New research explains how a synthetic gene module controlled by the happiness hormone dopamine produces an agent that lowers blood pressure, opening up new avenues for therapies.
University of Utah researchers have found that deficiency of an antioxidant response protein called nuclear erythroid-2 like factor-2 (Nrf2) delays or prevents hypertrophic cardiomyopathy, a type of a heart failure in which the heart muscle grows abnormally thick.
High levels of HDL have been linked to increased breast cancer risks and to enhanced cancer aggressiveness in animal experiments. Now, a team of researchers has shown that an HDL receptor found on breast cancer cells may be responsible for this effect.
Cutting-edge research has provided a crucial breakthrough in understanding how blood clots form. The results of the study could potentially lead to the development of new drugs to treat one of the world's biggest killer illnesses.
A research team has found that triglycerides play a causal role in coronary artery disease (CAD), the most common form of heart disease and the leading cause of death in the U.S. The study suggests that lowering triglyceride levels through treatment may help reduce the risk of CAD.
A global hunt for genes that influence heart disease risk has uncovered 157 changes in human DNA that alter the levels of cholesterol and other blood fats– a discovery that could lead to new medications. Each of the changes points to genes that can modify levels of cholesterol and other blood fats.
A simple video camera paired with complex algorithms appears to provide an accurate means to remotely monitor heart and respiration rates day or night, researchers report. The inexpensive method for monitoring the vital signs without touching a patient could have major implications for telemedicine.
Hypertrophic cardiomyopathy (HCM)— a disease in which cardiac muscle thickens, weakening the heart— can be prevented from developing for several months in mice by reducing production of a mutant protein, according to a new study. The work takes a first step toward being able to treat or prevent the leading cause of sudden death in athletes and sudden heart-related death in people under 30 in the United States.
Researchers found that dying heart cells are kept alive with spikes of oxygen. The research shows that dying heart cells still contain enough oxygen for metabolism, and additional short-term spikes of oxygen keep the cells alive and active.
Physical activity is potentially as effective as many drug interventions for patients with existing cardiovascular diseases and other chronic conditions. In the few conditions where the life-saving benefits of exercise have been studied, physical activity was often found to be as effective as drugs at reducing the risk of death.
Men who have low testosterone levels may have a slightly elevated risk of developing or dying from heart disease, according to a recent study. Over time, low testosterone may contribute to an increase in body fat, loss of body hair and muscle bulk.
Translational researchers are developing a richer understanding of atherosclerosis in humans, revealing a key role for stem cells that promote inflammation. The research extends to humans previous findings that revealed that high levels of LDL (“bad”) cholesterol promote atherosclerosis by stimulating production of hematopoietic stem/progenitor cells (HSPC’s).
The threat from a heart attack doesn't end with the event itself. Blockage of blood flow to the heart can cause irreversible cell death and scarring. Scientists are trying to address this problem by engineering cardiac tissue to patch up damaged areas. Now, researchers have fabricated fibers shaped like springs that allow engineered cardiac tissue to pump more like the real thing.
Whole-body MRI may serve as a valuable noninvasive tool for assessing the risk of heart attack and stroke in diabetic patients. Diabetes is a metabolic disease characterized by an increased concentration of glucose in the blood. There are 347 million diabetic patients worldwide, and the World Health Organization projects that diabetes will be the seventh leading cause of death by 2030.
A team of scientists at Karolinska Institutet and Harvard University has taken a major step towards treatment for heart attack, by instructing the injured heart in mice to heal by expressing a factor that triggers cardiovascular regeneration driven by native heart stem cells.
Chronic exposure to ground level ozone, a powerful greenhouse gas and a widespread air pollutant in many major cities, is linked to premature death from cardiovascular disease, finds a new study. The analysis also found a strong link between nitrogen dioxide, a marker for traffic pollution, and increased risk of death from lung cancer.
For the first time, it has been shown that an intensively active lifestyle can “completely prevent” bad diets from impairing sexual function, says a Johns Hopkins University urology fellow. Put another way, a recent rat study offers strong evidence that erectile dysfunction (ED) is more than just a bedroom bother. It may be one’s own natural biomarker for coronary artery disease.
Pulmonary hypertension, a deadly form of high blood pressure that develops in the lungs, may be caused by an inflammation-producing molecular pathway that damages the inner lining of blood vessels, according to a new study by researchers at the Stanford University School of Medicine.
Researchers at King's College London have for the first time highlighted the natural regenerative capacity of a group of stem cells that reside in the heart. This new study shows that these cells are responsible for repairing and regenerating muscle tissue damaged by a heart attack which leads to heart failure.
A new drug capable of inhibiting growth of Mycobacterium tuberculosis has been reported. The findings may improve therapeutic options for the treatment of drug resistant tuberculosis (TB). One-third of the world’s population is latently infected with M. tuberculosis and more than a million people die of TB each year.
When it comes to lung transplants, bigger may be better. That’s the main finding from a new study, which found that oversized lungs lead to improved survival following lung transplants, particularly among patients receiving double-lung transplants.
With modern surgical techniques increasingly able to save babies born with heart defects, biomedical researchers are hunting for ways to manage the subsequent rising prevalence of congenital heart disease. A research team has discovered a mutation to a gene that is key to cardiac development.
In older men, a natural antioxidant compound found in red grapes and other plants– called resveratrol– blocks many of the cardiovascular benefits of exercise, according to results from a recent research project. The research unusually suggests that eating a diet rich in antioxidants may actually counteract many of the health benefits of exercise.
In a new paper, a team of researchers show that the pulmonary vasculature, the blood vessels that connect the heart to the lung, develops even in the absence of the lung. Mice in which lung development is inhibited still have pulmonary blood vessels, which revealed that cardiac progenitors, or stem cells, are essential for cardiopulmonary co-development.
Another reason to eat breakfast: Skipping it may increase your chances of a heart attack. A study of older men found those who regularly skipped breakfast had a 27 percent higher risk of a heart attack than those who ate a morning meal.