Crescendo Biologics announces the Crescendo Mouse using antibody fragment technology that allows the efficient generation of high-quality fully human single domain antibody VH fragments from a transgenic mouse. VH fragments are next-generation antibody-based therapeutic proteins that have applications beyond the scope of full length antibodies.
Crescendo Biologics has established a colony of engineered mice completely devoid of endogenous antibody polypeptides. The proprietary ‘triple knockout’ mice are believed to be unique and have the immunoglobulin heavy chain (IgH), kappa light chain and lambda light chain loci all functionally silenced by large-scale genomic deletion.
The proteins OCT1 and OCT2 are directly involved in the absorption and excretion processes of food components and xenobiotic compounds in the liver, small intestine and kidney, as well as activity in other tissues such as brain, heart, stomach and skeletal muscle.
Researchers in North America and Europe are offered transgenic, knock-out and knock-in mutant mice. TransnetYX’s proprietary technologies for automated genetic testing and Internet biopsy submission and results reporting speeds the process, while ensuring quality and accuracy of test results.
Cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) Targeted Mutation Mouse models are offered for investigating the role of cyclooxygenases in inflammatory diseases. COX Targeted Mutation mice have disruptions in one of the two Pts (protaglandin-endoperoxide synthase) genes.
Recent studies indicate that the new NOD (non-obese diabetic) scid Spontaneous Mutant Model (NOD scid mouse), is a useful model for both cancer research and research in several immune-related disorders.
Recent studies indicate that the Bcrp Targeted Mutation Mouse from Taconic is a useful model for studies of in vivo drug disposition and the role of ATP-dependent transporters in inflammation.
COX-1 Targeted Mutation Mice reveal no physical differences compared to wild-type mice. Upon gross and microscopic examination, organ systems, including the gastrointestinal, respiratory and reproductive tract appear normal and healthy.
APP/Tau Microinjected Mouse serves as an effective model for studies in the mechanism and the development of drugs for the treatment of Alzheimer's Disease.
Funded by the National Cancer Institute, the Mouse Models of Human Cancer Consortium (MMHCC) supports the derivatization and validation of mouse models, as well as the generation of resources, information, and innovative approaches to the application of mouse models in cancer research.
The Lewis Rat model aids in studying the biological mechanisms of immunology and treatments for diabetes. This albino, inbred rat is commonly used to produce an autoimmune research model. Various autoimmune models can be produced by immunization with homologous tissue and adjuvant.
The Harlan 2003-2004 Product Guide offers over 240 stocks and strains, and contains pricing for laboratory animals produced in the US, including rats, mice, hamsters, guinea pigs, gerbils, cats, beagles, and mongrels.
APP Microinjected Mouse Model, Tg2576, can be used to study human Alzheimer's Disease (AD) and various cellular mechanisms. The mice carry the transgene for the Swedish mutation (APP 695 ), and Alzheimer's associated isoform of the human gene for amyloid precursor protein (APP).
Proprietary ERKO-? (Estrogen Receptor-beta) Targeted Mutation mouse model can be used to examine the role of estrogen receptors in both reproductive and non-reproductive development.