The new experimental assay can help scientists find the precise locations of repair of DNA damage caused by UV radiation and common chemotherapies. The invention could lead to better cancer drugs or improvements in the potency of existing ones.
'Network-guided association study,' or NetWAS, led to identification of gene interaction networks for organs as diverse as the kidney, the liver and the whole brain.
Results achieved in approximately six hours, compared to 60 hours with standard software.
The test can assess the risk for breast and ovarian cancer.
Researchers uncovered the critical role in pain processing of a gene associated with a rare disease. Their breakthrough, published in The Journal of Neuroscience, paves the way for a better understanding of chronic pain conditions.
The government is relying on some new technology - as well as a bit of luck - to track an outbreak of life-threatening listeria linked to Blue Bell ice cream products.
The intricately woven genetic makeup of Upland cotton has been decoded for the first time in the ancient plant’s history.
Routine genetic screening of children with CKD could lead to earlier, more precise diagnoses.
A genome-wide association study conducted by an international team led by the University of Southern California identified Nox3 as a critical gene for susceptibility to noise-induced hearing loss in mice. The gene, which is almost exclusively expressed in the inner ear, was identified in a study published in the April 16 edition of PLOS Genetics.
Findings identify a cause of the disease and highlight potential therapeutic approach.
More cancer patients are getting the genes in their tumors mapped to help guide their treatment. New research suggests that isn't always accurate enough, and a second test could help ferret out the culprit genes.
As personalized medicine is integrated into mainstream medical treatment, sequencing clinically relevant genes using the latest next generation sequencing (NGS) technologies will prove instrumental in guiding clinicians towards informed treatment decisions.
An international research project to sequence whole genomes from mountain gorillas has given scientists and conservationists new insight into the impact of population decline on these critically endangered apes. While mountain gorillas are extensively inbred and at risk of extinction, research published today in Science finds more to be optimistic about in their genomes than expected.
Thermo Scientific Peltier-cooled incubators feature solid-state Peltier cooling designed for biological and genomics laboratory researchers engaged in fruit fly and biochemical oxygen demand (BOD) research.
The first personalized cancer vaccine using genomics to define targets elicits robust immune responses, says a recent Science study.
Investigators have identified an inflammatory molecule that appears to play an essential role in the autoimmune disorder commonly known as lupus. Researchers describe finding that a protein that regulates certain cells in the innate immune system activates a molecular pathway known to be associated with lupus and that the protein’s activity is required for the development of lupus symptoms in a mouse model of the disease.
Genetic studies in humans, zebrafish and mice have revealed how two different types of genetic variations team up to cause a rare condition called Hirschsprung’s disease.
Researchers at the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences used information collected from hundreds of skin swabs to produce three-dimensional maps of molecular and microbial variations across the body.
Imaging tests like mammograms or CT scans can detect tumors, but figuring out whether a growth is or isn’t cancer usually requires a biopsy to study cells directly.
Playing music by professional musicians activates genes responsible for brain function and singing of songbirds.
Researchers have harnessed a technique known as CRISPR-Cas9 editing in an important and understudied species: the mosquito, Aedes aegypti, which infects hundreds of millions of people annually with the deadly diseases chikungunya, yellow fever, and dengue fever.
Nobody likes getting the flu, but for some people, fluids and rest aren’t enough. A small number of children who catch the influenza virus fall so ill they end up in the hospital — perhaps needing ventilators to breathe — even while their family and friends recover easily. New research helps explain why: a rare genetic mutation.
Using a novel approach that homes in on rare families severely affected by autism, a Johns Hopkins-led team of researchers has identified a new genetic cause of the disease.
A herd of 14 wild mares from Britain's Exmoor National Park were moved in January to the former Milovice military base, 35 kilometers (22 miles) northeast of Prague, the Czech capital.