HP Validated siRNAs are provided with full sequence information. They are validated for functionality by quantitative RT-PCR and provide >70% target gene knockdown in important gene families such as kinase and cancer-associated genes.
Beckman Coulter, Inc. has introduced two kits for multiplexed, quantitative gene expression analysis on their GenomeLab GeXP Genetic Analysis System. The new Human Breast CancerPlex and Human MetastasisPlex Kits assay multiple genes from a single RNA sample.
The Guava Cell Cycle Assay allows quick determination of G0/G1, S and G2/M cell cycle phases. Cell cycle phase percentages and counts are displayed on the same screen as acquisition, without requiring software set-up, making it easy to visualize the results in both histogram and statistical formats.
B-RAF assay detects V600E, the most common mutation in the B-RAF oncogene, which occurs in many types of cancer including melanoma, colorectal and lung.
The miRNA QRT-PCR detection kit uses a proprietary miRNA primer design approach to detect mature miRNA from as little as 15 ng of input, down to 100 copies, in less than three hours. Optimized QPCR reagents provide single nucleotide discrimination within and among miRNA families.
The Human Breast Cancer Plex and Human Metastasis Plex Kits assay multiple genes from a single RNA sample. Both kits run in 96-well plate format and provide high throughput. Up to 30 genes can be measured in each of hundreds of samples in one assay, useful for signature validation.
Millipore Corporation offers full-length mTOR kinase as part of their KinaseProfiler Service. The mTOR kinase has recently been linked to many important human diseases, including cancer, diabetes, obesity, cardiovascular disease ad neurological disorders.
SomaPlex slides, for screening protein biomarkers in human tumors, are arrays prepared from a vast collection of total protein lysates derived from numerous human tissues representing a range of cancer subtypes. Detailed clinical and histopathology is available for each sample.
BioStation CT cell culture observation and monitoring system allows users with minimal microscopy experience to conduct live cell imaging locally or by remote operation over a public or private network.
Source: VIB, Flanders Interuniversity Institute of Biotechnology
Three syngo software packages offer molecular imaging customers improved ease of use, improved accuracy and improved workflows in radiology, neurology, radiation oncology and general molecular imaging departments.
Source: The Scripps Research Institute
K-RAS Mutation Detection Kit (DsX, Manchester, UK) detects seven key mutations in the K-RAS gene.
The Agencourt AMPure PCR Purification System (Beckman Coulter, Inc., Fullerton, CA) has been validated for target preparation with the Genome-Wide Human SNP Array 5.0 by Affymetrix, Inc. (Santa Clara, CA). The SNP Array 5.
CAS HT Tube Formation Kit facilitates detection of inducers and inhibitors of endothelial cell tube formation.
DNA Analysis BeadChip HumanCNV370-Duo is a microarray that targets novel regions of the genome that show copy number variation (CNV). Copy number variations can occur when a region within a chromosome or an entire chromosome is randomly amplified or deleted.
Two kits are available from Beckman Coulter, Inc. for multiplexed, quantitative gene expression analysis on the GenomeLab GeXP Genetic Analysis System. The Human Breast Cancer Plex and Human Metastasis Plex kits assay multiple genes from a single RNA sample.
The NanoArrayer bench-top ultramicro- and nanoscale fluid delivery system is a multifaceted
Chemotaxis slide allows the motion tracking of slow migrating cells like chemotactic active cancer cells in gradients. Up until now, comparable cell-based assays have only allowed the tracking of fast migrating cells such as neutrophiles or dictiostelia.
TissueScan is an RT-PCR based system for fast and accurate gene expression profiling across a large number of cancer patient samples. High-quality cDNAs were prepared from 48 well-documented cancer biopsy samples, normalized and assembled into ready-to-use gene expression panels.
DNA methylation markers are a new and important class of biomarkers that are significant because of their correlation to gene activity. High levels of cytosine methylation in genomic regions (CpG islands) are often associated with decreased or completely inhibited gene expression.
ArrayAssist Copy Number Software (Stratagene Corp.) enables manipulation and analysis of the massive data sets generated by chromosomal copy number microarrays. All ArrayAssist applications offer GeneChip-compatible status with the Affymetrix platform.
The PALM MicroBeam laser microdissection system provides for non-contact (contamination-free) isolation of homogeneous specimens from tissue or the acquisition of living cells, which facilitates the molecular analysis of DNA, RNA and proteins.
A flexible, high-throughput DNA methylation profiling technology has been introduced that is capable of surveying up to 1,536 methylation sites across 96 samples simultaneously. Illumina Inc.
A diverse selection of cyclin-dependent kinase (CDK) inhibitors is available from Axxora. The family of inhibitors consists of over 35 reagents, including selective inhibitors for CDK-1, CDK-2, CDK-4, CDK-5, and GSK-3B as well as other enzymes.