Researchers have completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutations not previously found in cervical cancer, including at least one for which targeted treatments have been approved for other forms of cancer.
Cancer investigators have genetically engineered a new mouse that mimics a common form of leukemia in humans. Studying the model could lead to new understanding of the disease, they say.
New research has shown that cells demonstrate remarkable flexibility and versatility when it comes to how they divide– a finding with potential links to the underlying causes of many cancers.
In the study, published online in Cell Reports, scientists found that inhibiting the action of a protein called BRD4 caused cancer cells to die in a mouse model of malignant peripheral nerve sheath tumors (MPNSTs). Learn more...
Biologists at The Johns Hopkins University have discovered that low oxygen conditions, which often persist inside tumors, are sufficient to initiate a molecular chain of events that transforms breast cancer cells from being rigid and stationery to mobile and invasive.
Scientists have obtained the first detailed molecular structure of a member of the Tet family of enzymes. The finding is important for the field of epigenetics because Tet enzymes chemically modify DNA, changing signposts that tell the cell's machinery "this gene is shut off" into other signs that say "ready for a change."
Researchers from the Boston area, Mexico and Norway have completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutations not previously found in cervical cancer, including at least one for which targeted treatments have been approved for other forms of cancer.
Researchers at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have discovered a mechanism by which certain adult stem cells suppress their ability to initiate skin cancer during their dormant phase—an understanding that could be exploited for better cancer-prevention strategies. Learn more...
Researchers have discovered a cause of aging in mammals that may be reversible. The essence of this finding is a series of molecular events that enable communication inside cells between the nucleus and mitochondria.
Researchers have identified how the ‘wall’ around cancer tumors functions and how to break it down, enabling the body’s own defenses to reach and kill the cancer cells within.
Metabolism was lost in the shadows of cancer research for decades but has recently been reclaiming some of the spotlight. Now, research has shown that aerobic glycolysis is not the consequence of the cancerous activity of malignant cells but is itself a cancerous event.
The insidious beauty of cancer is that it disguises itself as normal cells fooling the immune system until it can grow into proportions that are unmanageable or untreatable. Researchers have thought if they could help the immune system identify and fight cancer cells they could improve the patient’s prognosis.
Dr. Janet Rowley, a pioneer in cancer genetics research, has died at age 88. Rowley spent most of her career at the University of Chicago, where she also obtained her medical degree.
A new study shows that ALK and ROS1 gene rearrangements known to drive subsets of lung cancer are also present in some colorectal cancers.
For some cancer patients, the mental fogginess that develops with chemotherapy lingers long after treatment ends. Now, research in breast cancer patients may offer an explanation.
A controversial oil and natural gas drilling technique called hydraulic fracturing, or fracking, uses many chemicals that can disrupt the body’s hormones, according to new research.
A novel way to speed the testing of cancer drugs and quickly separate winners from duds has yielded its first big result: an experimental medicine that shows promise against a hard-to-treat form of breast cancer.
Exercise might help women beat breast cancer. Researchers found it can ease the achy joints and muscle pain that lead many patients to quit taking medicines that treat the disease and lower the risk of a recurrence.
Scientists have identified a unique class of breast cancer cells that lead the process of invasion into surrounding tissues, the first step in the deadly process of cancer metastasis, and have found a way to stop that invasion process in mice.
A statistical analysis using the natural and orthogonal interaction (NOIA) model may be a better way to analyze the genetic causes of cutaneous melanoma (CM), according to a new study.
A new finding by scientists has identified key steps that trigger the disintegration of cellular regulation that leads to cancer.
Tens of thousands of women each year might be able to skip at least some of the grueling treatments for breast cancer— which can include surgery, heavy chemo and radiation— without greatly harming their odds of survival, new research suggests.
A simple blood test will soon be able to catch the vast majority of a group of chronic blood cancers, a new study reveals. The scientists also identified a new gene, CALR, which is altered in 40 percent of blood disorders.
Scientists have devised the first method to measure the push and pull of cells as embryonic tissue develops. The cells’ tiny forces are measured in 3-D tissues and living embryos.