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UCLA to Help Biologists, Doctors Mine 'Big Data'

December 19, 2014 9:45 am | by Eryn Brown, UCLA | News | Comments

Millions upon millions of medical records and test results. Countless DNA sequences. Hard drives stuffed with images of all kinds - pictures of cells, scans of body parts. It's all part of the deluge of information often known as "big data," an ever-growing stockpile of digital material that scientists hope will reveal insights about biology and lead to improvements in medical care.
 

Stem Cells Faulty in Duchenne Muscular Dystrophy

December 17, 2014 4:03 pm | by Stanford University | News | Comments

Like human patients, mice with a form of Duchenne muscular dystrophy undergo progressive muscle...

Discovery May Explain Why We Gain Weight

December 12, 2014 8:57 am | News | Comments

Researchers believe they’re on track to solve the mystery of weight gain – and it has...

A Pill to Shed Fat?

December 9, 2014 8:30 am | News | Comments

Researchers have taken what they describe as “the first step toward a pill that can...

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‘Satiety Hormone’ Leptin Links Obesity to High Blood Pressure

December 5, 2014 1:42 pm | News | Comments

Leptin, a hormone that regulates the amount of fat stored in the body, also drives the increase in blood pressure that occurs with weight gain, according to researchers.                        

Mediterranean Diet Has Marked Impact on Aging

December 3, 2014 3:42 pm | by Brigham and Women’s Hospital | News | Comments

The  Mediterranean diet consistently has been linked with an array of health benefits, including decreased risk of chronic disease and cancer. Until now, however, no studies had associated the diet with longer telomeres, one of the biomarkers of aging. Read more...

In Healthy Gut, Microbes Wax, Wane Throughout Day

December 3, 2014 10:57 am | News | Comments

Taking a single snapshot of all the bacteria that live in a mouse’s–or person’s–stomach and intestines can capture the health of the organism’s digestive system and even their risk of developing immune diseases and cancers. But it might take more than one snapshot to get a full picture, Salk researchers have discovered. Read more...

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Another Case Against the Midnight Snack

December 3, 2014 10:49 am | News | Comments

These days, with the abundance of artificial light, TV, tablets and smartphones, adults and children alike are burning the midnight oil. What they are not burning is calories: with later bedtimes comes the tendency to eat. Read more...                                 

New FDA Rules Will Put Calorie Counts on Menus

November 25, 2014 1:00 pm | by Mary Clare Jalonick - Associated Press - Associated Press | News | Comments

Whether they want to or not, consumers will soon know how many calories they are eating when ordering off the menu at chain restaurants, picking up prepared foods at supermarkets and even eating a tub of popcorn at the movie theater.     

Cellular Origin of Fibrosis

November 21, 2014 10:00 am | News | Comments

Harvard Stem Cell Institute scientists at Brigham and Women’s Hospital say they have found the cellular origin of the tissue scarring caused by organ damage associated with diabetes, lung disease, high blood pressure, kidney disease, and other conditions. Read more...

Unwinding the Mysteries of the Cellular Clock

November 21, 2014 9:54 am | News | Comments

Human existence is basically circadian. Most of us wake in the morning, sleep in the evening, and eat in between. Body temperature, metabolism, and hormone levels all fluctuate throughout the day, and it is increasingly clear that disruption of those cycles can lead to metabolic disease. Read more...

Study: Obesity Fuels Silent Heart Damage

November 21, 2014 9:27 am | News | Comments

Using an ultrasensitive blood test to detect the presence of a protein that heralds heart muscle injury, researchers from Johns Hopkins and elsewhere have found that obese people without overt heart disease experience silent cardiac damage that fuels their risk for heart failure down the road. Read more...      

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Protein Linked to Aging May Be New Diabetes Target

November 6, 2014 1:38 pm | News | Comments

Researchers have identified a small protein with a big role in lowering plasma glucose and increasing insulin sensitivity. The report indicates that Sestrin 3 plays a critical role in regulating molecular pathways that control the production of glucose and insulin sensitivity in the liver.

Non-gluten Proteins May Play a Role in Celiac Disease

November 5, 2014 10:55 am | News | Comments

Although gluten-free foods are trendy among the health-conscious, they are necessary for those with celiac disease. But gluten, the primary trigger for health problems in these patients, may not be the only culprit.          

