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Study Affirms Value of Epigenetic Test for Prostate Cancer Markers

May 29, 2014 2:11 pm | News | Comments

A multicenter team of researchers report that a commercial test designed to rule out the presence of genetic biomarkers of prostate cancer may be accurate enough to exclude the need for repeat prostate biopsies in many— if not most— men.    

Five Blistering Sunburns Can Up Melanoma Risk 80 Percent

May 29, 2014 2:04 pm | News | Comments

The risk of developing the most deadly form of skin cancer, melanoma, was more closely related to sun exposure in early life than in adulthood in young Caucasian women, according to a new study.                

New Mechanism Explains How Cancer Cells Spread

May 29, 2014 1:33 pm | News | Comments

UT Southwestern Medical Center cancer researchers have identified a protein critical to the spread of deadly cancer cells and determined how it works, paving the way for potential use in diagnosis and eventually possible therapeutic drugs to halt or slow the spread of cancer.

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STI May Increase Prostate Cancer Risk

May 28, 2014 1:24 pm | News | Comments

Could a common sexually transmitted infection boost a man’s risk for prostate cancer? A new study is exploring the connection between prostate cancer and the parasite that causes trichomoniasis, the most common non-viral sexually transmitted infection in men and women.

Misguided DNA-Repair Proteins Caught in the Act

May 23, 2014 12:06 pm | News | Comments

Accumulation of DNA damage can cause aggressive forms of cancer and accelerated aging, so the body’s DNA repair mechanisms are normally key to good health. However, in some diseases the DNA repair machinery can become harmful. Now, scientists have discovered some of the key proteins involved in one type of DNA repair gone awry.

Researchers Identify Key Mechanism in Metabolic Pathway that Fuels Cancers

May 23, 2014 11:41 am | News | Comments

In a discovery at the Children’s Medical Center Research Institute at UT Southwestern (CRI), a research team has taken a significant step in cracking the code of an atypical metabolic pathway that allows certain cancerous tumors to thrive, providing a possible roadmap for defeating such cancers.

Signals Recruit Cells, Enable Breast Cancer Metastasis

May 23, 2014 11:37 am | News | Comments

Working with mice, researchers report they have identified chemical signals that certain breast cancers use to recruit two types of normal cells needed for the cancers’ spread.                     

Scientists ID Potential Way to Halt Pancreatic Cancer Spread

May 21, 2014 12:49 pm | Videos | Comments

Scientists have shown how switching off a key protein in pancreatic cells slows the spread of the disease to other tissues, a key step which can mean patients have just weeks to live.                    

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The Promise of Personalized Medicine: An Apples-to-Apples Approach

May 16, 2014 12:18 pm | Videos | Comments

In our sixth video, Andrew Wiecek wraps up the discussion by taking a look at one of the therapeutic areas that could be significantly improved by personalized medicine: cancer. The approach is similar to comparing apples to apples, he says.

Cancer’s Potential On-Off Switch

May 16, 2014 11:35 am | News | Comments

A team of researchers have proposed that an “on and off” epigenetic switch could be a common mechanism behind the development of different types of cancer. The current paradigm states that cancer develops from environmental and genetic changes to cancer progenitor cells. These changes are the result of mutations, exposure to toxic substances, or hormonal imbalances. Cancer progression, however, is extremely complex.

Red Wine May Not Prevent Heart Disease, Prolong Life

May 16, 2014 10:39 am | News | Comments

There is bad news for those who believe drinking red wine is protecting their hearts and extending their lives. A study found that a plant compound in grapes—resveratrol—may not provide such health benefits. The nine-year study found resveratrol had no significant effect on longevity, inflammation, cardiovascular disease, or cancer.

Measles Vaccine Can Kill Multiple Myeloma Cells

May 15, 2014 11:00 am | Videos | Comments

In a proof-of-principle clinical trial, researchers have demonstrated that virotherapy— destroying cancer with a virus that infects and kills cancer cells but spares normal tissues— can be effective against the deadly cancer multiple myeloma.   

