Pancreas cancer is notoriously impervious to treatment and resists both chemotherapy and radiotherapy. It has also been thought to provide few targets for immune cells, allowing tumors to grow unchecked. But new research shows that pancreas cancer “veils” itself from the immune system by recruiting specialized immune suppressor cells.
Chronic stress that produces inflammation and anxiety in mice appears to prime their immune systems for a prolonged fight, causing the animals to have an excessive reaction to a single acute stressor weeks later, new research suggests. After the mice recovered from the effects of chronic stress, a single stressful event 24 days later quickly returned them to a chronically stressed state in biological and behavioral terms.
A dramatic rise in thyroid cancer has resulted from overdiagnosis and treatment of tumors too small to ever cause harm, according to a study that found cases nearly tripled since 1975. The study is the latest to question whether all cancers need aggressive treatment.
The St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project has identified the most common genetic alteration ever reported in the brain tumor ependymoma and evidence that the alteration drives tumor development. The results provide a foundation for new research to improve diagnosis and treatment of ependymoma, the third most common brain tumor in children.
Scientists discovered that iron deficiency may increase stroke risk by making the blood more sticky. The findings could ultimately help with stroke prevention. The team found that iron deficiency increases the stickiness of platelets, which initiate blood clotting when they stick together. Although a link between iron deficiency and sticky platelets was first discovered almost 40 years ago, its role has been overlooked until now.
Research at the University of Liverpool has explained how cells behave when placed in a low oxygen environment, a development that could have implications for cancer patients and other serious illnesses. The research opens up the possibility of controlling the signals that keep cells alive, preventing the damages caused by ischemia—a restriction of blood supply to tissues. It could also work to help destroy cancer cells.
Jazz musicians are famous for their musical conversations — one improvises a few bars and another plays an answer. Now research shows some of the brain's language regions enable that musical back-and-forth much like a spoken conversation. It gives new meaning to the idea of music as a universal language.
Clemson University researchers have developed nanoparticles that can deliver drugs targeting damaged arteries, a non-invasive method to fight heart disease. One of the standard ways to treat clogged and damaged arteries currently is to implant vascular stents, which hold the vessels open and release such drugs as paclitaxel. The researchers hope their advanced nanoparticles could be used alongside stents or in lieu of them.
Scientists at The Wistar Institute have developed a mathematical method for classifying forms of glioblastoma, an aggressive and deadly type of brain cancer, through variations in the way these tumor cells “read” genes. Their system was capable of predicting the subclasses of glioblastoma tumors with 92 percent accuracy. With further testing, this could enable physicians to predict which forms of therapy would most benefit their patients.
A team reports that they have taken an important step toward the goal of growing replacement heart valves from a patient’s own cells by determining that the mechanical forces generated by the rhythmic expansion and contraction of cardiac muscle cells play an active role in the initial stage of heart valve formation.
Researchers exploring a possible link between metabolic defects and seizures have determined that diet could influence susceptibility to seizures, and they have identified a common diabetes drug that could be a useful treatment.
Researchers have developed the technology for a catheter-based device that would provide forward-looking, real-time, three-dimensional imaging from inside the heart, coronary arteries and peripheral blood vessels. With its volumetric imaging, the new device could better guide surgeons working in the heart, and potentially allow more of patients’ clogged arteries to be cleared without major surgery.
Abnormal number of chromosomes is often associated with cancer development. In a new study, researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes.
Researchers at BRIC, the University of Copenhagen, have identified a new type of regulatory blood cells that can combat such hyperactive T-cells in blood from patients with multiple sclerosis. By stimulating the regulatory blood cells, the researchers significantly decreased the level of brain inflammation and disease in a biological model.
A saliva test for teenage boys with mild symptoms of depression could help identify those who will later develop major depression, a new study says. Researchers measured the stress hormone cortisol in teenage boys and found that ones with high levels coupled with mild depression symptoms were up to 14 times more likely to suffer clinical depression later in life than those with low or normal cortisol levels.
Proteases are vital proteins that serve for order within cells. They break apart other proteins, ensuring that these are properly synthesized and decomposed. Proteases are also responsible for the pathogenic effects of many kinds of bacteria. Now chemists at the Technische Universitaet Muenchen (TUM) have discovered two hitherto unknown mechanisms of action that can be used to permanently disarm an important bacterial protease.
A region deep inside the brain controls how quickly people make decisions about love, according to new research at the University of Chicago. The finding, made in an examination of a 48-year-old man who suffered a stroke, provides the first causal clinical evidence that an area of the brain called the anterior insula “plays an instrumental role in love,” said UChicago neuroscientist Stephanie Cacioppo, lead author of the study.
University of Adelaide research has shown for the first time that grape seed can aid the effectiveness of chemotherapy in killing colon cancer cells as well as reducing the chemotherapy's side effects. The researchers say that combining grape seed extracts with chemotherapy has potential as a new approach for bowel cancer treatment - to both reduce intestinal damage commonly caused by cancer chemotherapy and to enhance its effect.
People living in cold, northern latitudes have bacteria in their guts that may predispose them to obesity, according to a new study. The researchers’ analysis of the gut microbes of more than a thousand people from around the world showed that those living in northern latitudes had more gut bacteria that have been linked to obesity than did people living farther south.
San Francisco Bay Area officials say a University of California, Berkeley, student infected with measles could have exposed thousands of others by attending classes and riding public transit. Public health officials said they confirmed that the student in his 20s was not vaccinated, and was likely infected with measles during a recent trip abroad.
Using videos that claim to teach toddlers, or flash cards for tots, may not be the best idea. Simply talking to babies is key to building crucial language and vocabulary skills — but sooner is better, and long sentences are good. So says research that aims to explain, and help solve, the troubling "word gap."
Women have a higher risk of blood clots that can cause strokes, heart attacks and other problems for 12 weeks after childbirth — twice as long as doctors have thought, new research finds. Strokes are still fairly rare right after pregnancy but devastating when they do occur and fatal about 10 percent of the time.
Stroke hospitalization and death rates may rise and fall with outdoor temperature and dew points. Researchers studied a sample of 134,510 people who were 18 or older when admitted to hospitals in 2009-10 for ischemic stroke — a stroke caused by a blood clot that blocks blood flow in or near the brain. They then obtained temperature and dew point data during that period.
The U.S. and 26 other nations are announcing a new collaboration to prevent and fight outbreaks of dangerous infectious diseases before they spread around the globe. U.S. health officials say the Global Health Security Agenda is a priority because there are too many blind spots — countries that lack the health care necessary to sound the alarm when a new infection emerges.
Researchers are actively working to understand how the brain translates fear into action. Scientists at Cold Spring Harbor Laboratory (CSHL) announced the discovery of a new neural circuit in the brain that directly links the site of fear memory with an area of the brainstem that controls behavior.