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Researchers Identify Enzyme Involved in Deadly Brain Tumors

January 18, 2013 11:41 am | News | Comments

One of the most common types of brain tumors in adults, glioblastoma multiforme, is one of the most devastating. Even with recent advances in surgery, radiation and chemotherapy, the aggressive and invasive tumors become resistant to treatment, and median survival of patients is only about 15 months.

Advancing Oncology Research: Novel Assays for Epigenetics Drug Discovery

January 7, 2013 11:38 am | by David Titus, PhD and Eric Morreale PhD, Life Sciences and Technology, PerkinElmer | Articles | Comments

Epigenetics research has expanded rapidly over the last several years, as evidenced by the exponential increase in published literature in this field. Breakthroughs have been made in the elucidation of basic epigenetic mechanisms such as histone modification, and with these advances have come an understanding of the critical role epigenetic modifications play in the development and progression of cancer.

Previous Studies on Toxic Effects of BPA Couldn’t be Reproduced

January 3, 2013 11:02 am | News | Comments

Following a three-year study using more than 2,800 mice, a University of Missouri researcher was not able to replicate a series of previous studies by another research group investigating the controversial chemical BPA. The MU study is not claiming that BPA is safe, but that the previous series of studies are not reproducible.

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Spread of Cancer Cells May Be Slowed by Targeting of Protein

December 19, 2012 11:24 am | News | Comments

The spread of cancer cells may be slowed by targeting the protein km23-1. A motor protein that transports cargo within the cell, km23-1 is also involved in the movement or migration of cells. Migration is necessary for cancer to spread, so understanding this cell movement is important for development of better cancer treatments.

New Technology May Enable Earlier Cancer Diagnosis

December 17, 2012 3:41 pm | by MIT | News | Comments

Finding ways to diagnose cancer earlier could greatly improve the chances of survival for many patients. One way to do this is to look for specific proteins secreted by cancer cells, which circulate in the bloodstream. However, the quantity of these biomarkers is so low that detecting them has proven difficult. A new technology may help to make biomarker detection much easier.

Study Unravels Biological Pathway That Controls the Leakiness of Blood Vessels

December 17, 2012 10:52 am | by Mayo Clinic | News | Comments

A research team has decoded the entire pathway that regulates leakiness of blood vessels — a condition that promotes a wide number of disorders, such as heart disease, cancer growth and spread, inflammation and respiratory distress. They say their findings suggest that several agents already being tested for other conditions might reverse vessel leakiness.

Biologists Engineer Algae to Make Complex Anti-Cancer ‘Designer’ Drug

December 17, 2012 9:57 am | News | Comments

Biologists at UC San Diego have succeeded in genetically engineering algae to produce a complex and expensive human therapeutic drug used to treat cancer. Their achievement opens the door for making these and other “designer” proteins in larger quantities and much more cheaply than can now be made from mammalian cells.

New Technology Allows Scientists to Capture and Preserve Cancer Cells Circulating in the Bloodstream

December 17, 2012 9:27 am | by RIKEN Advanced Science Institute | News | Comments

Scientists report a new nanoscale Velcro-like device that captures and releases tumor cells that have broken away from primary tumors and are circulating in the bloodstream. This new nanotechnology could be used for cancer diagnosis and give insight into the mechanisms of how cancer spreads throughout the body.

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Will Epigenetics Help Overcome Cisplatin Resistance in Ovarian Cancer?

March 29, 2012 12:24 pm | by Nicole Kelesoglu | Articles | Comments

Epigenetics researchers apply sophisticated techniques and rational multidimensional analyses to discover biomarkers for ovarian cancer.

Asuragen and Life Technologies Launch Leukemia Test

August 4, 2010 10:25 am | by Edited for tone and content by Lily Barback | Articles | Comments

Asuragen, Inc. and Life Technologies Corporation announced that they have completed CE-marking and commercial launch in Europe of the BCR/ABL1 Quant Test, Asuragen's clinically validated and cGMP manufactured test intended to aid clinicians in the monitoring and treatment of individuals afflicted with chronic myeloid leukemia (CML)

Rethinking the Classics

March 26, 2010 12:04 pm | by Jeffrey M. Perkel | Articles | Comments

The classic view of cancer is that it arises from the progressive accumulation of mutations. The cancer stem cell model, however, theorizes that tumors derive hierarchically from one or more progenitor cells.

