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The Lead

Noise-related Hearing Loss Might be in Your Genes

April 17, 2015 9:29 am | by Bevin Fletcher, Associate Editor | News | Comments

A genome-wide association study conducted by an international team led by the University of Southern California identified Nox3 as a critical gene for susceptibility to noise-induced hearing loss in mice.  The gene, which is almost exclusively expressed in the inner ear, was identified in a study published in the April 16 edition of PLOS Genetics.

Rare, Deadly Lymphoma Demystified

April 16, 2015 10:46 am | by Columbia University | News | Comments

Findings identify a cause of the disease and highlight potential therapeutic approach.

Study Questions Accuracy of Certain Tumor-only Gene Mapping

April 16, 2015 9:23 am | by Lauran Neergaard, Medical Writer, Associated Press | News | Comments

More cancer patients are getting the genes in their tumors mapped to help guide their treatment...

A Guide to Targeted NGS: Generating Accurate Data for Personalized Medicine

April 15, 2015 8:57 am | by Ellen Prediger, Ph.D., Senior Writer, Integrated DNA Technologies (IDT) | Articles | Comments

As personalized medicine is integrated into mainstream medical treatment, sequencing clinically...

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Mountain Gorilla Genome Study Provides Optimism About Population Numbers

April 14, 2015 10:41 am | by University of Cambridge | News | Comments

An international research project to sequence whole genomes from mountain gorillas has given scientists and conservationists new insight into the impact of population decline on these critically endangered apes. While mountain gorillas are extensively inbred and at risk of extinction, research published today in Science finds more to be optimistic about in their genomes than expected.

Peltier-Cooled Incubators

April 10, 2015 10:00 am | Product Releases | Comments

Thermo Scientific Peltier-cooled incubators feature solid-state Peltier cooling designed for biological and genomics laboratory researchers engaged in fruit fly and biochemical oxygen demand (BOD) research.

The First Personalized Genomic Cancer Vaccines

April 8, 2015 9:10 am | by Cynthia Fox, Science Writer | Articles | Comments

The first personalized cancer vaccine using genomics to define targets elicits robust immune responses, says a recent Science study.

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Study Identifies Protein Associated with Lupus

April 7, 2015 9:49 am | by Massachusetts General Hospital | News | Comments

Investigators have identified an inflammatory molecule that appears to play an essential role in the autoimmune disorder commonly known as lupus.  Researchers describe finding that a protein that regulates certain cells in the innate immune system activates a molecular pathway known to be associated with lupus and that the protein’s activity is required for the development of lupus symptoms in a mouse model of the disease.

New Genetic Clues Emerge on Origin of Hirschsprung's Disease

April 6, 2015 2:12 pm | by Johns Hopkins | News | Comments

Genetic studies in humans, zebrafish and mice have revealed how two different types of genetic variations team up to cause a rare condition called Hirschsprung’s disease.

3-D Human Skin Maps Aid Study of Relationships Between Molecules, Microbes and Environment

March 31, 2015 4:39 pm | by University of Calif, San Diego | News | Comments

Researchers at the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences used information collected from hundreds of skin swabs to produce three-dimensional maps of molecular and microbial variations across the body. 

MRI based on Sugar Molecule Can Tell Cancerous from Noncancerous Cells

March 30, 2015 4:51 pm | by Johns Hopkins University | News | Comments

Imaging tests like mammograms or CT scans can detect tumors, but figuring out whether a growth is or isn’t cancer usually requires a biopsy to study cells directly.

Playing Music By Professional Musicians Activates Genes For Learning and Memory

March 27, 2015 3:36 pm | by University of Helsinki | News | Comments

Playing music by professional musicians activates genes responsible for brain function and singing of songbirds.

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Researchers Master Gene Editing Technique in Mosquito

March 27, 2015 10:49 am | by Rockefeller University | News | Comments

Researchers have harnessed a technique known as CRISPR-Cas9 editing in an important and understudied species: the mosquito, Aedes aegypti, which infects hundreds of millions of people annually with the deadly diseases chikungunya, yellow fever, and dengue fever.

Genetic Mutation Explains Why, in Rare Cases, Flu Can Kill

March 27, 2015 10:39 am | by Rockefeller University | News | Comments

Nobody likes getting the flu, but for some people, fluids and rest aren’t enough. A small number of children who catch the influenza virus fall so ill they end up in the hospital — perhaps needing ventilators to breathe — even while their family and friends recover easily. New research helps explain why: a rare genetic mutation.

