Basal cell carcinomas develop mutations in a protein on the Hedgehog pathway to evade a common drug therapy. Targeting another portion of the pathway may be an effective alternative treatment.
A new study reveals an important connection between dozens of genes that may contribute to autism, a major step toward understanding how brain development goes awry in some individuals with the disorder.
Findings could help shed light on Alzheimer's, Parkinson's, ALS and other diseases.
Salk scientists re-engineered the bacterial defense system CRISPR to recognize HIV inside human cells and destroy the virus, offering a potential new therapy.
Discovery has implications for understanding epilepsy.
Apple teamed up with a handful of universities to create these medical research applications.
In the ongoing Ebola outbreak in West Africa, whose death toll is approaching 10,000, little information has been available about how the human immune response unfolds after infection. Researchers have now obtained a first look at the immune responses in four Ebola virus disease survivors who received care at Emory University Hospital in 2014, by closely examining their T cells and B cells during the acute phase of the disease.
A new study led by UNC researchers identifies both where in the brain and how a protein in the brain, called Neuropeptide Y or NPY, can act to suppress binge alcohol drinking. These findings suggest that restoring NPY may be useful for treating alcohol use disorders and may also protect some individuals from becoming alcohol dependent.
One of every eight patients might benefit from highly successful lymphoma drugs.
Getting a new drug to market is difficult, but the U.S. Food and Drug Administration (FDA) offers a number of ways to help the process along for promising drugs that have potential against serious diseases. One of these options is designation as a breakthrough therapy. This year a number of these therapies are targeted at fighting cancer.
People with anorexia nervosa and with body dysmorphic disorder have similar abnormalities in their brains that affect their ability to process visual information, a new UCLA study reveals.
In an advance that could lead to better identification of malignant pediatric adrenocortical tumors, and ultimately to better treatment, researchers have mapped the “genomic landscape” of these rare childhood tumors. Their genomic mapping has revealed unprecedented details, not only of the aberrant genetic and chromosomal changes that drive the cancer, but the sequence of those changes that trigger it.
Marking the progress in controlling its Ebola outbreak, the Liberian government dismantled a crematorium and removed drums containing the ashes of more than 3,000 Ebola victims cremated during the height of the epidemic, whose last patient was discharged last week.
Thyroid hormones have important and diverse roles in human health and regulate metabolic rate. Thyroid disease is common (affecting 5-10 per cent of the population) and synthetic thyroid hormones are one of the commonest drug therapies prescribed worldwide.
Newly discovered brain pathway overturns anatomy, could solve antipsychotic mystery.
Michael J. Fox Foundation and Alzheimer’s Association fund $2 million for research projects studying overlap in neurodegenerative diseases.
Stroke can lead to a wide range of problems such as depression and difficulty moving, speaking and paying attention. A new study has found compelling evidence that stroke damage to “cables” buried inside the brain plays an important role in these impairments.
Neuroscientists find that different parts of the brain work best at different ages.
Prenatal exposure to low doses of the environmental contaminants polychlorinated biphenyls, or PCBs, change the developing brain in an area involved in metabolism, and some effects are apparent even two generations later, a new study finds.
Researchers have developed a new technique to understand the actions of key proteins required for cancer cells to proliferate.
Thousands of genetic “dimmer” switches, regions of DNA known as regulatory elements, were turned up high during human evolution in the developing cerebral cortex, according to new research.
Testing breast cancer cells for how closely they resemble stem cells could identify women with the most aggressive disease, a new study suggests.
Implanted stem cells reduced symptoms of disease during experiment, researchers say.
Researchers at Aalto University and University of Turku have revealed how obesity is associated with altered opioid neurotransmission in the brain.