Scientists report that they observed a strong and selective immune response in chronic lymphocytic leukemia (CLL) patients who received, shortly after donor transplant, several doses of a “personalized” tumor vaccine, composed of their own inactivated leukemia cells combined with an immune stimulant.
Neurosurgeons from University of California, San Diego are among the first in the world to utilize real-time magnetic resonance imaging (MRI) guidance for delivery of gene therapy as a potential treatment for brain tumors. Using MRI navigational technology, neurosurgeons can inject a novel investigational gene therapy directly into a brain malignancy.
Cancer drugs known as ErbB inhibitors have shown great success in treating patients with various types of cancer, but due to ErbB drug resistance, many other patients do not respond or have tumors come back. A new study reveals that much of this resistance develops because a protein called AXL helps cancer cells to circumvent the drug's effects.
The painful, red skin that comes from too much time in the sun is caused by a molecule abundant in the skin's epidermis, a new study shows. Blocking this molecule, called TRPV4, greatly protects against the painful effects of sunburn. The research could yield a way to combat sunburn and possibly several other causes of pain.
Patients with celiac disease who had persistent intestine damage (identified with repeat biopsy) had a higher risk of lymphoma than patients whose intestines healed, according to a new study. The damage is due to a reaction to eating gluten, which is found in wheat, barley and rye.
Researchers have developed a new endoscopy technology that could make it easier for doctors to detect precancerous lesions in the colon. The new technique, known as photometric stereo endoscopy, can capture topographical images of the colon surface along with traditional two-dimensional images.
Glioblastoma is the most aggressive form of primary brain tumors. A team of brain tumor researchers has been using a unique way to peer into the brain to determine whether a certain drug therapy may be effective at treating these notoriously resistant brain tumors.
Research shows that if a patient's gastrointestinal tract remains healthy and functioning during chemotherapy treatment, the patient's chances of survival increase exponentially. Recently, scientists discovered a biological mechanism that preserves the gastrointestinal tracts in mice who were delivered lethal doses of chemotherapy.
One major hallmark of cancer cells is their ability to survive under stressful conditions. A new study reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress.
A long-standing mystery in cancer is how cancerous cells move from being dormant to being metastatic. Now, a team of researchers from Lawrence Berkeley Laboratory (LBL) and the Weill Cornell Medical College believe they have identified the microenvironment that contributes to the change of state of the cells.
A team of scientists has identified genes that are potential targets for therapeutic drugs against aggressive breast cancer. Out of the 1.5 million women diagnosed with breast cancer in the world annually, nearly one in seven of these is classified as triple negative.
Modern genomics has shown that just one DNA mutation can be the difference between successfully treating a disease and having it spread rampantly throughout the body. Now, researchers have developed a new method that can look at a specific segment of DNA and pinpoint a single mutation.
The taller a postmenopausal woman is, the greater her risk for developing cancer, according to a new study. Height was linked to cancers of the breast, colon, endometrium, kidney, ovary, rectum, and thyroid, as well as to multiple myeloma and melanoma.
Scientists have revealed new images which provide the clearest picture yet of how white blood immune cells attack viral infections and tumors. They show how the cells change the organization of their surface molecules when activated by a type of protein found on viral-infected or tumor cells.
Borrowing a tool from molecular biology, researchers have detected a tumor-associated genetic mutation in the cerebrospinal fluid (CSF) of a small number of patients with brain tumors. The investigators used digital versions of the gene-amplification technology polymerase chain reaction (PCR) to analyze bits of RNA carried in membrane-covered sacs.
The first time Miriam Lipton had breast cancer, her thick hair fell out two weeks after starting chemotherapy. The second time breast cancer struck, Lipton gave her scalp a deep chill and kept much of her hair — making her fight for survival seem a bit easier. Hair loss is one of chemotherapy's most despised side effects, not because of vanity but because it fuels stigma.
Protein production or translation is tightly coupled to a highly conserved stress response that cancer cells rely on for survival and proliferation, according to researchers. In mouse models of cancer, targeted therapeutic inhibition of translation disrupts this survival response, dramatically slowing tumor growth and potentially rendering drug-resistant tumors vulnerable to other therapies.
An experimental drug in early development for aggressive brain tumors can cross the blood-brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a new study. The laboratory and animal study also shows how the agent, called SapC-DOPS, targets tumor cells and blood vessels.
Surgeons may have a new way to smoke out cancer. An experimental surgical knife can help surgeons make sure they've removed all the cancerous tissue, doctors reported Wednesday. Surgeons typically use knives that heat tissue as they cut, producing a sharp-smelling smoke. The new knife analyzes the smoke and can instantly signal whether the tissue is cancerous or healthy.
Scientists have developed a histology expression predictor for the most common types of lung cancer: adenocarcinoma, carcinoid, small cell carcinoma and squamous cell carcinoma. This predictor can confirm histologic diagnosis in routinely collected paraffin samples of patients’ tumors and can complement and corroborate pathologists’ findings.
A new study reports the first proof of cancer’s ability to fuse with blood, giving cancer the ability to travel and seeding sites of metastasis around the body. The work used DNA fingerprinting of a bone marrow transplant patient with cancer, along with DNA fingerprinting of the patient’s bone marrow donor, to show that metastatic cancer cells carried parts of both genomes, fused together into a hybrid cancer cell.
A type of genetic abnormality linked to cancer is more common in people with type 2 diabetes than the rest of the population, a new study has found. People with type 2 diabetes are already known to have a higher risk of cancers, especially blood cancers like lymphoma and leukemia. The new study suggests that mutations called clonal mosaic events (CMEs) may partly explain why this is.
ASU's Paul Davies has proposed a new way to look at cancer, by tracing its deep evolutionary roots to the dawn of multicellularity more than a billion years ago. If this theory is correct, it promises to transform the approach to cancer therapy, and to link the origin of cancer to the origin of life and the developmental processes of embryos.
A pair of studies by a team of researchers sheds light on a biological process that is activated across a vast range of malignancies. Wnt proteins are a large family of proteins that activate signaling pathways (a set of biological reactions in a cell) to control several vital steps in embryonic development.
A team of scientists has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells. Their findings on telomeres, the stretches of DNA at the ends of chromosomes that protect our genetic code and make it possible for cells to divide, suggest a potential target for preventive measures against cancer, aging and other diseases.