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Scientists Report 'Squishy' Cells in Cancer Research

April 26, 2013 1:18 pm | by Arizona State University | News | Comments

A team of student researchers and their professors from 20 laboratories around the country are seeing a new view of cancer cells. The work could shed light on the transforming physical properties of these cells as they metastasize. Metastasis is a critical step in the progression of cancer– a period when the cancer spreads from one organ, or part, to another.

Coffee, with Pill, Reduces Breast Cancer Recurrence

April 25, 2013 11:03 am | News | Comments

Drinking coffee could decrease the risk of breast cancer recurring in patients taking the widely used drug Tamoxifen, a study has found. Patients who took the pill, along with two or more cups of coffee daily, reported less than half the rate of cancer recurrence.

Video Reveals How Drugs Kill Cancer

April 25, 2013 10:14 am | News | Comments

Scientists have discovered why a particular cancer drug is so effective at killing cells. Their findings could be used to aid the design of future cancer treatments. Using high-powered laser-based microscopes, researchers made videos of the process by which rituximab binds to a diseased cell and then attracts white blood cells known as natural killer (NK) cells to attack.

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Tiny, Untethered Surgical Tools Aid Biopsies

April 24, 2013 11:30 am | News | Comments

By using swarms of untethered grippers, each as small as a speck of dust, engineers and physicians say they have devised a new way to perform biopsies that could provide a more effective way to access narrow conduits in the body as well as find early signs of cancer or other diseases.

Breast Cancer Drug Enhanced for Aggressive Types

April 24, 2013 11:15 am | News | Comments

Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease. Now, a team of researchers has shown how to exploit tamoxifen’s secondary activities so that it might work on more aggressive breast cancer.

Small Molecule Destroys Potentially Dangerous Cells

April 23, 2013 12:52 pm | News | Comments

Pluripotent stem cells can turn, or differentiate, into any cell type in the body, such as nerve, muscle or bone, but inevitably some of these stem cells fail to differentiate and end up mixed in with their newly differentiated daughter cells.

Listeria Bacteria Targets Pancreatic Cancer

April 22, 2013 4:00 pm | by Einstein | News | Comments

Researchers have developed a therapy for pancreatic cancer that uses Listeria bacteria to selectively infect tumor cells and deliver radioisotopes into them. The experimental treatment dramatically decreased the number of metastases (cancers that have spread to other parts of the body) in a mouse model of highly aggressive pancreatic cancer without harming healthy tissue.

Gene Expression Data Yields Significant Tumor Breakthroughs

April 22, 2013 12:48 pm | News | Comments

A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer. The analysis also identified hundreds of potential drug targets that could cut off a tumor’s fuel supply or interfere with its ability to synthesize essential building blocks.

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Standing Room Only for Big Data

April 19, 2013 11:46 am | by Cynthia Fox | Articles | Comments

The popularity of Big Data projects was highly evident at the April 6-10 American Association of Cancer Research (AACR) meeting, whose theme was “personalizing cancer care through discovery science.” Session after session featuring TCGA was Standing Room Only (SRO). Washington Convention Center attendants struggled to keep up.

Study Reveals How Enzymes ‘Walk’ on DNA

April 19, 2013 11:44 am | News | Comments

Scientists have revealed how a bacterial enzyme has evolved an energy-efficient method to move long distances along DNA. The findings present further insight into the coupling of chemical and mechanical energy by a class of enzymes called helicases, a widely-distributed group of proteins, which in human cells are implicated in some cancers.

Cancer-causing DNA Breakdowns Explored

April 18, 2013 11:46 am | News | Comments

New research has thrown light on the way breakdowns in the DNA copying process inside cells can contribute to cancer and other diseases. A team of researchers discovered that the protein machines that copy DNA in a model organism pause frequently during this copying process, creating the potential for dangerous mutations to develop.

Researchers Test Caffeine's Effect on Cancer

April 18, 2013 11:04 am | News | Comments

Researchers are abuzz after using fruit flies to find new ways of taking advantage of caffeine’s lethal effects on cancer cells—results that could one day be used to advance cancer therapies for people. Previous research has established that caffeine interferes with processes in cancer cells that control DNA repair, a finding that has generated interest in using the stimulant as a chemotherapy treatment.

