Scientists have discovered, by studying the genetics of two families severely affected by eating disorders, two gene mutations that are associated with increased risk of developing eating disorders.
A world-first human study to assess the impact of sunscreen at the molecular level has shown that sunscreen provides 100 percent protection against all three forms of skin cancer, and it also shields the important p53 gene, a gene that works to prevent cancer.
What makes some people more prone to wedded bliss or sorrow than others? Researchers have found a major clue in our DNA. A gene involved in the regulation of serotonin can predict how much our emotions affect our relationships, according to a new study.
With high-tech optical tools and sophisticated mathematics, researchers have found a way to pinpoint the location of specific sequences along single strands of DNA, a technique that could someday help diagnose genetic diseases.
A research team has found that triglycerides play a causal role in coronary artery disease (CAD), the most common form of heart disease and the leading cause of death in the U.S. The study suggests that lowering triglyceride levels through treatment may help reduce the risk of CAD.
A new technique developed by researchers at the Stanford University School of Medicine could pave the way to an era of personalized epigenomics.The technique could quickly yield huge amounts of useful information about which genes are active in particular cells.
A global hunt for genes that influence heart disease risk has uncovered 157 changes in human DNA that alter the levels of cholesterol and other blood fats– a discovery that could lead to new medications. Each of the changes points to genes that can modify levels of cholesterol and other blood fats.
Little Amelia Sloan is a pioneer: Shortly after her birth, scientists took drops of the healthy baby's blood to map her genetic code. New parents soon can start signing up for smaller studies to explore if what's called genome sequencing — fully mapping someone's genes to look for health risks — should become a part of newborn care.
Hypertrophic cardiomyopathy (HCM)— a disease in which cardiac muscle thickens, weakening the heart— can be prevented from developing for several months in mice by reducing production of a mutant protein, according to a new study. The work takes a first step toward being able to treat or prevent the leading cause of sudden death in athletes and sudden heart-related death in people under 30 in the United States.
Researchers can now identify DNA regions within non-coding DNA, the major part of the genome that is not translated into a protein, where mutations can cause diseases such as cancer. Their approach reveals many potential genetic variants within non-coding DNA that drive the development of a variety of different cancers.
They were mystery diseases that had stumped doctors for years - adults with strange symptoms and children with neurological problems, mental slowness or muscles too weak to let them stand. Now scientists say they were able to crack a quarter of these cases by decoding the patients' genes.
Similar to using Python or Java to write code for a computer, chemists soon could be able to use a structured set of instructions to “program” how DNA molecules interact in a test tube or cell. The programming language for chemistry could streamline efforts to design a network that can guide the behavior of chemical-reaction mixtures.
Researchers say it’s clear that some cases of autism are hereditary, but have struggled to draw direct links between the condition and particular genes. Now a team has devised a process for connecting a suspect gene to its function in autism.
Selectively bred strains of laboratory rats that either prefer or avoid alcohol have been a mainstay of alcohol research for decades. Alcohol-preferring rats voluntarily consume much greater amounts of alcohol than do non-preferring rats. Now, scientists report that a specific gene plays an important role in the alcohol-consuming tendencies of both types of rats.
Scientists have identified an additional 48 genetic variants influencing the risk of developing multiple sclerosis. This work nearly doubles the number of known genetic risk factors and thereby provides additional key insights into the biology of this debilitating neurological condition.
Researchers have added a new layer of information to the Cancer Cell Line Encyclopedia related to the proteins around which DNA gets wrapped in the cell. This proteomics technique points the way to a potential drug target for pediatric acute lymphoblastic leukemia (ALL).
Scanning the DNA of nearly 5,000 tumor samples, a team of scientists has identified 140 regions of scrambled genetic code believed to contain many undiscovered cancer genes. The researchers said the mapping of the abnormal regions gives cancer scientists a starting point from which to search for as-yet undiscovered oncogenes and broken tumor-suppressor genes.
Like the plastic caps at the end of shoelaces, telomeres protect- in their case- the interior-gene containing parts of chromosomes that carry a cell's instructional material. Cancer cells are known to have short telomeres, but just how short they are from cancer cell to cancer cell may be a determining factor in a prostate cancer patient's prognosis, according to a new study.
This week, researchers announced that they had identified some rules that apply across cancers for a specific type of genetic mutation– somatic copy number alterations (SCNAs). SCNAs are deletions or duplications of certain regions of the genome, and are some of the most common mutations that occur in cancer.
With estimates of losing 15 to 40 percent of the world’s species over the next four decades– due to climate change and habitat loss, researchers ponder whether science should employ genetic engineering to the rescue. The technique would involve “rescuing a target population or species with adaptive alleles, or gene variants, using genetic engineering,” say the authors of new commentary on the subject.
In ongoing research aimed at battling obesity, UT Southwestern Medical Center researchers have deciphered how new fat cells are formed in energy-storing fat pads. In particular, researchers sought to find out the origin of “brown” fat cells and whether humans can make more of them in order to burn extra calories.
“Incredibly valuable,” is how Barrett Rollins, Chief Scientific Officer of the Dana Farber Cancer Institute, describes his hospital’s unprecedented Profile program. In that program, the largest of its kind, all adult cancer patients at two Boston hospitals—Dana Farber and Brigham Women’s—are offered some of the most extensive, next-generation-sequencing (NGS) testing in existence.
Researchers have discovered why a tiny alteration in a brain gene, found in 20 percent of the population, contributes to the risk for anxiety, depression and memory loss. Their discovery describes new functions for the alteration, a single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene.
Researchers have shown that a specific protein pair may be a successful prognostic biomarker for identifying smoking-related lung cancers. The protein— ASCL1— is associated with increased expression of the RET oncogene, a particular cancer-causing gene called RET.
A new study reveals a gene that is critical to the process of memory extinction. Enhancing the activity of this gene, known as Tet1, might benefit people with posttraumatic stress disorder (PTSD) by making it easier to replace fearful memories with more positive associations.