In an advance that could lead to better identification of malignant pediatric adrenocortical tumors, and ultimately to better treatment, researchers have mapped the “genomic landscape” of these rare childhood tumors. Their genomic mapping has revealed unprecedented details, not only of the aberrant genetic and chromosomal changes that drive the cancer, but the sequence of those changes that trigger it.
Researchers have developed a new technique to understand the actions of key proteins required for cancer cells to proliferate.
Testing breast cancer cells for how closely they resemble stem cells could identify women with the most aggressive disease, a new study suggests.
A provocative study in mice suggests something as simple as breathing in extra oxygen might give immune cells a boost in attacking cancer.
Tumor recurrence following a period of remission is the main cause of death in cancer. The ability of cancer cells to remain dormant during and following therapy, only to be reactivated at a later time, frequently with greater aggressiveness, is one of the least-understood aspects of the disease.
Tiny particles embedded in gel can turn off drug-resistance genes, then release cancer drugs.
Genetically engineered T memory stem cells (Tscm) can last more than 12 years in patients’ bodies, and can continually generate appropriate T cell armies for them, says an innovative study looking at two historic clinical trials.
A technique developed by researchers has implications for understanding how cancer cells evolve as a tumor grows or how a virus spreads and changes during an infection.
Scientists have used graphene to target and neutralize cancer stem cells while not harming other cells.
Researchers have identified a previously unknown effect of vitamin A in human embryonic development.
Investigators administered a customized genetic construct consisting of tiny rings of DNA, called DNA minicircles, to mice.
Like a stealth jet cloaks itself from radar, cancer cells cloak themselves within tumors by hiding behind a dense layer of cellular material known as stroma.
Using antibodies from camels and alpacas, scientists have found a way to deliver anticancer viruses directly to tumor cells, leaving other types of cells uninfected.
Nanometer-sized “drones” that deliver a special type of healing molecule to fat deposits in arteries could become a new way to prevent heart attacks caused by atherosclerosis.
Scientists are interested in using gels to deliver drugs because they can be molded into specific shapes and designed to release their payload over a specified time period. However, current versions aren’t always practical because must be implanted surgically.
Findings advance efforts to identify who would benefit from more aggressive therapy at earliest stages.
A MIT researcher wants to bring advances in drug delivery and biomaterials to the clinic.
Breast cancer, prostate cancer, and even routine infections. A new report ties these and other maladies to smoking and said an additional 60,000 to 120,000 deaths each year in the United States are probably due to tobacco use.
Most of the genetic mutations that cause cancer result from environmental ‘damage’ (for example, through smoking or as a result of over-exposure to sunlight) or from spontaneous errors as cells divide.
Silibinin has an outstanding safety profile in humans and is currently used for the treatment of liver disease and poisoning.
University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis. Their three-dimensional cell-culture system, adapted for high-throughput screening, has enabled them to identify small molecules that can inhibit adhesion and invasion, preventing ovarian cancers from spreading to nearby tissues.
The researchers, from Cancer Research UK's Health Behaviour Research Centre at University College London (UCL), interviewed almost 1,900 people aged 50-80 years old about their views on cancer screening.
Firsthand experience working in hospitals and clinics helped inspire third-year Stanford medical student Pelu Tran to explore a potential career path in the world of high-tech startups.
In the 1980s, immunotherapy researcher Lieping Chen, M.D., Ph.D., embraced the career goal of curing one cancer. That lofty-seeming goal is beginning to look more modest today. Recent clinical trials have shown that one cancer after another is vulnerable to immune modulation therapy, a cancer-fighting strategy Chen pioneered that for years was considered marginal.
Despite improvements in the past few decades with surgery, chemotherapy and radiation therapy, a predictably curative treatment for glioma does not yet exist. New insights into specific gene mutations that arise in this often deadly form of brain cancer have pointed to the potential of gene therapy, but it’s very difficult to effectively deliver toxic or missing genes to cancer cells in the brain.