Mice
Transgenic Mouse Generates Human Single Domain Antibody VH Fragments
January 16, 2013 2:39 pm | Product Releases | CommentsCrescendo Biologics announces the Crescendo Mouse using antibody fragment technology that allows the efficient generation of high-quality fully human single domain antibody VH fragments from a transgenic mouse. VH fragments are next-generation antibody-based therapeutic proteins that have applications beyond the scope of full length antibodies.
Triple Knockout Mouse
September 29, 2010 6:43 am | Product Releases | CommentsCrescendo Biologics has established a colony of engineered mice completely devoid of endogenous antibody polypeptides. The proprietary ‘triple knockout’ mice are believed to be unique and have the immunoglobulin heavy chain (IgH), kappa light chain and lambda light chain loci all functionally silenced by large-scale genomic deletion.
Mouse For ADME-Tox Research
November 27, 2007 6:11 am | Product Releases | CommentsThe proteins OCT1 and OCT2 are directly involved in the absorption and excretion processes of food components and xenobiotic compounds in the liver, small intestine and kidney, as well as activity in other tissues such as brain, heart, stomach and skeletal muscle.
Mouse Genotyping Service (9167)
November 15, 2006 9:46 am | Articles | CommentsResearchers in North America and Europe are offered transgenic, knock-out and knock-in mutant mice. TransnetYX’s proprietary technologies for automated genetic testing and Internet biopsy submission and results reporting speeds the process, while ensuring quality and accuracy of test results.
COX Targeted Mutation Models
January 12, 2005 5:53 am | Articles | CommentsCyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) Targeted Mutation Mouse models are offered for investigating the role of cyclooxygenases in inflammatory diseases. COX Targeted Mutation mice have disruptions in one of the two Pts (protaglandin-endoperoxide synthase) genes.
Non-Obese Diabetic SCID Mouse
January 12, 2005 5:53 am | Articles | CommentsRecent studies indicate that the new NOD (non-obese diabetic) scid Spontaneous Mutant Model (NOD scid mouse), is a useful model for both cancer research and research in several immune-related disorders.
Bcrp Targeted Mutation Mouse
December 14, 2004 12:32 pm | Articles | CommentsRecent studies indicate that the Bcrp Targeted Mutation Mouse from Taconic is a useful model for studies of in vivo drug disposition and the role of ATP-dependent transporters in inflammation.
Cyclooxygenase Targeted Mutation Mouse Models
November 12, 2004 10:20 am | Articles | CommentsCOX-1 Targeted Mutation Mice reveal no physical differences compared to wild-type mice. Upon gross and microscopic examination, organ systems, including the gastrointestinal, respiratory and reproductive tract appear normal and healthy.
Microinjected Mouse
October 5, 2004 4:57 am | Articles | CommentsAPP/Tau Microinjected Mouse serves as an effective model for studies in the mechanism and the development of drugs for the treatment of Alzheimer's Disease.
Mouse Models Of Human Cancer Consortium
July 12, 2004 10:48 am | Articles | CommentsFunded by the National Cancer Institute, the Mouse Models of Human Cancer Consortium (MMHCC) supports the derivatization and validation of mouse models, as well as the generation of resources, information, and innovative approaches to the application of mouse models in cancer research.
Inbred Rat Model
October 15, 2003 11:35 am | Articles | CommentsThe Lewis Rat model aids in studying the biological mechanisms of immunology and treatments for diabetes. This albino, inbred rat is commonly used to produce an autoimmune research model. Various autoimmune models can be produced by immunization with homologous tissue and adjuvant.
Lab Animal Product Guide
September 17, 2003 5:59 am | Articles | CommentsThe Harlan 2003-2004 Product Guide offers over 240 stocks and strains, and contains pricing for laboratory animals produced in the US, including rats, mice, hamsters, guinea pigs, gerbils, cats, beagles, and mongrels.
Model For Alzheimer's Disease
July 10, 2003 11:06 am | Articles | CommentsAPP Microinjected Mouse Model, Tg2576, can be used to study human Alzheimer's Disease (AD) and various cellular mechanisms. The mice carry the transgene for the Swedish mutation (APP 695 ), and Alzheimer's associated isoform of the human gene for amyloid precursor protein (APP).
ERKO Mouse Model
May 14, 2003 10:52 am | Articles | CommentsProprietary ERKO-? (Estrogen Receptor-beta) Targeted Mutation mouse model can be used to examine the role of estrogen receptors in both reproductive and non-reproductive development.
Transgenic Support Services
January 6, 2003 6:03 am | Articles | CommentsThe company can perform custom breeding of specific transgenic animal models to be delivered at a specified time. They can also maintain animals sent to them in an exclusive colony in isolators to be returned as needed.
