LTQ Orbitrap Discovery and LTQ Orbitrap XL mass spectrometers are offered for pharmaceutical, metabolomic, proteomics and biomarker discovery research. The LTQ Orbitrap Discovery is suited for general proteomics and metabolism applications, offering an alternative to Q-TOF systems. The hybrid LC-MS system achieves high-throughput, label-free profiling for differential expression while MSn capability makes the instrument useful in small molecule characterization and structural elucidation. The system provides up to 30K resolution power and a scan rate that enables separation of trace level, isobaric analytes. The Orbitrap XL features sensitivity in MS and MSn, rapid scan rate, high mass accuracy and up to 100K resolution power. The HCD octapole collision cell provides flexibility in MS/MS fragmentation applications including iTRAQ-based peptide quantitation, PTM analysis, de novo sequencing and metabolomics research. This proteomics platform is also compatible with, and upgradeable to use the Electron Transfer Dissociation (ETD) option for controlled dissociation of peptides and proteins.