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Immune Therapy Might be Effective for Multiple Myeloma

May 12, 2014 1:32 pm | News | Comments

A new study provides evidence that genetically modifying immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014.        

Autism-related Protein Plays Vital Role in Addiction

May 12, 2014 1:19 pm | Videos | Comments

Investigators report that a gene essential for normal brain development, and previously linked to Autism Spectrum Disorders, also plays a critical role in addiction-related behaviors.                   

Expanding the Power of RNA Interference

May 12, 2014 1:12 pm | News | Comments

Using nanoparticles designed and screened for endothelial delivery of short strands of RNA called siRNA, researchers were able to target RNAi to endothelial cells, which form the linings of most organs. This raises the possibility of using RNAi to treat many types of disease.

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Man's Best Friend Shares Similar 'Albino' Gene

May 12, 2014 1:05 pm | News | Comments

Researchers have identified a genetic mutation in Doberman pinschers that causes albinism in the breed, a discovery that has eluded veterinarians and breeders worldwide up until now.                   

Dopamine Turns Worker Ants into Warrior Queens

May 12, 2014 12:51 pm | News | Comments

The ritualized fighting behavior of one ant species is linked to increases in dopamine levels that trigger dramatic physical changes in the ants without affecting their DNA. The researchers studied Indian jumping ants (Harpegnathos saltator), which can undergo significant changes in physiology without any related changes to their DNA. Instead, the changes depend on which genes are turned on or off.

Newly Discovered Gene Linked to Esophageal Cancer

May 9, 2014 1:39 pm | News | Comments

A newly discovered gene linked to esophageal cancer holds the promise of new treatments for up to 15 percent of the 8,500 people diagnosed with esophageal cancer in the UK every year.                  

Microarray for Research into Haematological and Solid Cancers

May 9, 2014 1:18 pm | Product Releases | Comments

Oxford Gene Technology (OGT) released a new microarray designed to improve the accuracy and efficiency of cancer research. The CytoSure Cancer +SNP array (4x180k) combines long oligo array comparative genomic hybridisation (aCGH) probes with fully validated single nucleotide polymorphism (SNP) content.

Better Cognition Seen with Gene Carried by 1 in 5 People

May 9, 2014 12:56 pm | Videos | Comments

A scientific team has discovered that a common form of a gene already associated with long life also improves learning and memory, a finding that could have implications for treating age-related diseases like Alzheimer’s.         

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Cancer-focused Array for Malignancies, Tumors

May 8, 2014 2:02 pm | Product Releases | Comments

Oxford Gene Technology (OGT) offers the CytoSure Consortium Cancer +SNP array (4x180k). The array allows the simultaneous detection of copy number variation (CNV) and loss of heterozygosity (LOH), with a SNP resolution that enables reporting of LOH at 10Mb.

Mapping the Spider Genome

May 7, 2014 1:33 pm | News | Comments

For the first time, a group of Danish and Chinese researchers has sequenced the genome of the spider. This knowledge provides a much more qualified basis for studying features of the spider. It also shows that humans share certain genomic similarities with spiders.

Starting Signal for Antiviral Defense

May 7, 2014 1:21 pm | News | Comments

Cells have to protect themselves against damage in their genetic material for one thing, but also against attack from the outside, by viruses for example. They do this by using different mechanisms: special proteins search out and detect defects in the cell's own DNA, while the immune system takes action against intruders. Scientists have now shown that the two protective mechanisms are linked by a shared protein.

Detecting Fetal Chromosomal Defects Without Risk

May 7, 2014 12:21 pm | News | Comments

Chromosomal abnormalities that result in birth defects and genetic disorders remain a significant health burden, as some prenatal screenings are a potential risk to mother and unborn child. Now, scientists are investigating a new sequencing procedure that can be completed without harm to mother or fetus.

Genetic Risk Factor for Premature Birth Found

May 6, 2014 1:44 pm | News | Comments

Researchers at the University of California, San Diego School of Medicine have discovered a genetic risk factor for premature birth. The risk factor is related to a gene that codes for a protein that the scientists have found helps the body’s immune cells recognize and fight Group B Streptococcus (GBS) bacteria.

