Scientists have discovered that the presence of a specific protein can distinguish between prostate cancers that are aggressive and need further treatment from those that may never seriously harm the patient.
Understanding how and why cancer cells move away from their original location is important to find ways to stop the spread of the disease. New findings reveal how a protein, called ‘PRH’, is normally able to prevent cells from unnecessary migration. It is likely that this protein is less effective in cancer cells allowing the cells to venture away.
Scientists have found that the immune system’s behavior can act as an early warning alarm that detects cancer recurrence, and this could offer a chance for pre-emptive treatment before the disease takes hold for the second time. The study, in mice, involved researchers looking for early signs of the immune response ‘kicking in’ indicating that the cancer was once more awake.
A new method to take the DNA fingerprint of individual cancer cells is uncovering the true extent of cancer’s genetic diversity, new research reveals. The technique can identify the founding mutations from which a tumor evolved and then uses computer software to draw a map of the cancer’s family tree.
Mutations in the genes that defend the body against cancer-related viruses and other infections may play a larger role in breast cancer than previously thought. A researcher looked at the DNA sequences of breast cancers from 21 different women and found mutations in genes involved in immunity in every one of them. The mutations were each different, but all would have affected some aspect of pathogen recognition and defense.
Researchers have developed a new technique for fighting deadly and hard-to-treat pancreatic cancer that uses two different types of nanoparticles, the first type clearing a path into tumor cells for the second, which delivers chemotherapy drugs.
Researchers studying how cancer spreads into bone have made a surprising discovery that suggests several investigational anti-cancer therapies just entering the drug-development pipeline may not have the desired effect.
Women vaccinated with one dose of a human papillomavirus (HPV) vaccine had antibodies against the viruses that remained stable in their blood for four years, suggesting that a single dose of vaccine may be sufficient to generate long-term immune responses and protection against new HPV infections, and ultimately cervical cancer.
Nitric oxide (NO) is one of the most important signaling molecules in living cells, carrying messages within the brain and coordinating immune system functions. In many cancerous cells, levels are perturbed, but very little is known about how NO behaves in both healthy and cancerous cells.
Tumors become highly malignant when they acquire the ability to colonize other tissues and form metastases. Ludwig-Maximilians-Universität München researchers have identified a factor that promotes metastasis of colon tumors – and presents a possible target for therapy.
Cisplatin is a chemotherapy drug given to more than half of all cancer patients. The drug kills cells very effectively, but tumors can become resistant to the drug and grow back. A new study offers a possible way to overcome that resistance.
Scientists have demonstrated that that cancer cells need a protein called Bod1 to grow and divide. When this protein is removed, cancer cells lose control of cell division and die.
A bone drug already on the market for osteoporosis may kill chronic myelogenous leukemia (CML) stem cells thought to persist in the bone marrow after standard therapy, lowering the likelihood of disease recurrence, according to a new study.
Research into clinical use of microbeam radiation therapy (MRT) has been limited because of the sheer size of the technology required to generate the beams. Now, researchers have developed a new microbeam emitter which has scaled down the technology, opening the doors for clinical research.
Researchers have devised a new way to understand patterns of aneuploidy in tumors and have proposed that the phenomenon is a driver of cancer, rather than a result of it.
A research team demonstrated, for the first time, delivery of a drug that turns off a critical gene in the aggressive and incurable glioblastoma multiforme, increasing survival rates significantly in animals with the deadly disease.
Two subtypes of human papillomavirus (HPV) prevented by vaccines are half as likely to be found in African-American women as in white women with precancerous cervical lesions, according to researchers.
A fine-grained scan of DNA in lung cancer cells has revealed a gene fusion– a forced merger of two normally separate genes– that spurs the cells to divide rapidly, scientists report.
Hunting for compounds that target the cancer stem cells of the blood cancer acute myeloid leukemia (AML) is now easier thanks to work by a team of scientists who built a new cell culture model that mimics AML in its niche in the bone marrow and makes the search for promising new drugs more effective.
According to a new study, a novel mammography procedure could generate substantial added-value for the diagnosis of breast cancer in medical practice.
A novel combination of two oral targeted drugs dramatically slowed the growth of glioblastoma brain tumors in mice and significantly extended the animals’ survival, scientists report.
A new breast cancer risk gene has been discovered which explains the early-onset breast cancer in some multiple-case breast cancer families.
Cancer researchers have deciphered the operating principles of a genetic switch that cancer cells use to decide when to metastasize and invade other parts of the body.
In a small preliminary study, researchers say a blood test based on detection of epigenetic alterations may reveal the earliest signs of pancreatic cancer, a disease that is nearly always fatal because of its late diagnosis.