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Experimental Treatment Eradicates Acute Leukemia in Mice

February 27, 2014 1:49 pm | News | Comments

A team of scientists from UCLA's Jonsson Comprehensive Cancer Center has developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread.

Use of Acetaminophen During Pregnancy Linked to ADHD in Children

February 25, 2014 1:59 pm | News | Comments

Acetaminophen provides many people with relief from headaches and sore muscles. When used appropriately, it is considered mostly harmless. Over recent decades, the drug has become the medication most commonly used by pregnant women for fevers and pain.  Now, a long-term study by UCLA, in collaboration with the University of Aarhus in Denmark, has raised concerns about the use of acetaminophen during pregnancy.

An Essential Step Toward Printing Living Tissues

February 20, 2014 11:55 am | Videos | Comments

A new bioprinting method creates intricately patterned 3D tissue constructs with multiple types of cells and tiny blood vessels. The work represents a major step toward a longstanding goal of tissue engineers: creating human tissue constructs realistic enough to test drug safety and effectiveness.

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Robot May Accelerate Trials for Stroke Medications

February 12, 2014 12:12 pm | News | Comments

The development of drugs to treat acute stroke or aid in stroke recovery is an endeavor that only rarely pays off in the form of approval. Drug companies spend years testing safety and dosage in the clinic, only to find in Phase 3 clinical efficacy trials have little to no benefit. A robot developed at MIT may help speed up drug development, letting companies know earlier in the process whether a drug will work in stroke patients.

FDA Wants More Info on Female Libido Pill

February 11, 2014 8:07 am | by Matthew Perrone - AP Health Writer - Associated Press | News | Comments

The drugmaker working to develop a pill to boost sexual desire in women says regulators are demanding more studies on the experimental drug. Sprout Pharmaceuticals said that the Food and Drug Administration wants to see more data on how the company's drug, flibanserin, interacts with other medications and how it affects driving ability. Nearly 10 percent of women studied in company trials reported sleepiness while taking the daily pill.

Pharma Data Play Larger Role in Olympic Drug Tests

February 7, 2014 7:07 pm | by Matthew Perrone - AP Health Writer - Associated Press | News | Comments

Some of the world's biggest drugmakers are playing a larger role in anti-doping efforts at this year's Winter Olympics: They're providing information on drugs that once would have been considered proprietary trade secrets. GlaxoSmithKline, Amgen, and Roche are among the drugmakers that have begun sharing "confidential research and data" with anti-doping officials about experimental drugs they are developing.

Drug Discovery Potential of Natural Microbial Genomes

January 23, 2014 12:58 pm | News | Comments

Scientists at UCSD developed a new genetic platform that allows efficient production of naturally occurring molecules, and have used it to produce a novel antibiotic compound. The scientists harvested a set of genes predicted to encode a natural product from ocean bacteria, then used synthetic biology technology to identify and test a new antibiotic – taromycin A – found to be effective in fighting drug-resistant MRSA.

Carlyle Group Makes $4.15B Offer for J&J Business

January 16, 2014 2:42 pm | by LINDA A. JOHNSON - AP Business Writer - Associated Press | News | Comments

Johnson & Johnson has been offered $4.15 billion by The Carlyle Group for its Ortho-Clinical Diagnostics business, a year after J&J began reviewing strategic options for the blood-testing unit as part of a routine pruning of its extensive family of businesses. J&J has until March 31 to decide whether to accept the offer.

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Amgen, Illumina Team on Personalized Medicine Test

January 15, 2014 5:19 pm | by The Associated Press | News | Comments

Biotech drugmaker Amgen and Illumina, a maker of genetic testing equipment, said Wednesday they are developing a test that will identify patients who might be helped by Amgen's colon cancer drug Vectibix. Vectibix is approved as a treatment for colorectal cancer that has spread and hasn't rresponded to chemotherapy.

Researchers Identify Key Molecular Components Linking Circadian Rhythms and Cell Division Cycles

January 15, 2014 1:24 pm | News | Comments

Researchers at the University of Cincinnati (UC) have identified key molecular components linking circadian rhythms and cell division cycles in Neurospora crassa, providing insights that could lead to improved disease treatments and drug delivery.

Thinking Positive Can Help Migraine Drug Work

January 8, 2014 3:29 pm | by LAURAN NEERGAARD - AP Medical Writer - Associated Press | News | Comments

Talk about mind over matter: A quirky new study suggests patients' expectations can make a big difference in how they feel after treatment for a migraine.                            

