At the 61st ASMS conference, Bruker introduced new High-Definition capabilities in proteomics and biomarker research. Patented low-noise Captivespray nanoBooster ionization coupled with high-speed digitization Qq-TOF technology and steered by intelligent acquisition software defines complex samples sharply. The novel High-Definition accurate mass spectrometer, impact HD is the latest innovation in Bruker’s UHR-TOF product line. It opens up enhanced analytical performance levels for all applications where trace analysis from complex, high-background matrices is challenge—such as biomarker research, identification of impurities or residue screening. Thanks to extreme sensitivity broad mass-transfer ion optics and fast 50Gbit/sec sampling technology a dynamic range of 5 orders of magnitude is achieved in one second of LC time. Wide dynamic range at high speed is a prerequisite for high-resolution detection of low-abundance compounds in sharp UHPLC peaks and permits direct quantitation without re-run. The HD performance is directed by intelligent self-optimizing Instant Expertise software. MSMS acquisition parameters are dynamically adapted precisely to the incident sample, independent of sample amount or complexity, translating directly into higher productivity and expert-caliber results first time. Bruker also introduced the CaptiveSpray nanoBooster, which complements all Bruker LCMS instruments for new performance levels in proteomics and glycoanalysis. The new version of Bruker’s CaptiveSpray source employs a novel dopant-enriched gas ionization environment to boost sensitivity, enhance charge state and reduce background noise to drive up protein ID rates. The ability to engineer enhanced charge state is especially beneficial on Bruker’s amazon ETD ion trap in the structural analysis of glycopeptides by ETD.
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