Immune cells undergo ‘spontaneous’ changes on a daily basis that could lead to cancers if not for the diligent surveillance of our immune system, scientists have found. The research team from the Walter and Eliza Hall Institute found that the immune system was responsible for eliminating potentially cancerous immune B cells in their early stages, before they developed into B-cell lymphomas (also known as non-Hodgkin’s lymphomas).
In one of the first studies to show a significant association between BPA and cancer development, University of Michigan School of Public Health researchers have found liver tumors in mice exposed to the chemical via their mothers during gestation and nursing.
Antioxidant vitamins are assumed to be cancer fighters, although research in smokers found high doses may raise their risk of tumors. A new study may help explain the paradox. Scientists gave antioxidants to mice that had early-stage lung cancer, and watched the tumors multiply and found that the animals died twice as fast as untreated mice. The reason: The extra vitamins apparently blocked one of the body's key cancer-fighting mechanisms.
One of every 10 clinical trials for adults with cancer ends prematurely because researchers can't get enough people to test new treatments, scientists report. The surprisingly high rate reveals not just the scope and cost of wasted opportunities that deprive patients of potential advances, but also the extent of barriers such as money, logistics, and even the mistaken fear that people won't get the best care if they join these experiments.
A team of researchers at the University of Toronto has discovered a method of assembling “building blocks” of gold nanoparticles as the vehicle to deliver cancer medications or cancer-identifying markers directly into cancerous tumors.
New work from Rice University researchers shows promise for zeroing in on cancer’s core decision network that cancer cells use to decide when to metastasize and invade other parts of the body. This could help in waging ‘a cyber war on cancer.’
A study across many cancer types reveals that the universe of cancer mutations is much bigger than previously thought. By analyzing the genomes of thousands of patients’ tumors, a Broad Institute-led research team has discovered many new cancer genes — expanding the list of known genes tied to these cancers by 25 percent.
Cold Spring Harbor Laboratory (CSHL) scientists have developed a new method to rapidly create much better mouse models for metastatic prostate cancer. This discovery allows scientists to investigate the causes of the disease while at the same time testing new therapeutics to treat it.
Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease.
Dana-Farber Cancer Institute scientists have developed a mathematical model to predict how a patient’s tumor is likely to behave and which of several possible treatments is most likely to be effective. Researchers combined several types of data from pre- and post-treatment biopsies of breast tumors to obtain a molecular picture of how the cancer evolved as a result of chemotherapy.
Cancer cells have something that every prisoner longs for— a master key that allows them to escape. A study describes how a protein that promotes tumor growth also enables cancer cells to use this key and metastasize.
New findings from the team of Claudine Kraft at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna give insights into how cells dispose of their waste. Malfunctions in this process have been linked to Alzheimer’s disease and cancer.
Biotech drugmaker Amgen and Illumina, a maker of genetic testing equipment, said Wednesday they are developing a test that will identify patients who might be helped by Amgen's colon cancer drug Vectibix. Vectibix is approved as a treatment for colorectal cancer that has spread and hasn't rresponded to chemotherapy.
Immunotherapy—the art and science of training peoples’ immune systems to fight their own cancers—was named Breakthrough of the Year by Science. Prominently mentioned was an approach seeing clinical success: genetically tweaking patients’ own T cells to make them more potent, proliferative, and targeted.
Breast cancer stem cells exist in two different states and each state plays a role in how cancer spreads, according to an international collaboration of researchers. Their finding sheds new light on the process that makes cancer a deadly disease.
A new study suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par-4, another potent tumor suppressor protein that induces cell death in cancer cells.
Researchers have revealed a new, powerful technique to visualize the shape and motion of RNA at the atomic level using nuclear magnetic resonance spectroscopy (NMR).
Artificial bone marrow may be used to reproduce hematopoietic stem cells. A prototype has now been developed by scientists. The porous structure possesses essential properties of natural bone marrow and can be used for the reproduction of stem cells at the laboratory.
Researchers have discovered a promising strategy for treating cancers that are caused by one of the most common cancer-causing changes in cells.
A cancer-research team has identified a protein that may be a major culprit when breast cancer metastasizes to the brain. The cancer’s spread to the brain is often undetected until patients start to develop symptoms such as seizures, headaches, and trouble thinking.
By attaching a cancer-killer protein to white blood cells, biomedical engineers have demonstrated the annihilation of metastasizing cancer cells traveling throughout the bloodstream.
Researchers have completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutations not previously found in cervical cancer, including at least one for which targeted treatments have been approved for other forms of cancer.
Cancer investigators have genetically engineered a new mouse that mimics a common form of leukemia in humans. Studying the model could lead to new understanding of the disease, they say.
New research has shown that cells demonstrate remarkable flexibility and versatility when it comes to how they divide– a finding with potential links to the underlying causes of many cancers.
In the study, published online in Cell Reports, scientists found that inhibiting the action of a protein called BRD4 caused cancer cells to die in a mouse model of malignant peripheral nerve sheath tumors (MPNSTs). Learn more...