Crescendo Biologics announces the Crescendo Mouse using antibody fragment technology that allows the efficient generation of high-quality fully human single domain antibody VH fragments from a transgenic mouse. VH fragments are next-generation antibody-based therapeutic proteins that have applications beyond the scope of full length antibodies.
Crescendo Biologics has established a colony of engineered mice completely devoid of endogenous antibody polypeptides. The proprietary ‘triple knockout’ mice are believed to be unique and have the immunoglobulin heavy chain (IgH), kappa light chain and lambda light chain loci all functionally silenced by large-scale genomic deletion.
The Lewis Rat model aids in studying the biological mechanisms of immunology and treatments for diabetes. This albino, inbred rat is commonly used to produce an autoimmune research model. Various autoimmune models can be produced by immunization with homologous tissue and adjuvant.