Scientists at The University of Texas at Austin have discovered that a protein produced by the influenza A virus helps it outwit one of our body's natural defense mechanisms. That makes the protein a potentially good target for antiviral drugs directed against the influenza A virus.
A study reports that a rare genetic disease, while depleting patients of infection-fighting antibodies, may actually protect them from certain severe or recurrent viral infections. Researchers found that HIV and influenza viruses replicate in the cells of people with congenital disorder of glycosylation type IIb (CDG-IIb) at a much lower rate than in healthy donor cells, creating fewer and less infectious viruses.
Stem cells culled from bone marrow may prove beneficial in stroke recovery. In an analysis of published research, neurologist Dr. Steven Cramer and biomedical engineer Weian Zhao identified 46 studies that examined the use of mesenchymal stromal cells—a type of multipotent adult stem cells mostly processed from bone marrow—in animal models of stroke. They found MSCs to be significantly better than control therapy in 44 of the studies.
In the last decade, hundreds of studies have been conducted looking for polymorphisms associated with a greater propensity to suffer some of the most frequent human tumors. These tests, called GWAS, have found a common problem: many times the tiny genetic change observed appears to have no activity or function to explain because it is associated with more cancer.
UT Southwestern Medical Center researchers have demonstrated in both cancer cell lines and in mice that blocking critical DNA repair mechanisms could improve the effectiveness of radiation therapy for highly fatal brain tumors called glioblastomas.
Researchers have found that abnormal levels of lipid molecules in the brain can affect the interaction between two key neural pathways in early prenatal brain development, which can trigger autism. And, environmental causes such as exposure to chemicals in some cosmetics and common over-the-counter medication can affect the levels of these lipids, according to the researchers.
Scientists at the Salk Institute have uncovered details into a surprising—and crucial—link between brain development and a gene whose mutation is tied to breast and ovarian cancer. Aside from better understanding neurological damage associated in a small percentage of people susceptible to breast cancers, the new work also helps to better understand the evolution of the brain.
Comprehensive genomic analysis of low-grade brain tumors sorts them into three categories, one of which has the molecular hallmarks and shortened survival of glioblastoma multiforme, the most lethal of brain tumors, researchers reported at the American Association for Cancer Research Annual Meeting 2014.
In mammals, embryonic cranial development is modular and step-wise: The individual cranial bones form according to a defined, coordinated schedule. The typical increase in the size of the brain in mammals in the course of evolution ultimately triggered changes in this developmental plan, as a study conducted on embryos of 134 species of animal reveals.
The push and pull of physical force can cause profound changes in the behavior of a cell. Two studies from researchers working at the UNC Lineberger Comprehensive Cancer Center reveal how cells respond to mechanical manipulation, a key factor in addressing the underlying causes of cancer and other diseases.
The spread of the antibiotic-resistant pathogen MRSA (methicillin-resistant Staphylococcus aureus) remains a concerning public health problem, especially among doctors trying to determine appropriate treatment options for infected patients. Bacterial pathogens, such as MRSA, cause disease in part due to toxicity, or the bacterium's ability to damage a host's tissue.
The more cups of coffee a person drank, the lower the risk for developing hepatocellular carcinoma (HCC), the most common type of liver cancer, according to new research.
Subpopulations of breast cancer cells sometimes cooperate to aid tumor growth, according to Penn State College of Medicine researchers, who believe that understanding the relationship between cancer subpopulations could lead to new targets for cancer treatment.
An antimicrobial agent found in common household soaps, shampoos, and toothpastes may be finding its way inside human noses where it promotes the colonization of Staphylococcus aureus bacteria and could predispose some people to infection.
Green tea is said to have many putative positive effects on health. Now, researchers at the University of Basel are reporting first evidence that green tea extract enhances the cognitive functions, in particular the working memory. The Swiss findings suggest promising clinical implications for the treatment of cognitive impairments in psychiatric disorders such as dementia.
Resistance to an entire class of antibiotics—aminoglycosides—has the potential to spread to many types of bacteria, according to new biochemistry research. A mobile gene called NpmA was discovered in E. coli bacteria isolated from a Japanese patient several years ago. Global spread of NpmA and related antibiotic resistance enzymes could disable an entire class of tools doctors use to fight serious or life-threatening infections.
Researchers have devised a way to quickly bring to the clinic the technique of using blood samples to diagnose many types of solid cancers, or to monitor the amount of cancer in a patient’s body and responses to treatment.
Researchers have succeeded in developing a method fast enough to observe immediate changes in the function of the brain even when watching a movie. When we watch a movie, our brains react to it immediately in a way similar to other people's brains.
In a new study, researchers solved an age-old mystery of touch: how cells just beneath the skin surface enable us to feel fine details and textures.
Scientists may have discovered a new way to treat a type of childhood brain tumor that has proved incurable up until now, according to a recent study.
Researchers have generated a 3-D model of the human malaria parasite genome at three different stages in the parasite’s life cycle— the first time such 3-D architecture has been generated during the progression of the life cycle of a parasite.
A research team was able to demonstrate for the first time that caffeine has a positive effect on tau deposits in Alzheimer's disease. Tau deposits, along with beta-amyloid plaques, are among the characteristic features of Alzheimer's disease.
In their pursuit of understanding how pain works at the molecular level, a research team has found a new function for MicroRNAs, short stretches of genetic material that signal genes to turn on or off.
Chances are you've heard of mapping genes to diagnose rare diseases, predict your risk of cancer and tell your ancestry. But to uncover food poisonings? The nation's disease detectives are beginning a program to try to outsmart outbreaks by routinely decoding the DNA of potentially deadly bacteria and viruses.
Under stress from chemotherapy or radiation, some cancer cells dodge death by consuming a bit of themselves, allowing them to essentially sleep through treatment and later awaken as tougher, resistant disease. Interfering with a single cancer-promoting protein and its receptor can turn this resistance mechanism into lethal, runaway self-cannibalization.