Twelve years ago, researchers found that a protein called Set2 plays a role in how yeast genes are expressed– specifically how DNA gets transcribed into messenger RNA. Now, it has been discovered that Set2 is also a major player in DNA repair, a complicated and crucial process that can lead to the development of cancer cells.
New genomic research revealed that two common gene variants that lead to longer telomeres, the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging, also significantly increase the risk of developing the deadly brain cancers known as gliomas.
Vitamin D has been shown to play an important role in liver function. Now, a new study in Western Europeans shows that vitamin D lowers the risk of developing hepatocellular carcinoma (HCC), the main form of liver cancer.
Metastatic cancer cells, which can migrate from primary tumors to seed new malignancies, have thus far been resistant to the current arsenal of anticancer drugs. Now, researchers have identified a critical weakness that actually exploits one of these cells’ apparent strengths—their ability to move and invade tissues.
Improved diagnosis and management of one of the most common cancers in men- prostate cancer- could result from research, which has discovered that seminal fluid (semen) contains biomarkers for the disease.
Surgery and radiation for a glioblastoma have only limited effectiveness because the tumor is particularly aggressive, infiltrating brain tissue surrounding the primary tumor. Scientists have developed a technique designed to open the blood-brain barrier at targeted locations just far enough to allow the passage of drug-bearing nanoparticles.
A test that counts the number of locations in tumor specimens where tumor cells may invade blood vessels predicted the risk of distant spread, or metastasis, for the most common type of breast cancer.
Researchers are reporting promising treatment milestones for patients with deadly skin and lung cancers who are being treated with an experimental drug called MK-3475.
New research confirms a vulnerability to lung cancer can be inherited and implicates the BRCA2 gene as harboring one of the involved genetic mutations. The study scanned the genomes of more than 11 thousand individuals of European descent to look for common variations associated with non-small cell carcinoma. The analysis showed that variations in the BRCA2 and CHEK2 genes can significantly increase an individual's risk for lung cancer.
Among men treated for prostate cancer, those who received radiation therapy were more likely to develop bladder or rectal cancer, according to a new study.
A multicenter team of researchers report that a commercial test designed to rule out the presence of genetic biomarkers of prostate cancer may be accurate enough to exclude the need for repeat prostate biopsies in many— if not most— men.
The risk of developing the most deadly form of skin cancer, melanoma, was more closely related to sun exposure in early life than in adulthood in young Caucasian women, according to a new study.
UT Southwestern Medical Center cancer researchers have identified a protein critical to the spread of deadly cancer cells and determined how it works, paving the way for potential use in diagnosis and eventually possible therapeutic drugs to halt or slow the spread of cancer.
Could a common sexually transmitted infection boost a man’s risk for prostate cancer? A new study is exploring the connection between prostate cancer and the parasite that causes trichomoniasis, the most common non-viral sexually transmitted infection in men and women.
Accumulation of DNA damage can cause aggressive forms of cancer and accelerated aging, so the body’s DNA repair mechanisms are normally key to good health. However, in some diseases the DNA repair machinery can become harmful. Now, scientists have discovered some of the key proteins involved in one type of DNA repair gone awry.
In a discovery at the Children’s Medical Center Research Institute at UT Southwestern (CRI), a research team has taken a significant step in cracking the code of an atypical metabolic pathway that allows certain cancerous tumors to thrive, providing a possible roadmap for defeating such cancers.
Working with mice, researchers report they have identified chemical signals that certain breast cancers use to recruit two types of normal cells needed for the cancers’ spread.
Scientists have shown how switching off a key protein in pancreatic cells slows the spread of the disease to other tissues, a key step which can mean patients have just weeks to live.
In our sixth video, Andrew Wiecek wraps up the discussion by taking a look at one of the therapeutic areas that could be significantly improved by personalized medicine: cancer. The approach is similar to comparing apples to apples, he says.
A team of researchers have proposed that an “on and off” epigenetic switch could be a common mechanism behind the development of different types of cancer. The current paradigm states that cancer develops from environmental and genetic changes to cancer progenitor cells. These changes are the result of mutations, exposure to toxic substances, or hormonal imbalances. Cancer progression, however, is extremely complex.
There is bad news for those who believe drinking red wine is protecting their hearts and extending their lives. A study found that a plant compound in grapes—resveratrol—may not provide such health benefits. The nine-year study found resveratrol had no significant effect on longevity, inflammation, cardiovascular disease, or cancer.
In a proof-of-principle clinical trial, researchers have demonstrated that virotherapy— destroying cancer with a virus that infects and kills cancer cells but spares normal tissues— can be effective against the deadly cancer multiple myeloma.
Breastfeeding, tubal ligation– also known as having one’s “tubes tied”– and oral contraceptives may lower the risk of ovarian cancer for some women with BRCA gene mutations, according to a new comprehensive analysis.
Much like using dimmer switches to brighten or darken rooms, biochemists have identified a protein that can be used to slow down or speed up the growth of brain tumors in mice.
Cervical cancer rates in the United States are higher than previously believed, particularly among 65- to 69-year-old women and African-American women, according to a study led by a researcher at the University of Maryland School of Medicine.