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Antibody a Possible Blood Cancer Treatment

May 6, 2013 4:10 pm | News | Comments

A single antibody could be the key to treating multiple myeloma, or cancer of the blood, currently without cure or long-term treatment. Using a "biological library" of thousands of antibodies, researchers singled out antibody BI-505, shown to have a powerful effect on the tumor cells.

More Vitamin D May Not Be Better

May 2, 2013 11:33 am | News | Comments

In recent years, healthy people have been bombarded by stories in the media and on health websites warning about the dangers of too-low vitamin D levels, and urging high doses of supplements to protect against everything from hypertension to hardening of the arteries to diabetes.

Physical by Smartphone a Growing Possibility

May 2, 2013 12:20 am | by LAURAN NEERGAARD - AP MEDICAL WRITER | News | Comments

It's not a "Star Trek" tricorder, but by hooking a variety of gadgets onto a smartphone you could almost get a complete physical- without the paper gown or even a visit to the doctor's office. Blood pressure? Just plug the arm cuff into the phone for a quick reading.


SARS Treatment Works on Novel Coronoavirus

May 1, 2013 9:27 am | News | Comments

Scientists used lab-grown human lung cells to study the cells’ response to infection by a novel human coronavirus (called nCoV) and compiled information about which genes are significantly disrupted in early and late stages of infection.

Toxic, Foul-smelling Gas Reduces Arthritis Swelling

April 30, 2013 11:59 am | News | Comments

A gas associated with the smell of rotten eggs has proven to effectively reduce joint swelling, in research which could lead to advances in the treatment of arthritis. Scientists have discovered that a novel drug molecule, which slowly generates the gas hydrogen sulfide (H2S), effectively reduces swelling and inflammation in arthritic joints.

Cancer Cell Mapping May Yield New Drugs

April 29, 2013 12:13 pm | News | Comments

For the first time, researchers have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. Since tumours are highly dependent on the transportation of nutrients in order to be able to grow rapidly, the researchers are hoping that the study will form the basis for new strategies to fight cancer cells.

New Antibodies Help Fight Stubborn Bacteria

April 25, 2013 12:03 pm | News | Comments

In an advance toward coping with bacteria that shrug off existing antibiotics and sterilization methods, scientists are reporting development of a new family of selective antimicrobial agents that do not rely on traditional antibiotics.

Coffee, with Pill, Reduces Breast Cancer Recurrence

April 25, 2013 11:03 am | News | Comments

Drinking coffee could decrease the risk of breast cancer recurring in patients taking the widely used drug Tamoxifen, a study has found. Patients who took the pill, along with two or more cups of coffee daily, reported less than half the rate of cancer recurrence.


Video Reveals How Drugs Kill Cancer

April 25, 2013 10:14 am | News | Comments

Scientists have discovered why a particular cancer drug is so effective at killing cells. Their findings could be used to aid the design of future cancer treatments. Using high-powered laser-based microscopes, researchers made videos of the process by which rituximab binds to a diseased cell and then attracts white blood cells known as natural killer (NK) cells to attack.

Breast Cancer Drug Enhanced for Aggressive Types

April 24, 2013 11:15 am | News | Comments

Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease. Now, a team of researchers has shown how to exploit tamoxifen’s secondary activities so that it might work on more aggressive breast cancer.

Novel Therapy Safe for ALS

April 24, 2013 9:24 am | News | Comments

An investigational treatment for an inherited form of Lou Gehrig’s disease has passed an early phase clinical trial for safety, researchers report. The researchers have shown that the therapy produced no serious side effects in patients with the disease, also known as amyotrophic lateral sclerosis (ALS). The phase 1 trial’s results also demonstrate that the drug was successfully introduced into the central nervous system.

Small Molecule Destroys Potentially Dangerous Cells

April 23, 2013 12:52 pm | News | Comments

Pluripotent stem cells can turn, or differentiate, into any cell type in the body, such as nerve, muscle or bone, but inevitably some of these stem cells fail to differentiate and end up mixed in with their newly differentiated daughter cells.

Gene Expression Data Yields Significant Tumor Breakthroughs

April 22, 2013 12:48 pm | News | Comments

A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer. The analysis also identified hundreds of potential drug targets that could cut off a tumor’s fuel supply or interfere with its ability to synthesize essential building blocks.


