Behavioral abnormalities are traditionally thought to originate in the brain. But a new study has found that inner-ear dysfunction can directly cause neurological changes that increase hyperactivity. The study, conducted in mice, also implicated two brain proteins in this process, providing potential targets for intervention.
A team of scientists have shown that a protein once thought to inhibit the growth of tumors is instead required for initial tumor growth. The findings could point to a new approach to cancer treatment. The focus of the study was angiomotin, a protein that coordinates cell migration, especially during the start of new blood vessel growth and proliferation of other cell types.
The ability to distinguish between the sounds generated from your own movements and those coming from the outside world is important for learning how to speak or play a musical instrument. Now, researchers have developed the first diagram of the brain circuitry that enables this complex interplay between the motor system and the auditory system to occur.
Imagine being able to take a drug that can reduce the rate at which you age. New research is making this dream one step closer to reality. A new study provides evidence that aging works through a special set of genes that everyone has: the rDNA genes.
Researchers have identified a compound that dramatically bolsters learning and memory when given to mice with a Down syndrome-like condition on the day of birth. The study reports that the single-dose treatment appears to enable the cerebellum of the rodents’ brains to grow to a normal size.
It probably won't become as popular as "Grand Theft Auto," but a specialized video game may help older people boost mental skills like handling multiple tasks at once. In a preliminary study, healthy volunteers ages 60 to 85 showed gains in their ability to multitask, to stay focused on a boring activity and to keep information in mind.
Researchers have shown that they can turn genes on or off inside yeast and human cells by controlling when DNA is copied into messenger RNA— an advance that could allow scientists to better understand the function of those genes. The technique could also make it easier to engineer cells that can monitor their environment, produce a drug or detect disease.
Phase 1 Clinical Trial (SAV CT 01) of the first and only preventative HIV vaccine based on a genetically modified killed whole virus (SAV001-H) has been successfully completed with no adverse effects in all patients, Western and Sumagen Canada Inc. announced.
Among scientists, the role of proteins called sirtuins in enhancing longevity has been hotly debated, driven by contradictory results from many different scientists. New research has identified the mechanism by which a specific sirtuin protein called Sirt1 operates in the brain to bring about a significant delay in aging and an increase in longevity.
A genetic mutation that can lead to hemorrhagic stroke has been identified by scientists– along with a drug to potentially treat it. COL4a2 is a protein that is expressed by the gene of the same name, which forms a structure outside the cell called a basement membrane. Scientists have now identified for the first time that accumulation of the mutant protein inside the cell can influence the development of haemorrhagic stroke.
A stress-related protein genetically linked to depression, anxiety and other psychiatric disorders contributes to the acceleration of Alzheimer’s disease, a new study has found. When the protein FKBP51 partners with another protein, Hsp90, the team prevents the brain from clearing the toxic tau protein, associated with Alzheimer’s disease.
Scientists estimate that there is a minimum of 320,000 viruses in mammals awaiting discovery. Collecting evidence of these viruses, or even a majority of them, they say, could provide information critical to early detection and mitigation of disease outbreaks in humans.
For the first time, it has been shown that an intensively active lifestyle can “completely prevent” bad diets from impairing sexual function, says a Johns Hopkins University urology fellow. Put another way, a recent rat study offers strong evidence that erectile dysfunction (ED) is more than just a bedroom bother. It may be one’s own natural biomarker for coronary artery disease.
A precisely designed macromolecule that mimics the binding of HIV to immune system cells could be used to stop the virus from physically entering the body, according to a new study. The researchers created the large molecule with several sugar molecules, known as glycopolymers.
For years, physicians around the world have watched as strain after strain of the deadly bacteria mycobacterium tuberculosis evolves resistance to drugs. A new method of analyzing whole genome sequences of TB, applied to a massive set of strains of the bacteria collected from clinics around the world, has revealed 39 new genes associated with elevated drug resistance.
Being short on cash may make you a bit slower in the brain, a new study suggests. People worrying about having enough money to pay their bills tend to lose temporarily the equivalent of 13 IQ points, scientists found when they gave intelligence tests to shoppers at a New Jersey mall and farmers in India.
Months before the NFL and former players agreed to settle their concussion-related lawsuits, a Detroit-based neurologist began what he calls a "landmark study" on the brains of 50 former players. Dr. Randall Benson sounded skeptical of the NFL's future research plans when it was announced the league agreed to give $765 million to diagnose and compensate potentially thousands of retired players.
A test designed to measure levels of normal and abnormal forms of the huntingtin protein— the mutated form of which causes Huntington’s disease (HD)— was successful in detecting levels of the mutant protein, in a large multicenter study of individuals at risk for the devastating neurological disorder. The team also found changes in levels of the mutated protein that might predict when symptoms will appear.
By lowering the expression of a single gene, researchers have extended the average lifespan of a group of mice by about 20 percent— the equivalent of raising the average human lifespan by 16 years, from 79 to 95. The research team targeted a gene called mTOR, which is involved in metabolism and energy balance, and may be connected with the increased lifespan associated with caloric restriction.
International research with participation of Danish investigators from University of Copenhagen shows that one in four Danes has serious problems with the trillion of bacteria living in their intestines. The problems appear to be associated with increased risk of obesity and diabetes.
Four people have been hospitalized and 160 quarantined after a 15-year-old boy who ate marmot meat died of the bubonic plague last week, the Kyrgyz Ministry of Health said today. The ministry in the Central Asian nation said the boy told medics he spent the previous week camping in the mountains where he had eaten barbecued marmot, a large ground squirrel that typically lives in mountainous areas.
New research from Cincinnati Children’s Hospital Medical Center provides evidence that gene-environment interactions are a major contributor to preterm birth and that using a combinatory treatment strategy can prevent preterm delivery in a mouse model.
A possible biomarker that may identify potential alcoholics—before they ever become alcoholics—has been found in a new study. The biomarker: a surge of the native chemical dopamine in the brain, viewed via a PET (Positron Emission Tomography) scan, when at-risk people drink.
Of the over 1,900 errors already reported in the gene responsible for cystic fibrosis (CF), it is unclear how many of them actually contribute to the inherited disease. Now a team of researchers reports significant headway in figuring out which mutations are benign and which are deleterious.
Cocaine can speedily rewire high-level brain circuits that support learning, memory and decision-making, according to new research from UC Berkeley and UCSF. The findings shed new light on the frontal brain’s role in drug-seeking behavior and may be key to tackling addiction.