Abiraterone acetate, a recently FDA-approved drug used to treat men with metastatic castration-resistant prostate cancer and marketed as Zytiga, significantly delays progression of pain and quality of life deterioration when taken in conjunction with prednisone. The design of the study emphasized the importance of patient reported-outcomes in evaluating new treatments.
Working with mice, researchers have discovered that weeks of treatment with a repurposed FDA-approved drug halted the growth of— and ultimately left no detectable trace of— brain tumor cells taken from adult human patients. The scientists targeted a mutation in the IDH1 gene first identified in human brain tumors called gliomas by a team cancer researchers in 2008.
Working with cells in test tubes and in mice, researchers have discovered that a chemical commonly used as a dog food preservative may prevent the kind of painful nerve damage found in the hands and feet of four out of five cancer patients taking the chemotherapy drug Taxol.
It happens too often: A doctor isn't sure what's causing someone's feverish illness but prescribes antibiotics just in case, drugs that don't work if a virus is the real culprit. Now, Duke University researchers are developing a blood test to more easily tell when a respiratory illness is due to a virus and not a bacterial infection, hoping to cut the dangerous overuse of antibiotics and speed the right diagnosis.
The top doctor for Green Berets and other elite Army commandos has told troops to immediately stop taking mefloquine, an anti-malaria drug found to cause permanent brain damage in rare cases. The ban among special operations forces is the latest development in a long-running controversy over over mefloquine.
A research team has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central nervous system, producing mental fogginess similar to “chemo brain.” The researchers also report they’ve discovered an existing drug compound that appears to counteract or rescue brain cells from the adverse effects of the breast cancer drug.
Scientists have found a way to make dramatic improvements to the cancer cell-killing power of vinblastine, one of the most successful chemotherapy drugs of the past few decades. The team’s modified versions of vinblastine showed 10 to 200 times greater potency than the clinical drug.
Researchers from Columbia University Medical Center, working with collaborators at the Hospital for Special Surgery, created a fleet of “nano-robots” that can home in on specific cells and mark them with a fluorescent tag for drug therapy or destruction.
For the first time, the government is estimating how many people die from drug-resistant bacteria each year - more than 23,000, or about as many as those killed annually by flu. The Centers for Disease Control and Prevention released the number to spotlight the growing threat of germs that are hard to treat because they've become resistant to drugs.
The reasons behind why it often takes people several weeks to feel the effect of newly prescribed antidepressants remains somewhat of a mystery– and likely, a frustration to both patients and physicians. Researchers have been working to find out why and if there is anything that can be done to shorten the time in which antidepressants kick in.
Using large and frequent doses of the painkiller codeine may actually produce heightened sensitivity to pain, without the same level of relief offered by morphine, according to new research. The study is believed to be the world's first experimental study comparing the pain relieving and pain worsening effects of both codeine and morphine.
TV ads tout testosterone treatments for "low T," but surprising new research shows a different hormone may play a role in less sex drive and more fat as men age. Estrogen- the female hormone- is needed by men, too, and the study gives the first clear evidence that too little of it can cause certain "male menopause" symptoms.
Researchers have identified a compound that dramatically bolsters learning and memory when given to mice with a Down syndrome-like condition on the day of birth. The study reports that the single-dose treatment appears to enable the cerebellum of the rodents’ brains to grow to a normal size.
Phase 1 Clinical Trial (SAV CT 01) of the first and only preventative HIV vaccine based on a genetically modified killed whole virus (SAV001-H) has been successfully completed with no adverse effects in all patients, Western and Sumagen Canada Inc. announced.
A precisely designed macromolecule that mimics the binding of HIV to immune system cells could be used to stop the virus from physically entering the body, according to a new study. The researchers created the large molecule with several sugar molecules, known as glycopolymers.
For years, physicians around the world have watched as strain after strain of the deadly bacteria mycobacterium tuberculosis evolves resistance to drugs. A new method of analyzing whole genome sequences of TB, applied to a massive set of strains of the bacteria collected from clinics around the world, has revealed 39 new genes associated with elevated drug resistance.
Researchers from King’s College London and the University of Nottingham have identified neuroimaging markers in the brain which could help predict whether people with psychosis respond to antipsychotic medications or not. Identifying individuals at greatest risk of not responding to existing medications could help in the search for improved medications, and may eventually help clinicians personalize treatment plans.
A team of chemists has used a temperature-sensitive polymer to regulate DNA interactions in both a DNA-mediated assembly system and a DNA-encoded drug-delivery system. Their findings may improve how nanomaterials self-assemble into functional devices and how anticancer drugs, including doxorubicin, are delivered into the body.
A scientific breakthrough by researchers at the University of Kent has revealed how vitamin B12, antipernicious anaemia factor, is made– a challenge often referred to as "the Mount Everest of biosynthetic problems." Vitamin B12 is pieced together as an elaborate molecular jigsaw involving around 30 individual components.
An investigational malaria vaccine has been found to be safe, to generate an immune system response, and to offer protection against malaria infection in healthy adults, according to recent early-stage clinical trial results. The vaccine is composed of live, weakened sporozoites of the most deadly of the malaria-causing parasites.
A plastic material already used in absorbable surgical sutures and other medical devices shows promise for continuous administration of antibiotics to patients with brain infections, scientists are reporting in a new study. Use of the material could reduce the need for weeks of costly hospital stays now required for such treatment.
Scientists report that they observed a strong and selective immune response in chronic lymphocytic leukemia (CLL) patients who received, shortly after donor transplant, several doses of a “personalized” tumor vaccine, composed of their own inactivated leukemia cells combined with an immune stimulant.
A new drug capable of inhibiting growth of Mycobacterium tuberculosis has been reported. The findings may improve therapeutic options for the treatment of drug resistant tuberculosis (TB). One-third of the world’s population is latently infected with M. tuberculosis and more than a million people die of TB each year.
In a small clinical study, researchers administered a new method for treating chronic wounds using a novel ultrasound applicator that can be worn like a band-aid. The applicator delivers low-frequency, low-intensity ultrasound directly to wounds, and was found to significantly accelerate healing.
Scientists are reporting progress in the search for the first broad-spectrum drugs to combat human rhinoviruses (HRVs), which cause humanity’s most common infectious diseases. Although many HRV infections cause mild disease, they can lead to dangerous complications for millions of people with asthma and chronic obstructive pulmonary disease.