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New Target Found for Chronic Pain Treatment

May 22, 2014 1:57 pm | News | Comments

Researchers have found a new target for treating chronic pain: an enzyme called PIP5K1C. The research shows that PIP5K1C controls the activity of cellular receptors that signal pain.                   

Printing Replacements

May 22, 2014 1:44 pm | by Robert Fee, Editor-in-Chief, Bioscience Technology | Articles | Comments

3-D printing promises to revolutionize engineering, and many speculate that it could have a huge impact on medicine, too. Many speculate that useful organs grown in the lab three-dimensionally on scaffolds is now closer to fact than fiction.

Neutron Beams Reveal How Antibodies Cluster in Solution

May 20, 2014 2:00 pm | News | Comments

Results from neutron spin-echo analysis are an important advance towards enabling subcutaneous injections of concentrated biopharmaceuticals used to treat cancer and autoimmune disorders (e.g. arthritis, multiple sclerosis). The insights obtained could help drug companies reduce the viscosity and mitigate phase separation in injectable biopharmaceuticals.

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Measles Vaccine Can Kill Multiple Myeloma Cells

May 15, 2014 11:00 am | Videos | Comments

In a proof-of-principle clinical trial, researchers have demonstrated that virotherapy— destroying cancer with a virus that infects and kills cancer cells but spares normal tissues— can be effective against the deadly cancer multiple myeloma.   

Anti-Depressant Reduces Alzheimer’s Plaque Growth by 78 Percent

May 14, 2014 2:03 pm | by Cynthia Fox | Articles | Comments

A common antidepressant can dramatically halt growth of Alzheimer’s plaque. A team from Missouri and Pennsylvania report today in Science Translational Medicine this reduction occurs in both humans and mice. It gives the drug, the selective serotonin reuptake inhibitor (SSRI) citalopram, a possible future role as a prophylactic—the first in Alzheimer’s Disease (AD), if bigger studies are supportive.

ED Drug Restores Blood Flow in Muscular Dystrophy

May 8, 2014 1:45 pm | News | Comments

Researchers have found that a commonly prescribed drug restores blood flow to oxygen-starved muscles of boys with Duchenne muscular dystrophy, a genetic muscle-wasting disease.                     

MERS Experts Working on Way to Block Virus

May 6, 2014 12:45 pm | News | Comments

A team of researchers is creating molecules designed to shut down the Middle East respiratory syndrome coronavirus, or MERS-CoV, that recently arrived in the United States.                       

Researchers ID Potential New Strategy to Treat Ovarian Cancer

April 28, 2014 1:33 pm | News | Comments

Scientists studying cancerous tumor tissues in a laboratory believe they have identified a potential new strategy to treat ovarian cancer by targeting ovarian tumor growth through the inhibition of the development of new tumor blood vessels.   

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Statins May Lead Some Patients to Pig Out

April 24, 2014 9:20 pm | by Lindsey Tanner - AP Medical Writer | News | Comments

Ten years of U.S. data suggest that calorie and fat intake increased among statin users during the decade, an indication that many patients might be abandoning heart-healthy lifestyles and assuming that drugs alone will do the trick, the study authors said.

Gene Determines If Aspirin Can Lower Colon Cancer Risk

April 24, 2014 1:00 pm | News | Comments

The humble aspirin may have just added another beneficial effect beyond its ability to ameliorate headaches and reduce the risk of heart attacks: lowering colon cancer risk among people with high levels of a specific type of gene.     

Fast Way to Measure DNA Repair

April 22, 2014 2:57 pm | News | Comments

A team of researchers has developed a test that can rapidly assess several DNA repair systems, which could help determine individuals’ risk of developing cancer and help doctors predict how a given patient will respond to chemotherapy drugs.   

'Molecular Tweezer' is a Step Toward Parkinson’s Treatment

April 21, 2014 2:43 pm | Videos | Comments

The most effective way to tackle debilitating diseases is to punch them at the start and keep them from growing. Research shows that a small “molecular tweezer” keeps proteins from clumping, the first step of disorders such as Parkinson’s disease, Alzheimer’s disease and Huntington’s disease.

Drawing a Ring Around Antiviral Immunity

April 15, 2014 11:37 am | News | Comments

If you follow cancer biology, then you’ve probably heard of ubiquitin before. In a recent paper researchers provided a structural rationale for how ubiquitin helps RIG-I do its job— and how that might help keep the immune system from getting out of hand.

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Regenerating Muscle in Duchenne Muscular Dystrophy: Age Matters

April 14, 2014 1:50 pm | News | Comments

A team of scientists published details of how a class of drugs called “HDACis” drive muscle-cell regeneration in the early stages of dystrophic muscles, but fail to work in late stages. The findings are key to furthering clinical development of HDACis for Duchenne muscular dystrophy (DMD), an incurable muscle-wasting disease.

