The mechanism by which some bacteria are able to survive antibacterial treatment has been revealed for the first time by Hebrew University of Jerusalem researchers. Their work could pave the way for new ways to control such bacteria. Learn more...
In a new study, researchers evaluated a patient with a genetic skin disorder known as epidermolysis bullosa (EB) nearly seven years after he had undergone a gene therapy procedure as part of a clinical trial. The study revealed that a small number of skin stem cells transplanted into the patient's legs were sufficient to restore normal skin function, without causing any adverse side effects.
A safe and effective malaria vaccine is high on the wish list of most people concerned with global health. Results published this week in PLOS Pathogens suggest how a leading vaccine candidate could be vastly improved.
A new study suggests that a history of concussion involving at least a momentary loss of consciousness may be related to the buildup of Alzheimer's-associated plaques in the brain. The research is published in the Dec. 26, 2013, online issue of Neurology, the medical journal of the American Academy of Neurology.
Researchers at Oregon Health & Science University have discovered that an antioxidant designed by scientists more than a dozen years ago to fight damage within human cells significantly helps symptoms in mice that have a multiple sclerosis-like disease.
In the study, published online in Cell Reports, scientists found that inhibiting the action of a protein called BRD4 caused cancer cells to die in a mouse model of malignant peripheral nerve sheath tumors (MPNSTs). Learn more...
University at Buffalo research published today in Infection and Immunity shows that Streptococcus pneumoniae and Streptococcus pyogenes do persist on surfaces for far longer than has been appreciated. The findings suggest that additional precautions may be necessary to prevent infections, especially in settings such as schools, daycare centers and hospitals.
Sanford-Burnham Medical Research Institute scientists have discovered a new molecule that forms when certain white blood cells—macrophages—are stimulated in response to pathogens. The molecule, termed "THRIL," helps regulate the immune response and shows an association with Kawasaki disease.
Published in the Journal Proceedings of the National Academy of Sciences, senior author, Associate Professor Katherine Kedzierska from the Department of Microbiology and Immunology said that being able to predict which patients will be more susceptible to the emerging influenza strain, will allow clinicians to better manage an early intervention strategy.
Biologists at The Johns Hopkins University have discovered that low oxygen conditions, which often persist inside tumors, are sufficient to initiate a molecular chain of events that transforms breast cancer cells from being rigid and stationery to mobile and invasive.
Scientists have obtained the first detailed molecular structure of a member of the Tet family of enzymes. The finding is important for the field of epigenetics because Tet enzymes chemically modify DNA, changing signposts that tell the cell's machinery "this gene is shut off" into other signs that say "ready for a change."
Researchers from the Boston area, Mexico and Norway have completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutations not previously found in cervical cancer, including at least one for which targeted treatments have been approved for other forms of cancer.
An international team of researchers in Mexico and the United States has uncovered a new genetic clue that contributes to an increased risk of developing type 2 diabetes, particularly the elevated risk among Mexican and other Latin American populations.
Substance P and calcitonin gene-related peptide are the main neuropeptides in peripheral nerve ganglia, which can anterogradely transmit nociceptive information to the central nervous system. Findings published in Neural Regeneration Research suggest that these neuropeptides may possibly serve as an index for evaluating early peripheral nerve injury.
Using high-resolution functional MRI (fMRI) imaging in patients with Alzheimer's disease and in mouse models of the disease, Columbia University Medical Center (CUMC) researchers have clarified three fundamental issues about Alzheimer's: where it starts, why it starts there and how it spreads. In addition to advancing understanding of Alzheimer's, the findings could improve early detection of the disease. Learn more...
Researchers have discovered a cause of aging in mammals that may be reversible. The essence of this finding is a series of molecular events that enable communication inside cells between the nucleus and mitochondria.
Researchers have identified how the ‘wall’ around cancer tumors functions and how to break it down, enabling the body’s own defenses to reach and kill the cancer cells within.
Virulent, drug-resistant forms of E. coli that have recently spread around the world emerged from a single strain of the bacteria– not many different strains, as has been widely supposed.
Researchers report promising steps toward the creation of a universal flu vaccine, one that could be produced more quickly and offer broader protection than the virus-specific inoculants available today.
A genetic trait known to make some people especially sensitive to stress also appears to be responsible for a 38 percent increased risk of heart attack or death in patients with heart disease, scientists report.
State health researchers have discovered the first new strain of botulism in four decades, but decided to withhold publishing the genetic code because of bioterrorism concerns.
Can an experimental drug developed to treat epilepsy block the AIDS virus? A preliminary lab study suggests it's possible, and researchers are eager to try it in people.
Health advocates cheered last month’s FDA proposal to ban partially hydrogenated oils— which contain trans fats that increase the risk of heart disease— but some wonder whether the substitutes for these fats will be any healthier.
Metabolism was lost in the shadows of cancer research for decades but has recently been reclaiming some of the spotlight. Now, research has shown that aerobic glycolysis is not the consequence of the cancerous activity of malignant cells but is itself a cancerous event.
A mosquito-borne virus that kills about half of the people it infects uses a never-before-documented mechanism to “hijack” one of the cellular regulatory systems of its hosts to suppress immunity, according to scientists.