A new study suggests that antibiotic exposure during a critical window of early development disrupts the bacterial landscape of the gut, home to trillions of diverse microbes, and permanently reprograms the body’s metabolism, setting up a predisposition to obesity.
UT Southwestern Medical Center researchers successfully used a new gene editing method to correct a mutation that leads to Duchenne muscular dystrophy (DMD) in a mouse model of the condition. Researchers used a technique called CRISPR/Cas9-mediated genome editing, which can precisely remove a mutation in DNA, allowing the body’s DNA repair mechanisms to replace it with a normal copy of the gene.
It's an eye-catching angle in the story of an experimental treatment for Ebola: The drug comes from tobacco plants that were turned into living pharmaceutical factories. Using plants this way — sometimes called "pharming" — can produce complex and valuable proteins for medicines.
With new advanced techniques developed by the Copenhagen Center for Glycomics at the University of Copenhagen it is possible to study cells in greater detail than ever before. The findings may, in the long term, improve the treatment of high cholesterol.
Children with sensory processing disorder (SPD) have decreased white matter brain connections in sensory regions very different from those with autism, say researchers. Their study is the first to compare, and find critical differences in, brain connectivity in autism versus SPD versus controls.
Gene-based personalized medicine has many possibilities for diagnosis and targeted therapy, but one big bottleneck: the expensive and time-consuming DNA-sequencing process. Now, researchers have found that nanopores in the material molybdenum disulfide (MoS2) could sequence DNA more accurately, quickly and inexpensively than anything yet available.
An Iowa drug developer says it has enough doses of a possible vaccine for the deadly Ebola virus to launch an initial round of human testing. NewLink Genetics Chief Financial Officer Gordon Link says the timing of the trials is uncertain, but the company is receiving help from a number of sources to speed up the process.
A modified version of the Clostridium novyi (C. novyi-NT) bacterium can produce a strong and precisely targeted anti-tumor response in rats, dogs and now humans, according to a new report.
A large international study questions the conventional wisdom that most people should cut back on salt, suggesting that the amount most folks consume is OK for heart health - and too little may be as bad as too much.
Releasing genetically engineered fruit flies into the wild could prove to be a cheap, effective and environmentally friendly way of pest control according to scientists at the University of East Anglia and Oxitec Ltd. This collaborative research study, with UEA shows that this approach is effective and once appropriate regulatory approvals are received the technology will offer growers a safe and effective route to protect their crops.
It has been more than 20 years since scientists discovered that mutations in the gene huntingtin cause the devastating progressive neurological condition Huntington’s disease. Surprisingly little, however, has been known about the gene’s role in normal brain activity. Now, new research shows it plays a critical role in long-term memory.
Researchers are reporting that they have developed a “self-fitting” material that expands with warm salt water to precisely fill bone defects that occur as a result of injury, birth defect or surgery to remove a tumor.
Oncologists are melding magnetic resonance imaging (MRI) technology with a traditional ultrasound prostate exam to create a three-dimensional map of the prostate that allows physicians to view growths that were previously undetectable.
A leading physician in Sierra Leone's fight against Ebola has died from the disease, an official said Wednesday, as it emerged that another top doctor had been considered to receive an experimental drug but did not get it and later died.
Blood expression levels of genes targeted by the stress hormones called glucocorticoids could be a physical measure, or biomarker, of risk for developing Post-Traumatic Stress Disorder (PTSD), according to a new study.
A gene discovery brings scientists closer to developing therapeutic agents that could slow down bone loss and regenerate lost bone, which could provide relief for millions suffering from aging-related bone loss.
Playing with the portions of good and not-so-good-for-you foods is better than trying to eliminate bad foods, according to a new study. The idea is to not give up entirely foods that provide pleasure but aren’t nutritious.
A Spanish missionary priest being treated for Ebola died Tuesday in a Madrid hospital amid a worldwide debate over who should get experimental Ebola treatments. After holding a teleconference with medical experts around the world, the WHO declared it is ethical to use unproven Ebola drugs and vaccines in the current outbreak.
There have been stunning “firsts” in research on idiopathic pulmonary fibrosis (IPF), a mysterious disease that stiffens and stills the lungs, killing half its victims in three years. In May, results of Phase 3 clinical trials on the first two effective drugs for IPF were published in the New England Journal of Medicine (NEJM). And in June, the first paper explaining IPF was published in Science Translational Medicine.
Scientists from the University of Leeds have discovered a gene that plays a vital role in blood vessel formation, research which adds to our knowledge of how early life develops. The discovery could also lead to greater understanding of how to treat cardiovascular diseases and cancer.
Researchers have discovered a previously unknown cardiac molecule that could provide a key to treating, and preventing, heart failure. The newly discovered molecule provides the heart with a tool to block a protein that orchestrates genetic disruptions when the heart is subjected to stress, such as high blood pressure.
Wrapping wound dressings around fingers and toes can be tricky, but for burn victims, guarding them against infection is critical. Today, scientists are reporting the development of novel, ultrathin coatings called nanosheets that can cling to the body’s most difficult-to-protect contours and keep bacteria at bay.
In creating an adhesive patterned after glue produced by the lowly underwater sandcastle worm, researchers are reporting today that they may have solved the problem of premature births that sometimes result from fetal surgery. It also could open up numerous opportunities to safely perform more complex fetal surgeries in the future.
For the millions of adults and children in the U.S. who have to shun nuts to avoid an allergic reaction, help could be on the way. Scientists are now developing a method to process cashews—and potentially other nuts—that could make them safer to eat for people who are allergic to them.
A large-scale University-led study involving more than 180,000 people shows that patients treated with a drug widely prescribed for type 2 diabetes can live longer than people without the condition. The findings indicate that a drug known as metformin, used to control glucose levels in the body and already known to exhibit anticancer properties, could offer prognostic and prophylactic benefits to people without diabetes.