US Jury Hits Takeda, Eli Lilly with $9B Penalty

April 8, 2014 9:19 am | by Yuri Kageyama - AP Business Writer - Associated Press | News | Comments

A U.S. jury ordered Japanese drugmaker Takeda Pharmaceutical Co. and its U.S. counterpart, Eli Lilly and Co., to pay $9 billion in punitive damages over a diabetes medicine linked to cancer. The drug companies said Tuesday they will "vigorously challenge" the decision. The U.S District Court in western Louisiana ordered a $6 billion penalty for Takeda and $3 billion for its business partner and co-defendant Eli Lilly.

Caffeine Can Target Tau Deposits in Alzheimer's

April 7, 2014 12:33 pm | News | Comments

A research team was able to demonstrate for the first time that caffeine has a positive effect on tau deposits in Alzheimer's disease. Tau deposits, along with beta-amyloid plaques, are among the characteristic features of Alzheimer's disease. 

FDA OKs 1st Hay Fever Allergy Immunotherapy Tablet

April 2, 2014 12:20 pm | by The Associated Press | News | Comments

The U.S. Food and Drug Administration has approved the first tablet for gradually reducing hay fever allergy symptoms, an alternative to uncomfortable allergy-desensitizing shots. Oralair, a tablet that dissolves quickly under the tongue, is approved for patients aged 10 through 65. It's to be...

Using Light-Heated Water to Deliver Drugs

April 1, 2014 2:25 pm | News | Comments

Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using light to activate drug-delivering nanoparticles and other targeted therapeutic substances inside the body.

Tamiflu-resistant Influenza: Parsing the Genome for the Culprits

March 31, 2014 2:43 pm | News | Comments

It doesn’t take long for the flu virus to outsmart Tamiflu. EPFL scientists have developed a tool that reveals the mutations that make the virus resistant, and they have identified new mutations that may render ineffective one of the few treatments currently available on the market.

Relaxed Blood Pressure Guidelines Cut Millions from Needing Medication

March 31, 2014 2:20 pm | News | Comments

New guidelines that ease the recommended blood pressure could result in 5.8 million U.S. adults no longer needing hypertension medication. The findings are the first peer-reviewed analysis to quantify the impact of guidelines announced in February by the Eighth Joint National Committee. In a divisive move, the committee relaxed the blood pressure goal in adults 60 years and older to 150/90, instead of the previous goal of 140/90.

UV Exposure Found to Lower Folate Levels in Young Women

March 21, 2014 2:02 pm | News | Comments

Women who are pregnant or trying to become pregnant and taking a folic acid supplement may be at risk of reducing their folate benefit through sun exposure, a new QUT study has warned. A study of 45 young healthy women in Brisbane aged 18 to 47, showed high rates of sun exposure accounted up to a 20 per cent reduction in folate levels.

Switching an Antibiotic On and Off with Light

March 21, 2014 1:43 pm | News | Comments

Scientists of the KIT and the University of Kiev have produced an antibiotic, whose biological activity can be controlled with light. Thanks to the robust diarylethene photoswitch, the antimicrobial effect of the peptide mimetic can be applied in a spatially and temporally specific manner. This might open up new options for the treatment of local infections, as side effects are reduced.

Cholesterol Transporter Structure Decoded

March 21, 2014 1:25 pm | News | Comments

Scientists in Göttingen have solved the high-resolution structure of the molecular transporter TSPO, which introduces cholesterol into mitochondria. This protein also serves as a docking site for diagnostic markers and different drugs, such as Valium. The detailed knowledge of its three-dimensional shape and function opens up new diagnostic and therapeutic perspectives.

Half of US Adults 40 to 75 Eligible for Statins

March 19, 2014 5:17 pm | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

Almost half of Americans ages 40 to 75 and nearly all men over 60 qualify to consider cholesterol-lowering statin drugs under new heart disease prevention guidelines, an analysis concludes. It's the first independent look at the impact of the guidelines issued in November and shows how dramatically they shift more people toward treatment.

Fast Synthesis Could Boost Drug Development

March 19, 2014 10:38 am | News | Comments

Small protein fragments, also called peptides, are promising as drugs because they can be designed for very specific functions inside living cells. Insulin and the HIV drug Fuzeon are some of the earliest successful examples, and peptide drugs are expected to become a $25 billion market by 2018. However, a major bottleneck has prevented peptide drugs from reaching their full potential: Manufacturing the peptides takes several weeks.

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