Funded by the National Cancer Institute, the Mouse Models of Human Cancer Consortium (MMHCC) supports the derivatization and validation of mouse models, as well as the generation of resources, information, and innovative approaches to the application of mouse models in cancer research.
Nucleostemin protein is found in the nucleoli of CNS stem cells, embryonic stem cells, and several cancer cell lines, and partly controls stem and cancer cell proliferation. It is not found in the differentiated cells of most adult tissues.
This kinase research solutions company is currently shipping 21 different core kinase enzymes for biomolecular screening in 24 hours at a new fixed price per milligram (mg). Cancer, diabetes, and inflammation targets are available in quantities ranging from 5 μg to milligram.
To aid research investigations on the putative role of H. pylori infection in the etiopathogenesis of gastric ulcer and/or gastric adenocarcinoma/lymphoma, Advanced Biotechnologies Inc (ABI) offers H. pylori
By Mark Terry Ovarian cancer is usually diagnosed when the cancer has already progressed to Stage 3 or 4. "At that point," says Rebecca Sutphen, MD, director, Cancer Genetic Counseling and Testing Service, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla., "the cure rate is only in the range of 25%. The problem has always been that we have no early detection strategy."
By Mark Terry Aurora kinases play a central role in controlling cell division, and have been implicated in many types of human cancer. They are shown to be deregulated in leukemia, colon, and breast cancers.
By Catherine Shaffer A team of researchers at Thomas Jefferson University, Philadelphia, led by Carlo Croce, MD, has created a powerful tool for the characterization of microRNAs or miRNAs, the newest members of the growing family of genetically significant small RNAs.
By Mark Terry CTI Molecular Imaging Inc., Knoxville, Tenn., announced at the 2004 annual meeting of the Society of Nuclear Medicine held the week of June 20th in Philadelphia, that it has formed a separate company
By Catherine Shaffer A new study published in Cancer Cell zeros in on the transcriptional regulator TAL1 (or SCL) as a culprit in the most deadly form of T cell acute lymphoblastic leukemia (T-ALL), accounting for a significant minority of all cases. Patients with T-ALL induced by TAL1 activation
By Don Monroe A small-molecule treatment for breast cancer that targets the urokinase-type plasminogen activator (uPA) system has entered phase I clinical trials. The Fox Chase Cancer Center, Philadelphia
By Catherine Shaffer Merck Co. Inc., Whitehouse Station, N.J., is gambling on an old technology to overcome obstacles in delivering new DNA vaccines. The global pharmaceutical company has recently signed an agreement with Genetronics Biomedical Corp., San Diego, to license their MedPulser DNA Delivery System, an electroporation device.
Matrix metalloproteinases (MMPs) are a group of Zn2+ dependent endopeptidases involved in remodeling and degradation of the extracellular membrane (ECM).
An expanded SNP discovery service has been launched for pre-validated sequencing assays of kinases, genes implicated in many human diseases.
New 450 kb probe detects alterations to the HER-2/ neu proto-oncogene (also called ERBB2), and is over-expressed in some breast, ovarian, prostate, and colorectal cancers, playing a possible role in tumor-cell proliferation, tumor invasion, and tumor metastasis.
Epidermal Growth Factor receptor (EGFr) 170 kDa membrane protein is expressed in many normal epithelial tissues, particularly in the basal layers of stratified or pseudostratified and squamous epitheliums.
By Catherine Shaffer The use of gene therapy in the treatment of brain cancer is hindered by drug delivery problems. Large molecules such as monoclonal antibodies and viral vectors cannot cross the blood-brain barrier. A featured article in the June 1 issue of Clinical Cancer Research now describes the successful delivery of a nonviral RNAi gene therapy to brain tumors in mice, resulting in a significant increase in survival times.
GeneFishing Technology offers a unique approach for identifying only authentic Differentially Expressed Genes (DEGs) in two or more nucleic acid samples. This technology improves specificity of PCR amplification, enabling researchers to find only real PCR products as a result.
Array-Ready Oligo Set for the Xenopus tropicalis genome contains 10,898 70-mer probes representing Xenopus transcripts.
Agilent Mouse Oligo Microarray Kit G4121A provides the ability to conduct genome-wide profiling research to better understand adverse drug reactions, physiological effects of toxins and toxic substances, and to study genetic diseases such as cancer.
Mutations in the K- ras gene codon 12 region can lead to colon, pancreas, liver, spleen, stomach, lung and other cancers. The CDKN2A/P16 gene is a familial melanoma gene. Routine PCR and DNA sequencing methods can identify exactly which point mutation is present in patient tissue samples.
By Mark Terry Cells have a finite number of divisions, and at each division, chromosome ends, or telomeres, shorten. When the telomeres diminish to a certain length, a number of complex pathways are triggered that halt cell division. In cancer, though, this signaling pathway is disrupted, resulting in unrestrained cell growth.
by Mark Terry Researchers at the Fox Chase Cancer Center, Philadelphia, linked Alzheimer's disease (AD) to a protein that helps cancer cells resist anti-tumor drugs. The protein, ABCA2, is associated with resistance to the cancer drug estramustine. It has also been linked to myelination and nervous system development. Involved in cellular transport, ABCA2 has also been associated with cholesterol loading. A recent report suggests there may be a connection between the transport molecule and the mechanisms behind AD.
by Mark Terry Researchers identified a relationship between the inverse expression of pRb2/p130 and vascular endothelial growth factor (VEGF) and tumor aggressiveness. Together, they may act as a biomarker for hepatocarcinoma (HCC) or liver cancer.
by Elizabeth Tolchin With so much genetic expression data being produced by microarrays in the study of cancer, knowing the extent to which these studies agree can provide valuable insight. That is just what researchers from Johns Hopkins University, Baltimore, set out to find.
by Elizabeth Tolchin Taking a unique approach to gene therapy, researchers at the University of Texas, M.D. Anderson Cancer Center, Houston, are investigating a new delivery method of the p53 gene for prevention of oral cancer.