A team of scientists from UCLA's Jonsson Comprehensive Cancer Center has developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread.
“Sprouted” garlic—old garlic bulbs with bright green shoots emerging from the cloves — is considered to be past its prime and usually ends up in the garbage can. But scientists are reporting that this type of garlic has even more heart-healthy antioxidant activity than its fresher counterparts.
New acquaintances are often judged by their handshake. Research has now recognized the simple squeeze as an important diagnostic tool in assessing strength and quality of life among critical care patients. In a recent study, Concordia professor Robert Kilgour and his colleagues at the McGill Nutrition and Performance Laboratory confirmed a link between handgrip strength and survival rates.
A DNA test of a pregnant woman's blood is more accurate than current methods of screening for Down syndrome and other common disorders, new research finds. If other studies bear this out, it could transform prenatal care.
Are the eggs produced by adolescent girls the same as the ones produced by adult women? A recent study published in Human Molecular Genetics by Professor Kui Liu from the University of Gothenburg in Sweden shows compelling evidence that there are two completely distinct types of eggs in the mammalian ovary—“the first wave” and “the adult wave”.
A new study comparing siblings who were fed differently during infancy suggests that breast-feeding might be no more beneficial than bottle-feeding for 10 of 11 long-term health and well-being outcomes in children age 4 to 14. The outlier was asthma, which was associated more with breast-feeding than with bottle-feeding.
Acetaminophen provides many people with relief from headaches and sore muscles. When used appropriately, it is considered mostly harmless. Over recent decades, the drug has become the medication most commonly used by pregnant women for fevers and pain. Now, a long-term study by UCLA, in collaboration with the University of Aarhus in Denmark, has raised concerns about the use of acetaminophen during pregnancy.
Cardiac arrhythmia is one of the most common diseases encountered in clinical cardiology. High-speed electrophysiological imaging using fluorescent probes has yielded tremendous insights into the basic mechanisms of arrhythmias and the effects of anti-arrhythmic drugs. However, optical mapping, as it is known to the cardiac research community, has remained relegated to the isolated (i.e. explanted) heart.
When a University of Oklahoma researcher and an international team of experts analyzed the dental calculus or plaque from teeth preserved for 1,000 years, the results revealed human health and dietary information never seen before. The team discovered disease-causing bacteria in a German Medieval population, which is the same or very similar to inflammatory disease-causing bacteria in humans today.
Ovarian cancer accounts for more deaths of American women than any other cancer of the female reproductive system. A researcher has proposed a new strategy to tackle an aggressive subtype of ovarian cancer using a new nanoscale drug-delivery system designed to target specific cancer cells.
New research from Queen Mary University of London has discovered 11 new DNA sequence variants in genes influencing high blood pressure and heart disease. Identifying the new genes contributes to our growing understanding of the biology of blood pressure and, researchers believe, will eventually influence the development of new treatments.
To remain healthy, the body’s cells must properly manage their waste recycling centers. Problems with these compartments, known as lysosomes, lead to a number of debilitating and sometimes lethal conditions. Researchers have identified an unusual cause of the lysosomal storage disorder called mucolipidosis III, at least in a subset of patients.
Researchers at the Perelman School of Medicine, University of Pennsylvania, have been studying the molecular mechanisms underpinning sleep. Now they report that the pathways of aging and sleep intersect at the circuitry of a cellular stress response pathway, and that by tinkering with those connections, it may be possible to alter sleep patterns in the aged for the better—at least in fruit flies.
A new bioprinting method creates intricately patterned 3D tissue constructs with multiple types of cells and tiny blood vessels. The work represents a major step toward a longstanding goal of tissue engineers: creating human tissue constructs realistic enough to test drug safety and effectiveness.
The mice in Scott Delp's lab, unlike their human counterparts, can get pain relief from the glow of a yellow light. Right now these mice are helping scientists to study pain—how and why it occurs and why some people feel it so intensely without any obvious injury. But Delp, a professor of bioengineering and mechanical engineering, hopes one day the work he does with these mice could also help people who are in chronic, debilitating pain.
Binge drinking impairs the healing of broken bones. It can do this weeks after a binge. And it can leave in its wake permanently inferior bone, according to recent studies. One reason: alcohol slows down mesenchymal (bone, fat, and cartilage) stem cells (MSCs), in the bloodstream, trying to home to fracture sites. And when MSCs finally reach fracture sites, alcohol keeps them from properly replacing lost cells.
ASU scientists, along with colleagues at Argonne National Laboratory, have reported advances toward perfecting a functional artificial leaf. Designing an artificial leaf that uses solar energy to convert water cheaply and efficiently into hydrogen and oxygen is one of the goals of BISfuel—the Energy Frontier Research Center.
Researchers exploring a possible link between metabolic defects and seizures have determined that diet could influence susceptibility to seizures, and they have identified a common diabetes drug that could be a useful treatment.
A new layer in the human cornea—discovered by researchers at The University of Nottingham last year—plays a vital role in the structure of the tissue that controls the flow of fluid from the eye, research has shown. The findings could shed new light on glaucoma, a devastating disease caused by defective drainage of fluid from the eye and the world’s second leading cause of blindness.
A saliva test for teenage boys with mild symptoms of depression could help identify those who will later develop major depression, a new study says. Researchers measured the stress hormone cortisol in teenage boys and found that ones with high levels coupled with mild depression symptoms were up to 14 times more likely to suffer clinical depression later in life than those with low or normal cortisol levels.
University of Adelaide research has shown for the first time that grape seed can aid the effectiveness of chemotherapy in killing colon cancer cells as well as reducing the chemotherapy's side effects. The researchers say that combining grape seed extracts with chemotherapy has potential as a new approach for bowel cancer treatment - to both reduce intestinal damage commonly caused by cancer chemotherapy and to enhance its effect.
San Francisco Bay Area officials say a University of California, Berkeley, student infected with measles could have exposed thousands of others by attending classes and riding public transit. Public health officials said they confirmed that the student in his 20s was not vaccinated, and was likely infected with measles during a recent trip abroad.
Women have a higher risk of blood clots that can cause strokes, heart attacks and other problems for 12 weeks after childbirth — twice as long as doctors have thought, new research finds. Strokes are still fairly rare right after pregnancy but devastating when they do occur and fatal about 10 percent of the time.
Scientists have identified genetic traits in cattle that might allow farmers to breed livestock with increased resistance to bovine tuberculosis (TB). The study, which compared the genetic code of TB-infected animals with that of disease-free cattle, could help to impact on a disease that leads to major economic losses worldwide.
Scientists report that they have developed a novel compound that appears to protect mice against developing movement problems associated with Parkinson’s disease (PD). The research could one day in the future translate into a therapy that could halt the progression of PD and thereby prevent the symptoms of the disease.