HTRF Assays For cGMP, PGE2 And Cortisol

Tue, 10/10/2006 - 10:47am

Related to important targets in the fields of inflammation and metabolic diseases, the assays for cGMP, PGE2, and cortisol integrate proprietary d2 acceptor dye, optimizing assay robustness, performance, and stability. The first assay is designed for the quantification of cGMP (Cyclic Guanosine 3’, 5’-cyclic monophosphate), addressing the needs of screening targets such as guanylyl cyclases or a number of cGMP-regulated phosphodiesterases (PDEs); the second quantifies PGE2 (Prostaglandin E2), an essential inflammation mediator, either in cell supernatants or directly in the presence of whole cells; the third assay enables rapid and accurate cortisol measurement, even in complex samples such as liver microsomes, whole cells, and animal serum.


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