The BioSpectrum 800 Imaging System is a fully motorized and automated light-tight darkroom with 8.3 mega-pixel image capture capability. Fast capture time capability combines with SameSpots Analysis Software (Nonlinear Dynamics) to accelerate and simplify workflow. The system accommodates a variety of gel sizes. Together, the instrument and software provide the ability to analyse enough replicates for true statistical power in only a matter of hours. Running enough replicates is key to generating robust and reliable data from proteomics research.