Advertisement
Pharma
Subscribe to Pharma
View Sample

FREE Email Newsletter

Cholesterol Transporter Structure Decoded

March 21, 2014 1:25 pm | News | Comments

Scientists in Göttingen have solved the high-resolution structure of the molecular transporter TSPO, which introduces cholesterol into mitochondria. This protein also serves as a docking site for diagnostic markers and different drugs, such as Valium. The detailed knowledge of its three-dimensional shape and function opens up new diagnostic and therapeutic perspectives.

Fast Synthesis Could Boost Drug Development

March 19, 2014 10:38 am | News | Comments

Small protein fragments, also called peptides, are promising as drugs because they can be designed for very specific functions inside living cells. Insulin and the HIV drug Fuzeon are some of the earliest successful examples, and peptide drugs are expected to become a $25 billion market by 2018. However, a major bottleneck has prevented peptide drugs from reaching their full potential: Manufacturing the peptides takes several weeks.

Heart Scans Only Useful in Prescribing Statins Under Certain Conditions

March 13, 2014 1:55 pm | News | Comments

As long as inexpensive statins, which lower cholesterol, are readily available and patients don’t mind taking them, it doesn’t make sense to do a heart scan to measure how much plaque has built up in a patient’s coronary arteries before prescribing the pills, according to a new study.

Advertisement

In First Moments of Infection, a Division and a Decision

March 7, 2014 1:21 pm | News | Comments

Using technologies and computational modeling that trace the destiny of single cells, researchers at the University of California, San Diego School of Medicine describe for the first time the earliest stages of fate determination among white blood cells called T lymphocytes, providing new insights that may help drug developers create more effective, longer-lasting vaccines against microbial pathogens or cancer.

Immune System-based Therapy Produces Lasting Remissions in Melanoma Patients

March 4, 2014 12:59 pm | News | Comments

A drug that unleashes the immune system to attack cancer can produce lasting remissions and hold the disease in check – for more than two years, in some cases – in many patients with advanced melanoma, according to a new study. The study provides the longest-term look so far at how melanoma patients have fared since receiving the drug, nivolumab, in a Phase 1 clinical trial.

Ancient Chinese Medicine Put Through its Paces for Pancreatic Cancer

March 3, 2014 11:29 am | News | Comments

The bark of the Amur cork tree (Phellodendron amurense) has traveled a centuries-long road with the healing arts. Now it is being put through its paces by science in the fight against pancreatic cancer, with the potential to make inroads against several more.

Study Pinpoints Protective Mutations for Type 2 Diabetes

March 3, 2014 11:03 am | News | Comments

A team of researchers identified mutations in a gene that can reduce the risk of developing type 2 diabetes, even in people who have risk factors such as obesity and old age. The results focus the search for developing novel therapeutic strategies for type 2 diabetes; if a drug can be developed that mimics the protective effect of these mutations, it could open up new ways of preventing this devastating disease.

Experimental Treatment Eradicates Acute Leukemia in Mice

February 27, 2014 1:49 pm | News | Comments

A team of scientists from UCLA's Jonsson Comprehensive Cancer Center has developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread.

Advertisement

Use of Acetaminophen During Pregnancy Linked to ADHD in Children

February 25, 2014 1:59 pm | News | Comments

Acetaminophen provides many people with relief from headaches and sore muscles. When used appropriately, it is considered mostly harmless. Over recent decades, the drug has become the medication most commonly used by pregnant women for fevers and pain.  Now, a long-term study by UCLA, in collaboration with the University of Aarhus in Denmark, has raised concerns about the use of acetaminophen during pregnancy.

An Essential Step Toward Printing Living Tissues

February 20, 2014 11:55 am | Videos | Comments

A new bioprinting method creates intricately patterned 3D tissue constructs with multiple types of cells and tiny blood vessels. The work represents a major step toward a longstanding goal of tissue engineers: creating human tissue constructs realistic enough to test drug safety and effectiveness.

Robot May Accelerate Trials for Stroke Medications

February 12, 2014 12:12 pm | News | Comments

The development of drugs to treat acute stroke or aid in stroke recovery is an endeavor that only rarely pays off in the form of approval. Drug companies spend years testing safety and dosage in the clinic, only to find in Phase 3 clinical efficacy trials have little to no benefit. A robot developed at MIT may help speed up drug development, letting companies know earlier in the process whether a drug will work in stroke patients.

