A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle, a disorder that often leads to heart failure, researchers report. Cardiac hypertrophy, which afflicts one in 500 people, can be caused by high blood pressure or inherited through genes that control contraction of the heart.
An international group of scientists has shown that a drug candidate designed by scientists significantly increases exercise endurance in animal models. These findings could lead to new approaches to helping people with conditions that acutely limit exercise tolerance.
If the heart following a heart attack is not sufficiently supplied with blood, heart tissue dies. In adult humans, the ability to heal itself is hardly developed. Scientists have now observed in the embryo of the zebrafish that muscle cells migrate from the undamaged atrium into the ventricle and thus significantly contribute to regeneration.
New insights into why obese cigarette smokers experience a high risk of heart disease suggest that cigarette smoke affects the activity of hundreds of key genes that both protect the heart and lungs and expose them to damage. The study suggests that the effects may be especially profound in obese nonsmokers who inhale “sidesteam smoke” from cigarettes smoldering nearby.
Researchers have found that, across a variety of neurodegenerative diseases, cerebrovascular disease affecting circulation of blood in the brain was significantly associated with dementia. The researchers contend that people already exhibiting clinical features of Alzheimer's disease and other memory impairments may benefit from effective therapies currently available to reduce vascular problems.
People with cheerful temperaments are significantly less likely to suffer a coronary event such as a heart attack or sudden cardiac death, new research suggests. The researchers say their study shows that a general sense of well-being actually reduces the chances of a heart attack.
Paralytic drugs like succinylcholine (SC) are often used during surgery or when critically ill patients require endotracheal intubation. But if the drug is not swiftly cleared from the patient’s system, the results can be deadly. A new study shows that the plant-produced recombinant human enzyme butyrylcholinesterase (BChE) can rapidly reverse paralysis of the airways (or apnea) caused by succinylcholine.
Aspirin has been widely used for more than 50 years as a common, inexpensive blood thinner for patients with heart disease and stroke, but doctors have little understanding of how it works and why some people benefit and others don’t. Now, researchers have developed a blood-based test of gene activity that has been shown to accurately identify who will respond to the aspirin therapy.
A chemical component present in the nightshade family of plants is one of the world’s most tenaciously addictive substances. It is the nicotine contained in tobacco and found in high concentrations in cigarettes. Smoking remains a global scourge; in the U.S. it is the leading source of preventable death. Researchers have launched an ambitious new project, designed to attack nicotine dependence in a radically new way.
Researchers at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have successfully established the foundation for using hematopoietic (blood-producing) stem cells from the bone marrow of patients with sickle cell disease to treat the disease.
DNA fragments in your blood may someday help doctors quickly learn if chest pain means you have narrowed heart arteries, according to a new study. The study involved 282 patients, ages 34 to 83, who reported chest pain and were suspected of having coronary artery disease. Researchers used computed tomography imaging to look for hardened, or calcified, buildup in the blood vessels that supply the heart.
Engineers from Queen Mary, University of London have developed the world’s most precise computer simulation of how red blood cells might travel around the body to help doctors treat people with serious circulatory problems. The simulations, the largest of their kind, take into account the many forces acting on red blood cells as they travel through the blood vessels, which affect how the cells interact and stick to each other.
Male twin Vietnam veterans with post-traumatic stress disorder (PTSD) were more than twice as likely as those without PTSD to develop heart disease during a 13-year period, according to a study supported by the National Institutes of Health. This is the first long-term study to measure the association between PTSD and heart disease using objective clinical diagnoses combined with cardiac imaging techniques.
Researchers at MIT’s Computer Science and Artificial Intelligence Laboratory have developed a new algorithm that can accurately measure the heart rates of people depicted in ordinary digital video by analyzing imperceptibly small head movements that accompany the rush of blood caused by the heart’s contractions.
A scientific team led by researchers from the University of California, San Diego School of Medicine visually monitored the dynamic cellular events that take place when cardiac regeneration occurs in zebrafish after cardiac ventricular injury. Their findings provide evidence that various cell lines in the heart are more plastic, or capable of transformation into new cell types, than previously thought.
Human bone breaks down and regenerates naturally all the time, in a perfectly balanced dance that maintains skeletal integrity. As people age, bone tends to deteriorate faster, causing osteoporosis and other disorders. Smoking artificially accelerates bone degeneration as well. For the first time, researchers have described the mechanics of how certain toxic compounds in smoke break down bone.
A new study shows that a protein called MCL-1, which promotes cell survival, is essential for normal heart function. The study found that deletion of the gene encoding MCL-1 in adult mouse hearts led to rapid heart failure within two weeks, and death within a month.
A new study confirms directly what scientists previously knew only indirectly: The poisonous “rotten egg” gas hydrogen sulfide is generated by our body’s growing cells. Hydrogen sulfide, or H2S, is normally toxic, but in small amounts it plays a role in cardiovascular health.
The heart's regular rhythm is regulated by a bundle of cells called "the pacemaker." Previously, scientists found that many cases of inherited arrhythmias originating in the pacemaker could be attributed to functional defects in the channels responsible for the flow of sodium and calcium. Now, researchers have discovered a previously unidentified potassium channel in the cardiac pacemaker which helps to regulate the heartbeat.
A 20-year puzzle as to how the heart regulates contraction appears to have been solved by researchers. Their findings, published in the journal Biophysics, pave the way to improving our understanding of what goes wrong when the heart fails.
Cardiac arrhythmia is one of the most common diseases encountered in clinical cardiology. High-speed electrophysiological imaging using fluorescent probes has yielded tremendous insights into the basic mechanisms of arrhythmias and the effects of anti-arrhythmic drugs. However, optical mapping, as it is known to the cardiac research community, has remained relegated to the isolated (i.e. explanted) heart.
A new gene associated with a form of congenital heart disease in newborn babies– known as “a hole in the heart” has been discovered by researchers. The discovery will help lead to better understanding of why some patients are born with the disorder.
In a medical first, doctors used plastic particles and a 3-D laser printer to create an airway splint to save the life of a baby boy who used to stop breathing nearly every day. It's the latest advance from the booming field of regenerative medicine, making body parts in the lab.
Over the past few decades, scientists have developed many devices that can reopen clogged arteries, including angioplasty balloons and metallic stents. While generally effective, each of these treatments has drawbacks, including the risk of side effects.
Academic researchers have found that breathing motor vehicle emissions triggers a change in high-density lipoprotein (HDL) cholesterol, altering its cardiovascular protective qualities so that it actually contributes to clogged arteries.