Scientists identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code for proteins like regular RNA. Instead, this particular lncRNA acts as an on/off switch for a key gene whose excessive activity is tied to inflammation and cancer, COX-2.
Vitamin D deficiency was an indicator of aggressive prostate cancer and spread of the disease in European-American and African-American men who underwent their first prostate biopsy because of abnormal prostate-specific antigen and/or digital rectal examination test results, according to a study.
Researchers have successfully used stem cells derived from human body fat to deliver biological treatments directly to the brains of mice with glioblastomas, the most common and aggressive form of brain tumor, significantly extending their lives.
Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors to hereditary cancer risk in the human population. Now, investigators are reporting a new mechanism by which BRCA gene loss may accelerate cancer-promoting chromosome rearrangements.
Researchers found that the protein DAZAP1 plays a key role in the regulation of many genes through a process known as alternative splicing, and when highly expressed in cancer cell line experiments, DAZAP1 was shown to inhibit several types of cancer cells from dividing and moving.
Scientists have identified one of the molecular pathways that resveratrol, the component of grapes and red wine associated with health benefits, uses to achieve its beneficial action.
Scientists studying cancerous tumor tissues in a laboratory believe they have identified a potential new strategy to treat ovarian cancer by targeting ovarian tumor growth through the inhibition of the development of new tumor blood vessels.
Using a mixture of cervical cancer cells and a hydrogel substance that resembles an ointment balm, an engineer has devised a method for 3-D printing tumors that could soon be taking cancer research out of the petri dish.
Federal health regulators have cleared a genetic test from Roche as a first-choice screening option for cervical cancer. It was a role previously reserved for the Pap smear, the decades-old mainstay of women's health.
New research reveals that a process that forms a key element in the development of the nervous system may also play a pivotal role in the spread of breast cancer.
The humble aspirin may have just added another beneficial effect beyond its ability to ameliorate headaches and reduce the risk of heart attacks: lowering colon cancer risk among people with high levels of a specific type of gene.
Some manufacturers are turning away from using triclosan as an antimicrobial ingredient in soaps, toothpastes and other products over health concerns. Now, scientists are reporting new evidence that appears to support these worries.
Measuring tumors’ oxygen levels could help doctors make decisions about treatments, but there’s currently no reliable, noninvasive way to make such measurements. However, a new an injectable device that reveals oxygen levels over several weeks could change that.
Researchers have identified an important enzyme pathway that helps prevent new cells from receiving too many or too few chromosomes, a condition that has been directly linked to cancer and other diseases.
The process of metastasis is still poorly understood. Now, a research team has developed a simple test that can reveal the evolutionary relationships among various tumor sites within a patient, information that may someday help with treatment planning.
A dream solution to cancer metastasis has been to develop a method that can track and kill the cancer cells that are on the move. The complexity at which those cancer cells operate has long been a formidable obstacle to stopping metastases, which cause 90 percent of cancer deaths, but that may change.
A team of researchers has developed a test that can rapidly assess several DNA repair systems, which could help determine individuals’ risk of developing cancer and help doctors predict how a given patient will respond to chemotherapy drugs.
Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers have discovered a biomarker called CD61 that appears responsible for inducing tumor metastasis by enhancing the stem cell-like properties of cancer cells.
A single type of cell in the lining of the bladder is responsible for most cases of invasive bladder cancer, according to researchers. This study is the first to pinpoint the normal cell type that can give rise to invasive bladder cancers.
Although doctors have long known that people with Down syndrome have a heightened risk of developing acute lymphoblastic leukemia (ALL) during childhood, they haven’t been able to explain why. Now, a team investigators has uncovered a connection between the two conditions.
The presence of chronic inflammation in benign prostate tissue was associated with high-grade, or aggressive, prostate cancer, and this association was found even in those with low prostate-specific antigen (PSA) levels, according to a new study.
Researchers have discovered an unexpected phenomenon in the organs that produce sperm in fruit flies: when a certain kind of stem cell is killed off experimentally, another group of non-stem cells can come out of retirement to replace them.
Size doesn’t matter as long as long as you can get the job done. That said, one may be forgiven the impression that larger molecules—antibodies and related constructs, or T cells themselves being used in immunotherapies—were preferentially presented at American Association of Cancer Research annual conference
Scientists have uncovered a new way the immune system may fight cancers and viral infections. The finding could aid efforts to use immune cells to treat illness. The research, in mice, suggests that some organs have the immunological equivalent of “neighborhood police” – specialized squads of defenders that patrol only one area, a single organ, instead of an entire city, the body.
The potential of immunotherapies drew large interest at this year's American Association for Cancer Research annual meeting. And the new data are particularly striking for their clinical results—reporting once uncommon at this basic research meeting.