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Microarray Scanner for in vitro Diagnostics

May 5, 2014 1:54 pm | Product Releases | Comments

The SureScan Dx from Agilent Technologies Inc. is a microarray scanner indicated for use in a clinical laboratory environment when measuring fluorescence signals of labeled DNA or RNA targets hybridized to microarrays used as part of a validated diagnostic assay.

Immune System Linked to Neurodegeneration

May 5, 2014 11:56 am | News | Comments

Researchers have demonstrated how genetic variations among healthy, young individuals can influence immune cell function. Many of those variants are also genetic risk factors for common diseases later in life, offering new insight into disease pathology.

30-year Puzzle in Breast Cancer Solved

May 2, 2014 1:29 pm | News | Comments

Scientists at the Fred Hutchinson Cancer Research Center demonstrate that mice lacking one copy of a gene called CTCF have abnormal DNA methylation and are markedly predisposed to cancer. CTCF is a very well-studied DNA binding protein that exerts a major influence on the architecture of the human genome, but had not been previously linked to cancer.

Automated Next Generation Sequencing Applications

May 1, 2014 2:21 pm | Product Releases | Comments

Beckman Coulter Life Sciences, through a partnership with Illumina, offers automated methods to improve processes and throughput in next generation sequencing (NGS) sample preparation. Under the agreement, Beckman Coulter will use its experience in automated NGS sample preparation to develop, distribute and support automation for Illumina’s TruSeq and Nextera sample preparation kits and Illumina will provide technical expertise on chemistry and protocols.

The Power of Personalized Medicine: It’s in the Stars

May 1, 2014 2:13 pm | Videos | Comments

This six-part video series from both Bioscience Technology and Drug Discovery & Development explains what personalized medicine is, how it works and the potential of this concept. In today's video, Rob Fee returns to discuss the power of genetic testing and preemptive medicine. But how do you learn if you carry risky genes, and most importantly, what do you do with that information? 

Novel Regulator of Key Gene Expression in Cancer Identified

May 1, 2014 1:58 pm | News | Comments

Scientists identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code for proteins like regular RNA. Instead, this particular lncRNA acts as an on/off switch for a key gene whose excessive activity is tied to inflammation and cancer, COX-2.

Breast Cancer Clue

April 30, 2014 12:43 pm | News | Comments

Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors to hereditary cancer risk in the human population. Now, investigators are reporting a new mechanism by which BRCA gene loss may accelerate cancer-promoting chromosome rearrangements.

Researchers ID 'Master Regulator' Role for Protein in Cancer Cells

April 30, 2014 12:29 pm | News | Comments

Researchers found that the protein DAZAP1 plays a key role in the regulation of many genes through a process known as alternative splicing, and when highly expressed in cancer cell line experiments, DAZAP1 was shown to inhibit several types of cancer cells from dividing and moving.

Research Sees Overlap in Altered Genes Found in Schizophrenia, Autism, and Intellectual Disability

April 29, 2014 12:53 pm | News | Comments

A multinational team of scientists presents new evidence supporting the theory that in at least some cases of schizophrenia, autism and intellectual disability (ID), malfunctions in some of the same genes are contributing to pathology. 

Variable Gene Expression in Zebrafish

April 28, 2014 2:10 pm | News | Comments

Early embryonic development of vertebrates is controlled by the genes and their “grammar.” Decoding this grammar might help understand the formation of abnormalities or cancer or develop new medical drugs. For the first time, it is now found by a study that various mechanisms of transcribing DNA into RNA exist during gene expression in the different development phases of zebrafish.

Tracking the Origin of Huntington’s Disease in the Brain

April 28, 2014 1:59 pm | News | Comments

The gene mutation that causes Huntington’s disease appears in every cell in the body, yet kills only two types of brain cells. Why? Scientists used a unique approach to switch the gene off in individual brain regions and zero in on those that play a role in causing the disease in mice.

Controlling Fear by Modifying DNA

April 28, 2014 1:15 pm | News | Comments

For many people, fear of flying or of spiders is more than just a momentary increase in heart rate and a pair of sweaty palms, it’s a hard-core phobia. Now, a team of researchers may have found a way to silence the gene that feeds this fear.   

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