A test that counts the number of locations in tumor specimens where tumor cells may invade blood vessels predicted the risk of distant spread, or metastasis, for the most common type of breast cancer.
Researchers are reporting promising treatment milestones for patients with deadly skin and lung cancers who are being treated with an experimental drug called MK-3475.
Scientists have been linking an increasing range of behaviors and inclinations from monogamy to addiction to animals’, including humans’, underlying biology. To that growing list, they’re adding division of labor—at least in killer bees.
Eating seems to be a rather basic biological task. Yet chewing requires a complex interplay between the tongue and jaw. If the act weren't coordinated, the chewer would end up biting more tongue than food. Researchers used a tracing technique in mice to map the underlying brain circuitry that keeps mealtime relatively painless.
A Purdue University-led research team has figured out how to disable a part of the SARS virus responsible for hiding it from the immune system; a critical step in developing a vaccine against the deadly disease. The findings also have potential applications in the creation of vaccines against other coronaviruses, including MERS.
Biomedical engineering students have designed a lightweight, easy-to-conceal shirt-like garment to deliver life-saving shocks to patients experiencing serious heart problems. The students say their design improves upon a wearable defibrillator system that is already in use.
By analyzing the blood of almost 100 treated and untreated HIV-infected volunteers, a team of scientists has identified previously unknown characteristics of B cells in the context of HIV infection.
Researchers at King’s College London have discovered how a molecular ‘scaffold’ which allows key parts of cells to interact, comes apart in dementia and motor neuron disease (such as ALS), revealing a potential new target for drug discovery.
Researchers have found a new type of neuron in the adult brain that is capable of telling stem cells to make more new neurons. Though the experiments are in their early stages, the finding opens the tantalizing possibility that the brain may be able to repair itself from within.
Children who later develop autism are exposed to elevated levels of steroid hormones (for example testosterone, progesterone and cortisol) in the womb, according to scientists. The finding may help explain why autism is more common in males than females. However, the researchers caution it should not be used to screen for the condition.
Women age 55 or younger may fare worse than their male counterparts after having a heart attack, according to new research presented at the American Heart Association’s Quality of Care and Outcomes Research Scientific Sessions 2014. Researchers studied records and interviews of 3,501 people (67 percent women) who had heart attacks in the United States and Spain in 2008-12.
New research confirms a vulnerability to lung cancer can be inherited and implicates the BRCA2 gene as harboring one of the involved genetic mutations. The study scanned the genomes of more than 11 thousand individuals of European descent to look for common variations associated with non-small cell carcinoma. The analysis showed that variations in the BRCA2 and CHEK2 genes can significantly increase an individual's risk for lung cancer.
Studying mice, researchers have found a way to prevent nonalcoholic fatty liver disease, the most common cause of chronic liver disease worldwide. Blocking a path that delivers dietary fructose to the liver is what prevented mice from developing the condition.
Symmetry is an inherent part of development. As an embryo, an organism’s brain and spinal cord, like the rest of its body, organize themselves into left and right halves as they grow. But a certain set of nerve cells do something unusual: they cross from one side to the other. New research in mice delves into the details of the molecular interactions that help guide these neurons toward this anatomical boundary.
Many people with cystic fibrosis develop diabetes. The reasons for this have been largely unknown, but now researchers have identified a molecular mechanism that contributes to the raised diabetes risk.
Twenty years after the hormone leptin was found to regulate metabolism, appetite, and weight through brain cells called neurons, researchers have found that the hormone also acts on other types of cells to control appetite.
Duke researchers Peter Larsen, Ryan Campbell and Anne Yoder used high-throughput sequencing on sifaka blood samples to generate sequence data for more than 150,000 different sifaka antibodies -- protective molecules that latch on to bacteria, viruses and other foreign invaders in the body and fight them off before they cause infection.
It’s almost axiomatic that misfolded proteins compromise how cells normally function and cause debilitating human disease, but how these proteins are detected and degraded within the body is not well understood. Neurodegenerative diseases exact a devastating toll on aging populations throughout the world.
A sensor which can be used to screen for diabetes in resource-poor settings has been developed by researchers and tested in diabetic patients, and will soon be field tested in sub-Saharan Africa.
People with high levels of cynical distrust, which is defined as the belief that others are mainly motivated by selfish concerns, may be more likely to develop dementia, according to new research.
Among men treated for prostate cancer, those who received radiation therapy were more likely to develop bladder or rectal cancer, according to a new study.
Researchers identified within animal models an enzyme that links genetic pathways that control aging with the death of dopamine neurons– a clinical hallmark of Parkinson’s disease.
A multicenter team of researchers report that a commercial test designed to rule out the presence of genetic biomarkers of prostate cancer may be accurate enough to exclude the need for repeat prostate biopsies in many— if not most— men.
The risk of developing the most deadly form of skin cancer, melanoma, was more closely related to sun exposure in early life than in adulthood in young Caucasian women, according to a new study.
In a new study, researchers show for the first time how the brain re-wires and fine-tunes its connections differently depending on the relative timing of sensory stimuli. In most neuroscience textbooks today, there is a widely held model that explains how nerve circuits might refine their connectivity based on patterned firing of brain cells, but it has not previously been directly observed in real time.