Engineers hope a new type of vaccine they have shown to work in mice will one day make it cheaper and easy to manufacture on-demand vaccines for humans. Immunizations could be administered within minutes where and when a disease is breaking out.
The Food and Drug Administration approved 27 first-of-a-kind drugs in 2013, down from 39 new medications in 2012, which was a 15-year high.
Scientists have revealed an atomic-level view of a genetic defect that causes a form of muscular dystrophy, myotonic dystrophy type 2, and have used this information to design drug candidates with potential to counter those defects.
Biologists at The Johns Hopkins University have discovered that low oxygen conditions, which often persist inside tumors, are sufficient to initiate a molecular chain of events that transforms breast cancer cells from being rigid and stationery to mobile and invasive.
Scientists have obtained the first detailed molecular structure of a member of the Tet family of enzymes. The finding is important for the field of epigenetics because Tet enzymes chemically modify DNA, changing signposts that tell the cell's machinery "this gene is shut off" into other signs that say "ready for a change."
A team of researchers from Canada has developed a class of compounds which may help eradicate a neglected tropical disease that is currently hard to kill in its chronic form. The research was published ahead of print in Antimicrobial Agents and Chemotherapy.
Scientists at The Scripps Research Institute (TSRI) have demonstrated a drug-discovery strategy with a double payoff—it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work. To illustrate the power of the innovative technique, the TSRI researchers used it to identify a compound that shows promise for treating obesity-linked diabetes. Learn more...
Researchers have identified how the ‘wall’ around cancer tumors functions and how to break it down, enabling the body’s own defenses to reach and kill the cancer cells within.
Researchers report promising steps toward the creation of a universal flu vaccine, one that could be produced more quickly and offer broader protection than the virus-specific inoculants available today.
Can an experimental drug developed to treat epilepsy block the AIDS virus? A preliminary lab study suggests it's possible, and researchers are eager to try it in people.
New recommendations for using X-rays promise to speed investigations aimed at understanding the structure and function of biologically important proteins– information critical to the development of new drugs.
In a new study researchers have found a way of reducing ALS disease toxicity, which slows the dysfunction of neurons and shows that a parallel mechanism can reduce toxicity in mammalian cells.
There's more disappointing news about multivitamins: Two major studies found popping the pills didn't protect aging men's brains or help heart attack survivors.
Scientists have discovered a key process during the invasion of the blood cell by the Malaria parasite, and more importantly, found a way to block this invasion.
A novel way to speed the testing of cancer drugs and quickly separate winners from duds has yielded its first big result: an experimental medicine that shows promise against a hard-to-treat form of breast cancer.
Widely used treatments for type 2 diabetes have different effects on the hearts of men and women, even as the drugs control blood sugar equally well in both sexes, according to new research.
British Prime Minister David Cameron says he hopes to kick-start an international effort to find a cure or effective treatment for dementia by 2025.
Researchers reported that a virulent new strain of influenza appears to retain its ability to cause serious disease in humans even after it develops resistance to antiviral medications.
Researchers have discovered a gene that may reveal whether people are likely to respond well to SSRI antidepressants, both generally and in specific formulations.
Researchers have found that a new kind of gene therapy led to a dramatic decline in bleeding events in dogs with naturally occurring hemophilia A.
Researchers reported promising outcomes data for the first group of boys with X-linked severe combined immunodeficiency syndrome (SCID-X1), a fatal genetic immunodeficiency also known as "bubble boy" disease, who were treated as part of an international clinical study of a new form of gene therapy.
Triplets-and-more increasingly are the result of drugs given to women to make them produce eggs — not from using multiple embryos from IVF, or lab-dish fertilization, new research shows.
Researchers have identified a protein that causes loss of function in immune cells combatting HIV. The scientists report that the protein, Sprouty-2, is a promising target for future HIV drug development.
A government study offers a new theory on why the whooping cough vaccine doesn't seem to be working as well as expected. The research suggests that while the vaccine may keep people from getting sick, it doesn't prevent them from spreading whooping cough to others.