Breastfeeding May Lower Ovarian Cancer Risk in Women with BRCA Mutations

May 14, 2014 12:50 pm | News | Comments

Breastfeeding, tubal ligation– also known as having one’s “tubes tied”– and oral contraceptives may lower the risk of ovarian cancer for some women with BRCA gene mutations, according to a new comprehensive analysis.          

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Scientists Slow Brain Tumor Growth in Mice

May 13, 2014 12:55 pm | News | Comments

Much like using dimmer switches to brighten or darken rooms, biochemists have identified a protein that can be used to slow down or speed up the growth of brain tumors in mice.                     

Cervical Cancer Rates Higher Than Reported

May 12, 2014 1:32 pm | News | Comments

Cervical cancer rates in the United States are higher than previously believed, particularly among 65- to 69-year-old women and African-American women, according to a study led by a researcher at the University of Maryland School of Medicine.

Immune Therapy Might be Effective for Multiple Myeloma

May 12, 2014 1:32 pm | News | Comments

A new study provides evidence that genetically modifying immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014.        

Newly Discovered Gene Linked to Esophageal Cancer

May 9, 2014 1:39 pm | News | Comments

A newly discovered gene linked to esophageal cancer holds the promise of new treatments for up to 15 percent of the 8,500 people diagnosed with esophageal cancer in the UK every year.                  

Microarray for Research into Haematological and Solid Cancers

May 9, 2014 1:18 pm | Product Releases | Comments

Oxford Gene Technology (OGT) released a new microarray designed to improve the accuracy and efficiency of cancer research. The CytoSure Cancer +SNP array (4x180k) combines long oligo array comparative genomic hybridisation (aCGH) probes with fully validated single nucleotide polymorphism (SNP) content.

App Offers Quick, Inexpensive Melanoma Screening

May 7, 2014 1:00 pm | News | Comments

An app called DermoScreen, which would allow users to take a photo of a suspicious mole or lesion with your phone, run it through an embedded software program and find out within a few seconds if it is likely to be cancerous, is currently being evaluated for further testing.

'Bad' Cholesterol Helps Cancer Spread

May 7, 2014 12:48 pm | News | Comments

In a world-first, researchers have discovered one of the main reasons behind why cancer spreads throughout the body: the help of "bad" cholesterol. The research found that LDL regulates the machinery that controls cell migration.       

Having Eczema May Reduce Skin Cancer Risk

May 6, 2014 12:31 pm | News | Comments

Eczema caused by defects in the skin could reduce the risk of developing skin cancer, according to new research. The immune response triggered by eczema could help prevent tumor formation by shedding potentially cancerous cells from the skin.   

30-year Puzzle in Breast Cancer Solved

May 2, 2014 1:29 pm | News | Comments

Scientists at the Fred Hutchinson Cancer Research Center demonstrate that mice lacking one copy of a gene called CTCF have abnormal DNA methylation and are markedly predisposed to cancer. CTCF is a very well-studied DNA binding protein that exerts a major influence on the architecture of the human genome, but had not been previously linked to cancer.

Novel Regulator of Key Gene Expression in Cancer Identified

May 1, 2014 1:58 pm | News | Comments

Scientists identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code for proteins like regular RNA. Instead, this particular lncRNA acts as an on/off switch for a key gene whose excessive activity is tied to inflammation and cancer, COX-2.

Vitamin D Deficiency May Be Linked to Aggressive Prostate Cancer

May 1, 2014 1:46 pm | News | Comments

Vitamin D deficiency was an indicator of aggressive prostate cancer and spread of the disease in European-American and African-American men who underwent their first prostate biopsy because of abnormal prostate-specific antigen and/or digital rectal examination test results, according to a study.

Human Fat: A Trojan Horse to Fight Brain Cancer?

May 1, 2014 1:13 pm | News | Comments

Researchers have successfully used stem cells derived from human body fat to deliver biological treatments directly to the brains of mice with glioblastomas, the most common and aggressive form of brain tumor, significantly extending their lives.

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