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Patient-relevant Preclinical Models Using Image-guided Small Animal Irradiation

October 28, 2014 11:33 am | by Dr. Rajendra Kumari, Chief Scientific Officer, PRECOS Ltd., a Crown Bioscience Company | Articles | Comments

Radiotherapy is a primary, adjuvant or neoadjuvant treatment for a number of different cancers, such as glioblastoma, breast, lung and prostate. Image-guided radiation therapy (IGRT) is used to reduce the amount of radiation delivered to the normal tissue surrounding the targeted tumor. However, in the preclinical setting, the use of IGRT is less common.

Two Stem Cell Beliefs Debunked

October 27, 2014 2:48 pm | News | Comments

Two recent papers may have upturned two common beliefs about adult stem cells: One reported that there appears to be stem cells in the esophagus, while the other reported that a fetal stem cell that can become either a liver cell or an endothelial cell.

Heart Drug Helps Treat ALS in Mice

October 27, 2014 2:31 pm | News | Comments

Digoxin, a medication used in the treatment of heart failure, may be adaptable for the treatment of amyotrophic lateral sclerosis (ALS), a progressive, paralyzing disease, suggests new research.                  

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Dietary Flavanols Reverse Age-related Memory Decline

October 27, 2014 2:26 pm | Videos | Comments

Dietary cocoa flavanols—naturally occurring bioactives found in cocoa—reversed age-related memory decline in healthy older adults, according to a new study.                           

Lipids, Not Calories, Trigger a Strong Insulin Response

October 27, 2014 2:16 pm | News | Comments

Researchers studying lipoproteins in Drosophila melanogaster found that that the blood-brain barrier is a main sensor to report the nutritional status, especially the lipid composition of consumed food, to special neurons that regulate insulin release.

Researchers Observe Brain Development in Utero

October 27, 2014 2:03 pm | Videos | Comments

New investigation methods using functional magnetic resonance tomography (fMRT) offer insights into fetal brain development. These in vivo observations will uncover different stages of the brain's development.              

New Home Test Shakes Up Colon Cancer Screening

October 27, 2014 8:30 am | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

Starting Monday, millions of people who have avoided colon cancer screening can get a new home test that's noninvasive and doesn't require the icky preparation most other methods do. The test is the first to look for cancer-related DNA in stool. 

Governors Stress Home Quarantine for Ebola Workers

October 27, 2014 3:26 am | by Frank Eltman - Associated Press - Associated Press | News | Comments

A nurse who protested being kept in a tent in New Jersey over the weekend despite lacking symptoms after caring for Ebola patients in West Africa was to be released Monday as scientists and federal officials clashed with state officials over quarantine policies.

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Proteins Direct Precursors of Pyramidal Cells to Their Destination

October 24, 2014 11:26 am | News | Comments

Researchers have now discovered that FLRT proteins on the surface of progenitor cells can induce repellent and attractant signals depending on its binding partner.                         

New Weight Loss Regulation Clues Discovered

October 24, 2014 11:18 am | News | Comments

A hormone seen as a popular target to develop weight loss drugs works by directly targeting the brain and triggering previously unknown activity in the nervous system, obesity researchers have found.                

Brain Remains Stable During Learning, Model Shows

October 24, 2014 10:28 am | News | Comments

Complex biochemical signals that coordinate fast and slow changes in neuronal networks keep the brain in balance during learning, according to an international team of scientists.                     

Thyroid Cancer Genome Analysis Finds Markers of Aggressive Tumors

October 24, 2014 10:21 am | News | Comments

A new comprehensive analysis of thyroid cancer from The Cancer Genome Atlas Research Network has identified markers of aggressive tumors, which could allow for better targeting of appropriate treatments to individual patients.       

Protein Discovery May Unlock New HIV Treatment

October 24, 2014 10:16 am | Videos | Comments

Like a slumbering dragon, HIV can lay dormant in a person’s cells for years, evading medical treatments only to wake up and strike at a later time, quickly replicating itself and destroying the immune system. Scientists have now uncovered a new protein that participates in active HIV replication.

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Scientists ID Gene Required for Recovery from Bacterial Infection

October 24, 2014 10:07 am | News | Comments

Researchers have uncovered the genes that are normally activated during recovery from bacterial infection. The finding could lead to ways to jumpstart this recovery process and possibly fend off autoimmune diseases and chronic inflammatory disorders.

WHO: Millions of Ebola Vaccine Doses Ready in 2015

October 24, 2014 10:00 am | by Maria Cheng - AP Medical Writer - Associated Press | News | Comments

The World Health Organization says millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines will start being tested in March.                 

NYC Tries to Ease Ebola Fear After Doctor Infected

October 24, 2014 2:26 am | by Jonathan Lemire and Colleen Long - Associated Press - Associated Press | News | Comments

Officials tried to tamp down New Yorkers' fears Friday after a doctor was diagnosed with Ebola in a city where millions of people squeeze into crowded subways, buses and elevators every day.                 

Scientists to Use Tiny Particles to Fight Big Diseases

October 23, 2014 12:49 pm | Videos | Comments

Physicians will tell you: They are not winning the war on ovarian cancer. But researchers have combined medicine and advanced nanotechnological engineering to create a smarter, more targeted therapy that could overcome the most lethal gynecologic cancer.

New ALS-associated Gene Identified

October 23, 2014 12:33 pm | News | Comments

Using an innovative exome sequencing strategy, a team of international scientists has shown that TUBA4A, the gene encoding the Tubulin Alpha 4A protein, is associated with familial amyotrophic lateral sclerosis (ALS).         

Study Clarifies How Body Defends Against Harmful Bacteria

October 23, 2014 12:14 pm | News | Comments

Researchers have identified an unusual process by which the body can sense the presence of pathogenic bacteria and destroy them. Rather than detect the microbes directly, individual cells monitor how the bacteria interfere with the functioning of energy-producing cellular structures called mitochondria.

Fast Modeling of Cancer Mutations

October 23, 2014 12:06 pm | News | Comments

Researchers now developed a new way to model the effects of these genetic mutations in mice. The approach, based on the genome-editing technique known as CRISPR, is much faster than existing strategies, which require genetically engineering mice that carry the cancerous mutations.

Real-time System Monitors Dangerous Bacteria in the Body

October 23, 2014 11:56 am | News | Comments

Combining a PET scanner with a new chemical tracer that selectively tags specific types of bacteria, researchers working with mice report they have devised a way to detect and monitor in real time infections with a class of dangerous Gram-negative bacteria.

U.S. to Track Everyone Coming from Ebola Nations

October 23, 2014 8:30 am | by Mike Stobbe - AP Medical Writer - Associated Press | News | Comments

All travelers who come into the U.S. from three Ebola-stricken West African nations will now be monitored for three weeks, the latest step by federal officials to keep the disease from spreading into the country.            

Tackling Blindness, Deafness Through Neuroengineering

October 22, 2014 2:26 pm | News | Comments

The Bertarelli Program in Translational Neuroscience and Neuroengineering, a collaborative program between Harvard Medical School and the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, has announced a new set of grants worth $3.6 million for five research projects.

Childhood Autism Linked to Air Toxics

October 22, 2014 2:13 pm | News | Comments

Children with autism spectrum disorder (ASD) were more likely to have been exposed to higher levels of certain air toxics during their mothers’ pregnancies and the first two years of life compared to children without the condition, according to a new study.

Hidden Subpopulation of Melanoma Cells Discovered

October 22, 2014 1:40 pm | News | Comments

Researchers have pinpointed a set of intriguing characteristics in a previously unknown subpopulation of melanoma cancer cells in blood vessels of tumors.                           

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