The calorie-burning triggered by cold temperatures can be achieved biochemically– without the chill– raising hopes for a weight-loss strategy focused on the immune system rather than the brain, according to a new study.
Metastatic cancer cells, which can migrate from primary tumors to seed new malignancies, have thus far been resistant to the current arsenal of anticancer drugs. Now, researchers have identified a critical weakness that actually exploits one of these cells’ apparent strengths—their ability to move and invade tissues.
A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism. These networks may offer attractive targets for developing new autism drugs or repurposing existing drugs that act on components of the networks.
Improved diagnosis and management of one of the most common cancers in men- prostate cancer- could result from research, which has discovered that seminal fluid (semen) contains biomarkers for the disease.
You are what you eat, but researchers are beginning to realize that what and when you eat is controlled by a myriad of underlying biological triggers acting in concert.
A new study shows how exposure to air pollution early in life produces harmful changes in the brains of mice, including an enlargement of part of the brain that is seen in humans who have autism and schizophrenia.
Surgery and radiation for a glioblastoma have only limited effectiveness because the tumor is particularly aggressive, infiltrating brain tissue surrounding the primary tumor. Scientists have developed a technique designed to open the blood-brain barrier at targeted locations just far enough to allow the passage of drug-bearing nanoparticles.
By studying laboratory mice, scientists have succeeded in plotting the labyrinthine paths of some of the largest nerve cells in the mammalian brain: cholinergic neurons, the first cells to degenerate in people with Alzheimer’s disease.
A new report offers the strongest evidence yet that a mysterious Middle East virus spreads from camels to people. Researchers studied the illness of a 44-year-old camel owner in Saudi Arabia, who died in November of Middle East respiratory syndrome, or MERS.
Limiting saturated fat could help people whose genetic make-up increases their chance of being obese, according to a new study. The findings could be useful in identifying people who are predisposed to obesity and could ultimately lead to personalized dietary recommendations.
A test that counts the number of locations in tumor specimens where tumor cells may invade blood vessels predicted the risk of distant spread, or metastasis, for the most common type of breast cancer.
Researchers are reporting promising treatment milestones for patients with deadly skin and lung cancers who are being treated with an experimental drug called MK-3475.
Scientists have been linking an increasing range of behaviors and inclinations from monogamy to addiction to animals’, including humans’, underlying biology. To that growing list, they’re adding division of labor—at least in killer bees.
Eating seems to be a rather basic biological task. Yet chewing requires a complex interplay between the tongue and jaw. If the act weren't coordinated, the chewer would end up biting more tongue than food. Researchers used a tracing technique in mice to map the underlying brain circuitry that keeps mealtime relatively painless.
A Purdue University-led research team has figured out how to disable a part of the SARS virus responsible for hiding it from the immune system; a critical step in developing a vaccine against the deadly disease. The findings also have potential applications in the creation of vaccines against other coronaviruses, including MERS.
Biomedical engineering students have designed a lightweight, easy-to-conceal shirt-like garment to deliver life-saving shocks to patients experiencing serious heart problems. The students say their design improves upon a wearable defibrillator system that is already in use.
By analyzing the blood of almost 100 treated and untreated HIV-infected volunteers, a team of scientists has identified previously unknown characteristics of B cells in the context of HIV infection.
Researchers at King’s College London have discovered how a molecular ‘scaffold’ which allows key parts of cells to interact, comes apart in dementia and motor neuron disease (such as ALS), revealing a potential new target for drug discovery.
Researchers have found a new type of neuron in the adult brain that is capable of telling stem cells to make more new neurons. Though the experiments are in their early stages, the finding opens the tantalizing possibility that the brain may be able to repair itself from within.
Children who later develop autism are exposed to elevated levels of steroid hormones (for example testosterone, progesterone and cortisol) in the womb, according to scientists. The finding may help explain why autism is more common in males than females. However, the researchers caution it should not be used to screen for the condition.
Women age 55 or younger may fare worse than their male counterparts after having a heart attack, according to new research presented at the American Heart Association’s Quality of Care and Outcomes Research Scientific Sessions 2014. Researchers studied records and interviews of 3,501 people (67 percent women) who had heart attacks in the United States and Spain in 2008-12.
New research confirms a vulnerability to lung cancer can be inherited and implicates the BRCA2 gene as harboring one of the involved genetic mutations. The study scanned the genomes of more than 11 thousand individuals of European descent to look for common variations associated with non-small cell carcinoma. The analysis showed that variations in the BRCA2 and CHEK2 genes can significantly increase an individual's risk for lung cancer.
Studying mice, researchers have found a way to prevent nonalcoholic fatty liver disease, the most common cause of chronic liver disease worldwide. Blocking a path that delivers dietary fructose to the liver is what prevented mice from developing the condition.
Symmetry is an inherent part of development. As an embryo, an organism’s brain and spinal cord, like the rest of its body, organize themselves into left and right halves as they grow. But a certain set of nerve cells do something unusual: they cross from one side to the other. New research in mice delves into the details of the molecular interactions that help guide these neurons toward this anatomical boundary.