Recently, doctors have begun to categorize breast cancers into four main groups according to the genetic makeup of the cancer cells. Which category a cancer falls into generally determines the best method of treatment. But cancers in one of the four groups— called "basal-like" or "triple-negative" breast cancer (TNBC)— have been particularly tricky to treat because they usually don't respond to the "receptor-targeted" treatments.
Researchers have identified mutations responsible for more than half of a subtype of childhood brain tumor that takes a high toll on patients. Researchers also found evidence the tumors are susceptible to drugs already in development. The study focused on a family of brain tumors known as low-grade gliomas (LGGs).
Like finally seeing all the gears of a watch and how they work together, researchers have, for the first time ever, solved the puzzle of how the various components of an entire telomerase enzyme complex fit together and function in a three-dimensional structure.
In a provocative new study, scientists reported Wednesday that they were able to “see” pain on brain scans and, for the first time, measure its intensity and tell whether a drug was relieving it. Though the research is in its early stages, it opens the door to a host of possibilities.
In the search for new antibiotics, researchers are taking an unusual approach: They are developing peptides, short chains of protein building blocks that effectively inhibit a key enzyme of bacterial metabolism. The road from gene to protein has an important stop along the way: ribonucleic acid, or RNA.
Tiny versions of the reflectors on sneakers and bicycle fenders that help ensure the safety of runners and bikers at night are moving toward another role in detecting bioterrorism threats and diagnosing everyday infectious diseases, scientists said.
Scientists described evidence that natural substances extracted from unroasted coffee beans can help control the elevated blood sugar levels and body weight that underpin type 2 diabetes. Their presentation on chlorogenic acids― widely available as a dietary supplement was part of the 245th National Meeting and Exposition of the American Chemical Society (ACS).
Researchers have identified a new set of genetic markers for Alzheimer’s that point to a second pathway through which the disease develops.
For 42 years, Muammar Gaddafi ran a ruthless regime in Libya. Although deposed in 2011, one of his sad legacies is a series of mass graves containing an estimated 20,000 human remains. But with this discovery comes a chance to solve decades-old missing person cases. Using forensic DNA identification technologies, scientists employed by the Libyan government will soon begin this process. But first they need the tools and the training.
Most of us born after 1960 have missed out on what was, since ancient times, “mankind’s first stem cell transplant.” For umbilical cords of most born after 1960 were—are—clamped right after birth. This denied us a last blast of stem-cell rich placenta blood, 40% of our circulation, before our first breath.
President Barack Obama on Tuesday proposed an effort to map the brain's activity in unprecedented detail, as a step toward finding better ways to treat such conditions as Alzheimer's, autism, stroke and traumatic brain injuries.
A new study defines previously unknown properties of transmitted HIV-1, the virus that causes AIDS.
An intuitive approach, which co-opts the body’s own molecular machinery, has led to massive expansions of umbilical cord blood cells. It and other new approaches “will revolutionize all transplantation,” says University of Minnesota Blood and Marrow Transplantation Director John Wagner.
A team of researchers has generated new insight on how a stem cell’s environment influences what type of cell a stem cell will become. They have shown that whether human mesenchymal stem cells turn into fat or bone cells depends partially on how well they can “grip” the material they are growing in.
In a laboratory study pairing food chemistry and cancer biology, scientists tested the potentially harmful effect of foods and flavorings on the DNA of cells. They found that liquid smoke flavoring, black and green teas and coffee activated the highest levels of a well-known, cancer-linked gene called p53.
Engineers have developed a portable device to count white blood cells that needs less than a pinprick's worth of blood and takes just minutes to run.
Microarrays started as research tools and now often appear in clinical applications. To survey some of the hybridization systems available for this technology, we talked with experts from Agilent, SciGene, and Tecan.
Researchers have identified a humanized monoclonal antibody that targets and directly kills chronic lymphocytic leukemia (CLL) cells. The findings represent a potential new therapy for treating at least some patients with CLL, the most common type of blood cancer in the United States.
The first multi-gene test that can help predict cancer patients' responses to treatment using the latest DNA sequencing techniques has been launched in the NHS. The test detects mutations across 46 genes in cancer cells.
Under the crushing weight of many new studies finding even small head injuries can cause massive damage, the National Football League (NFL) has launched a new $60 million brain initiative. The initiative is co-sponsored by General Electric (GE).
Ever find yourself racking your brain on a Monday morning to remember where you put your car keys? When you do find those keys, you can thank the hippocampus, a brain region responsible for storing and retrieving memories of different environments- such as that room where your keys were hiding in an unusual spot.
Inflammation is stirring up headlines again. Anti-inflammatory aspirin prevented thousands more cancers. The anti-inflammatory “miracle molecule” resveratrol came back. Psychologists report inflammation is stoked by even minor tensions. And archaeologists say all this knowledge is long overdue, as even Egyptian mummies have clogged arteries. We have been plagued by inflammation since the time of the Pharaohs.
An interdisciplinary team of mechanical engineers and autism experts at Vanderbilt University have developed a system that demonstrates that robotic systems may be powerful tools for enhancing the basic social learning skills of children with autism spectrum disorder.
Researchers in Germany said Tuesday they have completed the first high-quality sequencing of a Neanderthal genome and are making it freely available online for other scientists to study. The genome produced from remains of a toe bone found in a Siberian cave is far more detailed than a previous Neanderthal genome sequenced three years ago by the same team.