Regardless of their stage or type, cancers appear to share a telltale signature of widespread changes to the so-called epigenome, according to a team of researchers. In a study of a broad variety of cancers the investigators say they have found widespread and distinctive changes to chemical marks known as methyl groups attached to DNA.
Researchers have devised a new way to separate cells by exposing them to sound waves as they flow through a tiny channel. Their device could be used to detect the extremely rare tumor cells that circulate in cancer patients’ blood.
Cancer, while always dangerous, truly becomes life-threatening when cancer cells begin to spread to different areas throughout the body. Now, researchers have discovered that a molecule used as a communication system by bacteria can be manipulated to prevent cancer cells from spreading.
A large new study found that when post-menopausal women stop physical activity, their odds of developing breast cancer rise. But, the study also found that breast cancer risk drops surprisingly rapidly after exercise starts.
Researchers have developed a new integrated approach to pinpoint the genetic “drivers” of cancer, uncovering eight genes that could be viable for targeted breast cancer therapy.
Research shows that nerves may play a critical role in stomach cancer growth and that blocking nerve signals using surgery or Botox (onabotulinumtoxinA) could be an effective treatment for the disease.
Scientists have made it easier to predict both breast cancer relapses and responses to chemotherapy, through the identification of a unique gene, a new study shows.
NGS is revolutionizing the field of genome biology, with much faster data generation, increased accuracy, and a dramatic reduction of sequencing costs. Multiple genomes can now be sequenced in parallel by a single instrument in a matter of days. In the medical field, NGS is already having an impact in genetic screening and holds great potential in oncology, given the genetic aspects of cancerous disease.
Links between a number of common respiratory diseases and an increased risk of developing lung cancer have been found in a large pooled analysis of seven studies involving more than 25,000 individuals.
Melbourne researchers have revealed the critical importance of highly specialized immune cells, called natural killer cells, in killing melanoma cells that have spread to the lungs. These natural killer cells could be harnessed to hunt down and kill cancers that have spread in the body.
A modified version of the Clostridium novyi (C. novyi-NT) bacterium can produce a strong and precisely targeted anti-tumor response in rats, dogs and now humans, according to a new report.
In this episode of Bioscience Technology This Week, Rob Fee discusses how studying fruit flies could revolutionize diabetes research. Our second story focuses on how venom could form the basis of a new class of cancerfighting drugs.
Scientists have known for decades that cancer can be caused by genetic mutations, but more recently they have discovered that chemical modifications of a gene can also contribute to cancer. These alterations, known as epigenetic modifications, control whether a gene is turned on or off.
Oncologists are melding magnetic resonance imaging (MRI) technology with a traditional ultrasound prostate exam to create a three-dimensional map of the prostate that allows physicians to view growths that were previously undetectable.
Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified a gene that contributes to the development of several childhood cancers, in a study conducted with mice designed to model the cancers. If the findings prove to be applicable to humans, the research could lead to new strategies for targeting certain childhood cancers at a molecular level.
Researchers from The University of Texas at Austin and five other institutions have created a molecule that can cause cancer cells to self-destruct by ferrying sodium and chloride ions into the cancer cells. These synthetic ion transporters confirm a two-decades-old hypothesis that could point the way to new anticancer drugs while also benefiting patients with cystic fibrosis.
Dangerous brain tumors hijack the brain’s existing blood supply throughout their progression, by growing only within narrow potential spaces between and along the brain’s thousands of small blood vessels, new research shows for the first time.
Researchers have hijacked a defense system normally used by bacteria to fend off viral infections and redirected it against the human papillomavirus (HPV), the virus that causes cervical, head and neck, and other cancers.Using the genome editing tool known as CRISPR, the Duke University researchers were able to selectively destroy two viral genes responsible for the growth and survival of cervical carcinoma cells.
Scientists from the University of Leeds have discovered a gene that plays a vital role in blood vessel formation, research which adds to our knowledge of how early life develops. The discovery could also lead to greater understanding of how to treat cardiovascular diseases and cancer.
Cancer cells that break away from tumors to go looking for a new home may prefer to settle into a soft bed. Some particularly enterprising cancer cells can cause a cancer to spread to other organs, called metastasis, or evade treatment to resurface after a patient is thought to be in remission. A team found that these so-called tumor-repopulating cells may lurk quietly in stiffer cellular environments, but thrive in a softer space.
Researchers with The Cancer Genome Atlas (TCGA) Research Network have completed the largest, most diverse tumor genetic analysis ever conducted, revealing a new approach to classifying cancers. The work not only revamps traditional ideas of how cancers are diagnosed and treated, but could also have a profound impact on the future landscape of drug development.
It's long been known that faulty BRCA genes greatly raise the risk for breast cancer. Now, scientists say a more recently identified, less common gene - called PALB2 - can do the same.
Researchers have achieved a technical breakthrough that should result in speedier diagnosis of cancer and various pre-natal conditions. The key discovery lies in a new tool that allows researchers to load long strands of DNA into a tunable nanoscale imaging chamber in ways that maintain their structural identity and under conditions that are similar to those found in the human body.
A large DNA analysis of people with and without pancreatic cancer has identified several new genetic markers that signal increased risk of developing the highly lethal disease, scientists report.
Researchers report that dietary capsaicin– the active ingredient in chili peppers– produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.