Research shows that if a patient's gastrointestinal tract remains healthy and functioning during chemotherapy treatment, the patient's chances of survival increase exponentially. Recently, scientists discovered a biological mechanism that preserves the gastrointestinal tracts in mice who were delivered lethal doses of chemotherapy.
One major hallmark of cancer cells is their ability to survive under stressful conditions. A new study reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress.
A long-standing mystery in cancer is how cancerous cells move from being dormant to being metastatic. Now, a team of researchers from Lawrence Berkeley Laboratory (LBL) and the Weill Cornell Medical College believe they have identified the microenvironment that contributes to the change of state of the cells.
A team of scientists has identified genes that are potential targets for therapeutic drugs against aggressive breast cancer. Out of the 1.5 million women diagnosed with breast cancer in the world annually, nearly one in seven of these is classified as triple negative.
Modern genomics has shown that just one DNA mutation can be the difference between successfully treating a disease and having it spread rampantly throughout the body. Now, researchers have developed a new method that can look at a specific segment of DNA and pinpoint a single mutation.
The taller a postmenopausal woman is, the greater her risk for developing cancer, according to a new study. Height was linked to cancers of the breast, colon, endometrium, kidney, ovary, rectum, and thyroid, as well as to multiple myeloma and melanoma.
Scientists have revealed new images which provide the clearest picture yet of how white blood immune cells attack viral infections and tumors. They show how the cells change the organization of their surface molecules when activated by a type of protein found on viral-infected or tumor cells.
Borrowing a tool from molecular biology, researchers have detected a tumor-associated genetic mutation in the cerebrospinal fluid (CSF) of a small number of patients with brain tumors. The investigators used digital versions of the gene-amplification technology polymerase chain reaction (PCR) to analyze bits of RNA carried in membrane-covered sacs.
The first time Miriam Lipton had breast cancer, her thick hair fell out two weeks after starting chemotherapy. The second time breast cancer struck, Lipton gave her scalp a deep chill and kept much of her hair — making her fight for survival seem a bit easier. Hair loss is one of chemotherapy's most despised side effects, not because of vanity but because it fuels stigma.
Protein production or translation is tightly coupled to a highly conserved stress response that cancer cells rely on for survival and proliferation, according to researchers. In mouse models of cancer, targeted therapeutic inhibition of translation disrupts this survival response, dramatically slowing tumor growth and potentially rendering drug-resistant tumors vulnerable to other therapies.
An experimental drug in early development for aggressive brain tumors can cross the blood-brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a new study. The laboratory and animal study also shows how the agent, called SapC-DOPS, targets tumor cells and blood vessels.
Surgeons may have a new way to smoke out cancer. An experimental surgical knife can help surgeons make sure they've removed all the cancerous tissue, doctors reported Wednesday. Surgeons typically use knives that heat tissue as they cut, producing a sharp-smelling smoke. The new knife analyzes the smoke and can instantly signal whether the tissue is cancerous or healthy.
Scientists have developed a histology expression predictor for the most common types of lung cancer: adenocarcinoma, carcinoid, small cell carcinoma and squamous cell carcinoma. This predictor can confirm histologic diagnosis in routinely collected paraffin samples of patients’ tumors and can complement and corroborate pathologists’ findings.
A new study reports the first proof of cancer’s ability to fuse with blood, giving cancer the ability to travel and seeding sites of metastasis around the body. The work used DNA fingerprinting of a bone marrow transplant patient with cancer, along with DNA fingerprinting of the patient’s bone marrow donor, to show that metastatic cancer cells carried parts of both genomes, fused together into a hybrid cancer cell.
A type of genetic abnormality linked to cancer is more common in people with type 2 diabetes than the rest of the population, a new study has found. People with type 2 diabetes are already known to have a higher risk of cancers, especially blood cancers like lymphoma and leukemia. The new study suggests that mutations called clonal mosaic events (CMEs) may partly explain why this is.
ASU's Paul Davies has proposed a new way to look at cancer, by tracing its deep evolutionary roots to the dawn of multicellularity more than a billion years ago. If this theory is correct, it promises to transform the approach to cancer therapy, and to link the origin of cancer to the origin of life and the developmental processes of embryos.
A pair of studies by a team of researchers sheds light on a biological process that is activated across a vast range of malignancies. Wnt proteins are a large family of proteins that activate signaling pathways (a set of biological reactions in a cell) to control several vital steps in embryonic development.
A team of scientists has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells. Their findings on telomeres, the stretches of DNA at the ends of chromosomes that protect our genetic code and make it possible for cells to divide, suggest a potential target for preventive measures against cancer, aging and other diseases.
Researchers have found that nerves play a critical role in both the development and spread of prostate tumors. Their findings, using both a mouse model and human prostate tissue, may lead to new ways to predict the aggressiveness of prostate cancer and to novel therapies for preventing and treating the disease.
Parents who have been fretting over the low levels of arsenic found in apple juice can feel better about buying one of their kids' favorite drinks. The Food and Drug Administration is setting a new limit on the level of arsenic allowed in apple juice, after more than a year of public pressure from consumer groups worried about the contaminant's effects on children.
A mere 25 years ago, noncoding RNAs were considered nothing more than “background noise” in the overall genomic landscape. Now, two new studies reveal that one of these tiny noncoding molecules—microRNA-22—plays an outsized role in two types of cancer.
Genetic mutations aren’t the only thing that can keep a protein called PTEN from doing its tumor-suppressing job. Researchers have now discovered that four small chemical tags attached (reversibly) to the protein’s tail can have the same effect, and they say their finding may offer a novel path for drug design to keep PTEN working.
Micronuclei, erratic, small extra nuclei, which contain fragments, or whole chromosomes that were not incorporated into daughter cells after cell division, are associated with specific forms of cancer and are predictive of poorer prognosis. In a new study, a team of scientists found that disrupted micronuclei might play an even more active role in carcinogenesis than previously thought.
A new technique for detecting cancer by imaging the consumption of sugar with magnetic resonance imaging (MRI) has been unveiled by scientists. The breakthrough could provide a safer and simpler alternative to standard radioactive techniques and enable radiologists to image tumors in greater detail.
It’s a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body. UNC scientists used GEMMs to develop biomarkers for challenging molecular subtypes of human breast cancer, those for which there are fewer targets and therapies.