A new study provides evidence that genetically modifying immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014.
Investigators report that a gene essential for normal brain development, and previously linked to Autism Spectrum Disorders, also plays a critical role in addiction-related behaviors.
Using nanoparticles designed and screened for endothelial delivery of short strands of RNA called siRNA, researchers were able to target RNAi to endothelial cells, which form the linings of most organs. This raises the possibility of using RNAi to treat many types of disease.
Researchers have identified a genetic mutation in Doberman pinschers that causes albinism in the breed, a discovery that has eluded veterinarians and breeders worldwide up until now.
The ritualized fighting behavior of one ant species is linked to increases in dopamine levels that trigger dramatic physical changes in the ants without affecting their DNA. The researchers studied Indian jumping ants (Harpegnathos saltator), which can undergo significant changes in physiology without any related changes to their DNA. Instead, the changes depend on which genes are turned on or off.
A newly discovered gene linked to esophageal cancer holds the promise of new treatments for up to 15 percent of the 8,500 people diagnosed with esophageal cancer in the UK every year.
Oxford Gene Technology (OGT) released a new microarray designed to improve the accuracy and efficiency of cancer research. The CytoSure Cancer +SNP array (4x180k) combines long oligo array comparative genomic hybridisation (aCGH) probes with fully validated single nucleotide polymorphism (SNP) content.
A scientific team has discovered that a common form of a gene already associated with long life also improves learning and memory, a finding that could have implications for treating age-related diseases like Alzheimer’s.
Oxford Gene Technology (OGT) offers the CytoSure Consortium Cancer +SNP array (4x180k). The array allows the simultaneous detection of copy number variation (CNV) and loss of heterozygosity (LOH), with a SNP resolution that enables reporting of LOH at 10Mb.
For the first time, a group of Danish and Chinese researchers has sequenced the genome of the spider. This knowledge provides a much more qualified basis for studying features of the spider. It also shows that humans share certain genomic similarities with spiders.
Cells have to protect themselves against damage in their genetic material for one thing, but also against attack from the outside, by viruses for example. They do this by using different mechanisms: special proteins search out and detect defects in the cell's own DNA, while the immune system takes action against intruders. Scientists have now shown that the two protective mechanisms are linked by a shared protein.
Chromosomal abnormalities that result in birth defects and genetic disorders remain a significant health burden, as some prenatal screenings are a potential risk to mother and unborn child. Now, scientists are investigating a new sequencing procedure that can be completed without harm to mother or fetus.
Researchers at the University of California, San Diego School of Medicine have discovered a genetic risk factor for premature birth. The risk factor is related to a gene that codes for a protein that the scientists have found helps the body’s immune cells recognize and fight Group B Streptococcus (GBS) bacteria.
The SureScan Dx from Agilent Technologies Inc. is a microarray scanner indicated for use in a clinical laboratory environment when measuring fluorescence signals of labeled DNA or RNA targets hybridized to microarrays used as part of a validated diagnostic assay.
Researchers have demonstrated how genetic variations among healthy, young individuals can influence immune cell function. Many of those variants are also genetic risk factors for common diseases later in life, offering new insight into disease pathology.
Scientists at the Fred Hutchinson Cancer Research Center demonstrate that mice lacking one copy of a gene called CTCF have abnormal DNA methylation and are markedly predisposed to cancer. CTCF is a very well-studied DNA binding protein that exerts a major influence on the architecture of the human genome, but had not been previously linked to cancer.
Beckman Coulter Life Sciences, through a partnership with Illumina, offers automated methods to improve processes and throughput in next generation sequencing (NGS) sample preparation. Under the agreement, Beckman Coulter will use its experience in automated NGS sample preparation to develop, distribute and support automation for Illumina’s TruSeq and Nextera sample preparation kits and Illumina will provide technical expertise on chemistry and protocols.
This six-part video series from both Bioscience Technology and Drug Discovery & Development explains what personalized medicine is, how it works and the potential of this concept. In today's video, Rob Fee returns to discuss the power of genetic testing and preemptive medicine. But how do you learn if you carry risky genes, and most importantly, what do you do with that information?
Scientists identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code for proteins like regular RNA. Instead, this particular lncRNA acts as an on/off switch for a key gene whose excessive activity is tied to inflammation and cancer, COX-2.
Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors to hereditary cancer risk in the human population. Now, investigators are reporting a new mechanism by which BRCA gene loss may accelerate cancer-promoting chromosome rearrangements.
Researchers found that the protein DAZAP1 plays a key role in the regulation of many genes through a process known as alternative splicing, and when highly expressed in cancer cell line experiments, DAZAP1 was shown to inhibit several types of cancer cells from dividing and moving.
A multinational team of scientists presents new evidence supporting the theory that in at least some cases of schizophrenia, autism and intellectual disability (ID), malfunctions in some of the same genes are contributing to pathology.
Early embryonic development of vertebrates is controlled by the genes and their “grammar.” Decoding this grammar might help understand the formation of abnormalities or cancer or develop new medical drugs. For the first time, it is now found by a study that various mechanisms of transcribing DNA into RNA exist during gene expression in the different development phases of zebrafish.
The gene mutation that causes Huntington’s disease appears in every cell in the body, yet kills only two types of brain cells. Why? Scientists used a unique approach to switch the gene off in individual brain regions and zero in on those that play a role in causing the disease in mice.
For many people, fear of flying or of spiders is more than just a momentary increase in heart rate and a pair of sweaty palms, it’s a hard-core phobia. Now, a team of researchers may have found a way to silence the gene that feeds this fear.