Using high-resolution functional MRI (fMRI) imaging in patients with Alzheimer's disease and in mouse models of the disease, Columbia University Medical Center (CUMC) researchers have clarified three fundamental issues about Alzheimer's: where it starts, why it starts there and how it spreads. In addition to advancing understanding of Alzheimer's, the findings could improve early detection of the disease. Learn more...
Scientists at The Scripps Research Institute (TSRI) have demonstrated a drug-discovery strategy with a double payoff—it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work. To illustrate the power of the innovative technique, the TSRI researchers used it to identify a compound that shows promise for treating obesity-linked diabetes. Learn more...
Using the largest dated evolutionary tree of flowering plants ever assembled, a new study suggests how plants developed traits to withstand low temperatures, with implications that human-induced climate change may pose a bigger threat than initially thought to plants and global agriculture.
Researchers have discovered a cause of aging in mammals that may be reversible. The essence of this finding is a series of molecular events that enable communication inside cells between the nucleus and mitochondria.
An international research team has completed the first high-quality genome sequence of a Neanderthal, deepening knowledge about the genetic connections and population histories of ancient and modern humans.
Researchers have identified how the ‘wall’ around cancer tumors functions and how to break it down, enabling the body’s own defenses to reach and kill the cancer cells within.
Virulent, drug-resistant forms of E. coli that have recently spread around the world emerged from a single strain of the bacteria– not many different strains, as has been widely supposed.
Researchers report promising steps toward the creation of a universal flu vaccine, one that could be produced more quickly and offer broader protection than the virus-specific inoculants available today.
A genetic trait known to make some people especially sensitive to stress also appears to be responsible for a 38 percent increased risk of heart attack or death in patients with heart disease, scientists report.
State health researchers have discovered the first new strain of botulism in four decades, but decided to withhold publishing the genetic code because of bioterrorism concerns.
Can an experimental drug developed to treat epilepsy block the AIDS virus? A preliminary lab study suggests it's possible, and researchers are eager to try it in people.
Health advocates cheered last month’s FDA proposal to ban partially hydrogenated oils— which contain trans fats that increase the risk of heart disease— but some wonder whether the substitutes for these fats will be any healthier.
Metabolism was lost in the shadows of cancer research for decades but has recently been reclaiming some of the spotlight. Now, research has shown that aerobic glycolysis is not the consequence of the cancerous activity of malignant cells but is itself a cancerous event.
A mosquito-borne virus that kills about half of the people it infects uses a never-before-documented mechanism to “hijack” one of the cellular regulatory systems of its hosts to suppress immunity, according to scientists.
New recommendations for using X-rays promise to speed investigations aimed at understanding the structure and function of biologically important proteins– information critical to the development of new drugs.
Scientists have discovered that as the brain reorganizes connections throughout our life, the process begins earlier in girls which may explain why they mature faster during the teenage years.
A research team has found no evidence of an association between iron levels in the body and the risk of atherosclerosis, the hardening and narrowing of the arteries that leads to cardiovascular disease.
A new study shows that ALK and ROS1 gene rearrangements known to drive subsets of lung cancer are also present in some colorectal cancers.
Scientists have confirmed that variations in a particular gene play a key role in the autism spectrum condition known as Asperger Syndrome, and that variations in the same gene are also linked to differences in empathy levels.
Researchers have isolated a gene, DCC, which is responsible for dopamine connection in the medial prefrontal cortex during adolescence and established that dysfunction of this gene during adolescence leads to behavioral consequences in adulthood.
Prescribing an apple a day to all adults aged 50 and over would prevent or delay around 8,500 vascular deaths such as heart attacks and strokes every year in the UK, according to a new study.
Many older adults with high blood pressure can be treated less aggressively, which could mean taking fewer pills to get it under control, according to new treatment guidelines from an expert panel.
Chinese authorities said Wednesday that a 73-year-old Chinese woman died after being infected with a bird flu strain that had sickened a human for the first time, a development that the World Health Organization called "worrisome."
Researchers have discovered a tube-shaped structure that forms temporarily in a certain type of virus to deliver its DNA during the infection process and then dissolves after its job is completed.