Scientists at The Scripps Research Institute (TSRI) have identified a new cellular pathway that is affected in cystinosis, a rare genetic disorder that can result in eye and kidney damage.
A vial of rare snake venom refused to give up its secret formula for lethality; its toxins had no effect on the proteins that most venoms target.
Ebola has claimed nearly 9,000 lives in West Africa over the past year, although new infections have dropped dramatically in recent months.
Next-generation sequencing (NGS) technology can now profile highly damaged DNA samples that contain 75 percent less base-pair information, compared with previous systems. This is a significant improvement for law enforcement in cases involving missing persons or unidentified human remains.
MicroRNA are the tiny non-coding RNA molecules that help determine whether genes are expressed or silenced.
Scientists have developed a potential new therapy based on an unlikely model: immune molecules from cows.
Researchers have revealed new insights into possible ways to vaccinate people to generate potent antibodies of the type that are predicted to offer protection against diverse strains of the highly mutable HIV.
Several state legislatures are debating vaccine-related measures as dozens of people have fallen ill from a measles outbreak that started at Disneyland in December and spread beyond the theme park.
A team of researchers are working on a diagnostic machine that can detect Ebola virus and other dangerous microbes.
Researchers said they can tell who will become depressed or anxious in response to stressful life events, as far as four years down the road.
Scientists have found diverse genomic changes in single neurons from the brains of Alzheimer’s patients, pointing to an unexpected factor that may underpin the most common form of the disease.
A preliminary study suggests stem cell transplantation may reverse disability and improve quality of life for patients with relapsing-remitting multiple sclerosis.
Humans have fewer remnants of viral DNA in their genes compared to other mammals.
Despite improvements in the past few decades with surgery, chemotherapy and radiation therapy, a predictably curative treatment for glioma does not yet exist. New insights into specific gene mutations that arise in this often deadly form of brain cancer have pointed to the potential of gene therapy, but it’s very difficult to effectively deliver toxic or missing genes to cancer cells in the brain.
Oxford Gene Technology (OGT) offers the CytoSure Consortium Cancer +SNP array (4x180k). The array allows the simultaneous detection of copy number variation (CNV) and loss of heterozygosity (LOH), with a SNP resolution that enables reporting of LOH at 10Mb.
Researchers have determined that two mutations on a single gene can interact in a way that lowers the carrier's risk for a heart attack. The variants are found in a gene called DBH, which regulates an enzyme involved in the conversion of dopamine to norepinephrine - both of which are important chemical messengers and hormones.
The thousands of mitochondrial DNA (mtDNA) molecules present in each cell are known primarily for their role converting food and oxygen into energy. But Yale researchers have identified an unexpected relationship between mtDNA and the innate immune response.
Britain's House of Commons gave preliminary approval to permitting scientists to create babies from the DNA of three people, a technique that could protect some children from inheriting potentially fatal diseases from their mothers. Read more...
New research could lead to a better understanding of how the brain works in people with autism.
President Obama held a press conference revealing new details surrounding the Precision Medicine initiative he announced during the State of The Union.
Researchers have begun to appreciate the importance of copy number variation when considering the connections between DNA and disease.
For the first time, scientists have revealed a mechanism underlying the cellular degeneration of upper motor neurons, a small group of neurons in the brain recently shown to play a major role in ALS pathology.
For people with pancreatitis, a noncancerous inflammation of the tiny ducts in the 6-inch organ, the discomfort can be devastating.
People who carry a variant of a gene that is associated with longevity also have larger volumes in a front part of the brain involved in planning and decision-making, according to researchers at UC San Francisco.