On-demand Vaccines Possible with Engineered Nanoparticles

January 8, 2014 11:58 am | News | Comments

Engineers hope a new type of vaccine they have shown to work in mice will one day make it cheaper and easy to manufacture on-demand vaccines for humans. Immunizations could be administered within minutes where and when a disease is breaking out.

New Drug Approvals from FDA Declined in 2013

January 3, 2014 10:50 am | by Matthew Perrone -- AP Health Writer -- Associated Press | News | Comments

The Food and Drug Administration approved 27 first-of-a-kind drugs in 2013, down from 39 new medications in 2012, which was a 15-year high.                                

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Scientists Uncover Detailed Picture of Muscular Dystrophy Defect

January 2, 2014 12:04 pm | News | Comments

Scientists have revealed an atomic-level view of a genetic defect that causes a form of muscular dystrophy, myotonic dystrophy type 2, and have used this information to design drug candidates with potential to counter those defects.      

Low Oxygen Conditions Promote Breast Cancer Spread

December 26, 2013 11:40 am | News | Comments

Biologists at The Johns Hopkins University have discovered that low oxygen conditions, which often persist inside tumors, are sufficient to initiate a molecular chain of events that transforms breast cancer cells from being rigid and stationery to mobile and invasive. 

First Structure of Enzyme that Removes Methylation Obtained

December 26, 2013 11:28 am | News | Comments

Scientists have obtained the first detailed molecular structure of a member of the Tet family of enzymes. The finding is important for the field of epigenetics because Tet enzymes chemically modify DNA, changing signposts that tell the cell's machinery "this gene is shut off" into other signs that say "ready for a change."

New Drug Candidates for Chagas Disease Show Promise

December 26, 2013 10:45 am | News | Comments

A team of researchers from Canada has developed a class of compounds which may help eradicate a neglected tropical disease that is currently hard to kill in its chronic form. The research was published ahead of print in Antimicrobial Agents and Chemotherapy.

Innovative Screening Strategy Uncovers New Drugs, Biology

December 23, 2013 11:15 am | News | Comments

Scientists at The Scripps Research Institute (TSRI) have demonstrated a drug-discovery strategy with a double payoff—it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work. To illustrate the power of the innovative technique, the TSRI researchers used it to identify a compound that shows promise for treating obesity-linked diabetes. Learn more...

Study IDs, Breaks Down 'Wall' Around Tumors

December 20, 2013 12:12 pm | News | Comments

Researchers have identified how the ‘wall’ around cancer tumors functions and how to break it down, enabling the body’s own defenses to reach and kill the cancer cells within.                     

One Step Closer to a 'Universal' Flu Vaccine

December 20, 2013 11:49 am | News | Comments

Researchers report promising steps toward the creation of a universal flu vaccine, one that could be produced more quickly and offer broader protection than the virus-specific inoculants available today.              

Drug Blocks HIV in Lab, Human Tests Planned

December 19, 2013 2:51 pm | by MALCOLM RITTER - AP Science Writer - Associated Press | News | Comments

Can an experimental drug developed to treat epilepsy block the AIDS virus? A preliminary lab study suggests it's possible, and researchers are eager to try it in people.                        

Lessening X-ray Damage is Healthy for Protein Discovery

December 19, 2013 11:18 am | News | Comments

New recommendations for using X-rays promise to speed investigations aimed at understanding the structure and function of biologically important proteins– information critical to the development of new drugs.            

ALS Toxicity Reduced in Animal Models

December 17, 2013 11:10 am | News | Comments

In a new study researchers have found a way of reducing ALS disease toxicity, which slows the dysfunction of neurons and shows that a parallel mechanism can reduce toxicity in mammalian cells.                   

Vitamins Don't Block Disease, Studies Say

December 16, 2013 5:54 pm | by LAURAN NEERGAARD - AP Medical Writer - Associated Press | News | Comments

There's more disappointing news about multivitamins: Two major studies found popping the pills didn't protect aging men's brains or help heart attack survivors.                          

Antibodies Block Malaria Invasion

December 16, 2013 11:43 am | News | Comments

Scientists have discovered a key process during the invasion of the blood cell by the Malaria parasite, and more importantly, found a way to block this invasion.                          

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