Children with rare mutations in two genes are about four times more likely to develop severe scoliosis than their peers with normal versions of the genes, scientists have found.
A new study shows that a tumor-associated lipid stimulates specific T cells, which efficiently kill leukemia cells both in vitro and in animal models.
Scientists from the Broad Institute and Massachusetts General Hospital (MGH) have conducted a first-of-its-kind study that characterizes the cellular diversity within glioblastoma tumors from patients. The study, which looked at the expression of thousands of genes in individual cells from patient tumors, revealed that the cellular makeup of each tumor is more heterogeneous than previously suspected.
Bacteria that cause ulcers in humans undergo accelerated evolution during the initial stages of infection, allowing them to evade the immune system, according to new research. The study shows, for the first time, and in real-time, the interplay between the human immune system and invading bacteria that allows the bacteria to counter the immune response by quickly evolving.
A new drug target to fight Alzheimer's disease has been discovered by a research team led by Gong Chen, a professor of biology and the Verne M. Willaman Chair in Life Sciences at Penn State. The discovery also has potential for development as a novel diagnostic tool for Alzheimer's disease.
Scientists have made big progress on a "bionic pancreas" to free some people with diabetes from the daily ordeal of managing their disease. A wearable, experimental device passed a real-world test, constantly monitoring blood sugar and automatically giving insulin or a sugar-boosting drug as eeded, doctors said.
The human mind can rapidly absorb and analyze new information as it flits from thought to thought. These quickly changing brain states may be encoded by synchronization of brain waves across different brain regions, according to a new study.
An imbalance of female sex hormones among men in Western nations may be contributing to high levels of male obesity, according to new research. The study suggest that obesity among Western men could be linked with exposure to substances containing the female sex hormone estrogen.
A study breaks new ground in the understanding of the link between parents with attention deficit hyperactivity disorder (ADHD) and their children with ADHD or autism spectrum disorder (ASD).
Researchers have determined that a copper compound known for decades may form the basis for a therapy for amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease.
Researchers have found that persons with lower blood levels of vitamin D were twice as likely to die prematurely as people with higher blood levels of vitamin D.
A provocative new study links prolonged episodes of sepsis— a life-threatening infection and leading cause of death in hospitals— to the reactivation of otherwise dormant viruses in the body.
Fighting off illness- rather than the illness itself- causes sleep deprivation and affects memory, a new study has found. The study, carried out in flies, found that sickness induced insomnia is quite common.
Scientists have identified a novel approach to treating multiple sclerosis (MS) using human embryonic stem cells, offering a promising new therapy for more than 2.3 million people suffering from the debilitating disease.
The gluten-specific enzyme ALV003 reduces exposure to gluten and gluten’s potential harm in individuals suffering who have celiac disease, according to a new study.
Using a zebrafish model, investigators have identified a drug compound that appears to reverse arrhythmogenic cardiomyopathy (ACM), a hereditary disease and leading cause of sudden death in young people.
White-bread lovers take heart. Scientists are now reporting that this much-maligned food seems to encourage the growth of some of our most helpful inhabitants—beneficial gut bacteria. In addition to this surprising find, their study also revealed that when looking at effects of food on our “microbiomes,” considering the whole diet, not just individual ingredients, is critical.
A new study also offers insight into the mechanism of interactions of nanoparticles and DNA molecules near a lipid membrane. This understanding could inform the emerging use of nanoparticles as vehicles for delivering genes across cellular membranes.
Obesity surgery may keep diabetes in remission even after 15 years in some patients, a study suggests. Long-term results were missing for more than half the patients who began the study and remission rates dropped off considerably. But still, 35 out of 115 patients remained diabetes-free 15 years after surgery. Also, 20 years after surgery, about 25 patients remained free of diabetes complications including eye and kidney problems.
Using a type of human stem cell, researchers say they have created a 3-D complement of human retinal tissue in the laboratory, which includes functioning photoreceptor cells capable of responding to light, the first step in the process of converting it into visual images.
Researchers are a step closer to establishing the link between a protein with a split personality and type 1 diabetes. New research shows how the protein GAD65 changes its shape when it turns itself on and off. This characteristic may also link it to type 1 diabetes.
Researchers have discovered that oxytocin– a hormone associated with maternal nurturing, social attachments, childbirth and sex– is indispensable for healthy muscle maintenance and repair, and that in mice it declines with age.
A daily supplement of an extract found in tomatoes may improve the function of blood vessels in patients with cardiovascular disease, according to new research.
Scientists at UC Santa Barbara have designed a nanoparticle that has a couple of unique — and important — properties. Spherical in shape and silver in composition, it is encased in a shell coated with a peptide that enables it to target tumor cells. What’s more, the shell is etchable so those nanoparticles that don’t hit their target can be broken down and eliminated.
Researchers have found that hormone replacement therapy in young women with primary ovarian insufficiency (POI) led to increases in their bone mineral density, restoring levels to normal. The findings provide important treatment information for women with POI and their physicians.