Molecule Treats Leukemia by Blocking DNA Repair

April 17, 2013 10:44 am | News | Comments

Researchers have identified a molecule that prevents repair of some cancer cells, providing a potential new "genetic chemotherapy" approach to cancer treatment that could significantly reduce side effects and the development of treatment resistance compared with traditional chemotherapy.

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3 Cancer Scientists Awarded $500K NY Medical Prize

April 16, 2013 11:31 am | by The Associated Press | News | Comments

Three scientists at universities in Pennsylvania, Illinois and Oregon whose research has helped transform cancer treatment will share one of the richest prizes in medicine and biomedical research. Dr. Peter Nowell of the University of Pennsylvania, Dr. Janet Rowley of the University of Chicago...

Breast Cancer Treatment Improved by Nanodiamonds

April 16, 2013 10:55 am | News | Comments

Recently, doctors have begun to categorize breast cancers into four main groups according to the genetic makeup of the cancer cells. Which category a cancer falls into generally determines the best method of treatment. But cancers in one of the four groups— called "basal-like" or "triple-negative" breast cancer (TNBC)— have been particularly tricky to treat because they usually don't respond to the "receptor-targeted" treatments.

Melanoma-prone Fish Get DNA Decoded

April 16, 2013 10:37 am | News | Comments

Scientists have decoded the genome of the platyfish, a cousin of the guppy and a popular choice for home aquariums. Among scientists, the fish are meticulously studied for their tendency to develop melanoma and for other attributes more common to mammals, like courting prospective mates and giving birth to live young.

New Type of Bowel Cancer Discovered

April 15, 2013 11:41 am | News | Comments

A unique sub-type of bowel cancer has been discovered which has a worse outcome than other types of colon cancer and is resistant to certain targeted treatments, according to new research. Researchers analyzed tumors from 90 separate patients with stage II colon cancer and found that they could group the samples into three distinct sub-types.

Next-gen Sequencing Finds Brain Tumor Mutations

April 15, 2013 11:02 am | News | Comments

Researchers have identified mutations responsible for more than half of a subtype of childhood brain tumor that takes a high toll on patients. Researchers also found evidence the tumors are susceptible to drugs already in development. The study focused on a family of brain tumors known as low-grade gliomas (LGGs).

3-D Structure of Telomerase Enzyme Mapped

April 12, 2013 10:58 am | News | Comments

Like finally seeing all the gears of a watch and how they work together, researchers have, for the first time ever, solved the puzzle of how the various components of an entire telomerase enzyme complex fit together and function in a three-dimensional structure.

‘Protein Switch’ Can Pinpoint Cancer’s Key Players

April 11, 2013 10:28 am | News | Comments

Researchers have “rationally rewired” some of the cell’s smallest components to create proteins that can be switched on or off by command. These “protein switches” can be used to interrogate the inner workings of each cell, helping scientists uncover the molecular mechanisms of human health and disease.

New Brain Cancer Treatment is More Effective, Less Toxic

April 9, 2013 10:00 am | News | Comments

A Phase 2 clinical trial, described this week in the Journal of Clinical Oncology, tested a new protocol for treating a relatively rare form of brain cancer, primary CNS lymphoma, that may change the standard of care for this disease, according to doctors who led the research.

Engineered T Cells Kill Tumors, Spare Normal Tissue

April 8, 2013 11:09 am | News | Comments

The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs. Tumor antigens, unique proteins on the surface of a tumor, are potential targets for a normal immune response against cancer.

Revealing How Melanoma Evades Chemotherapy

April 8, 2013 9:40 am | News | Comments

Nitric oxide (NO), a gas with many biological functions in healthy cells, can also help some cancer cells survive chemotherapy. A new study reveals one way in which this resistance may arise, and raises the possibility of weakening cancer cells by cutting off their supply of NO.

Breakthrough Cancer-killing Treatment Has No Side-Effects

April 4, 2013 11:53 am | News | Comments

Cancer painfully ends more than 500,000 lives in the United States each year, according to the Centers for Disease Control and Prevention. The scientific crusade against cancer recently achieved a victory.

Lung Cancer Has Genetic Vulerability

April 4, 2013 11:21 am | News | Comments

Physician-researchers have identified a vulnerability of certain lung cancer cells– a specific genetic weakness that can be exploited for new therapies.

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