For years, physicians around the world have watched as strain after strain of the deadly bacteria mycobacterium tuberculosis evolves resistance to drugs. A new method of analyzing whole genome sequences of TB, applied to a massive set of strains of the bacteria collected from clinics around the world, has revealed 39 new genes associated with elevated drug resistance.
Researchers from King’s College London and the University of Nottingham have identified neuroimaging markers in the brain which could help predict whether people with psychosis respond to antipsychotic medications or not. Identifying individuals at greatest risk of not responding to existing medications could help in the search for improved medications, and may eventually help clinicians personalize treatment plans.
A team of chemists has used a temperature-sensitive polymer to regulate DNA interactions in both a DNA-mediated assembly system and a DNA-encoded drug-delivery system. Their findings may improve how nanomaterials self-assemble into functional devices and how anticancer drugs, including doxorubicin, are delivered into the body.
A scientific breakthrough by researchers at the University of Kent has revealed how vitamin B12, antipernicious anaemia factor, is made– a challenge often referred to as "the Mount Everest of biosynthetic problems." Vitamin B12 is pieced together as an elaborate molecular jigsaw involving around 30 individual components.
An investigational malaria vaccine has been found to be safe, to generate an immune system response, and to offer protection against malaria infection in healthy adults, according to recent early-stage clinical trial results. The vaccine is composed of live, weakened sporozoites of the most deadly of the malaria-causing parasites.
A plastic material already used in absorbable surgical sutures and other medical devices shows promise for continuous administration of antibiotics to patients with brain infections, scientists are reporting in a new study. Use of the material could reduce the need for weeks of costly hospital stays now required for such treatment.
Scientists report that they observed a strong and selective immune response in chronic lymphocytic leukemia (CLL) patients who received, shortly after donor transplant, several doses of a “personalized” tumor vaccine, composed of their own inactivated leukemia cells combined with an immune stimulant.
A new drug capable of inhibiting growth of Mycobacterium tuberculosis has been reported. The findings may improve therapeutic options for the treatment of drug resistant tuberculosis (TB). One-third of the world’s population is latently infected with M. tuberculosis and more than a million people die of TB each year.
In a small clinical study, researchers administered a new method for treating chronic wounds using a novel ultrasound applicator that can be worn like a band-aid. The applicator delivers low-frequency, low-intensity ultrasound directly to wounds, and was found to significantly accelerate healing.
Scientists are reporting progress in the search for the first broad-spectrum drugs to combat human rhinoviruses (HRVs), which cause humanity’s most common infectious diseases. Although many HRV infections cause mild disease, they can lead to dangerous complications for millions of people with asthma and chronic obstructive pulmonary disease.
One major hallmark of cancer cells is their ability to survive under stressful conditions. A new study reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress.
A team of scientists has identified genes that are potential targets for therapeutic drugs against aggressive breast cancer. Out of the 1.5 million women diagnosed with breast cancer in the world annually, nearly one in seven of these is classified as triple negative.
Many drugs, such as agents for cancer or autoimmune diseases, have nasty side effects because while they kill disease-causing cells, they also affect healthy cells. Now, a new study has demonstrated a technique for developing more targeted drugs, by using molecular “robots” to hone in on more specific populations of cells.
The Food and Drug Administration is warning consumers to avoid a vitamin B dietary supplement from Healthy Life Chemistry by Purity First because it contains two potentially dangerous anabolic steroids. The agency says the company's B-50 supplements tested positive for methasterone and and dimethazine.
Silk has walked straight off the runway and into the lab. According to a new study, silk implants placed in the brain of laboratory animals and designed to release a specific chemical, adenosine, may help stop the progression of epilepsy.
As the U.S. Food and Drug Administration (FDA) continues to finalize regulations to establish a pathway for approving biopharmaceutical or biosimilar drugs, leading branded drug manufacturers are looking ahead and lobbying state legislatures to enact laws that would limit the substitution of biogenerics for brand-name drugs.
Key molecular pathways that ultimately lead to late-onset Alzheimer’s disease, the most common form of the disorder, have been identified by researchers. The study, which used a combination of systems biology and cell biology tools, presents a new approach to Alzheimer’s disease research and highlights several new potential drug targets.
The discovery of a gene's function in E. coli and other bacteria might lead to a probiotic to prevent the most common type of kidney stone, according to a new study. The team made the discovery during a study of genes in Acetobacter aceti, a harmless bacterium that is typically used to convert wine to vinegar.
Researchers have unraveled the secret to byssus threads, the tiny natural bungee cords that mussels use to dangle loosely from rocks, piers or ships. Byssus threads, they found, are composed of a well-designed combination of soft, stretchy material on one end and much stiffer material on the other.
For the first time, scientists are working on developing a ‘nano-coating’ that would protect a vaccine from its environment both in transit and for storage. Using the latest chemistry advances, researchers hope to show how nano-silica can be grown around individual vaccine molecules, enabling a vaccine to be taken anywhere in the world without refrigeration.
An international team has determined and analyzed the three-dimensional atomic structure of the human glucagon receptor. The receptor, found mainly on liver and kidney cells, helps regulate glucose levels in the bloodstream and is the target of potential therapeutic agents for type 2 diabetes.
A research team has discovered a new chemical compound from an ocean microbe in a preliminary research finding that could one day set the stage for new treatments for anthrax and other ailments such as methicillin-resistant Staphylococcus aureus (MRSA).
An experimental drug in early development for aggressive brain tumors can cross the blood-brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a new study. The laboratory and animal study also shows how the agent, called SapC-DOPS, targets tumor cells and blood vessels.
Technological advancements of analytical instrumentation platforms coupled with demand for higher sensitivity in many life science applications have led to a critical need for significant improvement in the cleanliness of plastic consumables.
A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle, a disorder that often leads to heart failure, researchers report. Cardiac hypertrophy, which afflicts one in 500 people, can be caused by high blood pressure or inherited through genes that control contraction of the heart.