For the first time, scientists have used new technology which analyses the whole genome to find the cause of a genetic disease in what was previously referred to as “junk DNA.”
A team of scientists have identified a novel therapeutic approach for the most frequent genetic cause of ALS, a disorder of the regions of the brain and spinal cord that control voluntary muscle movement, and frontotemporal degeneration, the second most frequent dementia.
In the first in-depth analysis of DNA methylation in fat, a process that affects the regulation of genes, researchers have linked regions of methylation to metabolic traits such as high body mass index (BMI) and obesity.
A study new study found that an enzyme that edits RNA may loosen the genome’s control over invasive snippets of DNA that affect how genes are expressed. In fruit flies, that newly understood mechanism appears to contribute to differences among individuals such as eye color and life span.
Researchers report that disrupting the light-dark cycle of mice increased their susceptibility to inflammatory disease, indicating that the production of a key immune cell is controlled by the body’s circadian clock.
Two groups of scientists have made complementary discoveries that break new ground on efforts to turn back the body’s clock on cellular activity, paving the way for a better understanding of stem cells, tissue growth and regeneration.
A new computational method has been shown to quickly assign, order and orient DNA sequencing information along entire chromosomes.
It might seem obvious that humans are elegant and sophisticated beings in comparison to lowly bacteria. But when it comes to genes, a scientist wants to turn conventional wisdom about human and bacterial evolution on its head.
For animal species that cannot be distinguished using their external characteristics, genetic techniques such as DNA barcoding can help to identify cryptic species. Now, an international team of researchers has demonstrated how a bacterial infection can mimic cryptic speciation in butterflies.
Researchers have linked a species of intestinal bacteria known as Prevotella copri to the onset of rheumatoid arthritis, the first demonstration in humans that the chronic inflammatory joint disease may be mediated in part by specific intestinal bacteria.
New research shows that chronic stress changes gene activity in immune cells before they reach the bloodstream. With these changes, the cells are primed to fight an infection or trauma that doesn’t actually exist, leading to an overabundance of the inflammation that is linked to many health problems.
A rudimentary form of life that is found in some of the harshest environments on earth is able to sidestep normal replication processes and reproduce by the back door, researchers at The University of Nottingham have found. The study centers on Haloferax volcanii—part of a family of single-celled organisms called archaea that until recently were thought to be a type of bacteria.
Researchers have found that a gene already implicated in human speech disorders and epilepsy is also needed for vocalizations and synapse formation in mice.
Ten years after the SARS outbreak, scientists have uncovered genome sequences of a new virus closely related to the SARS coronavirus that erupted in Asia in 2002 to 2003, which caused a global pandemic crisis.
Researchers have devised a new way to understand patterns of aneuploidy in tumors and have proposed that the phenomenon is a driver of cancer, rather than a result of it.
In two comprehensive studies, scientists have discovered new associations of two major type 2 diabetes risk genotypes and altered plasma concentrations of metabolic products.
A research team demonstrated, for the first time, delivery of a drug that turns off a critical gene in the aggressive and incurable glioblastoma multiforme, increasing survival rates significantly in animals with the deadly disease.
Structures that put a spin on light reveal tiny amounts of DNA with 50 times better sensitivity than the best current methods, a new research collaboration has shown.
A fine-grained scan of DNA in lung cancer cells has revealed a gene fusion– a forced merger of two normally separate genes– that spurs the cells to divide rapidly, scientists report.
The largest international Alzheimer's disease genetics collaboration to date has found 11 new genetic areas of interest that contribute to late onset Alzheimer's Disease (LOAD).
What is it that makes facial morphology so distinct? A new study has now shown that gene enhancers– regulatory sequences of DNA that act to turn-on or amplify the expression of a specific gene– are major players in craniofacial development.
An analysis of the genomes of 12,000 addicts and non-addicts revealed some unexpected risk factors for dependence on opiates, a new study shows.
Researchers have discovered a novel genetic cause of severe obesity which, although relatively rare, demonstrates for the first time that genes can reduce basal metabolic rate.
A new breast cancer risk gene has been discovered which explains the early-onset breast cancer in some multiple-case breast cancer families.