Testosterone treatments may increase risks for heart attacks, strokes and death in older men with low hormone levels and other health problems, a big Veterans Affairs study suggests.
The generic anticonvulsant medication gabapentin shows promise as an effective treatment for alcohol dependence, based on the results of a 150-patient clinical trial of the medication. The study found that alcohol dependent patients using gabapentin were more likely to stop drinking or refrain from heavy drinking than those taking placebo.
An experimental vaccine to protect against respiratory syncytial virus (RSV), a leading cause of illness and hospitalization among very young children, elicited high levels of RSV-specific antibodies when tested in animals, according to a new report.
Cisplatin is a chemotherapy drug given to more than half of all cancer patients. The drug kills cells very effectively, but tumors can become resistant to the drug and grow back. A new study offers a possible way to overcome that resistance.
A bone drug already on the market for osteoporosis may kill chronic myelogenous leukemia (CML) stem cells thought to persist in the bone marrow after standard therapy, lowering the likelihood of disease recurrence, according to a new study.
A team of scientists created and characterized a new molecule, using elements of Clostridium botulinum and Clostridium tetani neurotoxins, that was able to alleviate hypersensitivity to inflammatory pain.
Doctors may one day be able to control a patient's HIV infection in a new way: injecting swarms of germ-fighting antibodies, two new studies suggest. In monkeys, that strategy sharply reduced blood levels of a cousin of HIV.
A new type of “good cholesterol,” made in the lab, could one day deliver drugs to where they are needed in the body to treat disease or be used in medical imaging, according to scientists.
Two subtypes of human papillomavirus (HPV) prevented by vaccines are half as likely to be found in African-American women as in white women with precancerous cervical lesions, according to researchers.
In a pair of landmark studies that exploit the genetic sequencing of the “missing link” cold virus, rhinovirus C, scientists have constructed a 3-D model of the pathogen that shows why there is no cure yet for the common cold.
Mice models of Alzheimer's treated with one abdominal injection of an antibody fragment designed by researchers showed, after only five days, improved memory and ability to learn as the result of less aggregated toxins and an increase in the number of neurons.
The considerable diversity of HIV worldwide represents a critical challenge for designing an effective HIV vaccine. Now, a scientific team has shown that bioinformatically optimized HIV vaccine antigens might be useful in the design of a global HIV vaccine.
A novel combination of two oral targeted drugs dramatically slowed the growth of glioblastoma brain tumors in mice and significantly extended the animals’ survival, scientists report.
Researchers have published the most comprehensive review of the benefits and risks of a daily dose of prophylactic aspirin and warn that greater understanding of side effects is needed.
A promising technique for treating human eye disease has proven effective in preclinical studies and may lead to new treatments to prevent blindness, according to new experiments.
To overcome triple negative breast cancer's eventual resistance to drugs, chemical engineers have designed nanoparticles that now only carry a cancer drug, but also carry short strands of RNA that can shut off one of the genes that cancer cells use to escape the drug.
Researchers have created a massive online database that matches thousands of genes linked to cancer and other diseases with various drugs that target those genes.
Scientists have identified a set of compounds that may be used to treat MS in a new way: by boosting a population of progenitor cells that can in turn repair MS-damaged nerve fibers.
Often deadly “triple-negative” breast cancers might be effectively treated in many cases with a drug that targets a previously unknown vulnerability in the tumors, according to a new study. Researchers found blocking cystine from entering triple-negative breast cancer cells can significantly inhibited their growth in culture and when the cancer cells were transplanted into mice.
Hold your nose and don't spit out your coffee: Doctors have found a way to put healthy people's poop into pills that can cure serious gut infections - a less yucky way to do "fecal transplants." Canadian researchers tried this on 27 patients and cured them all after strong antibiotics failed to help.
The longest, most comprehensive follow-up yet of women given hormone pills during landmark government research found many health risks faded and some unexpected benefits emerged, but advice remains unchanged: Use hormones only short term if needed to relieve hot flashes and other menopause symptoms.
Engineers have developed a new type of nanoparticle that protects a vaccine long enough to generate a strong immune response— not only in the lungs, but also in mucosal surfaces far from the vaccination site, such as the gastrointestinal and reproductive tracts.
Clinicians should be extra vigilant when prescribing antidepressants as they could pose a risk of type 2 diabetes, researchers have warned. A systematic review showed that people taking antidepressants are at a higher risk of type 2 diabetes.
Abiraterone acetate, a recently FDA-approved drug used to treat men with metastatic castration-resistant prostate cancer and marketed as Zytiga, significantly delays progression of pain and quality of life deterioration when taken in conjunction with prednisone. The design of the study emphasized the importance of patient reported-outcomes in evaluating new treatments.
Working with mice, researchers have discovered that weeks of treatment with a repurposed FDA-approved drug halted the growth of— and ultimately left no detectable trace of— brain tumor cells taken from adult human patients. The scientists targeted a mutation in the IDH1 gene first identified in human brain tumors called gliomas by a team cancer researchers in 2008.