On this episode of Bioscience Technology This Week, Christina Jakubowski covers a genetic mutation that allows high-altitude-dwelling Tibetans to survive in the peaks of the Tibetan Plateau. Our second story looks at how minor infections increase stroke risk in children.
Stem cell biologists have found a way to reprogram a patient’s skin cells into cells that mimic...
A newborn screening test for severe combined immunodeficiency (SCID) reliably identifies infants...
On this episode of Bioscience Technology This Week, Christina Jakubowski highlights the...
Scientists have made it easier to predict both breast cancer relapses and responses to chemotherapy, through the identification of a unique gene, a new study shows.
Medical researchers have used DNA sequencing to identify a gene variant responsible for causing lupus in a young patient. The development shows that, for the first time, it is feasible for researchers to identify the individual causes of lupus in patients by using DNA sequencing.
A single factor can reset the immune system of mice to a state likely similar to what it was 500 million years ago. Scientists reactivated expression of an ancient gene in mice, which is not normally expressed in the mammalian immune system, and found that the animals developed a fish-like thymus.
NGS is revolutionizing the field of genome biology, with much faster data generation, increased accuracy, and a dramatic reduction of sequencing costs. Multiple genomes can now be sequenced in parallel by a single instrument in a matter of days. In the medical field, NGS is already having an impact in genetic screening and holds great potential in oncology, given the genetic aspects of cancerous disease.
A team of researchers has uncovered some of the strongest evidence yet that epigenetic changes in the brain play a role in Alzheimer’s disease. The current study found that chemical modifications to DNA within the ANK1 gene are strongly associated with measures of neuropathology in the brain.
A genetic variation linked to schizophrenia, bipolar disorder and severe depression wreaks havoc on connections among neurons in the developing brain, a team of researchers reports.
On this episode of Bioscience Technology This Week, Christina Jakubowski reports on the possibility of making nuts safer to eat for those with allergies. Our second story tackles important questions about which genes may drive antibiotic resistance.
UT Southwestern Medical Center researchers successfully used a new gene editing method to correct a mutation that leads to Duchenne muscular dystrophy (DMD) in a mouse model of the condition. Researchers used a technique called CRISPR/Cas9-mediated genome editing, which can precisely remove a mutation in DNA, allowing the body’s DNA repair mechanisms to replace it with a normal copy of the gene.
Gene-based personalized medicine has many possibilities for diagnosis and targeted therapy, but one big bottleneck: the expensive and time-consuming DNA-sequencing process. Now, researchers have found that nanopores in the material molybdenum disulfide (MoS2) could sequence DNA more accurately, quickly and inexpensively than anything yet available.
Releasing genetically engineered fruit flies into the wild could prove to be a cheap, effective and environmentally friendly way of pest control according to scientists at the University of East Anglia and Oxitec Ltd. This collaborative research study, with UEA shows that this approach is effective and once appropriate regulatory approvals are received the technology will offer growers a safe and effective route to protect their crops.
Scientists have known for decades that cancer can be caused by genetic mutations, but more recently they have discovered that chemical modifications of a gene can also contribute to cancer. These alterations, known as epigenetic modifications, control whether a gene is turned on or off.
It has been more than 20 years since scientists discovered that mutations in the gene huntingtin cause the devastating progressive neurological condition Huntington’s disease. Surprisingly little, however, has been known about the gene’s role in normal brain activity. Now, new research shows it plays a critical role in long-term memory.
Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified a gene that contributes to the development of several childhood cancers, in a study conducted with mice designed to model the cancers. If the findings prove to be applicable to humans, the research could lead to new strategies for targeting certain childhood cancers at a molecular level.
Plasmodium falciparum, the parasite that causes malaria, has proven notoriously resistant to scientists’ efforts to study its genetics. It can take up to a year to determine the function of a single gene, which has slowed efforts to develop new, more targeted drugs and vaccines.
Blood expression levels of genes targeted by the stress hormones called glucocorticoids could be a physical measure, or biomarker, of risk for developing Post-Traumatic Stress Disorder (PTSD), according to a new study.
A gene discovery brings scientists closer to developing therapeutic agents that could slow down bone loss and regenerate lost bone, which could provide relief for millions suffering from aging-related bone loss.
Researchers have hijacked a defense system normally used by bacteria to fend off viral infections and redirected it against the human papillomavirus (HPV), the virus that causes cervical, head and neck, and other cancers.Using the genome editing tool known as CRISPR, the Duke University researchers were able to selectively destroy two viral genes responsible for the growth and survival of cervical carcinoma cells.
Scientists from the University of Leeds have discovered a gene that plays a vital role in blood vessel formation, research which adds to our knowledge of how early life develops. The discovery could also lead to greater understanding of how to treat cardiovascular diseases and cancer.
Researchers with The Cancer Genome Atlas (TCGA) Research Network have completed the largest, most diverse tumor genetic analysis ever conducted, revealing a new approach to classifying cancers. The work not only revamps traditional ideas of how cancers are diagnosed and treated, but could also have a profound impact on the future landscape of drug development.
It's long been known that faulty BRCA genes greatly raise the risk for breast cancer. Now, scientists say a more recently identified, less common gene - called PALB2 - can do the same.
Your genes are blueprints for proteins, and molecules called microRNA can help to determine how often these genetic blueprints are manufactured into proteins. Researchers often ask what microRNA regulates a gene related to disease. Or what gene is regulated by a microRNA found in sick patients? The answers to these questions could help doctors and researchers manipulate protein levels in the body that cause disease.
Black truffles expensive and highly prized in the world of haute cuisine, but in the world of epigenetics, the fungi are of major interest for another reason: their unique pattern of DNA methylation, a biochemical process that chemically modifies nucleic acids without changing their sequence.
Researchers have achieved a technical breakthrough that should result in speedier diagnosis of cancer and various pre-natal conditions. The key discovery lies in a new tool that allows researchers to load long strands of DNA into a tunable nanoscale imaging chamber in ways that maintain their structural identity and under conditions that are similar to those found in the human body.
The tiny addition of a chemical mark atop a gene that is well known for its involvement in clinical depression and posttraumatic stress disorder can affect the way a person’s brain responds to threats, according to a new study.
A large DNA analysis of people with and without pancreatic cancer has identified several new genetic markers that signal increased risk of developing the highly lethal disease, scientists report.
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