The Waters SYNAPT MS, a quadrupole orthogonal acceleration, time-of-flight mass spectrometry platform, combines the companyâ€™s ACQUITY UltraPerformance LC (UPLC)separations, Exact Mass MSE data acquisition, and MassLynx Informatics to generate comprehensive data from complex biological samples. The platform provides an upgrade pathway to the SYNAPT High Definition MS (HDMS) system, which enables analysis of samples differentiated by size, shape and charge, as well as mass. Biomedical applications include proteomics, metabonomic profiling, biomarker discovery/validation and pharmaceutical R&D. The MALDI-enabled system enables researchers to perform MALDI imaging studies, primarily to determine the spatial localization of drugs, metabolites and peptides in biological tissues with high specificity and sensitivity. Patented TriWave technology, used in the HDMS systems, combines ion mobility-based measurements and separations with high-performance quadrupole, time-of-flight mass spectrometry.