Stem Cell Transplant Restores Memory, Learning

April 22, 2013 12:21 pm | News | Comments

For the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember. A new study shows that human stem cells can successfully implant themselves in the brain and then heal neurological deficits.

Researchers Test Caffeine's Effect on Cancer

April 18, 2013 11:04 am | News | Comments

Researchers are abuzz after using fruit flies to find new ways of taking advantage of caffeine’s lethal effects on cancer cells—results that could one day be used to advance cancer therapies for people. Previous research has established that caffeine interferes with processes in cancer cells that control DNA repair, a finding that has generated interest in using the stimulant as a chemotherapy treatment.

Protein Discovery Prevents HIV Reservoirs

April 17, 2013 1:11 pm | by Einstein | News | Comments

Researchers have discovered how the protein that blocks HIV-1 from multiplying in white blood cells is regulated. HIV-1 is the virus that causes AIDS, and the discovery could lead to novel approaches for addressing HIV-1 "in hiding"– namely eliminating reservoirs of HIV-1 that persist in patients undergoing antiretroviral therapy.

Molecule Treats Leukemia by Blocking DNA Repair

April 17, 2013 10:44 am | News | Comments

Researchers have identified a molecule that prevents repair of some cancer cells, providing a potential new "genetic chemotherapy" approach to cancer treatment that could significantly reduce side effects and the development of treatment resistance compared with traditional chemotherapy.

Anxious About Life? Tylenol May do the Trick

April 16, 2013 11:38 am | News | Comments

Researchers have found a new potential use for the over-the-counter pain drug Tylenol. Typically known to relieve physical pain, the study suggests the drug may also reduce the psychological effects of fear and anxiety over the human condition, or existential dread.

MRSA-killing Antibiotic Developed

April 12, 2013 12:03 pm | News | Comments

A new broad range antibiotic has been found to kill a wide range of bacteria, including drug-resistant Staphylococcus (MRSA) bacteria that do not respond to traditional drugs. The antibiotic, Epimerox, targets weaknesses in bacteria that have long been exploited by viruses that attack themeria.

TB Fighter, Promoter Reveals Split Identity

April 12, 2013 11:17 am | News | Comments

Tumor necrosis factor– normally an infection-fighting substance produced by the body– can actually heighten susceptibility to tuberculosis if its levels are too high. A new study shows how excess production of this disease-cell destroyer at first acts as a TB germ killer. But later the opposite occurs: Too much tumor necrosis factor encourages TB pathogens to multiply in the body.

New Way to Clear Cholesterol from Blood Discovered

April 11, 2013 10:50 am | News | Comments

Researchers have identified a new potential therapeutic target for lowering cholesterol that could be an alternative or complementary therapy to statins. Scientists in the lab of David Ginsburg at the Life Sciences Institute inhibited the action of a gene responsible for transporting a protein that interferes with the ability of the liver to remove cholesterol from the blood in mice.

Medication Nation: Study Shows Antibiotic Overuse

April 10, 2013 4:59 pm | by MIKE STOBBE - AP Medical Writer - Associated Press | News | Comments

U.S. doctors are prescribing enough antibiotics to give them to 4 out of 5 Americans every year, an alarming pace that suggests they are being overused, a new government study finds. Overuse is one reason antibiotics are losing their punch, making infections harder to treat.

Human 3D Skin Models

April 10, 2013 1:36 pm | by Scott Hickman, Marketing Manager, Toxicology, BioReliance Corporation | Articles | Comments

The development of the 3D reconstructed human skin micronucleus (RSMN) assay is the first to overcome the limitations of traditional cell culture methods. It can provide a more biologically relevant result than standard 2D in vitro genotoxicity assays, since it provides a functional stratum corneum, which accounts for permeability and appears to have a normal dermal metabolic capability.

Tiny Proteins Prevent Bacterial Gene Transcription

April 10, 2013 10:10 am | News | Comments

In the search for new antibiotics, researchers are taking an unusual approach: They are developing peptides, short chains of protein building blocks that effectively inhibit a key enzyme of bacterial metabolism. The road from gene to protein has an important stop along the way: ribonucleic acid, or RNA.

New Brain Cancer Treatment is More Effective, Less Toxic

April 9, 2013 10:00 am | News | Comments

A Phase 2 clinical trial, described this week in the Journal of Clinical Oncology, tested a new protocol for treating a relatively rare form of brain cancer, primary CNS lymphoma, that may change the standard of care for this disease, according to doctors who led the research.

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