Biotech drugmaker Amgen and Illumina, a maker of genetic testing equipment, said Wednesday they are developing a test that will identify patients who might be helped by Amgen's colon cancer drug Vectibix. Vectibix is approved as a treatment for colorectal cancer that has spread and hasn't rresponded to chemotherapy.
Immunotherapy—the art and science of training peoples’ immune systems to fight their own cancers—was named Breakthrough of the Year by Science. Prominently mentioned was an approach seeing clinical success: genetically tweaking patients’ own T cells to make them more potent, proliferative, and targeted.
Breast cancer stem cells exist in two different states and each state plays a role in how cancer spreads, according to an international collaboration of researchers. Their finding sheds new light on the process that makes cancer a deadly disease.
A new study suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par-4, another potent tumor suppressor protein that induces cell death in cancer cells.
Researchers have revealed a new, powerful technique to visualize the shape and motion of RNA at the atomic level using nuclear magnetic resonance spectroscopy (NMR).
Artificial bone marrow may be used to reproduce hematopoietic stem cells. A prototype has now been developed by scientists. The porous structure possesses essential properties of natural bone marrow and can be used for the reproduction of stem cells at the laboratory.
Researchers have discovered a promising strategy for treating cancers that are caused by one of the most common cancer-causing changes in cells.
A cancer-research team has identified a protein that may be a major culprit when breast cancer metastasizes to the brain. The cancer’s spread to the brain is often undetected until patients start to develop symptoms such as seizures, headaches, and trouble thinking.
By attaching a cancer-killer protein to white blood cells, biomedical engineers have demonstrated the annihilation of metastasizing cancer cells traveling throughout the bloodstream.
Researchers have completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutations not previously found in cervical cancer, including at least one for which targeted treatments have been approved for other forms of cancer.
Cancer investigators have genetically engineered a new mouse that mimics a common form of leukemia in humans. Studying the model could lead to new understanding of the disease, they say.
New research has shown that cells demonstrate remarkable flexibility and versatility when it comes to how they divide– a finding with potential links to the underlying causes of many cancers.
In the study, published online in Cell Reports, scientists found that inhibiting the action of a protein called BRD4 caused cancer cells to die in a mouse model of malignant peripheral nerve sheath tumors (MPNSTs). Learn more...
Biologists at The Johns Hopkins University have discovered that low oxygen conditions, which often persist inside tumors, are sufficient to initiate a molecular chain of events that transforms breast cancer cells from being rigid and stationery to mobile and invasive.
Scientists have obtained the first detailed molecular structure of a member of the Tet family of enzymes. The finding is important for the field of epigenetics because Tet enzymes chemically modify DNA, changing signposts that tell the cell's machinery "this gene is shut off" into other signs that say "ready for a change."
Researchers from the Boston area, Mexico and Norway have completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutations not previously found in cervical cancer, including at least one for which targeted treatments have been approved for other forms of cancer.
Researchers at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have discovered a mechanism by which certain adult stem cells suppress their ability to initiate skin cancer during their dormant phase—an understanding that could be exploited for better cancer-prevention strategies. Learn more...
Researchers have discovered a cause of aging in mammals that may be reversible. The essence of this finding is a series of molecular events that enable communication inside cells between the nucleus and mitochondria.
Researchers have identified how the ‘wall’ around cancer tumors functions and how to break it down, enabling the body’s own defenses to reach and kill the cancer cells within.
Metabolism was lost in the shadows of cancer research for decades but has recently been reclaiming some of the spotlight. Now, research has shown that aerobic glycolysis is not the consequence of the cancerous activity of malignant cells but is itself a cancerous event.
The insidious beauty of cancer is that it disguises itself as normal cells fooling the immune system until it can grow into proportions that are unmanageable or untreatable. Researchers have thought if they could help the immune system identify and fight cancer cells they could improve the patient’s prognosis.
Dr. Janet Rowley, a pioneer in cancer genetics research, has died at age 88. Rowley spent most of her career at the University of Chicago, where she also obtained her medical degree.
A new study shows that ALK and ROS1 gene rearrangements known to drive subsets of lung cancer are also present in some colorectal cancers.
For some cancer patients, the mental fogginess that develops with chemotherapy lingers long after treatment ends. Now, research in breast cancer patients may offer an explanation.