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The Lead

Cellular Origin of Fibrosis

November 21, 2014 10:00 am | News | Comments

Harvard Stem Cell Institute scientists at Brigham and Women’s Hospital say they have found the cellular origin of the tissue scarring caused by organ damage associated with diabetes, lung disease, high blood pressure, kidney disease, and other conditions. Read more...

Study: Obesity Fuels Silent Heart Damage

November 21, 2014 9:27 am | News | Comments

Using an ultrasensitive blood test to detect the presence of a protein that heralds heart...

3-D-Printed Model Helps Treat Patients with Heart Disorders

November 20, 2014 10:43 am | News | Comments

An experimental 3-dimensional printed model of the heart may help surgeons treat patients...

Early Statin Use May Give Long-term Heart Benefits

November 19, 2014 2:57 pm | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

Research shows that taking a cholesterol-lowering drug for five years in middle age can lower...

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Mental Health Problems Increase Cardiovascular Disease Risk

November 19, 2014 2:18 pm | by Cynthia Fox, Science Writer | Articles | Comments

People with mental health problems are “significantly” more likely to have stroke or heart disease, according to a study unveiled at a recent Canadian Cardiovascular Congress.                    

Statins Reverse Learning Disabilities Caused by Genetic Disorder

November 17, 2014 11:05 am | News | Comments

UCLA scientists have discovered that statins, a popular class of cholesterol drugs, reverse the learning disabilities caused by a genetic disorder called Noonan syndrome. Read more..                            

Calculator Adds Up Cardio Risks

November 17, 2014 10:28 am | News | Comments

The new Healthy Heart Score developed by researchers at the Harvard T.H. Chan School of Public Health (HSPH) gives individuals an easy way to estimate their 20-year risk of developing cardiovascular disease (CVD) based on simple lifestyle habits. Read more...

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Imaging Method Could Improve Asthma Treatment

November 14, 2014 12:21 pm | News | Comments

A team of researchers have used a laser beam trap to examine how drug particles from asthma inhalers behave as they are projected through the air. Their findings could improve the effectiveness of inhalers for the over five million people in the UK suffering from asthma.

Gene Study Boosts Interest in Heart Drug

November 12, 2014 5:57 pm | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

Scientists have discovered gene mutations that give people naturally lower cholesterol levels and cut their risk of heart disease in half. That discovery may have a big implication for a blockbuster heart drug.           

Getting to the Heart of the Heart

November 6, 2014 2:13 pm | News | Comments

For years, a multidisciplinary research team has tracked an elusive creature, a complex of proteins thought to be at fault in some cases of sudden cardiac death. Now, they have finally captured images of the complex.          

Fruit Chemicals May Minimize Organ Damage After Heart Attack, Stroke

November 6, 2014 1:58 pm | News | Comments

Scientists have identified chemicals found in some everyday fruit that could protect vital organs from long-term damage following a heart attack or stroke, according to new research.                    

Genetic Damage Caused by Asthma Shows Up in Blood Stream

November 5, 2014 12:52 pm | News | Comments

Asthma may be more harmful than was previously thought, according to researchers who found that genetic damage is present in circulating, or peripheral, blood.                          

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Novel Ultrasound Technology Screens for Heart Conditions

October 30, 2014 1:41 pm | News | Comments

Engineers have determined for the first time the impact of a ring-shaped vortex on transporting blood flow in normal and abnormal ventricles within the human heart. In order to make the study possible, researchers have developed a novel ultrasound technology that makes screening cheaper and much easier.

World-First Embryonic Stem Cell Trial for the Heart

October 30, 2014 9:37 am | by Cynthia Fox, Science Writer | Articles | Comments

The first embryonic stem (ES) cell trial for severe heart failure is launching now in Paris. The long-awaited trial comes after much preclinical cell work on more than 350 rats, 50 immunodeficient mice and 32 non-human primates.       

DNA-repairing Enzyme Can Worsen Tissue Damage

October 28, 2014 3:04 pm | News | Comments

When tissues are deprived of blood, as happens during a stroke or heart attack, the lack of oxygen can cause serious damage. A new study shows that surprisingly, a DNA-repair enzyme called Aag actually makes this damage worse.       

Vitamin D Deficiency Ups Attack Risk in Asthmatics

October 28, 2014 2:03 pm | News | Comments

A new study points to a convenient, free way to manage acute asthmatic episodes— catching some rays outside. The research showed that asthmatics with vitamin D deficiency were 25 percent more likely to experience acute attacks.       

