If worry about skin cancer doesn't make you slather on sunscreen, maybe vanity will: New research provides some of the strongest evidence to date that near-daily sunscreen use can slow the aging of your skin. Ultraviolet rays that spur wrinkles and other signs of aging can quietly build up damage pretty much anytime you're in the sun — a lunchtime stroll, school recess, walking the dog — and they even penetrate car windows.
Many of the critical processes underlying cancer formation and eventual metastasis to other organs remain mysterious. In the quest for earlier diagnoses and more effective treatment, intensive research efforts have been applied to the search for biomarkers – presymptomatic signs of disease detectable in blood, saliva or other biofluids.
A simple vinegar test slashed cervical cancer death rates by one-third in a remarkable study of 150,000 women in the slums of India, where the disease is the top cancer killer of women. Doctors reported the results Sunday at a cancer conference in Chicago. Experts called the outcome "amazing" and said this quick, cheap test could save tens of thousands of lives each year in developing countries.
Doctors have shown that testing cervical tumors before treatment for vulnerability to chemotherapy predicts whether patients will do well or poorly with standard treatment. The study supports the future possibility of personalized medicine for cervical cancer, a tumor normally addressed with a one-size-fits-all approach.
Scientists have designed tiny spherical particles to float easily through the bloodstream after injection, then assemble into a durable scaffold within diseased tissue. An enzyme produced by a specific type of tumor can trigger the transformation of the spheres into netlike structures that accumulate at the site of a cancer.
Scientists have uncovered a survival mechanism that occurs in breast cells that have just turned premalignant- cells on the cusp between normalcy and cancers- which may lead to new methods of stopping tumors. Researchers report that a protein known as transforming growth factor beta, considered a tumor suppressor in early cancer development, can actually promote cancer once a cell drifts into a pre-cancerous state.
The human gut is loaded with commensal bacteria– “good” microbes that, among other functions, help the body digest food. The gastrointestinal tract contains literally trillions of such cells, and yet the immune system seemingly turns a blind eye.
Cancers of all types become most deadly when they metastasize and spread tumors throughout the body. Once cancer has reached this stage, it becomes very difficult for doctors to locate and treat the numerous tumors that can develop. Now, researchers have found a way to create radioactive nanoparticles that target lymphoma tumor cells wherever they may be in the body.
Genome sequencing of head and neck cancers may quickly—and soon—spur new therapies. There are 20 tumor types being studied by the massive, $100 million Cancer Genome Atlas (TCGA) project. Head and neck squamous cell carcinoma (HNSCC) is the eighth to be unveiled. The first, glioblastoma, has been cited in a whopping 2000-plus manuscripts.
A new method of measuring the variety of genetic mutations found in cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer. The research describes how a new way of measuring tumor heterogeneity was a better predictor of survival than are most traditional risk factors in a small group of patients with squamous cell carcinoma of the head and neck.
People who have non-melanoma skin cancer may be less likely to develop Alzheimer's disease, according to new research. The study showed that individuals with skin cancer were nearly 80 percent less likely to develop Alzheimer's disease compared with people who did not have skin cancer. No such association was found with other types of dementia, such as vascular dementia.
A soon-to-be-tested class of drug inhibitors were predicted to help a limited number of patients with B-cell lymphomas with mutations affecting the EZH2 protein. However, a research team now reports that these agents may, in fact, help a much broader cross section of lymphoma patients.
When cells suffer too much DNA damage, they are usually forced to undergo programmed cell death, or apoptosis. However, cancer cells often ignore these signals, flourishing even after chemotherapy drugs have ravaged their DNA. A new finding may offer a way to overcome that resistance.
A new, first-of-its-kind meta-analysis looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. The discovery of these genetic variations could ultimately help researchers better understand which men are at high risk and allow for early detection or prevention of the disease.
Very little has been known about the epigenetic events that occur prior to the invasive growth of head and neck squamous cell carcinomas and their spread to other parts of the body, or metastasis. Researchers discovered what could be a crucial step toward understanding the process that activates the cancer cells.
Approximately 90 percent of cancers start within tissues that form the inner linings of various organs. Decades of accumulated genetic mutations can, on occasion, induce cells specialized for growth in one-cell deep sheets to form disordered clumps that eventually become tumors.
The body's own immune system’s fight against breast cancer is controlled by genetic "fine tuners," known as microRNAs, according to a new study. Looking at 1,300 breast cancer samples, scientists found that the influence of these microRNAs, which help control how genes behave, varies between different subtypes of breast cancer.
A single antibody could be the key to treating multiple myeloma, or cancer of the blood, currently without cure or long-term treatment. Using a "biological library" of thousands of antibodies, researchers singled out antibody BI-505, shown to have a powerful effect on the tumor cells.
Combining two biological approaches, a research team from University of Michigan broke down the molecular signaling that leads to metastasis in prostate and breast cancer tumors. In the laboratory of Dr. Russell Taichman, one half of the lab looks at how very small embryonic-like cells (v-cells) help with tissue regeneration and wound healing, while the other half looks at how tumors metastasize to bone marrow.
Cancer chemotherapy can cause peripheral neuropathy—nerve damage often resulting in pain and muscle weakness in the arms and legs. Now, researchers have discovered that chemo also induces an insidious type of nerve damage inside bone marrow that can cause delays in recovery after bone marrow transplantation.
Researchers have identified a gene that, when repressed in tumor cells, puts a halt to cell growth and a range of processes needed for tumors to enlarge and spread to distant sites, in hope that this so-called “master regulator” gene may be the key to developing a new treatment for tumors resistant to current drugs.
By tracking changes in patients’ blood, scientists have created a new way of looking at how tumors evolve in real-time and develop drug resistance. The research used traces of tumor DNA, known as circulating tumor DNA (ctDNA), found in cancer patients’ blood to follow the progress of the disease as it changed over time and developed resistance to chemotherapy treatments.
A team of researchers has identified virtually all of the major mutations that drive acute myeloid leukemia (AML), a fast-growing blood cancer in adults that often is difficult to treat. The findings pave the way for developing better treatments for AML based on the genetic profile of a patient’s cancer.
For the first time, researchers have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. Since tumours are highly dependent on the transportation of nutrients in order to be able to grow rapidly, the researchers are hoping that the study will form the basis for new strategies to fight cancer cells.
Being pregnant while young is known to protect a women against breast cancer. But why? New research finds that Wnt/Notch signalling ratio is decreased in the breast tissue of mice which have given birth, compared to virgin mice of the same age.