Scientists at the Fred Hutchinson Cancer Research Center demonstrate that mice lacking one copy of a gene called CTCF have abnormal DNA methylation and are markedly predisposed to cancer. CTCF is a very well-studied DNA binding protein that exerts a major influence on the architecture of the human genome, but had not been previously linked to cancer.
Beckman Coulter Life Sciences, through a partnership with Illumina, offers automated methods to improve processes and throughput in next generation sequencing (NGS) sample preparation. Under the agreement, Beckman Coulter will use its experience in automated NGS sample preparation to develop, distribute and support automation for Illumina’s TruSeq and Nextera sample preparation kits and Illumina will provide technical expertise on chemistry and protocols.
This six-part video series from both Bioscience Technology and Drug Discovery & Development explains what personalized medicine is, how it works and the potential of this concept. In today's video, Rob Fee returns to discuss the power of genetic testing and preemptive medicine. But how do you learn if you carry risky genes, and most importantly, what do you do with that information?
Scientists identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code for proteins like regular RNA. Instead, this particular lncRNA acts as an on/off switch for a key gene whose excessive activity is tied to inflammation and cancer, COX-2.
Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors to hereditary cancer risk in the human population. Now, investigators are reporting a new mechanism by which BRCA gene loss may accelerate cancer-promoting chromosome rearrangements.
Researchers found that the protein DAZAP1 plays a key role in the regulation of many genes through a process known as alternative splicing, and when highly expressed in cancer cell line experiments, DAZAP1 was shown to inhibit several types of cancer cells from dividing and moving.
A multinational team of scientists presents new evidence supporting the theory that in at least some cases of schizophrenia, autism and intellectual disability (ID), malfunctions in some of the same genes are contributing to pathology.
Early embryonic development of vertebrates is controlled by the genes and their “grammar.” Decoding this grammar might help understand the formation of abnormalities or cancer or develop new medical drugs. For the first time, it is now found by a study that various mechanisms of transcribing DNA into RNA exist during gene expression in the different development phases of zebrafish.
The gene mutation that causes Huntington’s disease appears in every cell in the body, yet kills only two types of brain cells. Why? Scientists used a unique approach to switch the gene off in individual brain regions and zero in on those that play a role in causing the disease in mice.
For many people, fear of flying or of spiders is more than just a momentary increase in heart rate and a pair of sweaty palms, it’s a hard-core phobia. Now, a team of researchers may have found a way to silence the gene that feeds this fear.
A study tracing the evolution of HIV in North America has found evidence that the virus is slowly adapting over time to its human hosts. However, this change is so gradual that it is unlikely to have an impact on vaccine design.
Scientists have known that abnormal brain growth is associated with autism spectrum disorder. However, the relationship between the two has not been well understood. Now, scientists have shown that mutations in a specific gene that is disrupted in some individuals with autism results in too much growth throughout the brain.
Large sections of the genome that were once referred to as “junk” DNA have been linked to human heart failure, according to new research. So-called junk DNA was long thought to have no important role in heredity or disease because it doesn’t code for proteins.
Federal health regulators have cleared a genetic test from Roche as a first-choice screening option for cervical cancer. It was a role previously reserved for the Pap smear, the decades-old mainstay of women's health.
Researchers have successfully reprogrammed mature blood cells from mice into blood-forming hematopoietic stem cells (HSCs), using a cocktail of eight genetic switches called transcription factors.
The humble aspirin may have just added another beneficial effect beyond its ability to ameliorate headaches and reduce the risk of heart attacks: lowering colon cancer risk among people with high levels of a specific type of gene.
A newly identified genetic disorder associated with degeneration of the central and peripheral nervous systems in humans, along with the genetic cause, has been reported.
Australian researchers have combined cochlear implants with gene therapy in an experiment that improves the hearing of deafened animals. Cochlear implants partially restore hearing by emitting electrical impulses that activate auditory nerves in the brain.
Researchers have identified an important enzyme pathway that helps prevent new cells from receiving too many or too few chromosomes, a condition that has been directly linked to cancer and other diseases.
Scientists have now shown how double stranded RNA, such as viral genetic information, is prevented from entering the nucleus of a cell. During the immune response against viral infection, the protein ADAR1 moves from the cell nucleus into the surrounding cytoplasm.
A team of researchers has developed a test that can rapidly assess several DNA repair systems, which could help determine individuals’ risk of developing cancer and help doctors predict how a given patient will respond to chemotherapy drugs.
Muscle weakness from long-term alcoholism may stem from an inability of mitochondria, the powerhouses of cells, to self-repair, according to a new study. In the research, scientists found evidence that chronic heavy alcohol use affects a gene involved in mitochondrial repair and muscle regeneration.
Although doctors have long known that people with Down syndrome have a heightened risk of developing acute lymphoblastic leukemia (ALL) during childhood, they haven’t been able to explain why. Now, a team investigators has uncovered a connection between the two conditions.
Researchers have sequenced the entire genome and all the RNA products of the most important pathogenic lineage of Cryptococcus neoformans, a strain called H99.
In a feat of reverse tissue engineering, Stanford University researchers have begun to unravel the complex genetic coding that allows embryonic cells to proliferate and transform into all of the specialized cells that perform myriad biological tasks.