Babies’ Hearts May Beat Path to Heart Attack Treatments

October 17, 2014 11:50 am | Videos | Comments

The seemingly miraculous power of babies’ hearts to repair themselves after being injured has spurred a research team to investigate if this ability can be harnessed for new heart attack treatments.               

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Repair Process Suggests Potential Heart Attack Treatment Strategy

October 16, 2014 2:47 pm | News | Comments

Researchers have discovered that some scar-forming cells in the heart, known as fibroblasts, have the ability to become endothelial cells— the cells that form blood vessels. The finding could point the way toward a new strategy for treating people who have suffered a heart attack

Weight Gain Study Suggests Polyunsaturated Oil Healthier Option

October 16, 2014 2:33 pm | News | Comments

Short-term modest weight gains in healthy, normal weight young adults was associated with more bad cholesterol levels in those who ate muffins cooked using saturated oil. However, individuals in the same study who ate muffins made with polyunsaturated oils had improved blood cholesterol profiles, according to a new study. 

Explaining More About Airway Closure During Asthma Attacks

October 16, 2014 2:28 pm | News | Comments

In acute asthma, various triggers, including viral illnesses and aeroallergens, can cause acute narrowing of the airways leading to a life-threatening respiratory crisis and sometimes death. Researchers have identified a novel factor that puts the brakes on airway smooth-muscle contraction relevant to asthma.

Reversing Idiopathic Pulmonary Fibrosis

October 14, 2014 2:42 pm | by Cynthia Fox, Science Writer | Articles | Comments

Lethal fibrosis in lungs of mice with idiopathic pulmonary fibrosis (IPF) can be reversed, say researchers. No drug on the market can do this. But the crew pulled it off, in mice, by temporarily restoring (a mimic of) one of the body’s own anti-fibrosis agents, sharply reduced in IPF: microRNA-29.

Exercise Can Improve Memory in People Over 60

October 14, 2014 12:53 pm | News | Comments

A new study shows that physical activity can improve memory performance in older people through increasing volume and blood flow in an area of the brain called hippocampus.                       

Stress May be Harder on Women’s Hearts than Men’s

October 14, 2014 12:20 pm | News | Comments

Researchers have known for decades that stress contributes to heart disease. But a new analysis shows mental stress may tax women’s hearts more than men’s.                           

Making Old Lungs Look New Again

October 2, 2014 2:21 pm | News | Comments

New research shows that the lungs become more inflammatory with age and that ibuprofen can lower that inflammation. In fact, immune cells from old mouse lungs fought tuberculosis bacteria as effectively as cells from young mice after lung inflammation was reduced by ibuprofen.

Gene Interacts With Stress, Leads to Heart Disease

October 1, 2014 3:33 pm | News | Comments

A new genetic finding suggests that some people who are prone to hostility, anxiety and depression might also be hard-wired to gain weight when exposed to chronic stress, leading to diabetes and heart disease.           

Stem Cells Help Study How Mutation Affects Heart Health

September 26, 2014 8:30 am | News | Comments

Over 500 million people worldwide carry a genetic mutation that disables a common metabolic protein called ALDH2. The mutation, which predominantly occurs in people of East Asian descent, leads to an increased risk of heart disease and poorer outcomes after a heart attack. Now, have learned for the first time specifically how the mutation affects heart health.

Lost Protein Could Prevent Hardening of the Arteries

September 23, 2014 2:23 pm | News | Comments

Researchers have found that when the protein matrix metalloproteinase-14 (MMP-14) is reduced or lost, white blood cells, known as macrophages, become good and could prevent hardening of the arteries, rupture and sudden death.        

Nanotubes Help Healing Hearts Keep the Beat

September 23, 2014 1:59 pm | Videos | Comments

Carbon nanotubes serve as bridges that allow electrical signals to pass unhindered through new pediatric heart-defect patches invented at Rice University and Texas Children’s Hospital.                    

Airway Muscle-on-a-chip Mimics Asthma

September 23, 2014 1:46 pm | News | Comments

Hope for healthier airways may be on the horizon thanks to a human airway muscle-on-a-chip that could be used to test new drugs because it accurately mimics the way smooth muscle contracts in the human airway, under normal circumstances and when exposed to asthma triggers.

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