UT Arlington biochemists say their newly published study brings researchers a step closer to understanding how the commonly used synthetic compound bisphenol-A (BPA) may promote breast cancer growth. The researchers found that when breast cancer and mammary gland cells were exposed to BPA in lab tests, the BPA worked together with naturally present molecules, including estrogen, to create abnormal amounts of HOTAIR expression.
Researchers at the UNC School of Medicine have devised a new biochemical technique that will allow them and other scientists to delve much deeper than ever before into the specific cellular circuitry that keeps us healthy or causes disease. The method helps researchers study how specific proteins called kinases interact to trigger a specific cellular behavior, such as how a cell moves.
Biomarkers for bone formation and resorption predict outcomes for men with castration-resistant prostate cancer, a team of researchers have found. Their study also found that the markers identified a small group of patients who responded to the investigational drug atrasentan. The markers’ predictive ability could help clinicians match treatments with individual patients, track their effectiveness and affect clinical trial design.
Seemingly healthy cells may hide clues that lung cancer will later develop, according to a study led by researchers at The University of Texas MD Anderson Cancer Center. Examination of gene expression in patients with non-small cell lung cancer showed the area adjacent to tumors is rich with cancer markers. In addition, researchers discovered the previously unknown role of a cancer-promoting gene in the airways of smokers with lung cancer.
Breast cancer patients with high levels of vitamin D in their blood are twice as likely to survive the disease as women with low levels of this nutrient. Previous studies showed that low vitamin D levels were linked to a high risk of premenopausal breast cancer. That finding prompted research that questioned the relationship between 25-hydroxyvitamin D and breast cancer survival rates.
Using technologies and computational modeling that trace the destiny of single cells, researchers at the University of California, San Diego School of Medicine describe for the first time the earliest stages of fate determination among white blood cells called T lymphocytes, providing new insights that may help drug developers create more effective, longer-lasting vaccines against microbial pathogens or cancer.
At least two camps have formed in the “breast cancer stem cell” world. One camp believes most cancers may come from stem cells—or stem-like progenitors—gone awry. Others agree cancers can be most virulent when reaching a stem cell-like state—but believe they may come from both stem cells and mature cells gone awry.
A drug that unleashes the immune system to attack cancer can produce lasting remissions and hold the disease in check – for more than two years, in some cases – in many patients with advanced melanoma, according to a new study. The study provides the longest-term look so far at how melanoma patients have fared since receiving the drug, nivolumab, in a Phase 1 clinical trial.
In space, things don’t always behave the way we expect them to. In the case of cancer, researchers have found that this is a good thing: some tumors seem to be much less aggressive in the microgravity environment of space compared to their behavior on Earth.
The bark of the Amur cork tree (Phellodendron amurense) has traveled a centuries-long road with the healing arts. Now it is being put through its paces by science in the fight against pancreatic cancer, with the potential to make inroads against several more.
Scientist have carried out the first studies of living biological cells using high-energy X-rays. The new method shows clear differences in the internal cellular structure between living and dead, chemically fixed cells that are often analyzed.
A collaboration of researchers found an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults. The results suggest that the mutation plays a key role in the development of the disease, called fibrolamellar hepatocellular carcinoma, and may also underlie more common cancers as well.
New research suggests that a protein only recently linked to cancer has a significant effect on the risk that breast cancer will spread, and that lowering the protein’s level in cell cultures and mice reduces chances for the disease to extend beyond the initial tumor.
A team of scientists from UCLA's Jonsson Comprehensive Cancer Center has developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread.
New acquaintances are often judged by their handshake. Research has now recognized the simple squeeze as an important diagnostic tool in assessing strength and quality of life among critical care patients. In a recent study, Concordia professor Robert Kilgour and his colleagues at the McGill Nutrition and Performance Laboratory confirmed a link between handgrip strength and survival rates.
Cincinnati Cancer Center (CCC) and UC Cancer Institute researchers have found that a vaccine, targeting tumors that produce a certain protein and receptor responsible for communication between cells and the body’s immune system, could initiate the immune response to fight cancer.
A team of chemists is reporting a new way to detect just a few lurking tumor cells, which can be outnumbered a billion to one in the bloodstream by healthy cells. The researchers have constructed an ultrasensitive nanoprobe that can electrochemically sense as few as four circulating tumor cells, and it doesn’t require any enzymes to produce a detectable signal.
Using tiny particles designed to target cancer-fighting immune cells, Johns Hopkins researchers have trained the immune systems of mice to fight melanoma, a deadly skin cancer. The experiments represent a significant step toward using nanoparticles and magnetism to treat a variety of conditions, the researchers say.
Adult stem cells and cancer cells have many things in common, including an ability to migrate through tiny gaps in tissue. Both types of cells also experience a trade-off when it comes to this ability; having a flexible nucleus makes migration easier but is worse at protecting the nucleus’ DNA compared to a stiffer nucleus.
MIT engineers have developed a simple, cheap, paper test that could improve diagnosis rates and help people get treated earlier. The diagnostic, which works much like a pregnancy test, could reveal within minutes, based on a urine sample, whether a person has cancer.
Researchers report two breakthroughs in understanding lesions in the pancreas and its ducts and their role in pancreatic cancer: the development of the first mouse model that simulates a precursor lesion called intraductal papillary mucinous neoplasia (IPMN), and the identification of an enzyme, Brg1, that appears to help cause the formation of IPMN lesions while also suppressing another precursor lesion.
Ovarian cancer accounts for more deaths of American women than any other cancer of the female reproductive system. A researcher has proposed a new strategy to tackle an aggressive subtype of ovarian cancer using a new nanoscale drug-delivery system designed to target specific cancer cells.
Pancreas cancer is notoriously impervious to treatment and resists both chemotherapy and radiotherapy. It has also been thought to provide few targets for immune cells, allowing tumors to grow unchecked. But new research shows that pancreas cancer “veils” itself from the immune system by recruiting specialized immune suppressor cells.
A dramatic rise in thyroid cancer has resulted from overdiagnosis and treatment of tumors too small to ever cause harm, according to a study that found cases nearly tripled since 1975. The study is the latest to question whether all cancers need aggressive treatment.
The St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project has identified the most common genetic alteration ever reported in the brain tumor ependymoma and evidence that the alteration drives tumor development. The results provide a foundation for new research to improve diagnosis and treatment of ependymoma, the third most common brain tumor in children.