In what is believed to be the largest genetic analysis of what triggers and propels progression of tumor growth in a common childhood blood cancer, researchers report that they have identified a possible new drug target for treating the disease.
Just as no two people possess the same genetic makeup, a recent study has shown that no two single tumor cells in breast cancer patients have an identical genome.
On this episode of Bioscience Technology This Week, Editor-in-Chief Rob Fee reports on gold nanoparticles' promise in drug delivery. Our second story examines the work being done to decipher the wheat genome and the implications of this work.
A new study demonstrates that the ‘memory’ of nutrition during pregnancy can be passed through sperm of male offspring to the next generation, increasing risk of disease for grandchildren as well. In other words, to adapt an old maxim, ‘you are what your grandmother ate.’
Researchers say they have discovered a chemical alteration in a single human gene linked to stress reactions that could give doctors a simple blood test to reliably predict a person’s risk of attempting suicide.
Researchers have found a missing link that helps to explain how ALS, one of the world’s most feared diseases, paralyses and ultimately kills its victims. The breakthrough is helping them trace a path to a treatment or even a cure.
Using data from over 18,000 patients, scientists have identified more than two dozen genetic risk factors involved in Parkinson’s disease, including six that had not been previously reported.
In a massive effort to catalog the molecular causes of stomach cancer, scientists have identified four subtypes of tumors based on shared mutations and other molecular abnormalities.
Microorganisms can evade treatment by acquiring mutations in the genes targeted by antibiotics or antifungal drugs. Now, a new study has shown that microorganisms can use a temporary silencing of drug targets to gain the benefits of drug resistance without the commitment.
Only 8.2 percent of human DNA is likely to be doing something important – is “functional”– say researchers. This figure is very different from one given in 2012, when some scientists stated that 80 percent of our genome has some biochemical function.
Scientists have linked more than 100 spots in our DNA to the risk of developing schizophrenia, casting light on the mystery of what makes the disease tick. Such work could eventually point to new treatments, although they are many years away.
The HIV-1 virus has proved to be tenacious, inserting its genome permanently into its victims' DNA, forcing patients to take a lifelong drug regimen to control the virus and prevent a fresh attack. Now, a team of Temple University School of Medicine researchers has designed a way to snip out the integrated HIV-1 genes for good.
Mixed genes appear to drive hybrid birds to select more difficult routes than their parent species, according to new research from University of British Columbia zoologists. the researchers harnessed a flock of B.C. Swainson’s thrushes with tiny geolocating backpacks to map their routes as they migrated south through the U.S. to Central and South America.
Researchers have developed a powerful new single-cell technique to help investigate how the environment affects our development and the traits we inherit from our parents. The technique can be used to map all of the 'epigenetic marks' on the DNA within a single cell.
Most of the genetic risk for autism comes from versions of genes that are common in the population rather than from rare variants or spontaneous glitches, researchers have found. Heritability also outweighed other risk factors in this largest study of its kind to date.
A cross-disciplinary team is calling for public discussion about a potential new way to solve longstanding global ecological problems by using an emerging technology called “gene drives.” The advance could potentially lead to powerful new ways of combating malaria and other insect-borne diseases.
Scientists at the Salk Institute have identified a gene responsible for stopping the movement of cancer from the lungs to other parts of the body, indicating a new way to fight one of the world's deadliest cancers. By identifying the cause of this metastasis—which often happens quickly in lung cancer and results in a bleak survival rate—Salk scientists are able to explain why some tumors are more prone to spreading than others.
Economists at the University’s Centre for Competitive Advantage in the Global Economy (CAGE) have looked at why certain countries top the world happiness rankings. In particular they have found the closer a nation is to the genetic makeup of Denmark, the happier that country is. The research could help to solve the puzzle of why a country like Denmark so regularly tops the world happiness rankings.
It is something of an eternal question: Can we slow or even reverse the aging process? Even though genetic manipulations can, in fact, alter some cellular dynamics, little is known about the mechanisms of the aging process in living organisms. Now scientists from the Florida campus of The Scripps Research Institute have found in animal models that a single gene plays a surprising role in aging that can be detected early on in development.
Researchers have uncovered a genetic vulnerability of cancer cells that express telomerase— an enzyme that drives their unchecked growth— and showed that telomerase-expressing cells depend upon a gene named p21 for their survival.
Transplantation of Healthy New Brain Cells Reverses Learning and Memory Loss in Alzheimer’s Disease ModelJuly 16, 2014 2:10 pm | News | Comments
A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer’s disease, improving cognition to normal levels in aged mice.
Early maize farmers selected for genes that improved the harvesting of sunlight, a new detailed study of how plants use 'doubles' of their genomes reveals. The findings could help current efforts to improve existing crop varieties. Oxford University researchers captured a 'genetic snapshot' of maize as it existed 10 million years ago when the plant made a double of its genome—a 'whole genome duplication' event.
If you consider your friends family, you may be on to something. A new study finds that friends who are not biologically related still resemble each other genetically.
USC Stem Cell scientists have set a “mouse TRAP” to capture the early signs of kidney failure. Their new transgenic mouse line uses a technique called TRAP to extract cellular and genetic information from a variety of solid organs. TRAP involves attaching a fluorescent tag to the ribosomes of the cell type of interest. Scientists can then collect the tagged ribosomes and determine which active genes are ordering proteins to be made.