Cancer Biochip for Sequence Capture

August 26, 2009 12:43 pm | Product Releases | Comments

febit launched a human cancer biochip for HybSelect, febit's automated technology for sequence capture, enabling targeted Next-Generation Sequencing (NGS).

Single Cell Genome Amplification Kit

July 21, 2009 12:08 pm | Product Releases | Comments

Rubicon Genomics released its PicoPlex Single Cell Whole Genome Amplification (WGA) kit?a more rapid, accurate and reproducible method for amplifying single genomes than current technologies.

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SIRT1 Assay

July 21, 2009 12:08 pm | Product Releases | Comments

SIRT1 belongs to the class III family of HDACs, which are NAD+ dependent enzymes. SIRT1 modulators have been shown to play a beneficial role in treating diseases such as cancer, diabetes, metabolic disease and inflammation, making them attractive targets for the development of new drugs.

Active Kinases

June 15, 2009 8:43 am | Product Releases | Comments

Sigma-Aldrich introduced Precisio Kinases, a new collection of high quality active kinases that is expected to enable scientists to achieve greater insight into protein phosphorylation and cell signaling.

Cancer Research: Genomics Enters the Fray

February 18, 2009 6:28 am | Product Releases | Comments

caption Inset, President Nixon signing the National Cancer Act, December 23, 1971. (Source: NCI)

Vitamin E and Prostate Cancer: A Proteomics Approach Using 2-D Gel Analysis Software

February 18, 2009 6:28 am | Product Releases | Comments

caption Figure 1: Analysis of 2-D gel by Dymension software showing proteins that are up or down-regulated three hours after delta-tocotrienol treatment.

Genotyping Reagent Solution

January 22, 2009 9:57 am | Product Releases | Comments

Applied Biosystems, a division of Life Technologies, announced the availability of a new universal genotyping reagent solution that accelerates the generation of high-quality genotyping data for a host of life science applications.

PAR ELISA Assay

January 14, 2009 9:50 am | Product Releases | Comments

Trevigen introduces a highly sensitive, quantitative and validated assay to measure the effectiveness of PARP inhibitors in cell and tissue lysates for anticancer drug screening.

ECM-coated Tissue Culture Plates

December 17, 2008 6:19 am | Product Releases | Comments

Millipore has introduced a new line of tissue culture plates pre-coated with a selection of matrices that enhance cell growth and differentiation for stem cell, cancer, cell signaling, and other critical research applications.

Benchtop Flow Cytometry System

December 1, 2008 5:34 am | Product Releases | Comments

A range of assays, kits, flow cytometry systems, and service plans are available in an integrated benchtop flow cytometry portfolio.

With this assay, ADP is directly detected by a specific monoclonal antibody labeled with Eu

December 1, 2008 5:34 am | Product Releases | Comments

caption Fig.1: (a) Assay principle: HTRF Transcreener ADP assay principle: during the enzymatic step, the kinase catalyses the transfer of a phosphate group from ATP to a substrate. For ATPase, ATP is converted into ADP and inorganic phosphate. Then in the detection step, native ADP and d2 labeled ADP compete for the anti-ADP antibody labeled with Eu3+ Cryptate. The signal is inversely proportional to the concentration of ADP in the sample. (b) Standard curve: The standard curve is based on a mixture of ATP and ADP. ATP solutions are serially diluted in ADP solutions in order to mimic the conversion of ATP into ADP (from 0 to 100%): ADP concentration ranges from 0 to 100 µM final.

2D Gel Image Analysis Software

October 17, 2008 6:04 am | Product Releases | Comments

This 2D gel imager can analyze silver stained proteins derived from a prostate cancer (LNCaP) cell line treated with delta-tocotrienol, (a form of Vitamin E). Users can obtain meaningful data through manipulation of the gel images being produced to find out what is happening at the molecular level.

Plates For Genetic Case-Control Studies

October 17, 2008 6:03 am | Product Releases | Comments

This product line for disease case-control studies of DNA consists of 180 cases and 180 matched controls in ready-made 96- and 384-well plate formats with de-identified covariate data. Samples for diabetes, obesity, breast, colon, lung, and prostate cancer are available.

Antibody And Immunoassay Reference

September 17, 2008 10:59 am | Product Releases | Comments

This Antibodies and Kits Product Guide provides a comprehensive coverage of Millipore’s antibodies, immunoassay products and recombinant proteins for over 2500 unique targets.

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