How Bile Acids Could Fight Diabetes

November 4, 2014 2:50 pm | News | Comments

Scientists have shown that a receptor activated by bile acids can reduce fat-tissue inflammation and insulin resistance in obesity-linked diabetes.                              

Lipids, Not Calories, Trigger a Strong Insulin Response

October 27, 2014 2:16 pm | News | Comments

Researchers studying lipoproteins in Drosophila melanogaster found that that the blood-brain barrier is a main sensor to report the nutritional status, especially the lipid composition of consumed food, to special neurons that regulate insulin release.

New Weight Loss Regulation Clues Discovered

October 24, 2014 11:18 am | News | Comments

A hormone seen as a popular target to develop weight loss drugs works by directly targeting the brain and triggering previously unknown activity in the nervous system, obesity researchers have found.                

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Magnesium in Diet Cuts Diabetes Risk

October 20, 2014 11:49 am | News | Comments

Getting enough magnesium in the diet may reduce the risk of diabetes, especially for those who already show signs of heading that way, according to a new study.                         

Stem Cell-based Intestinal Tissue Implanted in Mice

October 20, 2014 10:21 am | Videos | Comments

Researchers have successfully transplanted “organoids” of functioning human intestinal tissue grown from pluripotent stem cells in a lab dish into mice– creating an unprecedented model for studying diseases of the intestine.        

Misfolded Proteins Clump Together in a Surprising Place

October 17, 2014 11:44 am | News | Comments

Scientists have made a surprising finding about the aggregates of misfolded cellular proteins that have been linked to aging-related disorders such as Parkinson’s disease.                       

Weight Gain Study Suggests Polyunsaturated Oil Healthier Option

October 16, 2014 2:33 pm | News | Comments

Short-term modest weight gains in healthy, normal weight young adults was associated with more bad cholesterol levels in those who ate muffins cooked using saturated oil. However, individuals in the same study who ate muffins made with polyunsaturated oils had improved blood cholesterol profiles, according to a new study. 

Embryonic Stem Cells in Trial for Diabetes

October 16, 2014 11:44 am | by Cynthia Fox, Science Writer | Articles | Comments

As San Diego’s ViaCyte was in the midst of launching the first FDA-approved embryonic stem (ES) cell clinical trial for diabetics last week, Boston’s Harvard University reported that cells made from ES cells “cured” diabetic mice.     

Sensors to Simplify Diabetes Management

October 13, 2014 12:50 pm | News | Comments

For many patients diagnosed with diabetes, treating the disease can mean a burdensome and uncomfortable lifelong routine of monitoring blood sugar levels and injecting the insulin that their bodies don't naturally produce. Now, tiny biosensors are being developed that could one day eliminate the need for these manual blood sugar tests.

'Good' Fat Can Fight Diabetes

October 10, 2014 10:38 am | Videos | Comments

Scientists have discovered a new class of molecules– produced in human and mouse fat– that protects against diabetes. The researchers found that giving this new fat to mice with the equivalent of type 2 diabetes lowered their elevated blood sugar.

Grapefruit Juice Stems Weight Gain in Mice

October 9, 2014 1:47 pm | News | Comments

Fad diets come and go, but might there be something to the ones that involve consuming grapefruit and grapefruit juice? New research suggests that a closer look at grapefruit juice is warranted.                

Sugar Linked to Memory Problems in Rats

October 8, 2014 12:35 pm | News | Comments

Studying rats as model subjects, scientists found that adolescents were at an increased risk of suffering negative health effects from sugar-sweetened beverage consumption.                       

MRI Detects Cognitive Decline Before Symptoms Appear

October 8, 2014 11:40 am | News | Comments

A magnetic resonance imaging (MRI) technique can detect signs of cognitive decline in the brain even before symptoms appear, according to a new study. The technique has the potential to serve as a biomarker in very early diagnosis of preclinical dementia.

Gene Mutation Could Prevent Weight Gain from High-sugar Diet

October 7, 2014 1:38 pm | News | Comments

Imagine being able to take a pill that lets you eat all of the ice cream, cookies, and cakes that you wanted– without gaining any weight. New research found a new way to suppress the obesity that accompanies a high-sugar diet, pinning it down to a key gene that pharmaceutical companies have already developed drugs to target.

Identical Twin Study Reveals Diabetes Clues

October 6, 2014 11:33 am | News | Comments

By studying identical twins, researchers have identified mechanisms that could be behind the development of type 2 diabetes. This may explain cases where one identical twin develops type 2 diabetes while the other remains healthy.      

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