Researchers completed a study that generated pseudogene expression profiles in 2,808 patient samples representing seven cancer types. The results indicated that the science of pseudogene expression analysis may very well play a key role in explaining how cancer occurs.
Scientists have shown that a member of the protein family known as SUMO (small ubiquitin-like modifier) is a key to why tumor cells multiply uncontrollably, especially in the case of glioblastoma.
A new study by radiation oncologists has found that proton beam therapy significantly improved disease free survival and tumor control when compared to IMRT in a variety of advanced head and neck cancers.
Researchers at the University of California, San Diego School of Medicine say a protein essential to regulating cell cycle progression – the process of cell division and replication – activates a key tumor suppressor, rather than inactivating it as previously thought.
A genomic analysis of clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, from 72 patients has uncovered 31 genes that are key to development, growth and spread of the cancer, according to researchers.
Almost 40 percent of pancreatic cancers– one of the deadliest forms of cancer– could be avoided in the UK through maintaining a healthy weight and not smoking, according to new research.
The risk of developing cancer increases with age. Factors like smoking and regular aspirin use also affect the risk of cancer—although in the opposite sense. Researchers from the University of Basel were now able to show that aspirin use and smoking both influence aging processes of the female genome that are connected to colorectal cancer.
A new study has revealed that the gene Metadherin— which is implicated in promoting the spread of breast cancer tumors— only stimulates tumor growth when the protein made by the gene interacts with a second protein known as SND1.
The longer a person took low-dose aspirin, the lower their risk for developing pancreatic cancer, according to a recently published study. Men and women who took low-dose aspirin regularly had 48 percent reduction in their risk for developing pancreatic cancer. Protection ranged from 39 percent reduction in risk for those who took low-dose aspirin for six years or less, to 60 percent reduction for those who took it for more than 10 years.
3-D mammograms may be better at finding cancer than regular scans, a large study suggests, although whether that means saving more lives isn't known. The study involved almost half a million breast scans, with more than one-third of them using relatively new 3-D imaging along with conventional scans.
Supercomputer simulations have shown that clusters of a protein linked to cancer warp cell membranes, according to scientists at The University of Texas Health Science Center at Houston (UTHealth) Medical School. This research on these protein clusters, or aggregates as scientists call them, could help guide design of new anticancer drugs.
Lung cancer causes more deaths in the U.S. than the next three most common cancers combined. The reason for the striking mortality rate is simple: poor detection. Lung cancer attacks without leaving any fingerprints, quietly afflicting its victims and metastasizing uncontrollably—to the point of no return. Now a new device may turn the tide by both accurately detecting lung cancer and identifying its stage of progression.
In the latest major study to consider whether the dangers of mammograms outweigh the benefits, experts say the tests can reduce the chances of dying from breast cancer by nearly 30 percent and that national screening programs should continue.
Everyone loves a grand slam: the crack of the bat, the arc of the ball as it sails over the fence, a tip of the batter’s cap, a triumphal trot around as the bases empty out, but really, it’s the lesser efforts that made it all possible—a double, a single, a walk—it’s the incremental gains that win the game. It’s called Small Ball. This year’s ASCO, absent the heavy hitters, was all about the small ball.
Melbourne researchers have shown a type of leukemia can be successfully ‘reversed’ by coaxing the cancer cells back into normal development. The discovery was made using a model of B-progenitor acute lymphoblastic leukemia (B-ALL), the most common cancer affecting children.
A new study shows that a tumor-associated lipid stimulates specific T cells, which efficiently kill leukemia cells both in vitro and in animal models.
Scientists from the Broad Institute and Massachusetts General Hospital (MGH) have conducted a first-of-its-kind study that characterizes the cellular diversity within glioblastoma tumors from patients. The study, which looked at the expression of thousands of genes in individual cells from patient tumors, revealed that the cellular makeup of each tumor is more heterogeneous than previously suspected.
Federal funding for cancer research has diminished over the last ten years, and the negative impact on research is now apparent. There were no blockbuster revelations, no flashy new kid on the block, no miracle cures at this year’s ASCO. Of the four studies selected for the plenary session (where presentations are often THE important findings of the conference), only one is predicted to have a major impact on patient care.
By themselves, PAX3 and MAML3 don’t cause any problems. However, when they combine during an abnormal but recurring chromosomal mismatch, they can be dangerous. The result is a chimera—a gene that is half of each—and that causes biphenotypic sinonasal sarcoma. The tumor usually begins in the nose and may infiltrate the rest of the face, requiring disfiguring surgery to save the individual.
Women who often indulge their cravings for hamburgers, steaks and other red meat may have a slightly higher risk of breast cancer, a new study suggests. Doctors have long warned that a diet loaded with red meat is linked to cancers including those of the colon and pancreas, but there has been less evidence for its role in breast cancer.
Scientists at UC Santa Barbara have designed a nanoparticle that has a couple of unique — and important — properties. Spherical in shape and silver in composition, it is encased in a shell coated with a peptide that enables it to target tumor cells. What’s more, the shell is etchable so those nanoparticles that don’t hit their target can be broken down and eliminated.
Twelve years ago, researchers found that a protein called Set2 plays a role in how yeast genes are expressed– specifically how DNA gets transcribed into messenger RNA. Now, it has been discovered that Set2 is also a major player in DNA repair, a complicated and crucial process that can lead to the development of cancer cells.
New genomic research revealed that two common gene variants that lead to longer telomeres, the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging, also significantly increase the risk of developing the deadly brain cancers known as gliomas.
Vitamin D has been shown to play an important role in liver function. Now, a new study in Western Europeans shows that vitamin D lowers the risk of developing hepatocellular carcinoma (HCC), the main form of liver cancer.
Metastatic cancer cells, which can migrate from primary tumors to seed new malignancies, have thus far been resistant to the current arsenal of anticancer drugs. Now, researchers have identified a critical weakness that actually exploits one of these cells’ apparent strengths—their ability to move and invade tissues.