A new bioprinting method creates intricately patterned 3D tissue constructs with multiple types of cells and tiny blood vessels. The work represents a major step toward a longstanding goal of tissue engineers: creating human tissue constructs realistic enough to test drug safety and effectiveness.
The mice in Scott Delp's lab, unlike their human counterparts, can get pain relief from the glow of a yellow light. Right now these mice are helping scientists to study pain—how and why it occurs and why some people feel it so intensely without any obvious injury. But Delp, a professor of bioengineering and mechanical engineering, hopes one day the work he does with these mice could also help people who are in chronic, debilitating pain.
Binge drinking impairs the healing of broken bones. It can do this weeks after a binge. And it can leave in its wake permanently inferior bone, according to recent studies. One reason: alcohol slows down mesenchymal (bone, fat, and cartilage) stem cells (MSCs), in the bloodstream, trying to home to fracture sites. And when MSCs finally reach fracture sites, alcohol keeps them from properly replacing lost cells.
Researchers exploring a possible link between metabolic defects and seizures have determined that diet could influence susceptibility to seizures, and they have identified a common diabetes drug that could be a useful treatment.
A new layer in the human cornea—discovered by researchers at The University of Nottingham last year—plays a vital role in the structure of the tissue that controls the flow of fluid from the eye, research has shown. The findings could shed new light on glaucoma, a devastating disease caused by defective drainage of fluid from the eye and the world’s second leading cause of blindness.
A saliva test for teenage boys with mild symptoms of depression could help identify those who will later develop major depression, a new study says. Researchers measured the stress hormone cortisol in teenage boys and found that ones with high levels coupled with mild depression symptoms were up to 14 times more likely to suffer clinical depression later in life than those with low or normal cortisol levels.
San Francisco Bay Area officials say a University of California, Berkeley, student infected with measles could have exposed thousands of others by attending classes and riding public transit. Public health officials said they confirmed that the student in his 20s was not vaccinated, and was likely infected with measles during a recent trip abroad.
Women have a higher risk of blood clots that can cause strokes, heart attacks and other problems for 12 weeks after childbirth — twice as long as doctors have thought, new research finds. Strokes are still fairly rare right after pregnancy but devastating when they do occur and fatal about 10 percent of the time.
Scientists report that they have developed a novel compound that appears to protect mice against developing movement problems associated with Parkinson’s disease (PD). The research could one day in the future translate into a therapy that could halt the progression of PD and thereby prevent the symptoms of the disease.
Researchers at Washington University School of Medicine in St. Louis have demonstrated a new approach to treating muscular dystrophy. Mice with a form of this muscle-weakening disease showed improved strength and heart function when treated with nanoparticles loaded with rapamycin, an immunosuppressive drug recently found to improve recycling of cellular waste.
Researchers at the NIST developed a new method for accurately measuring a key process governing a wide variety of cellular functions that may become the basis for a "health checkup" for living cells. The technique measures changes in a living cell's internal redox (reduction-oxidation) potential, a chemistry concept that expresses the favorability of reactions in which molecules or atoms either gain or lose electrons.
Whether lifting weights in a gym or just walking around the block, exercise has many benefits, such as helping people lose weight and build stronger muscles. Some studies suggest that it may reduce the risk of developing cancer and other diseases. Researchers now report that moderate, long-term physical activity appears to improve cardiovascular health in mice by targeting the heart cells’ powerhouses—the mitochondria.
Researchers have found that the melanopsin pigment in the eye is potentially more sensitive to light than its more famous counterpart, rhodopsin, the pigment that allows for night vision. Recent studies revealed the existence of a small number of intrinsically photosensitive nervous cells that regulate non-visual light responses.
In an attempt to learn how and why certain cancers spread to specific organs, researchers have developed a three-dimensional microfluidic platform that mimics the spread of breast cancer cells into a bonelike environment.
Testing for HGH, including samples from Sochi Olympic athletes, should resume after being stalled by an appeal case ruling last year, WADA director-general David Howman said. WADA also said it was "totally outrageous" that a Russian scientist reportedly offered to sell a potent and undetectable new muscle-building drug to undercover journalists. The substance, known as full size MGF, has only been trialed on animals.
Declines in the underlying brain skills needed to think, remember, and learn are normal in aging. Therapies to improve the cognitive health of older adults are critically important for lessening declines in mental performance as people age.
In his 2014 State of the Union address, President Obama referred to an August 2013 CDC study that showed a decline in the obesity rate among low-income preschool children. While the CDC report’s data is encouraging, a new study published by University of Illinois kinesiology and community health professor Ruopeng An shows the notion that the American obesity epidemic has begun to reverse may be premature.
University of Adelaide researchers have identified a key step for the future prevention of liver failure resulting from taking too much of the everyday painkiller paracetamol (also known as acetaminophen). The study pinpoints a target for new treatments to prevent the potentially lethal consequences of paracetamol overdose.
CVS Caremark is kicking the habit of selling tobacco products at its more than 7,600 drugstores nationwide as it focuses more on providing health care. The nation's second-largest drugstore chain said Wednesday that it will phase out cigarettes, cigars and chewing tobacco by Oct. 1, a move that will cost about $2 billion in annual revenue.
Designing nanomedicine to combat diseases is a hot area of scientific research, primarily for treating cancer, but very little is known in the context of atherosclerotic disease. Scientists have engineered a microchip coated with blood vessel cells to learn more about the conditions under which nanoparticles accumulate in the plaque-filled arteries of patients with atherosclerosis.
Adoption of new guidelines recommending screening mammography every two years for women ages 50 to 74 would result in breast cancer screening that is equally effective, while saving the United States $4.3 billion a year in health care costs, according to a study led by UC San Francisco.
Children newly diagnosed with Crohn’s disease may benefit from early treatment with the biologic drugs known as anti-TNF-α agents. Researchers compared the effectiveness of early (within three months after diagnosis) treatment with anti-TNF-α inhibitors, compared with early treatment with immunomodulatory drugs, in attaining clinical remission and facilitating growth in children with Crohn's disease.
In a study to be presented on Feb. 6 at 3 p.m. CST, at the Society for Maternal-Fetal Medicine’s annual meeting, The Pregnancy Meeting, in New Orleans, researchers will report that women ages 35 and older are at a decreased risk of having a child with a major congenital malformation, after excluding chromosomal abnormalities.
An experimental therapy that fed children with peanut allergies small amounts of peanut flour has helped more than 80 percent of them safely eat a handful of the previously worrisome nuts. Although experts say the results of the carefully monitored study are encouraging, they warn it isn't something that parents should try at home.
Those efforts to fight obesity in schools? Think younger. A new study finds that much of a child's "weight fate" is set by age 5, and that nearly half of kids who became obese by the eighth grade were already overweight when they started kindergarten.