New Genetic Variant That Causes Autism Identified

March 26, 2015 10:30 am | by Johns Hopkins University | News | Comments

Using a novel approach that homes in on rare families severely affected by autism, a Johns Hopkins-led team of researchers has identified a new genetic cause of the disease.

Czechs Deploy Wild Horses from Britain to Save Biodiversity

March 25, 2015 2:37 pm | by Karel Janicek, Associated Press | News | Comments

A herd of 14 wild mares from Britain's Exmoor National Park were moved in January to the former Milovice military base, 35 kilometers (22 miles) northeast of Prague, the Czech capital.

Blueprint Medicine Files for $100M IPO

March 24, 2015 5:02 pm | by Ryan Bushey, Associate Editor | News | Comments

The biotech firm is making a big bet on precision medicine.

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Genomewide Screen of Learning in Zebrafish Identifies Enzyme Important in Brain

March 24, 2015 11:18 am | by University of Pennsylvania | News | Comments

Researchers at the Perelman School of Medicine at the University of Pennsylvania describe the first set of genes important in learning in a zebrafish model in the journal Neuron this week.

Scientists Call for Freeze on Genome-Editing Method

March 20, 2015 4:18 pm | by Bevin Fletcher, Associate Editor | Articles | Comments

Designer babies? It’s far from a whimsy, and now a new technology that would make it possible to alter human DNA at the germline (meaning changing traits that can be inherited) has scientists calling for caution and a freeze. 

New Hope for Beating Deadly Hereditary Stomach and Breast Cancers

March 20, 2015 10:07 am | by University of Otago | News | Comments

Deadly familial stomach and lobular breast cancers could be successfully treated at their earliest stages, or even prevented, by existing drugs that have been newly identified by University of Otago cancer genetics researchers.

DNA Tests Help California Speed Up Dog Adoptions

March 19, 2015 3:43 pm | by Sue Manning, Associated Press | News | Comments

A quarter of the dogs taken in by one California animal shelter look like Chihuahuas. So how do you make a pet stand out when it's similar to so many other dogs at the shelter? Check the DNA.

British DNA Gives Window into Ancient Past

March 19, 2015 3:38 pm | by Malcolm Ritter, AP Science Writer | News | Comments

Genetic samples collected from across the United Kingdom are shedding light on the ancient past, including Viking invasions and a mystery about the arrival of the Anglo-Saxons.

Scientists Trace Genomic Evolution of High-risk Leukemia

March 19, 2015 10:53 am | by St. Jude Children's Research Hospital | News | Comments

Highly sensitive genomic analysis of acute lymphoblastic leukemia cells reveals for the first time how the malignant cells evolve to cause relapse.

Gene Discovery Provides Clue to How TB May Evade the Immune System

March 17, 2015 11:08 am | by University of Cambridge | News | Comments

The largest genetic study of tuberculosis (TB) susceptibility to date has led to a potentially important new insight into how the pathogen manages to evade the immune system.

New Gene Therapy for Hemophilia Shows Potential as Safe Treatment

March 16, 2015 10:08 am | by University of North Carolina | News | Comments

Research showed that bleeding events were drastically decreased in animals with hemophilia B. Using a viral vector to swap out faulty genes proved safe and could be used for the more common hemophilia A.

Human Genome Includes 'Foreign' Genes Not From Our Ancestors

March 13, 2015 10:01 am | by University of Cambridge | News | Comments

Many animals, including humans, acquired essential ‘foreign’ genes from microorganisms cohabiting their environment in ancient times, according to research published in the open access journal Genome Biology.

Study Shows Connection Between Key Autism Risk Genes in Human Brain

March 11, 2015 10:16 am | by Lindsay Borthwick, Yale | News | Comments

A new study reveals an important connection between dozens of genes that may contribute to autism, a major step toward understanding how brain development goes awry in some individuals with the disorder.                                                 

Researchers Map "Genomic Landscape" of Childhood Adrenocortical Tumors for First Time

March 9, 2015 10:15 am | by St. Jude Children's Research Hospital | News | Comments

In an advance that could lead to better identification of malignant pediatric adrenocortical tumors, and ultimately to better treatment, researchers have mapped the “genomic landscape” of these rare childhood tumors. Their genomic mapping has revealed unprecedented details, not only of the aberrant genetic and chromosomal changes that drive the cancer, but the sequence of those changes that trigger it.

Researchers Report New Gene Associated With Thyroid Levels

March 9, 2015 10:01 am | by University of Bristol | News | Comments

Thyroid hormones have important and diverse roles in human health and regulate metabolic rate. Thyroid disease is common (affecting 5-10 per cent of the population) and synthetic thyroid hormones are one of the commonest drug therapies prescribed worldwide.

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