Drug Discovery Potential of Natural Microbial Genomes

January 23, 2014 12:58 pm | News | Comments

Scientists at UCSD developed a new genetic platform that allows efficient production of naturally occurring molecules, and have used it to produce a novel antibiotic compound. The scientists harvested a set of genes predicted to encode a natural product from ocean bacteria, then used synthetic biology technology to identify and test a new antibiotic – taromycin A – found to be effective in fighting drug-resistant MRSA.

Amgen, Illumina Team on Personalized Medicine Test

January 15, 2014 5:19 pm | by The Associated Press | News | Comments

Biotech drugmaker Amgen and Illumina, a maker of genetic testing equipment, said Wednesday they are developing a test that will identify patients who might be helped by Amgen's colon cancer drug Vectibix. Vectibix is approved as a treatment for colorectal cancer that has spread and hasn't rresponded to chemotherapy.

Advertisement

Researchers Identify Key Molecular Components Linking Circadian Rhythms and Cell Division Cycles

January 15, 2014 1:24 pm | News | Comments

Researchers at the University of Cincinnati (UC) have identified key molecular components linking circadian rhythms and cell division cycles in Neurospora crassa, providing insights that could lead to improved disease treatments and drug delivery.

On-demand Vaccines Possible with Engineered Nanoparticles

January 8, 2014 11:58 am | News | Comments

Engineers hope a new type of vaccine they have shown to work in mice will one day make it cheaper and easy to manufacture on-demand vaccines for humans. Immunizations could be administered within minutes where and when a disease is breaking out.

Scientists Uncover Detailed Picture of Muscular Dystrophy Defect

January 2, 2014 12:04 pm | News | Comments

Scientists have revealed an atomic-level view of a genetic defect that causes a form of muscular dystrophy, myotonic dystrophy type 2, and have used this information to design drug candidates with potential to counter those defects.      

Low Oxygen Conditions Promote Breast Cancer Spread

December 26, 2013 11:40 am | News | Comments

Biologists at The Johns Hopkins University have discovered that low oxygen conditions, which often persist inside tumors, are sufficient to initiate a molecular chain of events that transforms breast cancer cells from being rigid and stationery to mobile and invasive. 

First Structure of Enzyme that Removes Methylation Obtained

December 26, 2013 11:28 am | News | Comments

Scientists have obtained the first detailed molecular structure of a member of the Tet family of enzymes. The finding is important for the field of epigenetics because Tet enzymes chemically modify DNA, changing signposts that tell the cell's machinery "this gene is shut off" into other signs that say "ready for a change."

New Drug Candidates for Chagas Disease Show Promise

December 26, 2013 10:45 am | News | Comments

A team of researchers from Canada has developed a class of compounds which may help eradicate a neglected tropical disease that is currently hard to kill in its chronic form. The research was published ahead of print in Antimicrobial Agents and Chemotherapy.

Innovative Screening Strategy Uncovers New Drugs, Biology

December 23, 2013 11:15 am | News | Comments

Scientists at The Scripps Research Institute (TSRI) have demonstrated a drug-discovery strategy with a double payoff—it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work. To illustrate the power of the innovative technique, the TSRI researchers used it to identify a compound that shows promise for treating obesity-linked diabetes. Learn more...

Study IDs, Breaks Down 'Wall' Around Tumors

December 20, 2013 12:12 pm | News | Comments

Researchers have identified how the ‘wall’ around cancer tumors functions and how to break it down, enabling the body’s own defenses to reach and kill the cancer cells within.                     

One Step Closer to a 'Universal' Flu Vaccine

December 20, 2013 11:49 am | News | Comments

Researchers report promising steps toward the creation of a universal flu vaccine, one that could be produced more quickly and offer broader protection than the virus-specific inoculants available today.              

Lessening X-ray Damage is Healthy for Protein Discovery

December 19, 2013 11:18 am | News | Comments

New recommendations for using X-rays promise to speed investigations aimed at understanding the structure and function of biologically important proteins– information critical to the development of new drugs.            

ALS Toxicity Reduced in Animal Models

December 17, 2013 11:10 am | News | Comments

In a new study researchers have found a way of reducing ALS disease toxicity, which slows the dysfunction of neurons and shows that a parallel mechanism can reduce toxicity in mammalian cells.                   

Antibodies Block Malaria Invasion

December 16, 2013 11:43 am | News | Comments

Scientists have discovered a key process during the invasion of the blood cell by the Malaria parasite, and more importantly, found a way to block this invasion.                          

X
You may login with either your assigned username or your e-mail address.
The password field is case sensitive.
Loading