Scientists have now shown how double stranded RNA, such as viral genetic information, is prevented from entering the nucleus of a cell. During the immune response against viral infection, the protein ADAR1 moves from the cell nucleus into the surrounding cytoplasm.
Ginseng can help treat and prevent influenza and respiratory syncytial virus (RSV), a...
An international research team identified a new superbug that caused a bloodstream infection in...
Researchers have sequenced the entire genome and all the RNA products of the most important...
Scientists have uncovered a new way the immune system may fight cancers and viral infections. The finding could aid efforts to use immune cells to treat illness. The research, in mice, suggests that some organs have the immunological equivalent of “neighborhood police” – specialized squads of defenders that patrol only one area, a single organ, instead of an entire city, the body.
The Ebola virus that has killed scores of people in Guinea this year is a new strain - evidence that the disease did not spread there from outbreaks in some other African nations, scientists report.
A mumps outbreak in central Ohio has grown to more than 200 confirmed cases, public health officials said. A total of 212 cases of the contagious viral illness, with 132 of those linked to Ohio State University, have been reported.
Builders and factory workers know that getting a job done right requires precision and specialized tools. The same is true when you’re building antibiotic compounds at the molecular level. New findings from North Carolina State University may turn an enzyme that acts as a specialized “wrench” in antibiotic assembly into a set of wrenches that will allow for greater customization.
Scientists at The University of Texas at Austin have discovered that a protein produced by the influenza A virus helps it outwit one of our body's natural defense mechanisms. That makes the protein a potentially good target for antiviral drugs directed against the influenza A virus.
A study reports that a rare genetic disease, while depleting patients of infection-fighting antibodies, may actually protect them from certain severe or recurrent viral infections. Researchers found that HIV and influenza viruses replicate in the cells of people with congenital disorder of glycosylation type IIb (CDG-IIb) at a much lower rate than in healthy donor cells, creating fewer and less infectious viruses.
The spread of the antibiotic-resistant pathogen MRSA (methicillin-resistant Staphylococcus aureus) remains a concerning public health problem, especially among doctors trying to determine appropriate treatment options for infected patients. Bacterial pathogens, such as MRSA, cause disease in part due to toxicity, or the bacterium's ability to damage a host's tissue.
An antimicrobial agent found in common household soaps, shampoos, and toothpastes may be finding its way inside human noses where it promotes the colonization of Staphylococcus aureus bacteria and could predispose some people to infection.
Resistance to an entire class of antibiotics—aminoglycosides—has the potential to spread to many types of bacteria, according to new biochemistry research. A mobile gene called NpmA was discovered in E. coli bacteria isolated from a Japanese patient several years ago. Global spread of NpmA and related antibiotic resistance enzymes could disable an entire class of tools doctors use to fight serious or life-threatening infections.
Researchers have generated a 3-D model of the human malaria parasite genome at three different stages in the parasite’s life cycle— the first time such 3-D architecture has been generated during the progression of the life cycle of a parasite.
Chances are you've heard of mapping genes to diagnose rare diseases, predict your risk of cancer and tell your ancestry. But to uncover food poisonings? The nation's disease detectives are beginning a program to try to outsmart outbreaks by routinely decoding the DNA of potentially deadly bacteria and viruses.
In successful research, any one path can quickly lead to new paths of even more promising results. This branching out of a research project couldn’t be more true than for a team of researchers at the UCSD’s Jacobs School of Engineering. UCSD researchers have developed “nanosponges” that were initially designed as a platform for cancer drug delivery and now are being developed to soak up the dangerous pore-forming toxin produced by MRSA.
An international team of scientists has identified the precise biochemical key that wakes up the body’s immune cells and sends them into action against invading bacteria and fungi. The patented work provides the starting point to understanding our first line of defense, and what happens when it goes wrong. It will lead to new ways of diagnosing and treating inflammatory bowel disease, peptic ulcers and even TB.
It doesn’t take long for the flu virus to outsmart Tamiflu. EPFL scientists have developed a tool that reveals the mutations that make the virus resistant, and they have identified new mutations that may render ineffective one of the few treatments currently available on the market.
For the millions of people forced to rely on a plastic tube to eliminate their urine, developing an infection is nearly a 100 percent guarantee after just four weeks. But with the help of a little bubble-blowing, biomedical engineers hope to bring relief to urethras everywhere.
Researchers at University College London developed a new antibacterial material which has potential for cutting hospital acquired infections. The combination of two simple dyes with nanoscopic particles of gold is deadly to bacteria when activated by light - even under modest indoor lighting. And in a first for this type of substance, it also shows impressive antibacterial properties in total darkness.
Scientists of the KIT and the University of Kiev have produced an antibiotic, whose biological activity can be controlled with light. Thanks to the robust diarylethene photoswitch, the antimicrobial effect of the peptide mimetic can be applied in a spatially and temporally specific manner. This might open up new options for the treatment of local infections, as side effects are reduced.
Babies born prematurely are surviving in increasing numbers. But many withstand complications of early birth only to suffer late-onset sepsis—life-threatening bloodstream infections that strike after infants reach 72 hours of age. While early-onset sepsis often is caused by pathogens acquired from the amniotic sac or birth canal, the causes of late-onset sepsis have been far less clear.
Problems arise when bad gut bacteria overtake friendly ones, or when the immune system is thrown off balance, as in Crohn's disease, celiac disease, and colorectal cancer. Doctors have struggled to diagnose these conditions early and accurately. But now a new engineered strain of E. coli bacteria could deliver status updates from this complex landscape to help keep gastrointestinal diseases at bay.
In response to drug-resistant “superbugs” that send millions of people to hospitals around the world, scientists are building tiny, “molecular drill bits” that kill bacteria by bursting through their protective cell walls. They presented some of the latest developments on these drill bits, better known to scientists as antimicrobial peptides (AMPs).
Discovering where a common virus hides in the body has been a long-term quest for scientists. Up to 80 percent of adults harbor the human cytomegalovirus (HCMV), which can cause severe illness and death in people with weakened immune systems. Now, researchers report that stem cells that encircle blood vessels can be a hiding place, suggesting a potential treatment target.
Early childhood caries, a highly aggressive and painful form of tooth decay that frequently occurs in preschool children, especially from backgrounds of poverty, may result from a nefarious partnership between a bacterium and a fungus. The resulting tooth decay can be so severe that treatment frequently requires surgery.
A team of University of Notre Dame researchers discovered a new class of antibiotics to fight bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and other drug-resistant bacteria that threaten public health. The new class, called oxadiazoles, was discovered in silico (by computer) screening and has shown promise in the treatment of MRSA in mouse models of infection.
The majority of pediatric Clostridium difficile infections, which are bacterial infections that cause severe diarrhea and are potentially life-threatening, occur among children in the general community who recently took antibiotics prescribed in doctor’s offices for other conditions, according to a new study by the Centers for Disease Control and Prevention.
Using technologies and computational modeling that trace the destiny of single cells, researchers at the University of California, San Diego School of Medicine describe for the first time the earliest stages of fate determination among white blood cells called T lymphocytes, providing new insights that may help drug developers create more effective, longer-lasting vaccines against microbial pathogens or cancer.
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