Scientists at the Salk Institute have identified a gene responsible for stopping the movement of cancer from the lungs to other parts of the body, indicating a new way to fight one of the world's deadliest cancers. By identifying the cause of this metastasis—which often happens quickly in lung cancer and results in a bleak survival rate—Salk scientists are able to explain why some tumors are more prone to spreading than others.
Researchers have uncovered a genetic vulnerability of cancer cells that express telomerase— an enzyme that drives their unchecked growth— and showed that telomerase-expressing cells depend upon a gene named p21 for their survival.
In recent years, aggressive research and substantial financial investments have been directed at discovering pre-symptomatic indicators of cancer, known as biomarkers. But as lead author researchers at Arizona State University’s Biodesign Institute emphasize in a new study, the quest for cancer biomarkers has been stymied by a number of factors. They describe a new technique for early disease detection, which they call immunosignaturing.
Scientists at the University of East Anglia have shown how the main psychoactive ingredient in cannabis could reduce tumor growth in cancer patients. Research reveals the existence of previously unknown signaling platforms which are responsible for the drug’s success in shrinking tumors. It is hoped that the findings could help develop a synthetic equivalent with anti-cancer properties.
Bowel cancer patients with high levels of vitamin D in their blood are more likely to survive the disease, a new study shows. Patients with the highest levels of vitamin D have half the risk of dying compared with those with the lowest levels, the findings reveal.
Researchers have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer. Knowledge of these genomic changes may expand the number of possible therapeutic targets for this disease and potentially identify a greater number of patients with treatable mutations because many potent cancer drugs that target these mutations already exist.
Mice exposed to low doses of arsenic in drinking water, similar to what some people might consume, developed lung cancer, researchers have found. Arsenic is present in the environment as a naturally occurring substance or due to contamination from human activity.
A breakthrough discovery into how living cells process and respond to chemical information could help advance the development of treatments for a large number of cancers and other cellular disorders that have been resistant to therapy. An international collaboration of researchers unlocked the secret behind the activation of the Ras family of proteins.
Insights into how cells move through the body could lead to innovative techniques to stop cancer cells from spreading and causing secondary tumors, according to new UCL research. Scientists discovered that cells can change into an invasive, liquid-like state to readily navigate the narrow channels in our body.
A few therapies derived from human medicine are available for dogs, but a very successful form of therapy by which antibodies inhibit tumor growth has not yet been available for animals. Now, scientists have developed, for the first time, antibodies to treat cancer in dogs.
An association between high blood cholesterol and breast cancer has been found in a study of more than 1 million patients over a 14-year time period in the UK.
Researchers completed a study that generated pseudogene expression profiles in 2,808 patient samples representing seven cancer types. The results indicated that the science of pseudogene expression analysis may very well play a key role in explaining how cancer occurs.
Scientists have shown that a member of the protein family known as SUMO (small ubiquitin-like modifier) is a key to why tumor cells multiply uncontrollably, especially in the case of glioblastoma.
A new study by radiation oncologists has found that proton beam therapy significantly improved disease free survival and tumor control when compared to IMRT in a variety of advanced head and neck cancers.
Researchers at the University of California, San Diego School of Medicine say a protein essential to regulating cell cycle progression – the process of cell division and replication – activates a key tumor suppressor, rather than inactivating it as previously thought.
A genomic analysis of clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, from 72 patients has uncovered 31 genes that are key to development, growth and spread of the cancer, according to researchers.
Almost 40 percent of pancreatic cancers– one of the deadliest forms of cancer– could be avoided in the UK through maintaining a healthy weight and not smoking, according to new research.
The risk of developing cancer increases with age. Factors like smoking and regular aspirin use also affect the risk of cancer—although in the opposite sense. Researchers from the University of Basel were now able to show that aspirin use and smoking both influence aging processes of the female genome that are connected to colorectal cancer.
A new study has revealed that the gene Metadherin— which is implicated in promoting the spread of breast cancer tumors— only stimulates tumor growth when the protein made by the gene interacts with a second protein known as SND1.
The longer a person took low-dose aspirin, the lower their risk for developing pancreatic cancer, according to a recently published study. Men and women who took low-dose aspirin regularly had 48 percent reduction in their risk for developing pancreatic cancer. Protection ranged from 39 percent reduction in risk for those who took low-dose aspirin for six years or less, to 60 percent reduction for those who took it for more than 10 years.
3-D mammograms may be better at finding cancer than regular scans, a large study suggests, although whether that means saving more lives isn't known. The study involved almost half a million breast scans, with more than one-third of them using relatively new 3-D imaging along with conventional scans.
Supercomputer simulations have shown that clusters of a protein linked to cancer warp cell membranes, according to scientists at The University of Texas Health Science Center at Houston (UTHealth) Medical School. This research on these protein clusters, or aggregates as scientists call them, could help guide design of new anticancer drugs.
Lung cancer causes more deaths in the U.S. than the next three most common cancers combined. The reason for the striking mortality rate is simple: poor detection. Lung cancer attacks without leaving any fingerprints, quietly afflicting its victims and metastasizing uncontrollably—to the point of no return. Now a new device may turn the tide by both accurately detecting lung cancer and identifying its stage of progression.
In the latest major study to consider whether the dangers of mammograms outweigh the benefits, experts say the tests can reduce the chances of dying from breast cancer by nearly 30 percent and that national screening programs should continue.
Everyone loves a grand slam: the crack of the bat, the arc of the ball as it sails over the fence, a tip of the batter’s cap, a triumphal trot around as the bases empty out, but really, it’s the lesser efforts that made it all possible—a double, a single, a walk—it’s the incremental gains that win the game. It’s called Small Ball. This year’s ASCO, absent the heavy hitters, was all about the small ball.