the disorder, have been identified by researchers. The study, which used a combination of systems biology and cell biology tools, presents a new approach to Alzheimer’s disease research and highlights several new potential drug targets.

Genetic Discovery Can Help Prevent Kidney Stones

July 25, 2013 9:59 am | News | Comments

The discovery of a gene's function in E. coli and other bacteria might lead to a probiotic to prevent the most common type of kidney stone, according to a new study. The team made the discovery during a study of genes in Acetobacter aceti, a harmless bacterium that is typically used to convert wine to vinegar.

Biomaterials Can Benefit from 'Mussel' Strength

July 24, 2013 10:56 am | News | Comments

Researchers have unraveled the secret to byssus threads, the tiny natural bungee cords that mussels use to dangle loosely from rocks, piers or ships. Byssus threads, they found, are composed of a well-designed combination of soft, stretchy material on one end and much stiffer material on the other.

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Nano-coating Can Preserve Vaccines

July 22, 2013 11:19 am | News | Comments

For the first time, scientists are working on developing a ‘nano-coating’ that would protect a vaccine from its environment both in transit and for storage. Using the latest chemistry advances, researchers hope to show how nano-silica can be grown around individual vaccine molecules, enabling a vaccine to be taken anywhere in the world without refrigeration.

3-D Structure of Key Glucose Regulator Analyzed

July 18, 2013 11:09 am | News | Comments

An international team has determined and analyzed the three-dimensional atomic structure of the human glucagon receptor. The receptor, found mainly on liver and kidney cells, helps regulate glucose levels in the bloodstream and is the target of potential therapeutic agents for type 2 diabetes.

Ocean Microbe Could Treat Anthrax, MRSA

July 18, 2013 10:31 am | News | Comments

A research team has discovered a new chemical compound from an ocean microbe in a preliminary research finding that could one day set the stage for new treatments for anthrax and other ailments such as methicillin-resistant Staphylococcus aureus (MRSA).

Nano Drug Crosses Blood-Brain Tumor Barrier

July 18, 2013 10:06 am | News | Comments

An experimental drug in early development for aggressive brain tumors can cross the blood-brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a new study. The laboratory and animal study also shows how the agent, called SapC-DOPS, targets tumor cells and blood vessels.

Leachables and Extractables as Factors Effecting Assay Results

July 17, 2013 9:53 am | by Kyle T. Harris, BioScience Applications Manager, Porex Corp. | Articles | Comments

Technological advancements of analytical instrumentation platforms coupled with demand for higher sensitivity in many life science applications have led to a critical need for significant improvement in the cleanliness of plastic consumables. 

MS Drug Promising for Heart Failure Prevention

July 17, 2013 9:38 am | News | Comments

A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle, a disorder that often leads to heart failure, researchers report. Cardiac hypertrophy, which afflicts one in 500 people, can be caused by high blood pressure or inherited through genes that control contraction of the heart.

Drug Candidate Can Increase Endurance

July 15, 2013 9:24 am | News | Comments

An international group of scientists has shown that a drug candidate designed by scientists significantly increases exercise endurance in animal models. These findings could lead to new approaches to helping people with conditions that acutely limit exercise tolerance.

Potential Markers for Childhood Arthritis Severity Found

July 12, 2013 11:39 am | News | Comments

Children who suffer from arthritis could one day receive more targeted treatment thanks to potential markers for the severity of the disorder. The early results of a world-first study looking have shown that changes in the levels of particular molecules known as prostanoids in the blood of these patients may predict the course of arthritis more accurately and help provide more individualized treatment.

Resuscitating Dead Data with Unified Laboratory Intelligence

July 10, 2013 10:35 am | by Ryan Sasaki, Director of Global Strategy, ACD/Labs | Articles | Comments

A recent survey from the International Data Corporation (IDC) suggests that knowledge workers spend 15-35% of their time searching for information. A previous study by the same firm estimated that an enterprise with 1,000 knowledge workers loses a minimum of $6 million a year in the time workers spend searching for, and not finding, needed information. These types of issues are very relevant in the pharmaceutical and chemical industries.

Plant-made Drug Reverses Breathing Paralysis

July 8, 2013 7:02 pm | by Arizona State University | News | Comments

Paralytic drugs like succinylcholine (SC) are often used during surgery or when critically ill patients require endotracheal intubation. But if the drug is not swiftly cleared from the patient’s system, the results can be deadly. A new study shows that the plant-produced recombinant human enzyme butyrylcholinesterase (BChE) can rapidly reverse paralysis of the airways (or apnea) caused by succinylcholine.

Compounds Identified to Battle Adenovirus

July 3, 2013 11:56 am | News | Comments

Scientists have identified two promising candidates for the development of drugs against human adenovirus, a cause of ailments ranging from colds to gastrointestinal disorders to pink eye. The researchers sifted through thousands of compounds to determine which might block the effects of a key viral enzyme they had previously studied in atomic-level detail.

Asthma Meds Improve Cognition in Down Syndrome Mice

July 3, 2013 11:27 am | News | Comments

An existing FDA-approved drug improves cognitive function in a mouse model of Down syndrome, according to a new study. The drug, an asthma medication called formoterol, strengthened nerve connections in the hippocampus, a brain center used for spatial navigation, paying attention and forming new memories, the study says.

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