Genome of Intestinal Disease Bacteria to be Sequenced

Wed, 01/22/2014 - 8:30am
Scientists in the Center for Genomic Research will decode and analyze the 510 archived isolates of Campylobacter from earlier collections of human feces. (Source: University of Liverpool)The University of Liverpool is set to decipher the genomes of the U.K.’s main bacterial cause of food poisoning which results in over 21,000 hospital admissions and 100 deaths each year.
Using the latest whole genome sequencing technologies available at the University’s Centre for Genomic Research, scientists will decode and analyze the 510 archived isolates of Campylobacter from earlier collections of human feces.
Campylobacter is widely recognized as the main bacterial cause of foodborne infections leading to diarrhea, and in 2010 was responsible for an estimated 21,300 hospital admissions and 100 deaths in the UK, at a cost of approximately 784 million pounds.
The new project is funded by the Food Standards Agency and, when it concludes in February 2015, scientists will have a greater understanding of sources and transmission routes associated with human Campylobacter. The Agency will then be able to use these results to directly benefit the public health benefits.
The bacterial isolates used in this study were obtained from fecal samples from thousands of people with symptoms of diarrhea and vomiting during two separate time periods (1993 to 1996 and 2008 to 2009).
The research will give scientists key information about the make-up of the U.K. Campylobacter population and will also link to other research at the University examining Campylobacter found in poultry and the general environment.
Professor of microbiology, Craig Winstanley, from the University’s Institute of Infection and Global Health is leading the project. He said: “Campylobacter causes misery for thousands of people in the U.K. every year.  The research will give us a much better idea of precisely how the bacteria get into humans and how this might be prevented.
“Working with the Food Standards Agency means that this work can then be turned into concrete public health benefits.”



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