In our sixth video, Andrew Wiecek wraps up the discussion by taking a look at one of the therapeutic areas that could be significantly improved by personalized medicine: cancer. The approach is similar to comparing apples to apples, he says.
A team of researchers have proposed that an “on and off” epigenetic switch could be a common mechanism behind the development of different types of cancer. The current paradigm states that cancer develops from environmental and genetic changes to cancer progenitor cells. These changes are the result of mutations, exposure to toxic substances, or hormonal imbalances. Cancer progression, however, is extremely complex.
There is bad news for those who believe drinking red wine is protecting their hearts and extending their lives. A study found that a plant compound in grapes—resveratrol—may not provide such health benefits. The nine-year study found resveratrol had no significant effect on longevity, inflammation, cardiovascular disease, or cancer.
In a proof-of-principle clinical trial, researchers have demonstrated that virotherapy— destroying cancer with a virus that infects and kills cancer cells but spares normal tissues— can be effective against the deadly cancer multiple myeloma.
Breastfeeding, tubal ligation– also known as having one’s “tubes tied”– and oral contraceptives may lower the risk of ovarian cancer for some women with BRCA gene mutations, according to a new comprehensive analysis.
Much like using dimmer switches to brighten or darken rooms, biochemists have identified a protein that can be used to slow down or speed up the growth of brain tumors in mice.
Cervical cancer rates in the United States are higher than previously believed, particularly among 65- to 69-year-old women and African-American women, according to a study led by a researcher at the University of Maryland School of Medicine.
A new study provides evidence that genetically modifying immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014.
A newly discovered gene linked to esophageal cancer holds the promise of new treatments for up to 15 percent of the 8,500 people diagnosed with esophageal cancer in the UK every year.
Oxford Gene Technology (OGT) released a new microarray designed to improve the accuracy and efficiency of cancer research. The CytoSure Cancer +SNP array (4x180k) combines long oligo array comparative genomic hybridisation (aCGH) probes with fully validated single nucleotide polymorphism (SNP) content.
An app called DermoScreen, which would allow users to take a photo of a suspicious mole or lesion with your phone, run it through an embedded software program and find out within a few seconds if it is likely to be cancerous, is currently being evaluated for further testing.
In a world-first, researchers have discovered one of the main reasons behind why cancer spreads throughout the body: the help of "bad" cholesterol. The research found that LDL regulates the machinery that controls cell migration.
Eczema caused by defects in the skin could reduce the risk of developing skin cancer, according to new research. The immune response triggered by eczema could help prevent tumor formation by shedding potentially cancerous cells from the skin.
Scientists at the Fred Hutchinson Cancer Research Center demonstrate that mice lacking one copy of a gene called CTCF have abnormal DNA methylation and are markedly predisposed to cancer. CTCF is a very well-studied DNA binding protein that exerts a major influence on the architecture of the human genome, but had not been previously linked to cancer.
Scientists identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code for proteins like regular RNA. Instead, this particular lncRNA acts as an on/off switch for a key gene whose excessive activity is tied to inflammation and cancer, COX-2.
Vitamin D deficiency was an indicator of aggressive prostate cancer and spread of the disease in European-American and African-American men who underwent their first prostate biopsy because of abnormal prostate-specific antigen and/or digital rectal examination test results, according to a study.
Researchers have successfully used stem cells derived from human body fat to deliver biological treatments directly to the brains of mice with glioblastomas, the most common and aggressive form of brain tumor, significantly extending their lives.
Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors to hereditary cancer risk in the human population. Now, investigators are reporting a new mechanism by which BRCA gene loss may accelerate cancer-promoting chromosome rearrangements.
Researchers found that the protein DAZAP1 plays a key role in the regulation of many genes through a process known as alternative splicing, and when highly expressed in cancer cell line experiments, DAZAP1 was shown to inhibit several types of cancer cells from dividing and moving.
Scientists have identified one of the molecular pathways that resveratrol, the component of grapes and red wine associated with health benefits, uses to achieve its beneficial action.
Scientists studying cancerous tumor tissues in a laboratory believe they have identified a potential new strategy to treat ovarian cancer by targeting ovarian tumor growth through the inhibition of the development of new tumor blood vessels.
Using a mixture of cervical cancer cells and a hydrogel substance that resembles an ointment balm, an engineer has devised a method for 3-D printing tumors that could soon be taking cancer research out of the petri dish.
Federal health regulators have cleared a genetic test from Roche as a first-choice screening option for cervical cancer. It was a role previously reserved for the Pap smear, the decades-old mainstay of women's health.
New research reveals that a process that forms a key element in the development of the nervous system may also play a pivotal role in the spread of breast cancer.
The humble aspirin may have just added another beneficial effect beyond its ability to ameliorate headaches and reduce the risk of heart attacks: lowering colon cancer risk among people with high levels of a specific type of gene.